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合并骨质疏松症的脊柱畸形长节段融合术后近端交界性后凸的危险因素

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中华骨科杂志 2024年第11期44卷 740-747页

作者：杨宏浩李章富张瀚文张希诺海涌首都医科大学附属北京朝阳医院骨科北京100020

目的探讨合并骨质疏松症的脊柱畸形长节段融合术后近端交界性后凸(proximal junctional kyphosis,PJK)的危险因素。方法回顾性分析2013年6月至2019年12月在北京朝阳医院骨科接受长节段脊柱融合术的骨质疏松性脊柱畸形患者76例,男19例、... 详细信息

目的探讨合并骨质疏松症的脊柱畸形长节段融合术后近端交界性后凸(proximal junctional kyphosis,PJK)的危险因素。方法回顾性分析2013年6月至2019年12月在北京朝阳医院骨科接受长节段脊柱融合术的骨质疏松性脊柱畸形患者76例,男19例、女57例,年龄(66.26±6.10)岁(范围54~78岁)。根据术后2年随访期间是否发生PJK分组,其中PJK组21例、非PJK组55例。对比两组患者临床资料、术前及术后脊柱骨盆参数、椎体亨氏单位(Hounsfield Unit,hu)值及椎旁肌形态。脊柱骨盆参数包括主弯Cobb角、腰椎前凸(lumbar lordosis,LL)、腰骶椎前凸(lumbosacral lordosis,LSL)、矢状面轴向距离(sagittal vertical axis,SVA)、T1骨盆角(T1 pelvic angle,TPA)、骨盆倾斜度(pelvic tilt,PT)、骶骨倾斜角(sacral slope,SS)、骨盆入射角(pelvic incidence,PI)。通过术前CT分别测量上端固定椎(upper instrumented vertebra,UIV),UIV远端第1个椎体(UIV+1)、UIV远端第2个椎体的hu值。通过术前MRI测量L4下终板水平椎旁肌的相对功能横截面积(relative functional cross-sectional area,rFCSA)和功能肌肉-脂肪指数(functional muscle-fat index,FMFI)。使用ROC曲线确定UIV、UIV+1、UIV+2椎体hu值及椎旁肌rFCSA、FMFI的最佳截断值。使用二分类变量logistic回归分析确定PJK的独立危险因素。结果PJK组与非PJK组患者术前PT(17.60°±8.39°和24.12°±9.37°)、术后LL(35.61°±10.62°和42.22°±13.11°)、LSL(30.24°±10.10°和35.87°±11.12°)、SVA(37.82°±20.46°和21.37°±17.35°)的差异均有统计学意义(Phu值(113.62±17.25和133.94±16.61)、UIV+1椎体hu值(123.14±16.03和138.27±13.69)、UIV+2椎体hu值(121.00±15.91和134.47±15.53)的差异均有统计学意义(Phu值[OR=0.938,95%CI(0.887,0.991),P=0.024]及椎旁肌rFCSA[OR=0.883,95%CI(0.792,0.983),P=0.023]为PJK的独立危险因素。结论合并骨质疏松症的脊柱畸形长节段融合术后矢状面序列恢复不佳、UIV椎体hu值降低、腰椎椎旁肌rFCSA降低会导致PJK发生风险增加。

关键词：骨质疏松脊柱融合术脊柱后凸危险因素

单眼形觉剥夺大鼠视皮层α-氨基-3-羟基-5-甲基异恶唑-4-丙酸受体GluR2的表达及其变化对微小兴奋性突触后电流的影响

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中华眼科杂志 2008年第11期44卷 976-980页

作者：郝瑞邢咏新赵堪兴天津医科大学眼科临床学院天津市眼科医院天津市眼科研究所 300020

目的观察单眼形觉剥夺大鼠视皮层中α-氨基-3-羟基-5-甲基异恶唑-4-丙酸（alphaamino-3-hydroxy-5-methyl-4-isoxazolepropionic acid，AMPA）受体的表达变化及其对突触后电流mEPSCs的影响，为研究其在视觉发育可塑性中的作用及机制做... 详细信息

