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A Clinical Observation of Functional Abdominal Pain Syndrome in Patients Treated by Traditional Chinese Spinal Orthopedic Manipulation

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Chinese Journal of Integrative Medicine 2018年第2期24卷 140-146页

作者： QU Liu-xin xing Li-yang Wanda Norman chen Hong LI Ming-ju GAO Song LI Ping Department of Chinese Orthopedics and Traumatology Zhongda Hospital School of Medicine Southeast UniversityNanjing 210009 China Department of Acupuncture and Moxibustion Zhongda Hospital School of Medicine Southeast University Nanjing 210009 China Acupuncturist at Gateway Sports Medicine Portland OR 97216 USA Department of Gastroenterology Zhongda Hospital School of Medicine Southeast University Naniina 210009. China

Objective： To evaluate the clinical effect of traditional Chinese spinal orthopedic manipulation（TCSOM） in treating patients with functional abdominal pain syndrome（FAPS） in comparison with Pinaverium Bromide（Dicetel, PBD）, and to assess a possible cause for FAPS. Methods： Eighty patients with FAPS were randomly and equally assigned to the TCSOM group and PBD group according to the random number table. All patients in the TCSOM group were treated with a maximum of 5 times of spinal manipulations. Patients in the PBD group were instructed to take 50 mg 3 times a day, consistently for 2 weeks. The symptoms of pre-and post-treatment were assessed on a visual analog scale（VAS） pain score. A symptom improvement rating（SIR） was implemented to evaluate the effects of the treatments. Results： The symptoms of 27 cases of the TCSOM group were relieved soon after the first TCSOM treatment and 9 cases were significantly improved. The VAS pain scores in the TCSOM group were significantly lower than those in the PBD group after 2 weeks treatment. According to the SIR based on VAS, the TCSOM group included 30 cases with excellent results, 7 cases with good, and 3 cases with poor. Adverse events to the treatment were not reported. Based on VAS, the PBD group reported 8 cases with excellent results, 10 cases with good and 22 cases with poor. There was a significant difference between the two groups（P〈0.01）. Conclusions： The displacement of intervertebral discs and/or vertebra in the thoracic or lumbar region seems to be a contributing factor in the symptoms of FAPS. TCSOM is an effective treatment for FAPS.

关键词： functional abdominal pain syndrome spinal manipulation orthopedic Jiaji(EX-B2) Back-Shu acupoints visual analog scale

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Biomedical Applications of MXenes:From Nanomedicine to Biomaterials

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Accounts of Materials Research 2022年第8期3卷 785-798页

作者： Liang chen Xinyue Dai Wei Feng yu chen Materdicine Lab School of Life SciencesShanghai UniversityShanghai 200444P.R.China School of Medicine Shanghai UniversityShanghai 200444P.R.China

CONSPECTUS:The rise of two-dimensional(2D)materials has led to significant interest in their potential applications for nanomedicine and biomaterials in the hope that they can overcome some intrinsic limitations of conventional theranostic ***,an emerging family of 2D materials mainly made of transition metal carbides/nitrides,have drawn substantial interest in biomedical applications because of their unique physicochemical *** remarkable photothermal energy-converting capability of MXenes allows photonic hyperthermia treatment in the second near-infrared biowindow with deep tissue *** diverse choice of metal elements in MXenes endows them with the aptitudes to act as contrast agents for computed tomography and magnetic resonance *** the understanding of pathological characteristics is improved,the desirable properties and performances of nanomedicine and biomaterials have become more comprehensive,which is unlikely to be accomplished with the formulation of MXenes *** this Account,we highlight recent progress in the biomedical applications of 2D MXenes ranging from nanomedicine and *** will start by introducing major synthetic techniques for fabricating MXenes with ultrathin 2D structures and nanoscale sizes for biomedical *** then elaborate how MXenes differ from other 2D materials,showing exclusive potential in biomedical *** diverse surface compositions allow the tuning of the bandgap and surface plasmon resonance effect,which is essential for nanodynamic *** transition metal elements in MXenes could render them with enzymatic activities for nanocatalytic *** also possess favorable biodegradability and biocompatibility,facilitating the potential clinical ***,the intrinsic properties of MXenes might be insufficient to fulfill some specific requirements in advanced biomedical *** instance,the therapeutic efficiency of MXenes alone would

