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Laparoscopic liver resection utilizing the ventral avascular area of the inferior vena cava:A retrospective cohort study

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World Journal of Gastroenterology 2025年第1期31卷 42-57页

作者： Kun Huang Zhu chen Heng Xiao Hai-Yang Hu xing-yu chen cheng-You Du Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China Department of General Surgery Mianyang Hospital of Traditional Chinese MedicineMianyang 621000Sichuan ProvinceChina

BACKGROUND Laparoscopic liver resection(LLR)can be challenging due to the difficulty of establishing a retrohepatic tunnel under *** the third hepatic hilum before parenchymal transection often leads to significant liver mobilization,tumor compression,and bleeding from the short hepatic veins(SHVs).This study introduces a novel technique utilizing the ventral avascular area of the inferior vena cava(IVC),allowing SHVs to be addressed after parenchymal transection,thereby reducing surgical complexity and improving outcomes in in situ *** To introduce and evaluate a novel LLR technique using the ventral avascular area of the IVC and compare its short-term outcomes with conventional *** The clinical cohort data of patients with pathologically confirmed hepatocellular carcinoma or intrahepatic cholangiocarcinoma who underwent conventional LLR and novel LLR between July 2021 and July 2023 at the First Affiliated Hospital of Chongqing Medical University were retrospectively *** novel LLR,we initially separated the caudate lobe from the IVC using dissecting forceps along the ventral avascular area of the ***,we transected the parenchyma of the left and right caudate lobes from the caudal side to the cephalic side using the avascular area as a ***,we addressed the SHVs and finally dissected the root of the right hepatic vein or left hepatic *** short-term postoperative outcomes and oncological results of the two approaches were evaluated and *** A total of 256 patients were included,with 150(58.59%)undergoing conventional LLR and 106(41.41%)undergoing novel *** novel technique resulted in significantly larger tumor resections(6.47±2.96 cm vs 4.01±2.33 cm,P<0.001),shorter operative times(199.57±60.37 minutes vs 262.33±83.90 minutes,P<0.001),less intraoperative blood loss(206.92±37.09 mL vs 363.34±131.27 mL,P<0.001),and greater resection volume(345.11±31.40 mL vs 264.38±31.98 mL,P<0.001)comp

关键词： Laparoscopic liver resection Inferior vena cava Retrohepatic tunnel Short hepatic veins Complex liver tumors Intraoperative bleeding control

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Unraveling the therapeutic potential of Calculus Bovis in liver cancer:A novel step for targeted cancer treatment

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World Journal of Gastroenterology 2025年第3期31卷 127-129页

作者： xing-yu chen Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

Hepatocellular carcinoma is one of the leading causes of cancer-related deaths globally,and effective treatments are urgently *** present study aimed to investigate the inhibitory effect of Calculus Bovis(CB)on liver cancer and the underlying *** inhibited M2 tumor-associated macrophage polarization and modulated the Wnt/β-catenin signaling pathway,thereby suppressing the proliferation of liver cancer *** inhibitory effect on liver cancer growth was confirmed by both in vivo and in vitro experiments(detailed by Huang et al).The present study provides a theoretical basis for the application of CB for the treatment of liver cancer,providing new avenues for liver cancer treatment.

关键词： Calculus Bovis Liver cancer M2 tumor-associated macrophage polarization Wnt/β-catenin Pathway Tumor microenvironment

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Microstructure recognition of steels by machine learning based on visual attention mechanism

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Journal of Iron and Steel Research International 2024年第4期31卷 909-923页

作者： xing-yu chen Lin cheng cheng-yang Hu yu-peng Zhang Kai-ming Wu The State Key Laboratory of Refractories and Metallurgy Hubei Province Key Laboratory of Systems Science on Metallurgical ProcessingInternational Research Institute for Steel TechnologyCollaborative Center on Advanced SteelsWuhan University of Science and TechnologyWuhan 430081HubeiChina Metals Valley and Band(Foshan)Metallic Composite Materials Co. Ltd.Foshan 528000GuangdongChina