目的观察单眼形觉剥夺大鼠视皮层中α-氨基-3-羟基-5-甲基异恶唑-4-丙酸（alphaamino-3-hydroxy-5-methyl-4-isoxazolepropionic acid，AMPA）受体的表达变化及其对突触后电流mEPSCs的影响，为研究其在视觉发育可塑性中的作用及机制做准备。方法实验研究。取14d龄健康Wistar大鼠40只，随机分为2组（Ⅰ、Ⅱ），每组20只，再随机分成A、B两组，每组10只。对实验组（I组）行单眼形觉剥夺，正常饲养1周后对IA组及ⅡA组常规心脏灌注、固定、切取视皮层，对组织切片行免疫组织化学法显色，显微镜观察AMPA受体GluR2的表达情况并进行图像分析，同时对ⅠB组及ⅡB组应用脑片膜片钳全细胞记录技术，获得大鼠视皮层神经元的细胞内微电极记录，记录突触后电流mEPSCs的变化。结果AMPA受体GluR2在正常发育组视皮层中的表达较单眼形觉剥夺组视皮层中的表达水平高，差异有统计学意义（P〈0．01）。脑片膜片钳记录结果显示：AMPA受体介导的初级视皮层2／3层的锥体神经元的微小突触后兴奋性电流（mEPSCs）幅值增高。结论大鼠出生后视皮层AMPA受体GluR2的水平受视觉刺激而发生变化，且其变化影响微小突触后兴奋性电流，提示其对出生后大鼠的视觉发育有着重要的生理作用。

关键词：视觉,单眼视觉障碍受体,AMPA 视皮质免疫组织化学大鼠

Surgical treatment of 82 patients with diabetic lower limb ischemia by distal arterial bypass

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Chinese Medical Journal 2007年第2期120卷 106-109页

作者： GU yong-quan ZHANG Jian QI Li-xing YU Heng-xi LI Jian-xin LI Xue-feng GUO Lian-rui LUO Tao CUI Shi-jun WANG Zhong-gao Department of Vascular Surgery Xuan Wu Hospital and Institute of Vascular Surgery Capital Medical University Beijing 100053 China

Background Diabetic lower limb ischemia is a serious complication of diabetes mellitus. This study was conducted to investigate the effectiveness of distal arterial bypass treatment in diabetic patients with lower limb ischemia. Methods From July 2000 to July 2004, 96 lower limbs of 82 diabetic patients （type 2） with severe lower limb ischemia were treated in Xuan Wu Hospital. Arterial bypass with femoro-popliteal polytetrafluoroethylene （PTFE） and graft-tibial autologous grafts was performed on 31 limbs （32.3%）. Popliteal-tibial artery bypass alone was performed on 22 limbs （22.9%）. Combined lilac artery stenting, femoro-popliteal artery PTFE graft bypass, and graft-tibial artery autologous graft bypass was performed on 12 limbs （12.5%）, and femoro-tibial artery graft bypass was performed on 10 limbs （10.4%）. Popliteal-tibial-pedal artery graft bypass was performed on 7 limbs （7.3%）. Results Arterial grafts in 92 limbs of 79 patients were patent on discharge. Three patients with 4 ischemic limbs （3.7%） died of respiratory failure 12 hours, 3 days and 7 days after operation respectively. Early operation success rate was 96.3% （79/82）. Graft patency rate of patients on discharge was 95.8% （92/96）. The short-term total effectiveness rate was 83.3% （80/96）. Foot ulcer healing rate was 35.7% （10/28）. 97.4% （75/77） patients were followed up for a mean of 13.5 months. The long-term total effective rate was 80.7% （71/88）. The total amputation rate was 4.5% （4/88）. Mortality was 4.5%. The total graft patency rate was 90.9% （80/88）.Conclusion In the treatment of diabetic foot, distal lower limb arterial bypass can help to avoid amputation or lower the amputation level, and may promote foot ulcer healing and improve patient＇s quality of life.

