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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第5期21卷 411-415页

作者： Tian-ming XUAN xing-xiang wang xiang-yuan PU Wei-li HAN Xiao-gang GUO Department of Cardiology the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Department of Lung Transplantation the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China

本文首次报告了重症新型冠状病毒肺炎(COVID-19)感染接受肺移植并行急症冠脉介入治疗的病例。通过对多学科协作成功救治的总结,为重症COVID-19救治提供经验。我们发现,重症COVID-19感染在肺移植术后可能出现多种危险因素诱发心肌梗死,... 详细信息

本文首次报告了重症新型冠状病毒肺炎(COVID-19)感染接受肺移植并行急症冠脉介入治疗的病例。通过对多学科协作成功救治的总结,为重症COVID-19救治提供经验。我们发现,重症COVID-19感染在肺移植术后可能出现多种危险因素诱发心肌梗死,急症冠脉介入治疗是救治此类患者的重要手段。

关键词：新型冠状病毒肺炎(COVID-19) 肺移植心肌梗死冠脉介入治疗

Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting xiang xiangxin xing Xuyun Hua Yuwen Zhang Xin Xue Jiajia Wu Mouxiong Zheng He wang Jianguang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le wang Wenwu Zhang Gang Li xing Cheng Peiqiang Su Yong Wan xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

Influence of Thinning on Soil CO_2 Efflux in Chinese Fir Plantations

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Pedosphere 2009年第3期19卷 273-280页

作者： wang Guang-Jun Forest Ecology Section Faculty of Life Sciences and Technology Central South University of Forestry and TechnologyChangsha 410006 （China）

Forest management is expected to influence soil CO2 effiux （FCO2） as a result of changes in microenvironmental conditions, soil microclimate, and root dynamics. Soil EGO2 rate was measured during the growing season of 2006 in both thinning and non-thinning locations within stands ranging from 0 to 8 years after the most recent thinning in Chinese fir （Cunninghamia lanceolata （Lamb.） Hook） plantations in Huitong Ecosystem Research Station, Hunan, China. Soil temperature and moisture were also measured to examine relationships between FCO2 and soil properties. Forest thinning resulted in huge changes in FCO2 that varied with time since cutting. Immediately following harvest （year 0） FCO2 in thinning area increased by about 30%, declined to 20%-27% below pre-cutting levels during years 4-6, and recovered to pre-cutting levels at 8 years post-cutting. A similar temporal pattern, but with smaller changes, was found in non-thinning locations. The initial increase in FCO2 could be attributed to a combination of root decay, soil disturbance, and increased soil temperature in gaps, while the subsequent decrease and recovery to the death and gradual regrowth of active roots. Strong effects of soil temperature and soil water content on FCO2 were found. Forest thinning mainly influenced FCO2 through changes in tree root respiration, and the net result was a decrease in integrated FCO2 flux through the entire felling cycle.

关键词： forest soil moisture soil properties soil respiration soil temperature

Effects of puerarin on number and activity of endothelial progenitor cells from peripheral blood

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Acta Pharmacologica Sinica 2004年第8期 71-77页

作者： Jun-hui ZHU, xing-xiang wang, Jun-zhu CHEN, Yun-peng SHANG, Jian-hua ZHU, Xiao-gang GUO, Jian SUNDepartment of Cardiovascular Diseases, the First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou 310003, China

AIM: To investigate whether puerarin can augment endothelial progenitor cells (EPCs) numbers, promote EPC proliferative, migratory, adhesive, and in vitro vasculogenesis capacity. METHODS: EPCs were characterized as adherent cells by double staining of DiLDL-uptake and lectin binding under a laser scanning confocal microscope. Expression of KDR, VEGFR-2, and AC 133 was detected by flow cytometry. EPCs proliferation, migration and in vitro vasculogenesis were determined with MTT assay, modified Boyden chamber assay, and in vitro vasculogenesis kit, respectively. EPCs adhesive assay was performed by replating those on fibronectin-coated dishes, then adherent cells were counted. RESULTS: Incubation of isolated human MNCs with puerarin 0.1-3 mmol/L increased the number of EPCs, EPC proliferative, migratory, adhesive, and in vitro vasculogenesis capacity in a concentration and time-dependent manner, which reached maximum at 3 mmol/L, 24 h (approximately 1-fold increase, P<0.01). CONCLUSION: Puerarin enhanced

