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Effectiveness of drug interventions in nonalcoholic fatty liver disease:A network meta-analysis

World Journal of Diabetes 2021年第9期12卷 1576-1586页

作者： Yi-Zhou Huang Gang-Yi Yang Cong Wang xing-yu chen Li-Li Zhang Department of Endocrinology The Second Affiliated HospitalChongqing Medical UniversityChongqing 404100China

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a major chronic liver disorder worldwide,and there is no established treatment for this *** conducted a network meta-analysis(NMA)to compare existing treatments,which include four classes of antidiabetic drugs,and examined the optimum treatments for *** To compare the effectiveness of different treatments for *** An NMA was conducted using Stata 14.0(Corporation LLC,College Station,United States)and R(X643.6.3 version)in this *** randomized controlled trials(RCTs)were searched in the PubMed,Cochrane Library,Embase,Medline and Web of Science databases from database inception to April *** researchers independently screened the available studies in strict accordance with inclusion and exclusion *** Cochrane Risk of Bias tool was used to evaluate the risk of bias of the included *** variables with and without dimensional differences were calculated as the standardized mean difference and weighted mean difference,*** inconsistency model and“nodesplitting”technique were used to test for *** plots were used to evaluate publication *** Twenty-two eligible RCTs involving 1377 participants were eventually included in our *** were pooled using a random-effects *** NMA results revealed that glucagon-like peptide-1 receptor agonists(GLP-1RAs)were the most effective treatment,yielding improvements in hepatic fat content(HFC),alanine aminotransferase(ALT),aspartate aminotransferase(AST),serumγ-glutamyl transferase(GGT)and body weight[surface under the cumulative ranking curve(SUCRA)=99.6%,92.6%,82.8%,92.3%and 99.6%,respectively],while thiazolidinediones(TZDs)were the best intervention for reducing the NAFLD activity score(NAS;SUCRA=98.9%).In addition,moderate performance was observed for the sodium glucose cotransporter-2 inhibitors groups(SUCRA=25.1%,66.2%,63.5%,58.2%and 71.9%for HFC,ALT,AST,GGT and body weight,respecti

关键词： Antidiabetic drugs Glucagon-like peptide-1 receptor agonists Nonalcoholic fatty liver disease Network meta-analysis Thiazolidinediones

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Maturity-onset diabetes of the young type 9 or latent autoimmune diabetes in adults:A case report and review of literature

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World Journal of Diabetes 2023年第7期14卷 1137-1145页

作者： Guang-Hong Zhou Min Tao Qing Wang xing-yu chen Jing Liu Li-Li Zhang Department of Endocrinology The Second Affiliated HospitalChongqing Medical UniversityChongqing 400010China

BACKGROUND Maturity-onset diabetes of the young(MODY)is a monogenic genetic disease often clinically misdiagnosed as type 1 or type 2 *** type 9(MODY9)is a rare subtype caused by mutations in the PAX4 ***,there are limited reports on PAX4-MODY,and its clinical characteristics and treatments are still *** this report,we described a Chinese patient with high autoimmune antibodies,hyperglycemia and a site mutation in the PAX4 *** SUMMARY A 42-year-old obese woman suffered diabetes ketoacidosis after consuming substantial amounts of *** had never had diabetes before,and no one in her family had ***,her autoantibody tested positive,and she managed her blood glucose within the normal range for 6 mo through lifestyle ***,her blood glucose gradually ***-generation sequencing and Sanger sequencing were performed on her *** results revealed that she and her mother had a heterozygous mutation in the PAX4 gene(c.314G>A,p.R105H),but her daughter did *** patient is currently taking liraglutide(1.8 mg/d),and her blood glucose levels are under *** cases were retrieved from PubMed to investigate the relationship between PAX4 gene mutations and *** We reported the first case of a PAX4 gene heterozygous mutation site(c.314G>A,p.R105H),which does not appear pathogenic to MODY9 but may facilitate the progression of latent autoimmune diabetes in adults.