U-Net has achieved good performance with the small-scale datasets through skip connections to merge the features of the low-level layers and high-level layers and has been widely utilized in biomedical image segmentation as well as recent microstructure image segregation of the *** representative visual attention mechanism modules,named as squeeze-and-excitation networks,convolutional block attention module,and extended calibration algorithm,were intro-duced into the traditional U-Net architecture to further improve the prediction *** is found that compared with the original U-Net architecture,the evaluation index of the improved U-Net architecture has been significantly improved for the microstructure segmentation of the steels with the ferrite/martensite composite microstructure and pearlite/ferrite composite microstructure and the complex martensite/austenite island/bainite microstructure,which demonstrates the advantages of the utilization of the visual attention mechanism in the microstructure *** reasons for the accuracy improvement were discussed based on the feature maps analysis.

关键词： Microstructure recognition-Steel Machine learning Visual attention mechanism Visualization

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Synthesis of new hyodeoxycholic acid thiosemicarbazone derivatives under solvent-free conditions using microwave

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Chinese Chemical Letters 2011年第4期22卷 405-408页

作者： Zhi Chuan Shi Zhi Gang Zhao xing Li Liu yu chen College of Chemistry and Environmental Protection Engineering Southwest University for NationalitiesChengdu 610041China

An efficient and simple method for synthesis of new hyodeoxycholic acid thiosemicarbazone derivatives under solvent-free conditions using microwave has been *** main advantages are short reaction times,good conversions and the environmentally friendly nature of the *** preliminary results indicate that some of these compounds possess inhibitory effects against ***.

关键词： Thiosemicarbazone Steroids Hyodeoxycholic acid Antimicrobial activity Microwave

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Lighting up nonbenzenoid acepleiadylene with ultra-narrowband emission through aromaticity modulation

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Science China Chemistry 2023年第12期66卷 3506-3510页

作者： Pengcai Liu Xiao-yu Tang cheng-Zhuo Du Rui Xue xing-yu chen Jiawen Cao Xiao-Ye Wang State Key Laboratory of Elemento-Organic Chemistry Frontiers Science Center for New Organic MatterCollege of ChemistryNankai UniversityTianjin 300071China

Nonbenzenoid polycyclic arenes have attracted great attention because of their unique topological structures and appealing properties;however,they are generally considered as poor luminescent materials due to the ring puckering behavior of the ***(APD),a nonbenzenoid isomer of pyrene,has been demonstrated as an excellent building block for optoelectronic applications,but its poor photoluminescence quantum yield(PLQY)has hampered its application in luminescent *** that the ring puckering character can be suppressed by increasing the rigidity of the nonhexagon rings,herein,we propose a novel strategy for enhancing the aromaticity of the nonhexagons to improve the PLQYs of APD ***-withdrawing cyano groups are introduced on the five-membered ring of APD to enhance the chargeseparated character and thus the aromaticity of the nonhexagons,endowing the cyano-substituted APDs(CNAPD and 2CNAPD)with better ***,the cyano substitution successfully suppresses the nonradiative energy dissipation caused by the ring puckering,improving the PLQY from 2.4%for APD to 14%for CNAPD,and to 63%for *** addition,the enhanced rigidity also suppresses the vibration sideband of the photoluminescence spectra,leading to an ultra-narrowband emission from 2CNAPD with a full-width at half-maximum(FWHM)of 13 nm(47 me V),which is a new record in organic *** results demonstrate that APD derivatives have great potential in highly efficient luminescent materials with high color purity via the aromaticity regulation strategy,which provides a novel concept for designing nonbenzenoid luminescent materials.

