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Microstructure evolution characterization of Ni-based GH4720Li superalloy during strain-controlled fatigue at 550℃

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Journal of Iron and Steel Research International 2021年第7期28卷 901-909页

作者： xing-fei xie Jing-long Qu Jin-hui Du Zhong-nan Bi Gaona Aero Material Co. Ltd.Beijing 100081China High Temperature Materials Research Institute Central Iron and Steel Research InstituteBeijing 100081China

High-temperature fatigue property of Ni-based GH4720Li superalloy at 550℃has been investigated at maximum strain from 0.8%to 1.1%.Microstructural characterization and oxidation behavior of superalloy during high-temperature fatigue have been analyzed by transmission electron microscopy and scanning transmission electron *** results show that a stable response following a slight cyclic hardening during initial cycles was revealed at the maximum strain from 0.8%to 1.0%.The stable response decreased with an increase in maximum *** cyclic hardening was observed at the maximum strain of 1.1%.There is difference in dislocation substructures between primary γ'precipitates and γ *** cell and mechanical twin were formed in the interior of primary γ'precipitates and γ *** primary γ'precipitate interface would migrate toward the interior of primary γ'precipitates along twin boundaries,leading to instability of primary γ'*** secondary γ'depleted zone was distinctly generated near the surface due to the decomposi-tion of secondary γ'*** crack initiation and propagation during high-temperature fatigue were found inside the secondary γ'depleted *** primary γ'precipitates could effectively hinder the crack ***-rich oxide films(Al_(2)O_(3))were initially produced at crack tips,because the rate of diffusion of Al was relatively higher than that of other elements at crack tips.

关键词： Ni-based superalloy High-temperature fatigue Transmission electron microscopy Scanning transmission electron microscopy Fatigue crack tip Oxide

Solidification behaviour and hot cracking susceptibility of a novel Ni-based superalloy

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Journal of Iron and Steel Research International 2024年第4期31卷 956-966页

作者： Yue Chen Shao-min Lv xing-fei xie Xiao-can Wen Jng-long Qu Jin-hui Du High-Temperature Materials Institute China Iron and Steel Research Institute Group Co.Ltd.Beijing 100081China Beijing GAONA Materials and Technology Co. Ltd.Beijing 100081China Sichuan CISRI-GAONA Forging Co. Ltd.Deyang 610000SichuanChina

A novel Ni-based superalloy GH4151,with a γ′ volume fraction of about 55%and a service temperature capability up to 8oo oC,was *** to the different cooling conditions of various regions during the solidification of ingots,significant cooling rate variations may lead to the occurrence of hot *** scanning laser microscope was utilised to investigate the solidification process and phase precipitation behaviour of the GH4151 under wide range cooling *** characteristics of L→γ transformation were analysed,and the growth rates of at each stage were *** segregation behaviour was predicted using the Scheil equation,and the predicted results match well with the experimental *** sensitivity coefficient for hot cracking was modified,and cracking sensitivity coefficient values for the alloy under different cooling rates were computed,revealing that the alloy is most susceptible to hot cracking at 10℃/min cooling ***,controlling the cooling rate can reduce the possibility of hot cracking in ingot.

关键词： Ni-based superalloy Solidification behaviour In-situ observation Clyne and Davies's criterion:Hot cracking susceptibility

Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin Luo Caiyan Wei Yaru Qiao Jiming xie Xianchao Pan Juan xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： xing-Hui Yu Yan xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

Joint toxicity of methamidophos and cadmium acting on Abelmoschus manihot

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Journal of Environmental Sciences 2005年第3期17卷 379-383页

作者： WANGXiao-fei ZHOUQi-xing KeyLaboratoryofTerrestrialEcologicalProcess InstituteofAppliedEcologyChineseAcademyofSciencesShenyang110016China／／GraduateSchooloftheChineseAcademyofSeiences.Beijing100039China

Joint toxicity of methamidophos and cadmium(Cd) on the ornamental Abelmoschus manihot was firstly examined and compared with single-factor effects of the two pollutants using ecotoxicological indexes including the inhibitory rate of seed germination, root elongation and inhibitory concentration 50%(IC_ 50). The results indicated that methamidophos and Cd had unobvious(p>0.05) effects on seed germination of the ornamental. There were significant(p20 mg/L). However, the analysis of joint effects indicated that there were antagonistic effects between Cd and methamidophos under all the treatments. At the high concentration of Cd, joint toxicity of methamidophos and Cd was more dependent on concentration of Cd.

关键词： joint toxicity cadmium methamidophos ornamental

Anisotropic optical and electric properties of β-gallium oxide

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Journal of Semiconductors 2023年第7期44卷 8-22页

作者： Yonghui Zhang fei xing School of Physics and Optoelectronic Engineering Shandong University of TechnologyZibo 255000China

The anisotropic properties and applications ofβ-gallium oxide(β-Ga_(2)O_(3))are comprehensively *** the anisotropic properties are essentially resulted from the anisotropic crystal *** process flow of how to exfoliate nanoflakes from bulk material is *** optical properties,including optical bandgap,Raman and photolumines-cence characters are comprehensively *** measurement configurations of angle-resolved polarized Raman spec-tra(ARPRS)are reviewed,with Raman intensity formulas calculated with Raman tensor *** method to obtain the Raman tensor elements of phonon modes through experimental fitting is also *** addition,the anisotropy in elec-tron mobility and affinity are *** applications,especially polarization photodetectors,based onβ-Ga_(2)O_(3)were summa-rized *** kinds of polarization detection mechanisms based on material dichroism,1D morphology and metal-grids are discussed *** review paper provides a framework for anisotropic optical and electric properties ofβ-Ga_(2)O_(3),as well as the applications based on these characters,and is expected to lead to a wider discussion on this topic.