关键词： Maturity-onset diabetes of the young PAX4 Latent autoimmune diabetes in adults Type 1 diabetes Case report

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Kondo scattering in underdoped Nd1-xSrxNiO2 infinite-layer superconducting thin films

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National Science Review 2023年第11期10卷 96-102页

作者： Ting-Na Shao Zi-Tao Zhang yu-Jie Qiao Qiang Zhao Hai-Wen Liu Xin-Xiang chen Wei-Min Jiang Chun-Li Yao xing-yu chen Mei-Hui chen Rui-Fen Dou Chang-Min Xiong Guang-Ming Zhang Yi-Feng Yang Jia-Cai Nie Department of Physics Beijing Normal University State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua University Frontier Science Center for Quantum Information Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences School of Physical Sciences University of Chinese Academy of Sciences Songshan Lake Materials Laboratory

The recent discovery of superconductivity in infinite-layer nickelates generates tremendous research endeavors, but the ground state of their parent compounds is still under debate. Here, we report experimental evidence for the dominant role of Kondo scattering in the underdoped Nd1-xSrxNiO2thin films. A resistivity minimum associated with logarithmic temperature dependence in both longitudinal and Hall resistivities are observed in the underdoped Nd1-xSrxNiO2samples before the superconducting transition. At lower temperatures down to 0.04 K, the resistivities become saturated, following the prediction of the Kondo model. A linear scaling behavior σx yAHE～ σx xbetween anomalous Hall conductivity σx yAHEand conductivity σx x is revealed, verifying the dominant Kondo scattering at low temperature. The effect of weak(anti-)localization is found to be secondary. Our experiments can help in clarifying the basic physics in the underdoped Nd1-xSrxNiO2infinite-layer thin films.

关键词： Kondo scattering superconductivity underdoped infinite-layer nickelate thin film

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Pichia pastoris composition expressed aerolysin mutant of Aeromonas veronii as an oral vaccine evaluated in zebrafish(Danio rerio)

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Marine Life Science & Technology 2024年第3期6卷 475-487页

作者： yuan-yuan Yao Qing-Shuang Zhang Shu-Bin Liu Hong-Wei Yang xing-yu chen Ya-Lin Yang chen-chen Gao Chao Ran Tsegay Teame Zhen Zhang Zhi-Gang Zhou Key Laboratory for Feed Biotechnology of the Ministry of Agriculture Institute of Feed Research of Chinese Academy of Agricultural SciencesBeijing 100081China Sino-Norway Fish Gastrointestinal Microbiota Joint Lab Institute of Feed Research of Chinese Academy of Agricultural SciencesBeijing 100081China Institute of Marine Sciences Shantou UniversityShantou 515063China Tigray Agricultural Research Institute(TARI)Mekelle Center Tigray 7101Ethiopia

Vaccines are one of the most practical means to stop the spreading of Aeromonas veronii in *** this study,virulence factor aerolysin mutant NTaer which has lost its hemolytic activity was used as a target *** pastoris constitutive secretory expression NTaer(GS115-NTaer)was used as a potential safe oral vaccine to evaluate its effectiveness on zebrafish *** result shows that vaccination of GS115-NTaer for four weeks did not affect the growth performance of the host,while eliciting an effective immune protective *** with the control group,the GS115-NTaer could significantly up-regulate the relative expression level of the intestinal tight junction protein 1α(TJP1α)gene,and significantly increased the contents of lysozyme(LYZ),complement C3 and C4 in the gut,indicating that the innate immune response of the fish was *** relative gene expression levels of macrophage-expressed gene 1(MPEG1)and T cell receptor(TCR-α)in the gut,and MPEG1,CD4,CD8,TCR-α,GATA3,and T-bet in the spleen were all increased significantly,indicating that the cellular immune response of the fish was ***,the contents of serum IgM and intestinal mucosa IgZ antibodies were significantly increased,which showed that humoral immunity was also ***,inoculation with GS115-NTaer significantly changed the structure of gut *** particular,the relative ratio of(Firmicutes+Fusobacteriota+Bacteroidota)/Proteobacteria was significantly higher than that of the control and GS115 ***,the vaccinated fish were challenged with ***,and the relative percent survival of GS115 and the GS115-NTear groups was 14.28%and 33.43%.This improvement of immunity was not only due to the specific immune response but also attributed to the improvement of innate immunity and the gut microbiota which was demonstrated by the germ-free zebrafish ***,this study provides information on the effectiveness of GS115-NTear

