检索结果-南通市图书馆

The Impact of Lipid-metabolizing Genetic Polymorphisms on Body Mass Index and Their Interactions with Soybean Food Intake: A Study in a Chinese Population

引用

Biomedical and Environmental Sciences 2014年第3期27卷 176-185页

作者： WANG Jin Wei TANG Xun LI Na WU Yi Qun LI Shuai LI Jin QIN Xue Ying ZHANG Zong Xin hu yong hua CHEN Da Fan Department of Epidemiology and Biostatistics School of Public HealthPeking University Health Science Center Fangshan District Bureau of Health The First Hospital of Fangshan District

Objective To evaluate the association of known polymorphisms in the lipid metabolic pathway with body mass index （BMI）, and estimate their interactions with soybean food intake. Methods A community-based cross-sectional survey was conducted in a Chinese Han population. BMI, soybean food intake, and single nucleotide polymorphisms of rs599839, rs3846662, rs3846663, rs12916, rs174547, rs174570, rs4938303, and rs1558861 were measured in 944 subjects. A multivariate logistic regression was used to analyze the association of the studied polymorphisms with BMIs. The expectation-maximization algorithm was employed to evaluate the extent of linkage disequilibrium between pairwise polymorphisms. The gene-environment interaction was assessed in the general multifactor dimensionality reduction model. Results The polymorphisms of rs3846662 and rs3846663 were associated with 10% highest BMIs when comparing to the 10% lowest values both in individuals and haplotype-based association tests. Although no statistically significant gene-environment interactions were found, people with the haplotype composed of C allele in rs3846662 and T allele in rs3846663 and low frequency of soybean intake had significantly hisher risk to overweight and obesity as compared with those with the haplotype consisting of T allele in rs3846662 and C allele in rs3846663 and highly frequent soybean food intake, with an odds ratio of 1.64 （95% confidence interval： 1.15-2.34, P〈0.01） after adjusting for the common confounders. Conclusion Our study has sugsested that rs3846662 and rs3846663 may be the potential candidate polymorphisms for obesity, and their effect on the pathogenesis could be mediated by the frequency of soybean food intake.

关键词： Body mass index Lipid metabolism Genetic epidemiology Haplotypes Gene-environment interaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

F-53B胁迫下污水厌氧处理系统及微生物群落的响应

引用

中国环境科学 2024年第2期44卷 721-729页

作者：郭雨婷刘亚军邓觅涂勋吴虎彬李昆李荣富吴永明南昌大学资源与环境学院鄱阳湖环境与资源利用教育部重点实验室江西南昌330031 江西省科学院微生物研究所江西南昌330096

通过构建厌氧反应体系,评估低浓度(1mg/L)和高浓度(10mg/L)氯化多氟醚磺酸盐(F-53B)胁迫下,厌氧处理系统出水水质、污泥性状和细菌群落的响应特征.结果表明,在F-53B的胁迫下,COD、氮(TN、NH_(4)^(+)-N)和磷(TP、PO_(4)^(3-)-P)在出水中... 详细信息

通过构建厌氧反应体系,评估低浓度(1mg/L)和高浓度(10mg/L)氯化多氟醚磺酸盐(F-53B)胁迫下,厌氧处理系统出水水质、污泥性状和细菌群落的响应特征.结果表明,在F-53B的胁迫下,COD、氮(TN、NH_(4)^(+)-N)和磷(TP、PO_(4)^(3-)-P)在出水中的含量会升高,而污泥相对生物量(MLVSS/MLSS)则出现下降,且F-53B的浓度越高影响越大.高通量测序分析发现,相较于对照组(0mg/L F-53B),仅高浓度F-53B胁迫下细菌群落的多样性(ACE、Chao1和PD指数)出现了显著下降.同时,研究还发现,随着高浓度F-53B暴露时间的延长,厚壁菌门的相对丰度逐渐增大,而变形菌门、拟杆菌门和硝化螺旋菌门的相对丰度逐渐降低.此外,基于FAPROTAX功能预测分析发现,F-53B胁迫下微生物表现出更低的氮(N)代谢潜力和更高的化能异养和发酵能力.冗余分析(RDA)表明,厚壁菌门主要受F-53B的正向影响,并与TN和NH_(4)^(+)-N呈正相关;而变形菌门受F-53B的负向影响,并与COD、TP和PO_(4)^(3-)-P呈正相关.揭示了新型氟化物—F-53B对污水厌氧处理系统的胁迫机制.