关键词： puerarin isoflavones vascular endothelium stem cells cell differentiation vascular endothelial growth factor confocal microscopy

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真实盈余管理的原因:一个前景理论的解释

管理工程学报 2017年第3期31卷 45-51页

作者：鲍学欣曹国华邢相春王鹏重庆大学经济与工商管理学院重庆400044 重庆交通大学航海学院重庆400074

本文利用2007-2012年间839个样本组成的面板数据,依据行为金融学中的"前景理论",在设定盈余管理双重阈值与市场阈值、盈余管理收益与风险(成本)的直线型关系与双对数型关系的基础上,实证检验了上市公司进行真实盈余管理的原因。研究发现... 详细信息

本文利用2007-2012年间839个样本组成的面板数据,依据行为金融学中的"前景理论",在设定盈余管理双重阈值与市场阈值、盈余管理收益与风险(成本)的直线型关系与双对数型关系的基础上,实证检验了上市公司进行真实盈余管理的原因。研究发现,前景理论可以对中国上市公司真实盈余管理行为进行解释:在盈余管理盈利区间,收益与风险呈现出显著地正相关关系;在损失区间,收益与风险表现为显著地负相关关系;并且,收益区间的系数关系要平缓于损失区间。同时,本文研究还发现,上市公司利用真实盈余管理替代应计盈余管理的真实目的在于追逐更为稳定的盈余收益。

关键词：前景理论真实盈余管理应计盈余管理

热水预处理过程中P因子对杨木半纤维素溶出效果的影响

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中国造纸 2018年第8期37卷 1-7页

作者：徐丰杨桂花吉兴香王强董吉冉陈嘉川齐鲁工业大学(山东省科学院)生物基材料与绿色造纸国家重点实验室/制浆造纸科学与技术教育部重点实验室山东济南250353

制浆前对生物质原料进行热水预处理,可以有效地提取半纤维素,这对于生物质高值化利用具有重要意义。本实验研究了不同工艺条件下杨木热水预处理过程中半纤维素糖类组分的溶出规律以及酸溶木素、乙酸和醛类物质随预水解因子(P因子)的变... 详细信息

制浆前对生物质原料进行热水预处理,可以有效地提取半纤维素,这对于生物质高值化利用具有重要意义。本实验研究了不同工艺条件下杨木热水预处理过程中半纤维素糖类组分的溶出规律以及酸溶木素、乙酸和醛类物质随预水解因子(P因子)的变化规律。结果表明,在热水预处理过程中,P因子较适宜的范围是685~1225,此范围内杨木中的半纤维素糖类能够较好地溶出,总木糖溶出率高达51.8%,预水解液中木糖、酸溶木素、乙酸、糠醛等含量与P因子的增加成正比,而低聚合度聚木糖(聚合度2~25)含量随P因子的增加先增加后降低。当P因子在717时,水解液中低聚合度聚木糖含量达最大值10.24 g/L,此P因子下原料中总木糖溶出率为44.2%,而且酸溶木素、乙酸、糠醛等非糖类物质含量较低,这有利于后续低聚合度聚木糖和木糖的分离提取生产功能性低聚木糖产品。

关键词：杨木热水预水解 P因子低聚木糖

企业技术管理体系平台建设研究——以大连机车车辆有限公司为例

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技术与创新管理 2017年第2期38卷 212-217页

作者：栾进兴王翔宇徐阳栾岚王禛中车大连机车车辆有限公司科技管理部辽宁大连116022

文中对大连机车车辆有限公司技术体系状况进行分析,提出完善技术管理创新体系,实施技术管理机制和制度创新,资源配置优化,提高自主创新能力,突破关键核心技术的改革方案,为创新驱动发展提供支撑。以科技项目管理为对象进行研究,通过与... 详细信息