关键词： nonbenzenoid arenes luminescence narrowband emission acepleiadylene

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Nonalcoholic fatty liver disease shows significant sex dimorphism

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World Journal of Clinical Cases 2022年第5期10卷 1457-1472页

作者： xing-yu chen Cong Wang Yi-Zhou Huang Li-Li Zhang The Second Affiliated Hospital Chongqing Medical UniversityChongqing 404100China

Nonalcoholic fatty liver disease(NAFLD),which has been renamed metabolic dysfunction-associated fatty liver disease,is a growing global medical *** incidence of NAFLD and its associated end-stage liver disease is increasing each year,and many research advancements have been achieved to *** review focuses on the current knowledge of the sex differences in NAFLD and does not elaborate on areas without *** have revealed significant sex differences in the prevalence,influencing factors,pathophysiology,complications and therapies of *** have a higher incidence than *** with women,men exhibit increased visceral fat deposition,are more susceptible to leptin resistance,lack estrogen receptors,and tend to synthesize fatty acids into fat *** patients will experience more severe hepatic fibrosis and a higher incidence of liver ***,once NAFLD occurs,women show a faster progression of liver fibrosis,higher levels of liver cell damage and inflammation and are less likely to undergo liver transplantation than *** general,men have more risk factors and more severe pathophysiological reactions than women,whereas the development of NAFLD is faster in women,and the treatments for women are more limited than those for ***,whether sex differences should be considered in the individualized prevention and treatment of NAFLD in the future is worth considering.

关键词： Nonalcoholic fatty liver disease Metabolic dysfunction-associated fatty liver disease Sex differences Estrogen Steatosis Cirrhosis

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Helicene-type β-isoindigo-based boron-dipyrromethene analogs with strong near-infrared chiroptical activity

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Aggregate 2024年第3期5卷 268-274页

作者： Ziwei chen Zhigang Ni xing-yu chen Yongqiang Xu Chunyan yu SiSi Wang Xiao-Ye Wang Hua Lu Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education and Key Laboratory of Organosilicon Material Technology of Zhejiang ProvinceCollege of MaterialChemistry and Chemical EngineeringHangzhou Normal UniversityHangzhouChina State Key Laboratory of Elemento-Organic Chemistry Frontiers Science Center for New Organic MatterCollege of ChemistryNankai UniversityTianjinChina

Near-infrared(NIR)chiroptical response has been less explored because it is chal-lenging to achieve both chirality and NIR absorption/***,we describe the design of heterohelicene-typeβ-isoindigo-based boron-dipyrromethene(BOD-IPY)analogs(β-IBs),which shift the absorption peak to 800 nm and produce signiﬁcant Cotton effects(127.8 M-1 cm-1)and absorbance dissymmetry factors(|gabs|3.5=×10-3).The luminescence dissymmetry factor(glum)and circu-larly polarized luminescence(CPL)brightness(BCPL)of up to 1.24×10-3 and 1.78 M-1 cm-1 were realized beyond 800 ***β-IBs are theﬁrst examples of helicene-type compounds with the highest gabs in the NIR region and CPL beyond 800 *** calculations demonstrate that the strong chiroptical activities are triggered by their large transition magnetic dipole *** study not only provides a new approach to the synthesis of a larger variety of unprecedented helicene-type BODIPY analogs but also demonstrates excellent NIR chiroptical properties.

关键词： BODIPY chiroptical activity circularly polarized luminescence helicene near-infrared

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Efficient recovery of tungsten from scheelite concentrates using a sulfur-phosphorus mixed acid leaching system

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Tungsten 2024年第4期6卷 821-832页

作者： Jiang-Tao Li Li-Li Gao Zhong-Wei Zhao Xu-Heng Liu xing-yu chen School of Metallurgy and Environment Central South UniversityChangsha410083China Key Laboratory of Hunan Province for Metallurgy and Material Processing of Rare Metals Changsha410083China