关键词：氯化多氟醚磺酸盐(F-53B) 污水厌氧处理微生物群落功能预测

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

渐进图像传输中基于失真的码率分配

引用

电子与信息学报 2005年第12期27卷 1969-1972页

作者：王红星张勇北京航空航天大学北京100083 海军航空工程学院电子工程系烟台264001

该文根据信源编码压缩比、信道码率及信道特征对渐进图像传输失真的影响，提出一种基于最小图像失真的动态码率分配策略。在总的码率限制下采用遍历搜索信道码率的方法，得出可用码率在信源编码和信道编码之间的最优分配，使端对端的失... 详细信息

该文根据信源编码压缩比、信道码率及信道特征对渐进图像传输失真的影响，提出一种基于最小图像失真的动态码率分配策略。在总的码率限制下采用遍历搜索信道码率的方法，得出可用码率在信源编码和信道编码之间的最优分配，使端对端的失真最小。

关键词：渐进图像联合信源信道编码码率分配

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Formation　of　the　Central－Asia　Coal－Formed　Gas　Accumulation　Domain　and　its 　Source　Rocks──Series　Study　Ⅰ　on　the　Central－Asia　Coal－formed　Gas　Accumulation　Domain

引用

石油勘探与开发 1995年第3期 117-124页

作者： Dai Jin-xing He Bin Sun yong-xiang Li Peng-ju Li Xian-qi(Research Institute of petroleum Exploration and Development, CNPC, Beijing, 100083)

ＦｏｒｍａｔｉｏｎｏｆｔｈｅＣｅｎｔｒａｌ－ＡｓｉａＣｏａｌ－ＦｏｒｍｅｄＧａｓＡｃｃｕｍｕｌａｔｉｏｎＤｏｍａｉｎａｎｄｉｔ８ＳｏｕｒｃｅＲｏｃｋｓ──ＳｅｒｉｅｓＳｔｕｄｙⅠｏｎｔｈｅＣｅｎｔｒａｌ－ＡｓｉａＣｏ... 详细信息

ＦｏｒｍａｔｉｏｎｏｆｔｈｅＣｅｎｔｒａｌ－ＡｓｉａＣｏａｌ－ＦｏｒｍｅｄＧａｓＡｃｃｕｍｕｌａｔｉｏｎＤｏｍａｉｎａｎｄｉｔ８ＳｏｕｒｃｅＲｏｃｋｓ──ＳｅｒｉｅｓＳｔｕｄｙⅠｏｎｔｈｅＣｅｎｔｒａｌ－ＡｓｉａＣｏａｌ－ｆｏｒｍｅｄＧａｓＡｃｃｕｍ...

关键词： Central-Asia Gas accumulation domain Coal-measure Gas source rocks

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Macular integrity assessment to determine the association between macular microstructure and functional parameters in diabetic macular edema

引用

International Journal of Ophthalmology(English edition) 2018年第7期11卷 1185-1191页

作者： Jian-Wei Wang Chuan-Hong Jie yong-Jian Tao Ning Meng Yuan-Chun hu Zheng-Zheng Wu Wen-Jing Cai Xi-Mei Gong Eye Hospital China Academy of Chinese Medical Sciences

AIM： To respectively evaluate macular morphological features and functional parameters by using spectraldomain optical coherence tomography（SD-OCT） and macular integrity assessment（MAIA） in patients with diabetic macular edema（DME）. METHODS： This prospective, non-controlled, open study included 61 eyes of 38 consecutive patients with DME. All patients underwent best-corrected visual acuity（BCVA） measurement, MAIA microperimetry, and SDOCT. DME morphology, including central retinal thickness（CRT） and central retinal volume（CRV）; integrity of the external limiting membrane（ELM） and photoreceptor inner segment/outer segment（IS/OS） junction; and the deposition of hard macular exudates were assessed within a 1000-μm central subfield area. MAIA microperimetry parameters evaluated were average threshold（AT）-retinal sensitivity, macular integrity index（MI）, fixation points within a circle of radius 1°（P1） and 2°（P2）, and bivariate contour ellipse area considering 63% and 95% of the fixation points（A63 and A95, respectively）. RESULTS： MI was significantly higher in eyes with disrupted ELM or IS/OS, compared with eyes with intact ELM and IS/OS. Values of BCVA（log MAR）, total AT, AT within 1000-μm diameter, P2, A63, A95, and CRT were significantly worse in eyes with disrupted IS/OS, compared with eyes with intact IS/OS. The values of BCVA（log MAR）, AT within 1000-μm diameter, and CRT were significantly worse in eyes with disrupted ELM, compared with eyes with intact ELM. These parameters were not significantly different between eyes with or without hard macular exudate deposition. CRV was not significantly different in the presence or absence of the integrity of ELM, IS/OS, or deposition of hard macular exudates. At the center, nasal and temporal sectors of the fovea, significant negative correlations were observed between retinal thickness and AT of the corresponding area. At the inferior and superior sectors of the fovea, no correlations were observed between retinal thickn