关键词： diabetic angiopathies diabetes complications lower extremity distal arterial bypass

一种基于非衍射波的高帧率超声成像发射系统的研究

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物理学报 2014年第19期63卷 420-425页

作者：韦永梅彭虎阜阳师范学院物理与电子科学学院阜阳236041 合肥工业大学医学工程学院合肥230026

基于非衍射波的高帧率(high frame rate,HFR)超声成像的前提是发射阵列波(array beam)声场,但由于阵列波的正弦函数特征使对超声发射信号加权处理变得比较困难,导致了发射系统复杂.针对这一问题,本文提出一种有效的解决方案.基于傅里叶... 详细信息

基于非衍射波的高帧率(high frame rate,HFR)超声成像的前提是发射阵列波(array beam)声场,但由于阵列波的正弦函数特征使对超声发射信号加权处理变得比较困难,导致了发射系统复杂.针对这一问题,本文提出一种有效的解决方案.基于傅里叶变换理论,从方波的能量成分主要集中在基波这一特性出发,采用单值方波对超声传感器发射信号进行加权,用一个功率信号源和简单的电子开关网络实现了HFR系统中所需要的发射电路.实验表明,这种方案对HFR的成像质量几乎没有什么影响,但大大简化了HFR成像系统,这为HFR超声成像方法在现有B超声系统上的实现提供了一个可行的方法.

关键词：超声成像电子开关功率信号源方波

Benefit of infusions with ibandronate treatment in children with osteogenesis imperfecta

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Chinese Medical Journal 2011年第19期124卷 3049-3053页

作者： LI Mei XIA Wei-bo xing Xiao-ping YU Wei hu Ying-ying JIANG Yan WANG Ou LIU Hai-juan HAN Lan-wen MENG Xun-wu XU Ling Department of Endocrinology Endocrine Key Laboratory of the Ministryof Health of China Peking Union Medical College Hospital Peking Union Medical CollegeChinese Academy of Medical Sciences Beijing 100730 China Department of Radiology Paeking Union Miedical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Beijing100730 China Department of Gynaecology and Obstetrics Peking Union Medical College Hospital Peking UnionMedical College Chinese Academy of Medical Sciences Beijing100730 China

Background Osteogenesis imperfecta （OI） is a rare bone disease and its effective treatment is relatively deficient. We tried to assess the effects of new bisphosphonate, ibandronate on children with *** In this open-label, prospective, controlled study, 30 children with OI were enrolled. They received either infusions of ibandronate （2 mg） in every three months or oral calcitriol 0.25 μg daily for 24 months. All patients took 500 mg calcium plus 200 U vitamin D daily together. The endpoints were the change of annual new fracture rate （observed by case history and X ray films of spine）, bone mineral density （BMD, measured by dual energy X-ray absortiometry）, serum concentration of carboxy-telopeptide cross-links of type Ⅰ collagen （CTX, bone resorption marker） and alkaline phosphatase （ALP, bone formation marker） during the *** After the cyclic infusions of ibandronate, the annual new fracture rate was significantly decreased from 1.9 to 0.13 time, obviously lower than that of calcitriol group, which decreased from 1.8 to 1.0 time after the treatment （P 〈0.001）.The significant increase of BMD at the lumbar spine, femoral neck, trochanter, total hip was found in the group of ibandronate by 59.0%, 42.0%, 47.5% and 36.6% in time dependent manner （compared with the baseline, P 〈0.001）. The increase of BMD in ibandronate group was greater than that of calcitriol group （P 〈0.001）. The concentrations of ALP and CTX were obviously decreased in ibandronate group, and the reduction of CTX was more significant than that of ALP （P 〈0.001）. The tolerance of the children to ibandronate was quite well. Mild fever and muscle pain were found in 9 cases within 1-3 days after the first infusion of ibandronate, which could relieve after 1-2 days without special *** The benefits of cyclic infusions of ibandronate to children with OI are significant because ibandronate could significantly reduce annual bone fracture rate, increase lumbar and hip BMD