关键词： Aeromonas veronii Aerolysin mutant NTaer Oral vaccine Immune response Gut microbiota

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Short-term effects of cupping and scraping therapy for chronic nonspecific low-back pain:A prospective,multicenter randomized trial

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Journal of Integrative Medicine 2024年第1期22卷 39-45页

作者： Jun-yan He Xiao-yu Tu Zi-fei Yin Hui Mu Ming-jun Luo xing-yu chen Wei-bin Cai Xue Zhao Can Peng Fan-fu Fang Can Lü Bai Li School of Traditional Chinese Medicine Naval Medical UniversityShanghai 200433China Department of Rehabilitation Medicine and Physiotherapy the First Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of Rehabilitation Medicine and Training PLA 458 HospitalGuangzhou 510602Guangdong ProvinceChina No.3 Ward of Acupuncture Rehabilitation Department Guangdong Second Traditional Chinese Medicine HospitalGuangzhou 510095Guangdong ProvinceChina

Background As one of the most common musculoskeletal ailments,chronic nonspecific low-back pain(CNLBP)causes persistent disability and substantial medical *** evidence shows that the incidence rate of CNLBP in young and middle-aged people who are demanded rapidly recovery and social contribution is *** guidelines indicate a reduced role for medicines in the management of *** The present study investigates the short-term effects of cupping and scraping therapy using a medicated balm,compared to nonsteroidal anti-inflammatory drug(NSAID)with a capsaicin plaster,in the treatment of ***,setting,participants and interventions We designed a prospective multicenter randomized clinical trial enrolling patients from January 1,2022 to December 31,2022.A total of 156 patients with CNLBP were randomized into two parallel *** sodium-sustained release tablets were administered orally to participants in the control group for one week while a capsaicin plaster was applied *** in the test group were treated with cupping and scraping using a medical device and medicated *** outcome measures Primary outcome was pain recorded using the visual analogue scale(VAS).Two secondary outcomes were recorded using the Japanese Orthopedic Association low-back pain scale(JOA)and the traditional Chinese medicine(TCM)syndrome integral scale(TCMS)as assessment *** Between baseline and postintervention,all changes in outcome metric scales were statistically significant(P<0.001).Compared to the control group,patients in the test group had a significantly greater treatment effect in all outcome variables,as indicated by lower VAS and TCMS scores and higher JOA scores,after the one-week intervention period(P<0.001).Further,according to the findings of multivariate linear regression analysis,the participants’pain(VAS score)was related to their marital status,age,smoking habits and body mass *** adverse r

关键词： Chronic nonspecific low-back pain Traditional Chinese medicine Cupping and scraping therapy

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Plasma pharmacological study on Da Huang Zhe Chong capsule on platelet aggregation of normal person

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Journal of Central South University of Technology 2005年第Z1期12卷 326-330页

作者： WANG Dong-sheng chen Fang-ping XIAO Chang-jiang HE Shi-lin FU Bin LI Xin CAO xing-yu chen Yan XIE Qin-zhi Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China Department of Traditional Chinese Medicine Xiangya Hospital Central South University Changsha 410008 China