关键词： diabetic retinopathy/complications macular edema visual fields retina/physiopathology optical coherence tomography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于印刷缺陷检测的图像配准方法研究

引用

光学技术 2017年第1期43卷 16-21页

作者：胡方尚郭慧邢金鹏王勇华东理工大学机械与动力工程学院上海200237 聊城大学东昌学院山东聊城252000 公安部上海消防研究所上海200438

图像配准是机器视觉和图像处理的重要研究内容,针对印刷缺陷检测中图像配准效率低、误差大等问题,提出了区别于普通连续色调图像的新方法。采用数学形态学和Hough变换的方法检测图像配准的旋转角和缩放因子,并基于相位相关原理对傅里叶... 详细信息

图像配准是机器视觉和图像处理的重要研究内容,针对印刷缺陷检测中图像配准效率低、误差大等问题,提出了区别于普通连续色调图像的新方法。采用数学形态学和Hough变换的方法检测图像配准的旋转角和缩放因子,并基于相位相关原理对傅里叶变换的范围进行改进,求取待检图像和标准图像之间的相对偏移量,最终实现文本印刷图像的高效配准。实验结果表明,平均配准误差控制在1个像素范围以内,而且整个配准过程在1s内完成,对文本图像具有较好地配准效果,能为文本印刷品的质量检测奠定良好的基础。

关键词：图像配准数学形态学 Hough变换相位相关文本图像

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prolonged parasite clearance in a Chinese splenectomized patient with falciparum malaria imported from Nigeria

引用

Infectious Diseases of Poverty 2017年第1期6卷 395-400页

作者： Hong-Wei Zhang San-Jin Li Tao hu yong-Min Yu Cheng-Yun Yang Rui-Min Zhou Ying Liu Jing Tang Jing-Jing Wang Xiu-Yun Wang yong-Xiang Sun Zhan-Chun Feng Bian-Li Xu Department of Parasite Disease Control and Prevention Henan Center for Disease Control and PreventionZhengzhouPeople’s Republic of China Department of Infectious Diseases the 6th People’s Hospital of ZhengzhouZhengzhou 450016People’s Republic of China School of Medicine and Health Management Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiPeople’s Republic of China

Background:The spleen plays a pivotal role in the rapid clearance of parasitized red blood cells in patients with falciparum malaria after artemisinin *** parasite clearance can be found in patients who have had a splenectomy,or those with hemoglobin abnormalities and/or reduced immunity,which are all distinguishable from artemisinin *** paper reports on a case of prolonged parasite clearance in a Chinese splenectomized patient with falciparum malaria imported from *** presentation:A 35-year-old Chinese male suffered 2 days of febrile illness after returning to Zhumadian city of Henan province from Nigeria on October 1,*** main symptoms were febrile,including the highest axillary temperature of 40℃,headache,and chills.A peripheral blood smear showed parasitemia(53913 asexual parasites/μl)of Plasmodium *** patient had not used any chemoprophylaxis against malaria in Nigeria when he worked there as a construction worker between 2009 and *** patient had three episodes of malaria in Nigeria and had a splenectomy due to a traffic accident 8 years ago from the time he was admitted to *** patient was orally administrated a total of 320 mg/2.56 g dihydroartemisinin-piperaquine for 2 days and intravenously administrated a total of 3000 mg artesunate for 18 *** axillary temperature of the patient ranged between 37.0 and 37.7℃ from Day 0 to Day 3,and blood microscopy revealed falciparum malaria parasitemia(26674 asexual parasites/μl)on Day *** patient was afebrile on Day 4,falciparum malaria parasitemia was continuously present and then gradually decreased on the next days,and was negative on Day *** patient was cured and left hospital on Day 24 after no plasmodium falciparum was found in the blood on Day 21 to Day *** mutation was found in the K13 propeller gene when compared with the PF3D7_1343700 K13 propeller gene reference ***:This is the first reported case in China of prolong

关键词： Falciparum malaria Artemisinin treatment Prolonged parasite clearance Splenectomy China Nigeria

来源：

维普期刊数据库

维普期刊数据库更多评论

在线全文

学校读者我要写书评

暂无评论

一种抗疲劳钎杆的理论与实验研究

引用

东北大学学报（自然科学版） 2006年第11期27卷 1279-1282页

作者：邢军钟勇宋守志东北大学资源与土木工程学院辽宁沈阳110004

基于有限寿命设计原理,运用波动力学、冲击钻进动力学,分析了钎杆抗断性能及其疲劳寿命影响因素,提出了具有低应力、高抗断阻力特性的薄壁管式钎杆结构·薄壁管式钎杆,以不增加钎钢消耗量为前提,通过显著增大钎杆外圆直径,达到提高钎杆... 详细信息