关键词： osteogenesis imperfecta ibandronate annual new fracture rate bone mineral density

Design,synthesis and biological activity of novel substituted pyrazole amide derivatives targeting Ec R/USP receptor

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Chinese Chemical Letters 2016年第4期27卷 566-570页

作者： Xi-Le Deng Jin Xie yong-Qiang Li De-Kai Yuan Xue-Ping hu Li Zhang Qing-Min Wang Ming Chi Xin-Ling Yang Department of Applied Chemistry College of Science China Agricultural University State Key Laboratory of Elemento-Organic Chemistry Research Institute of Elemento-Organic Chemistry Nankai University

In order to discover highly active ecdysone analogs, a series of new substituted pyrazole amide derivatives were obtained using structure-guided optimization method and further screened for their insecticidal activities, in the basis of the core structures of the two active compounds N-（3-methoxyphenyl）-3-（tert-butyl）-1-phenyl-1H-pyrazole-5-carboxamide（6e） and N-（4-（tert-butyl）phenyl）-3-（tert-butyl）-1-phenyl-1H-pyrazole-5-carboxamide（6i）, previously presented by us. The chemical structures of the title compounds were identified by spectral analyses. The preliminary bioassay results indicated that one among the synthesized pyrazole derivatives, compound 34, endowed with good activity against Mythimna Separata at 10 mg/L, which was equal to that displayed by the positive control tebufenozide. In addition, examples of molecular docking and molecular dynamics studies demonstrated that 34 may be the potential inhibitor to Ec R and its docking conformation was similar to that of tebufenozide. In addition, increasing the hydrophobic effect and considering the suitable bulk effect on pyrazole ring are beneficial to the inhibiting activity to Ec R and activity in vivo.

关键词： Moulting hormone Pyrazole amide Bioactivity Molecular docking Molecular dynamics simulation Insect growth regulators

Sesquiterpenes from the leaves of Nicotiana tabacum and their anti-tobacco mosaic virus activity

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Chinese Chemical Letters 2016年第5期27卷 753-756页

作者： Qin-Peng Shen xing-Meng Xu Lan Li Wei Zhao Neng-Jun Xiang Guang-Yu Yang yong-Kuan Chen Ming-Ming Miao Chun-Bo Liu Zhi-hua Liu Key Laboratory of Tobacco Chemistry of Yunnan Province China Tobacco Yunnan Industrial Co. Ltd. School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Nature Products Kunming Medical University

In searching for more bioactive compounds, phytochemical investigations on the acetone extract of the leaves ofNicotiana tabacurn resulted in the isolation of two new sesquiterpenes, nicosesquiterpene A and B （1 and 2）, along with four known sesquiterpene derivatives （3-6）. Structural elucidation of I and 2 was performed by spectral methods, such as HRMS, IR, UV, 1D and 2D NMR spectroscopy. Compounds 1 and 2 are the first naturally occurring pterosin-type sesquiterpene bearing an isopropyl moiety. Compounds 1-6 were also evaluated for their anti-tobacco mosaic virus （anti-TMV） activity. The results showed that compounds 1 and 2 exhibited high anti-TMV activity with inhibition rates of 36.7% and 45.6%, respectively, which is higher than that of positive control. The other compounds also showed potential activity with inhibition rates in the range of 22.7%-29.2%.

关键词： Sesquiterpenes Anti-tobacco mosaic virus activity (AntiTMV) Nicotiana tabacum Structural elucidation Ningnanmycin

一种扩大8mm波段综合孔径辐射计成像视场的方法

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红外与毫米波学报 2013年第1期32卷 50-55页

作者：胡岸勇苗俊刚北京航空航天大学电子信息工程学院北京100191

针对8 mm波段综合孔径辐射计射频前端电尺寸较大、采用常规Y形阵列布局系统成像视场范围小的缺点,首先提出了一种星形天线阵列布局,它使可视度函数采样点之间的间隔变为天线单元间隔的一半,从而使系统的成像视场扩大到原来的两倍;然后,... 详细信息

针对8 mm波段综合孔径辐射计射频前端电尺寸较大、采用常规Y形阵列布局系统成像视场范围小的缺点,首先提出了一种星形天线阵列布局,它使可视度函数采样点之间的间隔变为天线单元间隔的一半,从而使系统的成像视场扩大到原来的两倍;然后,针对星形阵列可视度函数采样点缺失的问题,研究了背景对消与凸集投影相结合的图像反演算法,并进行了成像仿真.仿真结果验证了该反演算法的有效性.

