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体外受精-胚胎移植术后妊娠合并血行播散型肺结核危重病2例报道及文献复习

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中国综合临床 2024年第4期40卷 302-306页

作者：王利艳李红高圆圆高明霞兰州大学第一临床医学院兰州730000 兰州大学第一医院重症医学科兰州730000 兰州大学第一医院生殖中心兰州730000

妊娠期急性血行播散型肺结核(acute hematogenous pulmonary tuberculosis,AHPTB)合并急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)和脓毒性休克,是一种罕见且致命的状态。现报道的两例患者均因输卵管因素行体外受精... 详细信息

妊娠期急性血行播散型肺结核(acute hematogenous pulmonary tuberculosis,AHPTB)合并急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)和脓毒性休克,是一种罕见且致命的状态。现报道的两例患者均因输卵管因素行体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)助孕,妊娠后发生危重AHPTB,随后出现呼吸衰竭。经过辅助呼吸、尽早抗结核以及对症治疗,两例患者病情均好转。对于结核高发地区因输卵管不孕行IVF-ET术后妊娠的女性,出现妊娠期持续发热、咳嗽、咳痰以及阴道出血等症状应警惕结核病的可能,并尽早排查。对于妊娠合并AHPTB的患者,应积极治疗、警惕病情恶化。

关键词：肺结核,急性血行播散型体外受精-胚胎移植妊娠

球面质心泰森多边形网格海浪预报的向量化检验方法

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海洋预报 2024年第2期41卷 34-43页

作者：谢明炎魏立新高元勇高志一国家海洋环境预报中心北京100081 国家海洋环境预报中心自然资源部海洋灾害预报技术重点实验室北京100081

提出一种适于并行计算设备的向量化检验方法。采用特征半径近似判别法选取搜索域内观测点平均值作为实测值,基于广播、索引等向量化方法及海浪平稳性条件实现模式和观测资料时间和空间的匹配,并将待检区域等分为若干块分别计算以免内存... 详细信息

提出一种适于并行计算设备的向量化检验方法。采用特征半径近似判别法选取搜索域内观测点平均值作为实测值,基于广播、索引等向量化方法及海浪平稳性条件实现模式和观测资料时间和空间的匹配,并将待检区域等分为若干块分别计算以免内存溢出。本算法可在中央处理器(CPU)和图形处理器(GPU)上运行,也适用于其它类型的模式网格。为评估算法实际效果,以有限体积海浪模式产生的球面质心泰森多边形网格预报产品和卫星沿轨道遥感产品分别作为待检和参考数据,结果表明CPU和GPU的计算结果一致;GPU的计算效率较CPU提高30倍;区块大小对效率提升有一定影响,需根据实际算例调试优化。

关键词：精度检验 GPU加速向量化高性能检验

A genomic association study revealing subphenotypes of childhood steroid-sensitive nephrotic syndrome in a larger genomic sequencing cohort

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Genes & Diseases 2024年第4期11卷 400-410页

作者： Han Chan Fenfen Ni Bo Zhao Huimin Jiang Juanjuan Ding Li Wang Xiaowen Wang Jingjing Cui Shipin Feng Xiaojie gao xueying Yang Huan Chi Hao Lee xuelan Chen Xiaoqin Li Jia Jiao Daoqi Wu gaofu Zhang Mo Wang Yupeng Cun Xiongzhong Ruan Haiping Yang Qiu Li Department of Nephrology Children's Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of PediatricsChongqing 400014China Department of Nephrology Shenzhen Children's HospitalShenzhenGuangdong 518034China Department of Nephrology Kunming Children's HospitalKunming Medical UniversityKunmingYunnan 650228China Department of Nephrology Wuhan Children's HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhanHubei 430015China Department of Nephrology Chengdu Women and Children Central HospitalChengduSichuan 610073China Pediatric Research Institute Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Department of Nephrology John Moorhead Research LaboratoryUniversity College London Medical SchoolRoyal Free CampusUniversity College LondonLondon NW32PFUnited Kingdom

Dissecting the genetic components that contribute to the two main subphenotypes of steroid-sensitive nephrotic syndrome(SSNS)using genome-wide association studies(GWAS)strategy is important for understanding the *** conducted a multicenter cohort study(360 patients and 1835 controls)combined with a GWAS strategy to identify susceptibility var-iants associated with the following two subphenotypes of ssNS:steroid-sensitive nephrotic syn-drome without relapse(SSNswR,181 patients)and steroid-dependent/frequent relapse nephrotic syndrome(SDNS/FRNS,179 patients).The distribution of two single-nucleotide poly-morphisms(SNPs)in ANKRD36 and ALPG was significant between SSNSWR and healthy controls,and that of two SNPs in GAD1 and HLA-DQA1 was significant between SDNS/FRNS and healthy ***,rs1047989 in HLA-DQA1 was a candidate locus for SDNS/FRNS but not for *** significant SNPs were observed between SSNSWR and SDNS/***,chromosome 2:171713702 in GAD1 was associated with a greater steroid dose(>0.75 mg/kg/d)upon relapse to first remission in patients with SDNS/FRNS(odds ratio=3.14;95%confidence interval,0.97-9.87;P=0.034).rs117014418 in APOL4 was significantly associated with a decrease in eGFR of greater than 20%compared with the baseline in SDNS/FRNS patients(P=0.0001).Protein-protein intersection network construction suggested that HLA-DQA1 and HLA-DQB1 function together through ***,SSNSWR belongs to non-HLA region-dependent nephropathy,and the HLA-DQA/DQB region is likely strongly associated with dis-ease relapse,especially in SDNS/*** study provides a novel approach for the GWAS strategy of SsNS and contributes to our understanding of the pathological mechanisms of SSNSWRandSDNS/FRNS.