关键词： impaired biomaterials alone

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Impact of preoperative carbohydrate loading on gastric volume in patients with type 2 diabetes

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World Journal of Clinical Cases 2022年第18期10卷 6082-6090页

作者： Xin-Qiang Lin yu-Ren chen Xiao chen yu-Ping Cai Jian-Xin Lin De-Ming Xu Xiao-Chun Zheng Department of Anesthesiology Affiliated Hospital of Putian CollegePutian Maternity and Child Care HospitalPutian 351100Fujian ProvinceChina Department of Anesthesiology Affiliated Hospital of Putian CollegePutian 351100Fujian ProvinceChina Department of Anesthesiology Shenli Clinical Medical College of Fujian Medical UniversityFujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

BACKGROUND Enhanced recovery after surgery advocates that consuming carbohydrates two hours before anesthesia is beneficial to the patient’s *** with diabetes are prone to delayed gastric *** guidelines for preoperative carbohydrate consumption in patients with diabetes remain controversial due to concerns about the risk of regurgitation,aspiration and *** gastric volume(GV)assessment and blood glucose monitoring can comprehensively evaluate the safety and feasibility of preoperative carbohydrate intake in type 2 diabetes(T2 D)*** To evaluate the impact of preoperative carbohydrate loading on GV before anesthesia induction in T2 D *** Patients with T2 D receiving surgery under general anesthesia from December 2019 to December 2020 were included.A total of 78 patients were randomly allocated to 4 groups receiving 0,100,200,or 300 m L of carbohydrate loading 2 h before anesthesia *** volume per unit weight(GV/W),Perlas grade,changes in blood glucose level,and risk of reflux and aspiration were evaluated before anesthesia *** No significant difference was found in GV/W among the groups before anesthesia induction(P>0.05).The number of patients with Perlas grade II and GV/W>1.5 m L/kg did not differ among the groups(P>0.05).Blood glucose level increased by>2 mmol/L in patients receiving 300 m L carbohydrate drink,which was significantly higher than that in groups 1 and 2(P<0.05).CONCLUSION Preoperative carbohydrate loading<300 m L 2 h before induction of anesthesia in patients with T2 D did not affect GV or increase the risk of reflux and *** glucose levels did not change significantly with preoperative carbohydrate loading of<200 m ***,300 m L carbohydrate loading may increase blood glucose levels in patients with T2 D before induction of anesthesia.

关键词： Type 2 diabetes Preoperative Carbohydrate loading Gastric volume Ultrasound assessment Hyperglycemia

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IMPULP:A Hardware Approach for In-Process Memory Protection via User-Level Partitioning

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Journal of Computer Science & Technology 2020年第2期35卷 418-432页

作者： Yang-Yang Zhao Ming-yu chen yu-Hang Liu Zong-Hao Yang Xiao-Jing Zhu Zong-Hui Hong yun-Ge Guo State Key Laboratory of Computer Architecture Institute of Computing TechnologyChinese Academy of Sciences Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China Peng cheng Laboratory Shenzhen 518055China

In recent years many security attacks occur when malicious codes abuse in-process memory *** to the increasing complexity,an application program may call third-party code which cannot be controlled by programmers but may contain security *** a result,the users have the risk of suffering information leakage and control flow ***,current solutions like Intel memory protection extensions(MPX)severely degrade performance,while other approaches like Intel memory protection keys(MPK)lack flexibility in dividing security *** this paper,we propose IMPULP,an effective and efficient hardware approach for in-process memory *** rationale of IMPULP is user-level partitioning that user code segments are divided into different security domains according to their instruction addresses,and accessible memory spaces are specified dynamically for each domain via a set of boundary *** instruction related to memory access will be checked according to its security domain and the corresponding boundaries,and illegal in-process memory access of untrusted code segments will be *** can be leveraged to prevent a wide range of in-process memory abuse attacks,such as buffer overflows and memory *** verification,an FPGA prototype based on RISC-V instruction set architecture has been *** present eight tests to verify the effectiveness of IMPULP,including five memory protection function tests,a test to defense typical buffer overflow,a test to defense famous memory leakage attack named Heartbleed,and a test for security *** execute the SPEC CPU2006 benchmark programs to evaluate the efficiency of *** performance overhead of IMPULP is less than 0.2%runtime on average,which is ***,the resource overhead is less than 5.5%for hardware modification of IMPULP.