关键词：综合孔径辐射计图像反演

Biphasic insulin aspart 30 improved glycemic control in Chinese patients with type 2 diabetes poorly controlled on oral glucose-lowering drugs： a subgroup analysis of the A1chieve study

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Chinese Medical Journal 2014年第2期127卷 208-212页

作者： Chen Liming xing Xiaoyan Lei Minxiang Liu Jie Shi yongquan Li Pengqiu Qin Guijun Li Chengjiang Li Yukun Wang Qing Gao Tianshu hu Ling Wang Yangwei Yang Wenying Key Laboratory of Hormones and Development (Ministry of Health) Metabolic Diseases Hospital & Tianjin Institute of Endocrinology Tianjin Medical University Tianjin 300070 China Department of Endocrinology China-Japan Friendship Hospital Beijing 100029 China Department of Endocrinology Xiangya Hospital of Central South University Changsha Hunan 410008 China Department of Endocrinology Shanxi Provincial People's Hospital Taiyuan Shanxi 030012 China Department of Endocrinology Shanghai Changzheng Hospital Shanghai 200032 China Sichuan Provincial People's Hospital Chengdu Sichuan 610072 China Department Of Endocrinology First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450052China Department of l~ndocrinology First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310003 China Department of Endocrinology Third Hospital of Hebei Medical University Shiiiazhuang Hebei 050051 China Department of Endocrinology China-Japan Union Hospital Changchun Jilin 130033 China University of Traditional Chinese Medicine Shenyang Liaoning 110032 China Department of Endocrinology Third Affiliated Hospital of Nanchang University Nanchang Jiangxi 330008 China Department of Endocrinology Shaanxi Provincial People's Hospital Xi'an Shaanxi 710068 China

Background The effectiveness and safety of initiating biphasic insulin aspart 30 in patients who were poorly controlled on oral glucose-lowering drugs were studied in randomized controlled trials,while results from clinical practice remain *** subgroup analysis was to provide such findings from a large-scale non-interventional *** A1chieve was a multinational,prospective,open-label,non-interventional,24-week study in patients with type 2 diabetes initiating insulin analogues in 28 countries across Asia,Africa,Europe,and Latin *** physician had taken the decision to use this insulin,any patient with type 2 diabetes who was not treated with or who had started the study insulin within 4 weeks before inclusion was *** were treated with study insulin alone or in combination with oral glucose-lowering *** on adverse drug reactions,hypoglycemia and glycemic control were collected at baseline,week 12 and *** is a report of a Chinese subgroup analysis from the A1chieve *** Totally,4 100 patients constituted this *** serious adverse drug reactions were *** of total,major,nocturnal hypoglycemic events （events/patient per year） were 1.47,0.10,0.31 at baseline and 1.35,0.00,0.22 at week 24,*** control was improved as measured by hemoglobin A1c （mean 9.3％ to 7.0％,reduction -2.3％）,fasting plasma glucose （mean 10.2 to 6.8 mmol/L,reduction-3.5 mmol/L） and postprandial plasma glucose （mean 14.4 to 8.8 mmol/L,reduction-5.6 mmol/L）,all P ＜*** in mean body weight was ＋0.3 kg （P ＜0.001）.Conclusion In this subgroup analysis of the A1chieve study,biphasic insulin aspart 30 improved glycemic control with low risk of hypoglycemia.

关键词： biphasic insulin aspart 30 Chinese type 2 diabetes oral glucose-lowering drugs