关键词： gallium oxide anisotropic dichroism polarization monoclinic

Bimetallic water oxidation: One-site catalysis with two-sites oxidation

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Journal of Energy Chemistry 2021年第12期30卷 1-7,I0001页

作者： fei xie Ming-Tian Zhang Center of Basic Molecular Science(CBMS) Department of ChemistryTsinghua UniversityBeijing 100084China

Water oxidation is the key half reaction to achieve full splitting of water to hydrogen and ***,a binuclear complex,[(L^(4-))Co_(2)~Ⅲ(OH)]ClO_(4),was reported as a stable and efficient homogenous catalyst for electrocatalytic water oxidation in 0.1 M phosphate buffer(pH 7.0).Cyclic voltammetry experiments indicated that the catalytic process proceed via "one-site catalysis with two-sites oxidation" mechanism in which both two metal sites store the required oxidation equivalents for water oxidation and O-O bond formation occurs by single-site water nucleophilic attack(WNA).

关键词： Water oxidation Bimetallic catalysis O-O bond formation Cobalt catalyst Oxygen evolution

Improvements in Long-Lead Prediction of Early-Summer Subtropical Frontal Rainfall Based on Arctic Sea Ice

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Journal of Ocean University of China 2019年第3期18卷 542-552页

作者： xing Wen HUANG fei Key Laboratory of Physical Oceanography Ocean University of China Qingdao 266100 China Laboratory for Ocean and Climate Dynamics Pilot National Laboratory for Marine Science and Technology (Qingdao) Qingdao 266100 China Ningbo Collaborative Innovation Center of Nonlinear Harzard System of Ocean and Atmosphere Ningbo University Ningbo 315211 China

Seasonal prediction of East Asia(EA) summer rainfall, especially with a longer-lead time, is in great demand, but still very challenging. The present study aims to make long-lead prediction of EA subtropical frontal rainfall(SFR) during early summer(May-June mean, MJ) by considering Arctic sea ice(ASI) variability as a new potential predictor. A MJ SFR index(SFRI), the leading principle component of the empirical orthogonal function(EOF) analysis applied to the MJ precipitation anomaly over EA, is defined as the predictand. Analysis of 38-year observations(1979-2016) revealed three physically consequential predictors. A stronger SFRI is preceded by dipolar ASI anomaly in the previous autumn, a sea level pressure(SLP) dipole in the Eurasian continent, and a sea surface temperature anomaly tripole pattern in the tropical Pacific in the previous winter. These precursors foreshadow an enhanced Okhotsk High, lower local SLP over EA, and a strengthened western Pacific subtropical high. These factors are controlling circulation features for a positive SFRI. A physical-empirical model was established to predict SFRI by combining the three predictors. Hindcasting was performed for the 1979-2016 period, which showed a hindcast prediction skill that was, unexpectedly, substantially higher than that of a four-dynamical models’ ensemble prediction for the 1979-2010 period(0.72 versus 0.47). Note that ASI variation is a new predictor compared with signals originating from the tropics to mid-latitudes. The long-lead hindcast skill was notably lower without the ASI signals included, implying the high practical value of ASI variation in terms of long-lead seasonal prediction of MJ EA rainfall.

关键词： East Asia subtropical frontal rainfall long-lead seasonal prediction Arctic sea ice Physical-empirical model

QoE-driven resource allocation for mobile IP services in wireless network

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Science China(Information Sciences) 2015年第1期58卷 222-231页

作者： fei ZeSong xing ChengWen LI Na School of Information Science and Engineering Beijing Institute of Technology

In this study, quality of experience(QoE)-driven resource allocation for multi-applications in Internet Protocol(IP)-based wireless networks is studied. Considering that the mean opinion score(MOS) summation maximization problem is not fair to satisfy heterogeneous users' QoE with various mobile applications, we apply multi-objective optimization method to maximize each user's MOS utility. At the beginning of this work, the relationship between MOS utility and user transmission rate for three multimedia applications, that is, File Download, Internet Protocol Television, and Voice over Internet Protocol are discussed. However, the relations under diverse evaluation models are quite different and users in various mobile applications have different requirements, which make the optimization problem difficult to solve. To meet each user's minimum rate requirement,the idea of Nash bargaining solution is applied in the Hungarian-based subcarrier assignment problem. Then to simplify the power allocation problem, the concept of equivalent channel is introduced. Further by applying the tolerance membership function, we develop a fuzzy Max-Min decision model for generating an optimal power allocation solution. Simulation results demonstrate the satisfying characteristics of the proposed algorithm in terms of MOS utility and average data rate.

关键词： quality of experience mean opinion score tolerance membership function fuzziness multi-objective optimization