关键词： in-process isolation memory protection out-of-bounds user-level partitioning

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Social–financial approach for analyzing financial transitions

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Financial Innovation 2023年第1期9卷 2228-2250页

作者： Xifeng Wu yue Shen Jin chen yu chen SCS Lab Department of Human and Engineered EnvironmentGraduate School of Frontier SciencesThe University of TokyoChiba 277‑8563Japan School of Economics and Management Tsinghua UniversityBeijing 100084China

This study proposes a social-financial approach(SFA)to fill the methodological research gap in strategic policy design for managing financial transitions during social *** SFA seeks to characterize inclusive transitions in response to innovation and analyze financial management in social *** a multilevel perspective,we combine evolutionary finance and inclusive growth analytics into this *** contend that the interaction between the different levels can be summarized as spontaneous adjustments and the alignment of financial elements with the *** who attempt to achieve their goals based on past performance evaluations and other forms of bounded rationality strive to cope with adjustments and further trigger a reorientation of the existing *** also developed a new configuration tool called the three-axis description to describe the evolution of financial transitions at different *** methods allow us to analyze the evolution of financial transition and efficiency,and we argue that market efficiency evolves in stages with the finan-cial ***,to demonstrate the capability of SFA to identify diverse financial transition pathways,we examined an example case:the establishment of the Bretton Woods System.

关键词： Social financial approach Financial transition Evolutionary finance Multilevel perspective Three-axis description Market efficiency

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Microstructural,crystallographic,and mechanical characteristics in Ni-Mn-Ga alloys directionally solidified under a transverse magnetic field

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Journal of Materials Science & Technology 2023年第11期142卷 10-21页

作者： Xi Li Long Hou Siyuan Yang Ting Zhou yue Wang xing yu Zongbin Li Daoyong Cong Yves Fautrelle Zhongming Ren Yanyan Zhu Shanghai Key Lab of Advanced High-Temperature Materials and Precision Forming Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Advanced Special Steels Shanghai UniversityShanghai 200072China Key Laboratory for Anisotropy and Texture of Materials Northeastern UniversityShenyang 110819China Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083China EPM-Madylam ENSHMG BPSt Martin d’Heres 38402 CEDEXFrance

In this study,the effect of transverse magnetic field-assisted directional solidification(MFADS)on the microstructures in Ni-Mn-Ga alloys has been *** results show that the magnetic field is capable of inducing transversal macrosegregation perpendicular to the magnetic field,causing the emergence of martensite clusters in the austenite ***,the magnetic field alleviates the microseg-regation on a dendritic scale and promotes the preferred growth of austenite *** the basis of the above investigation,several special samples are designed using the MFADS to study the crystallographic evolution and mechanical behavior during thermal/stress-induced martensite *** martensite cluster in the austenite matrix is used to investigate the martensite transformation and growth under cooling-heating *** crystallographic relationship and phase boundary microstructure between martensite and austenite have been *** addition,the microsegregation on a dendritic scale can significantly influence the martensite variant distribution,corresponding to the performance during compressive circles based on the analysis of the deformation gradient *** stress-induced superelasticity is closely dependent on orientation,well explained from the perspective of different resolved shear stress factors and correspondence variant pair formation transformation *** crystallographic evolution has been characterized during in-situ stress-induced *** findings not only deepen the understanding of martensite transformation and mechanical behavior under a thermal/stress field in Ni-Mn-Ga alloys but also propose a promising strategy to obtain microstructure-controllable functional alloys by MFADS.