文中对大连机车车辆有限公司技术体系状况进行分析,提出完善技术管理创新体系,实施技术管理机制和制度创新,资源配置优化,提高自主创新能力,突破关键核心技术的改革方案,为创新驱动发展提供支撑。以科技项目管理为对象进行研究,通过与同行业典型的案例分析比较,使提出的技术管理体系建设方案具有科学实用性;运用技术管理理论和方法,搭建技术管理体系平台,建立完善技术管理的机制与制度,出台十几项管理制度与标准,覆盖科技规划、科技投标、项目管理、成果管理、知识产权、RAMS体系、标准化管理、技术市场等业务的制度建设,使现行技术创新体系成功运行有了制度保障,为公司创新技术研发提供了支撑平台。

关键词：搭建平台创新驱动提供支撑

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文蛤红壳色选育系F_3的生长规律及模型

海洋渔业 2017年第4期39卷 411-418页

作者：吴杨平陈爱华张雨曹奕姚国兴蔡永祥王超江苏省海洋水产研究所江苏南通226007

为检验文蛤(Meretrix meretrix)红壳色选育系F_3的生长性能,连续比较了同等养殖条件下选育系F_3和自然对照组CG的生长情况,并采用Von Bertalanffy、Gompertz、Logistic和Brody 4种非线性模型对文蛤红壳色选育系F_3的生长参数进行生长模... 详细信息

为检验文蛤(Meretrix meretrix)红壳色选育系F_3的生长性能,连续比较了同等养殖条件下选育系F_3和自然对照组CG的生长情况,并采用Von Bertalanffy、Gompertz、Logistic和Brody 4种非线性模型对文蛤红壳色选育系F_3的生长参数进行生长模型构建,以研究文蛤红壳色选育系F_3的生长规律。结果表明,文蛤红壳色选育系F_3在浮游期、稚贝中间培育期和塘口养殖期内的生长均显著快于对照组CG(P<0.05),F_3的平均日生长率均大于CG,490日龄内F_3的壳长相对于CG平均增长率为34.05%。塘口养殖期间,6~9月是F_3生长最为快速阶段,且F_3较CG的粒重增长率在98.27%以上。文蛤红壳色选育系F_3的壳长和粒重之间遵循复合曲线Y=9.028×1.499W,R2=0.977。文蛤红壳色选育系F_3的壳长生长遵循Logistic生长模型,其在575日龄时出现快速生长,这为及时疏苗养殖提供了依据。

关键词：文蛤红壳色生长模型生长参数

内皮型一氧化氮合酶基因G894T多态性与青海省汉族妊娠高血压综合征的相关性

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解剖学报 2017年第3期48卷 353-357页

作者：李红荣李长兴王香林庄文婷闫帅李建华青海大学医学院基础医学部解剖学教研室西宁810001

目的探讨内皮型一氧化氮合酶(eNOS)G894T基因多态性与青海省汉族妊娠高血压综合征(PIH)的相关性。方法采用限制性片段长度多态性聚合酶链反应(PCR-RFLP)方法对138名妊娠高血压综合征患者和135名正常孕妇e NOS基因G894T多态性进行分型,... 详细信息

目的探讨内皮型一氧化氮合酶(eNOS)G894T基因多态性与青海省汉族妊娠高血压综合征(PIH)的相关性。方法采用限制性片段长度多态性聚合酶链反应(PCR-RFLP)方法对138名妊娠高血压综合征患者和135名正常孕妇e NOS基因G894T多态性进行分型,并测序验证。结果妊娠高血压综合征组基因型频率野生型(GG)、杂合子型(GT)和突变纯合子型(TT)分别为17.4%、82.6%、0;对照组分别为0、95.6%、4.4%,两组基因型频率分布有差异(P<0.05)。妊娠高血压综合征组e NOS等位基因频率G、T分别为58.7%、41.3%;对照组分别为47.8%、52.2%,两组比较差异有统计学意义(P<0.05),妊娠高血压综合征组G基因频率高于对照组。结论e NOS基因G894T多态性可能与青海省汉族妊娠高血压综合征有关,G等位基因可能为妊娠高血压综合征的易感基因(OR=1.229,95%CI:1.048~1.441),T等位基因可能为妊娠高血压综合征的保护基因。携带GG基因型的孕妇可作为青海省妊娠高血压综合征的易感人群。

关键词：妊娠高血压综合征多态性内皮型一氧化氮合酶限制性片段长度多态性聚合酶链反应孕妇