Objective To develop a plasma pharmacological method evaluates the effect of Da Huang Zhe Chong capsule on platelet aggregation and its mechanism, which is a representative Traditional Chinese Medicine Patent Prescription Promoting blood circulation by removing blood stasis. Methods Platelets specimens from healthy volunteers made serum and plasma with medicine, while platelet PRP were separated, which were divided into 8groups,i.e. auto-serum, allo-serum, serum with Da Huang Zhe Chong capsule , serum with aspirin, auto-plasma, plasma with Da Huang Zhe Chong capsule, plasma with aspirin, every group added to serum and plasma to hatch. After ADP and adrenalin were added into the specimens and hatched, the effects of specimens on platelet aggregation were observed. Results After ADP adrenalin were added, all the serum groups did not present platelet aggregation,while all the plasma group presented platelet aggregation. P1, P5, Pmax, t and TM have no significant difference (P＞0. 05) between auto-plasma group and allo-plasma group induced by ADP and adrenalin. P1, P5, t and Pmax have significant differences (P＜0. 01) and TM decreased significantly (P＜0. 05) comparing plasma group with Da Huang Zhe Chong capsule and plasma group of aspirin to allo-plasma group. P1, t and Pmax have significant difference (P＜0.05), and P5 and TM are simulate comparing plasma group with Da Huang Zhe Chong capsule to plasma group of aspirin. P1, P5, t and Pmax have significant differences (P＜0. 01), P1, TM have also significant(P＜0. 05), comparing plasma group of Da Huang Zhe Chong capsule with plasma of aspirin to allo-plasma group induced by adrenalin. P1 ,P5 and Pmax have significant differences (P＜0.05), and t and Pmax are simulate comparing plasma group with Da Huang Zhe Chong capsule with plasma group of aspirin. Conclusion The serum pharmacological study is inappropriate to study platelet aggregation in vitro. The plasma pharmacological study is inappropriate to study platelet aggrega

关键词： Da Huang Zhe Chong capsule plasma pharmacology platelet aggregation

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Modeling differential car-following behavior under normal and rainy conditions: A memory-based deep learning method with attention mechanism

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Chinese Physics B 2023年第6期32卷 187-202页

作者：柏海舰过晨晨丁恒卫立阳孙婷陈星宇 School of Automotive and Transportation Engineering Hefei University of TechnologyHefei 230009China State Key Laboratory of Cognitive Intelligence Hefei 230009China

In order to analyze and learn the difference in car-following behavior between normal and rainy days, we first collect car-following trajectory data of an urban elevated road on normal and rainy days by microwave radar and analyze the differences in speed, relative speed, acceleration, space headway, and time headway among data through statistics. Secondly, owing to the time-series characteristics of car-following data, we use the long short-term memory(LSTM) neural network optimized by attention mechanism(AM) and sparrow search algorithm(SSA) to learn the different car-following behaviors under different weather conditions and build corresponding models(ASL-Normal, ASL-Rain, where ASL stands for AM-SSA-LSTM), respectively. Finally, the simulation test shows that the mean square error(MSE) and reciprocal of time-to-collision(RTTC) of the ASL model are better than those of LSTM and intelligent diver model(IDM), which is closer to the real data. The ASL model can better learn different driving behaviors on normal and rainy days. However,it has a higher sensitivity to weather conditions from cross test on normal and rainy data-sets which need classification training or sample diversification processing. In the car-following platoon simulation, the stability performances of two models are excellent, which can describe the basic characteristics of traffic flow on normal and rainy days. Comparing with ASL-Rain model, the convergence time of ASL-Normal is shorter, reflecting that cautious driving behavior on rainy days will reduce traffic efficiency to a certain extent. However, ASL-Normal model produces a more severe and frequent traffic oscillation within a shorter period because of aggressive driving behavior on normal days.