In recent years,a new process for leaching scheelite concentrates with sulfur-phosphorus mixed acid has been successfully *** process suffers from the elimination of the retarding effect of calcium sulfate,the selective extraction of tungsten from the H_(3)PW_(12)O_(40)-H_(2)SO_(4)-H_(3)PO_(4)mixture solution,and the removal of introduced ***,in this paper,we investigated the inhibition measures of a calcium sulfate-blocking membrane,the selective extraction of tungsten by ion exchange,and the removal of phosphorus by the magnesium ammonium salt *** results showed that the addition of calcium sulfate whisker seeds and a higher H_(3)PO_(4)concentration inhibited spontaneous diffuse nucleation,promoted crystal growth,and avoided the formation of a dense blocking *** 98 wt.%of the scheelite concentrate was digested by H_(2)SO_(4)-H_(3)PO_(4).The selective adsorption of PW_(12)O_(40)^(3-)was realized using D301 resin,and the extraction efficiency of tungsten exceeded 99.9%.After desorption with ammonia water,PW_(12)O_(40)^(3-)was depolymerized into WO_(4)^(2-)and PO_(4)^(3-).99.9 wt.%of phosphorus was removed in the form of MgNH_(4)PO_(4)by the magnesium ammonium salt method,and the residual phosphorus concentration in the solution was lower than 10 mg·L^(-1).After purification,the highest-grade ammonium paratungstate product was prepared by evaporative crystallization.

关键词： Scheelite concentrates Sulfur-phosphorus mixed acid Calcium sulfate Ion exchange Tungsten

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A new angelol-type coumarin glucoside from Angelica pubescens

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Chinese Chemical Letters 2008年第10期19卷 1237-1239页

作者： Xi Fei Ding Xu Feng yun Fa Dong xing Zeng Zhao yu chen Ming Wang Jiangsu Center for Research ＆ Development of Medicinal Plants Jiangsu Institute of Botany China Academic of Science Nanfing Botanical GaMen Mere. Sun Yat-Sen Nanfing 210014 China

A new angelol-type coumarin glucoside, 6-[（1R,2R）-1, 2-dihydroxy-3-β-D-glucosyloxy-3-methylbutyl]-7-methoxycoumarin, was isolated from the roots of Angelica pubescens. Its structure was elucidated on the basis of s... 详细信息

关键词： Angelica pubescens UmbeUiferae Coumarin glucoside 6-[(1R,2R)-1,2-Dihydroxy-3-β-D-glucosyloxy-3-methylbutyl]-7-methoxy-coumarin

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Predictive Values of Postoperative and Dynamic Changes of Inflammation Indexes in Survival of Patients with Resected Colorectal Cancer

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Current Medical Science 2018年第5期38卷 798-808页

作者： Zi-quan ZHOU Shuo PANG xing-chen yu Qi XUE Hong-yu JIANG Xin-jun LIANG Li LIU Department of Epidemiology and Btostatistics the Ministry of Education Key Lab of Environment and HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Medical Oncology Hubei Cancer HospitalWuhan 430079China

The aim of the present study was to evaluate the prognostic potential of postoperative scores of inflammation indexes and the dynamic changes of scores before and after tumor resection in colorectal cancer *** study included 516 colorectal cancer patients with primary colorectal tumor *** regression was applied to estimate the associations of postoperative and dynamic changes of inflammation indexes with progression-free survival and overall *** results,we found that higher postoperative neutrophil to lymphocyte ratio (NLR),neutrophil and monocyte to lymphocyte ratio (NMLR),platelet to lymphocyte ratio (PLR) and systemic immune inflammation index (SII)were associated with shorter progression-free *** increased NLR,NMLR,PLR,SII and C-reaction protein (CRP)to albumin (ALB) ratio (CAR)were associated with poor progression-free survival,with HRs (95% CIs)of 1.92 (1.27-2.90),1.46(1.11-2.09),2.10(1.34-3.30),1.81(1.22-2.70)and 1.65(1.03-2.67), *** NMLR,SII,CAR,and their dynamic changes were also significantly correlated with overall survival,with the HRs (95% CIs)of 2.63(1.30-3.97), 2.44(1.43-4.17),2.74(1.31-5.74),2.08(1.21-3.60),1.97(1.12-3.45)and 2.55(1.21-5.38)*** conclusion,postoperative inflammation indexes and their dynamic changes,particularly for NMLR,SII and CAR are promising prognostic predictors of CRC patients.

关键词： colorectal cancer postoperative inflammation index dynamic change prognosis

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