基于有限寿命设计原理,运用波动力学、冲击钻进动力学,分析了钎杆抗断性能及其疲劳寿命影响因素,提出了具有低应力、高抗断阻力特性的薄壁管式钎杆结构·薄壁管式钎杆,以不增加钎钢消耗量为前提,通过显著增大钎杆外圆直径,达到提高钎杆抗断性能、降低钎杆循环应力水平的目的·同时,结合材料的S-N曲线和钎杆的理论载荷谱,运用电算程序,预估了新型结构钎杆的抗疲劳寿命·工业考核表明,薄壁管式钎杆的疲劳寿命达到1200m,比国产传统钎杆提高近70%·

关键词：钎杆管式结构力学分析疲劳寿命

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Characteristic Rainfall for Warning of Debris Flows

引用

Journal of Mountain Science 2010年第3期7卷 207-214页

作者： hu Kaiheng Cui Peng Wang Chuanchang Li yong Lu Xiaobing Key Laboratory of Mountain Hazards and Earth Surface Processes Chinese Academy of Sciences Chengdu 610041 China Institute of Mountain Hazards and Environment Chinese Academy of Sciences & Ministry of Water Conservancy Chengdu 610041 China Institute of Mechanics Chinese Academy of Sciences Beijing 100080 China

A characteristic rainfall is introduced to overcome the difficulties encountered in determining a critical rainfall value for triggering debris *** characteristic value is defined as the rainfall at which debris-flow occurrence probability shows a rapid increase,and can be used as a warning rainfall threshold for debris *** of recorded debris flows and 24-hour rainfall data at Jiangjia basin,Yunnan Province,in southwestern China,demonstrates the existence of such a characteristic *** was found that the characteristic rainfall corresponds to the daily rainfall of 90% cumulative probability by analyzing the basin's daily rainfall *** result provides a simple and useful method for estimating a debris-flow warning rainfall threshold from the daily rainfall *** was applied to estimate the debris-flow warning rainfall threshold for the Subaohe basin,a watershed in the 2008 Wenchuan earthquake zone with many physical characteristics similar to those of the Jiangjia basin.

关键词： Debris flow Wenchuan earthquake warning rainfall threshold statistics of daily rainfalldistribution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Yiguanjian decoction on cell differentiation and proliferation in CCl_4-treated mice

引用

World Journal of Gastroenterology 2012年第25期18卷 3235-3249页

作者： Xiao-Ling Wang Dong-Wei Jia hui-Yang Liu Xiao-Feng Yan Ting-Jie Ye Xu-Dong hu Bo-Qin Li yong-Liang Chen Ping Liu Department of Cell Biology College of Basic MedicineShanghai University of TraditionalChinese MedicineShanghai 210203China Department of Cell Biology Ex-perimental Center for Teaching and LearningShanghai Univer-sity of Traditional Chinese MedicineShanghai 210203China E-institute of Shanghai Municipal Education Com-mission Shanghai University of Traditional Chinese MedicineShanghai 210203China

AIM： To investigate the cellular mechanisms of action of Yiguanjian （YGJ） decoction in treatment of chronic hepatic injury. METHODS： One group of mice was irradiated, and received enhanced green fluorescent protein （EGFP）- positive bone marrow transplants followed by 13 wk of CCh injection and 6 wk of oral YGJ administration. A second group of Institute for Cancer Research mice was treated with 13 wk of CCI4 injection and 6 wk of oral YGJadministration. Liver function, histological changes in the liver, and Hyp content were analyzed. The expres- sion of m-smooth muscle actin （α-SMA）, F4/80, albumin （AIb）, EGFP, mitogen-activated protein kinase-2 （PKM2）, Ki-67, fetoprotein （AFP）, monocyte chemotaxis pro- tein-1 and CC chemokine receptor 2 were assayed. RESULTS： As hepatic damage progressed, EGFP-po- sitive marrow cells migrated into the liver and were mainly distributed along the fibrous septa. They showed a conspicuous coexpression of EGFP with ^-SMA and F4/80 but no coexpression with AIb. Moreover, the expression of PKM2, AFP and Ki-67 was enhanced dy- namically and steadily over the course of liver injury. YGJ abrogated the increases in the number of bone marrow-derived fibrogenic cells in the liver, inhibited expression of both progenitor and mature hepatocyte markers, and reduced fibrogenesis. CONCLUSION： YGJ decoction improves liver fibrosis by inhibiting the migration of bone marrow cells into the liver as well as inhibiting their differentiation and suppressing the proliferation of both progenitors and hepatocytes in the injured liver.

关键词： Yiguanjian decoction Bone marrow trans-plantation Hepatic progenitors Hepatocytes Hepaticinjury

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：