关键词： car-following behavior deep learning weather condition heterogeneous traffic flow

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AtPQT11,a P450 enzyme,detoxifies paraquat via N-demethylation

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Journal of Genetics and Genomics 2022年第12期49卷 1169-1173页

作者： Yi-Jie Huang yue-Ping Huang Jin-Qiu Xia Zhou-Ping Fu Yi-Fan chen Yi-Peng Huang Aimin Ma Wen-Tao Hou yu-xing chen Xiaoquan Qi Li-Ping Gao cheng-Bin Xiang Division of Life Sciences and Medicine Division of Molecular&Cell BiophysicsHefei National Science Center for Physical Sciencesat the MicroscaleMOE Key Laboratory for Membraneless Organelles and Cellular DynamicsUniversity of Science and Technologyof ChinaThe Innovation Academy of Seed DesignChinese Academy of SciencesHefeiAnhui 230027China School of Life Science Anhui Agricultural UniversityHefeiAnhui 230036China Key Laboratory of Plant Molecular Physiology Institute of BotanyThe Innovation Academy of Seed DesignChinese Academy of SciencesBeijing 100093China

Paraquat(1,1’-dimethyl-4,4’-bipyridinium dichloride,PQ)has been widely used as a broad spectrum nonselective herbicide in agriculture for decades(Baldwin et al.,1968).Plants absorb PQ from their environment and transport to the chloroplasts,the site of its action where it competes for electrons from photosystem I(PSI)and cyclically generates superoxide that is converted to H2O2by superoxide dismutases(SODs),resultantly accumulating a large amount of reactive oxygen species(ROS)and thereby killing plants(Farrington et al.,1973).

关键词： thereby converted resultant

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Gate tunable Rashba spin-orbit coupling at CaZrO_(3)/SrTiO_(3)heterointerface

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Chinese Physics B 2022年第6期31卷 615-619页

作者： Wei-Min Jiang Qiang Zhao Jing-Zhuo Ling Ting-Na Shao Zi-Tao Zhang Ming-Rui Liu Chun-Li Yao yu-Jie Qiao Mei-Hui chen xing-yu chen Rui-Fen Dou Chang-Min Xiong Jia-Cai Nie Department of Physics Beijing Normal UniversityBeijing 100875China State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China

High mobility quasi two-dimensional electron gas(2DEG)found at the CaZrO_(3)/SrTiO_(3) nonpolar heterointerface is attractive and provides a platform for the development of functional devices and *** we report that the carrier density and mobility at low temperature can be tuned by gate voltage at the CaZrO_(3)/SrTiO_(3) ***,the magnitude of Rashba spin-orbit interaction can be modulated and increases with the gate ***,the diffusion constant and the spin-orbit relaxation time can be strongly tuned by gate *** diffusion constant increases by a factor of~19.98 and the relaxation time is reduced by a factor of over three orders of magnitude while the gate voltage is swept from-50 V to 100 *** findings not only lay a foundation for further understanding the underlying mechanism of Rashba spin-orbit coupling,but also have great significance in developing various oxide functional devices.

关键词： CaZrO_(3)/SrTiO_(3),2DEG Rashba spin-orbit coupling gate voltage

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Removal of tungsten from molybdate solution by Fe-Mn binary oxide adsorbent

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Transactions of Nonferrous Metals Society of China 2017年第11期27卷 2492-2502页

作者： yun-feng SONG Li-hua HE xing-yu chen Zhong-wei ZHAO School of Metallurgy and Environment Central South University Changsha 410083 China Institute of Nuclear and New Energy Technology Tsinghua University Beijing 100084 China

Considering the different geochemical enrichment behaviors of W and Mo,Fe?Mn binary oxide(FMBO),ferric hydroxide(Fe(OH)3)and manganese dioxide(MnO2)were studied to separate W from molybdate solution,*** experimental results demonstrated that Fe?Mn binary oxide(FMBO)was the most suitable adsorbent for the *** a wide pH(6.9?11.3)region,more than80%W removal efficiency and less than3%Mo loss could be *** addition,the Fe?Mn binary oxide adsorbent can be regenerated by treating with3mol/L NaOH,and the W adsorption efficiency was retained after five adsorption?desorption?regeneration *** these indicate that the Fe?Mn binary oxides have the potential for the separation of W from molybdate solution.

关键词： tungsten removal molybdate solution Fe.Mn binary oxide adsorption

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