关键词： Magnetic field-assisted directional solidification Segregation Orientation Martensite transformation Superelasticity

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Association of the retinol to all-trans retinoic acid pathway with autism spectrum disorder

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World Journal of Pediatrics 2024年第10期20卷 1043-1058页

作者： yu-Ru Feng Qian Zhang Jing-Kun Miao Ting Yang Jie chen Hong-yu chen Qiu-Hong Mou Xue-Li Xiang Dan Long Qiu-Hong Wei yuan Wu Ting-yu Li Children Nutrition Research Center Chongqing Key Laboratory of Child Neurodevelopmental and Cognitive DisordersMinistry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChildren’s Hospital of Chongqing Medical UniversityNo 1362nd Zhongshan RdYuzhong DistrictChongqingChina Department of Pediatrics Women and Children’Hospital of Chongqing Medical UniversityChongqing Health Center for Women and ChildrenChongqingChina

Background Autism spectrum disorder(ASD)is a complex group of neurodevelopmental *** has highlighted a close association between the retinoic acid(RA)signaling pathway and *** study investigates alterations in the vitamin A(VA,retinol)to RA metabolic pathway in children with ASD and speculates on the underlying reasons for these *** propose a subtype characterized by downregulated RA signaling in ASD,laying the groundwork for precise diagnosis and treatment *** We included 489 children with ASD and 280 typically developing(TD)*** with ASD underwent evaluations of core symptoms and neuro-developmental levels,which were conducted by professional developmental behavior physicians using assessment *** VA and all-trans RA(atRA)levels were determined by high-performance liquid chromatography and ultra-high-performance liquid chromatography–tandem mass *** expression levels and concentrations of enzyme molecules such as retinol dehydrogenase 10 were assessed using quantitative polymerase chain reaction and enzyme-linked immunosorbent *** Children with ASD exhibited reduced serum atRA,accompanied by a downregulation of atRA synthesis *** reduction in serum atRA levels was linked not only to VA levels but also to the aberrant expression of metabolic enzymes responsible for ***,the serum atRA levels in children with ASD were more strongly correlated with core symptoms and neurodevelopmental levels than VA *** Children with ASD exhibited a dual regulation of reduced serum atRA levels,influenced by both VA levels and abnormal expression of atRA metabolic enzymes.

关键词： All-trans retinoic acid Autism spectrum disorder Retinoic acid signaling pathway Vitamin A Vitamin A metabolism

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Risk factors and managements of hemorrhage associated with pancreatic fistula after pancreaticoduodenectomy

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Hepatobiliary & Pancreatic Diseases International 2017年第5期16卷 537-544页

作者： xing Liang Li-Gang Shi Jun Hao An-An Liu Dan-Lei chen Xian-Gui Hu cheng-Hao Shao Department of Pancreatic-biliary Surgery Changzheng Hospital Second Military Medical University Department of Pancreatic Surgery Changhai Hospital Second Military Medical University

BACKGROUND: Post-pancreaticoduodenectomy pancreatic fistula associated hemorrhage (PPFH) is one of the leading lethal complications. Our study was to analyze the risk factors and managements of hemorrhage associated with pancreatic fistula after pancreaticoduodenectomy, and to evaluate treatment options. METHOD: We analyzed 445 patients who underwent pancreaticoduodenectomy or pylorus-preserving pancreaticoduodenectomy and evaluated the relevance between clinical data and PPFH. RESULTS: The incidence of postoperative pancreatic fistula (POPF) was 27.42% (122/445), and the incidence of PPFH was 4.49% (20/445). Among the 20 patients with PPFH, 7 died and 13 were cured. Interventional angiographic therapy was performed for 10 patients and 5 were successfully treated. Relaparotomy was performed for 5 patients and 2 were successfully cured. Univariate logistic regression analysis indicated that several risk factors were related to PPFH: the nature of tumor (carcinoid/low-grade or high-grade malignancy), preoperative day 1. serum prealbumin, preoperative day 1 total bilirubin (TBIL), operative time, blood loss in the operation, operative method (vascular resection and revascularization), postoperative day 3 TBIL, biliary fistula, and the grade of POPF. The multivariate stepwise logistic regression analysis demonstrated that the nature of tumor and the grade of POPF were independently risk factors of PPFH. Receiver operating characteristic curve indicated that preoperative day 1 serum prealbumin level <173 mg/L and postoperative day 3 TBIL ***/L were the risk factors of PPFH. CONCLUSIONS; The risk of PPFH was found to be increased with high potential malignancy and high grade of POPE Angiography-embolization is one of the major and effective therapies for PPFH. Extraluminal-intraluminal PPFH is more serious and needs more aggressive treatments.

关键词： pancreatic neoplasms pancreaticoduodenectomy postoperative pancreatic fistula hemorrhage risk factors

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Multimodal Machine Learning Guides Low Carbon Aeration Strategies in Urban Wastewater Treatment

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Engineering 2024年第5期36卷 51-62页

作者： Hong-cheng Wang yu-Qi Wang Xu Wang Wan-Xin Yin Ting-Chao yu chen-Hao Xue Ai-Jie Wang State Key Laboratory of Urban Water Resource and Environment School of Civil and Environmental EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Key Laboratory of Drinking Water Safety and Distribution Technology of Zhejiang Province College of Civil Engineering and ArchitectureZhejiang UniversityHangzhou 310058China

The potential for reducing greenhouse gas(GHG)emissions and energy consumption in wastewater treatment can be realized through intelligent control,with machine learning(ML)and multimodality emerging as a promising ***,we introduce an ML technique based on multimodal strategies,focusing specifically on intelligent aeration control in wastewater treatment plants(WWTPs).The generalization of the multimodal strategy is demonstrated on eight ML *** results demonstrate that this multimodal strategy significantly enhances model indicators for ML in environmental science and the efficiency of aeration control,exhibiting exceptional performance and *** random forest with visual models achieves the highest accuracy in forecasting aeration quantity in multimodal models,with a mean absolute percentage error of 4.4%and a coefficient of determination of *** testing in a full-scale plant reveals that the multimodal model can reduce operation costs by 19.8%compared to traditional fuzzy control *** potential application of these strategies in critical water science domains is *** foster accessibility and promote widespread adoption,the multimodal ML models are freely available on GitHub,thereby eliminating technical barriers and encouraging the application of artificial intelligence in urban wastewater treatment.

关键词： Wastewater treatment Multimodal machine learning Deep learning Aeration control Interpretable machine learning

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Effect of BaSO_(4) on phase composition and sintering process of iron ore fines

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Journal of Iron and Steel Research International 2022年第3期29卷 408-417页

作者： Jian-tao Ju chen-mei Tang Guang-heng Ji Xiang-dong xing Gui-qing Zhao Xin-tai Jiang Feng-lin Lu School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina Research Center of Metallurgical Engineering and Technology of Shaanxi Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina JISCO Iron and Steel Research Institute Jiayuguan735100ShaanxiChina

Iron ore containing BaSO_(4) may have a series of effects on the quality of the sinter and performance of the blast ***,the effect mechanism of BaSO_(4)(0-6.0 mass%)on the compressive strength,mineral composition,and microstructure of the sinter was *** experimental results show that the compressive strength of the sintered samples initially increases and then decreases when the BaSO_(4) content increases from 0 to 6.0 mass%,reaching a peak value of 12.78 kN with a BaSO_(4) content of 1.0 mass%.Thermal analysis indicates that BaSO_(4) initially decomposes to produce BaO at 1468 K in the presence of iron *** combines with Fe_(2)O_(3) forming barium ferrite(Ba_(2)Fe_(6)O_(11)),which exists in the sintered sample with a granular *** also dissolves in calcium ferrite and slag to promote the formation of calcium ferrite and barium glass,*** content of needle-like calcium ferrite gradually increases and then decreases with the increase in BaSO_(4) *** exists in a plate-like *** generation of dicalcium ferrite is promoted by increasing the BaSO_(4) addition from 2.0 to 6.0 mass%.

关键词： Sinter Barium sulfate Hematite Barium ferrite Mineral structure

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