关键词： Frequentrelapse Genome-wide association study Human leukocyte antigen region Steroid-sensitive nephrotic syndrome

Generating Baikal-GVD high energy cascade-like neutrino events with a GEANT4-based simulation toolkit

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Chinese Physics C 2024年第10期48卷 256-263页

作者： Zike Wang A.D.Avrorin Zhen Cao Mingjun Chen Peiyuan Chu Zh.-A.M.Dzhilkibaev Bo gao Tianqi Huang Jiali Liu Ying Qi Xiaohao You D.N.Zaborov Key Laboratory of Particle Astrophysics Experimental Physics Division&Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Institute for Nuclear Research of the Russian Academy of Sciences Moscow 117312Russia TIANFU Cosmic Ray Research Center Chengdu 610213China School of Science Tibet UniversityLhasa 850000China

Using the GEANT4 and Cosmic Ray Monte Carlo(CRMC)software packages,we developed a new simulation toolkit for astrophysical neutrino *** configuring the Baikal-GVD detector and comparing the vertex position and direction of incident particles,as well as the channel-by-channel signals,to the events detected by Baikal-GVD,we successfully generated 13 high-energy cascade neutrino events with the *** analysis revealed a systematic offset between the reconstructed shower position and the true interaction position,with a distance close to the scale of the shower maximum of−0.54±1.29 *** achieved a good linear relationship between the photoelectron number of neutrino events obtained by simulation and the real data measured by *** simulation toolkit could serve as a reliable basis for studying the performance of astrophysical neutrino telescopes.

关键词： high-energy neutrino cascade event simulation Cherenkov

A method for Improving the Efficiency of Pear Tree Crossbreeding

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Agricultural Biotechnology 2024年第2期13卷 25-26,42页

作者： Jintao XU Longfei LI Minghui JI Huan LIU Lijuan gao Yong GUO Yingjie WANG Baofeng HAO Changli Institute of Pomology Hebei Academy of Agriculture and Forestry SciencesChangli 066600China

In view of the short blooming period of pear tree crossbreeding and the complexity of pollination process, a method that can improve the efficiency of crossbreeding of pear trees was provided. Meanwhile, this method can also be applied to the study of pollen xenia effect, pollination tree selection and pure pollen collection in pear tree cultivation.

关键词： Pear tree Cross breeding Efficiency Method

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海战场时敏打击链动态集成模型研究

中国舰船研究 2024年第4期19卷 290-298页

作者：王兆杰刘坤马晶李旭胜李丁山孙牧高峰邢焕来冯力中国舰船研究院北京100192 西安交通大学电子与信息学部陕西西安710049 西南交通大学计算机与人工智能学院四川成都611756

[目的]围绕打击链的时敏性、重构性和覆盖性等,建模分析其核心逻辑,为提升对抗条件下的海战场作战资源动态管理能力提供模型方法支撑。[方法]首先,将海战场跨域协同作战相关的驱护舰艇、无人机、无人艇等典型的作战平台和要素抽象为探... 详细信息

[目的]围绕打击链的时敏性、重构性和覆盖性等,建模分析其核心逻辑,为提升对抗条件下的海战场作战资源动态管理能力提供模型方法支撑。[方法]首先,将海战场跨域协同作战相关的驱护舰艇、无人机、无人艇等典型的作战平台和要素抽象为探测、处理、决策、打击这4类资源节点,采用有向网络对打击链过程进行建模描述;然后,以最短时延为目标,考虑海战场作战空间广、节点间传输速率低、通信距离受限等约束,建立打击链动态集成优化数学模型,设计防空典型场景,演示打击链的最短时延分析,以及在节点缺失或被袭击时的抗毁重构分析,并定量描述在对抗条件下重组后打击链的最短时延、覆盖扇面指标变化情况;最后,针对乌克兰无人机集群袭击黑海舰队的典型战例,基于打击链模型分析黑海舰队抵抗乌克兰无人机集群袭击的能力。[结果]仿真结果表明,基于模型可生成多条时延最短的打击链,优化每条打击链的责任区域划分,从而形成针对多目标的海上杀伤网;打击链的抗毁重构往往需要付出时延增加、覆盖扇面减小等代价;也可以用于测试不同阵型下的抗饱和攻击能力等。[结论]所做研究验证了采用基于打击链模型分析海战体系的可行性,能够为后续面向杀伤网的未来海上联合作战体系设计等提供理论模型支撑。

关键词：打击链动态集成有向网络

电喷雾萃取电离-串联质谱测定鲜竹沥中的二苯并[a,h]蒽

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分析测试学报 2024年第8期43卷 1280-1286页

作者：幸慧玉周亮朱腾高康斯坦丁刘九梅陈焕文方小伟江西中医药大学药学院江西南昌330004 江西中医药大学生命样品直接质谱分析研究室江西南昌330004 江西省地质局物化探大队江西南昌330000 江西省检验检测认证总院检测认证技术发展研究院江西南昌330052

采用电喷雾萃取电离-串联质谱(EESI-MS/MS)技术,在优化条件下建立了鲜竹沥中二苯并[a,h]蒽(DBA)的快速检测方法。在正离子检测模式下,对离子传输管温度、喷雾电压、电喷雾溶剂流速、样品流速进行优化。以硝酸银的甲醇溶液为电喷雾溶剂,... 详细信息

采用电喷雾萃取电离-串联质谱(EESI-MS/MS)技术,在优化条件下建立了鲜竹沥中二苯并[a,h]蒽(DBA)的快速检测方法。在正离子检测模式下,对离子传输管温度、喷雾电压、电喷雾溶剂流速、样品流速进行优化。以硝酸银的甲醇溶液为电喷雾溶剂,诱导DBA和Ag+形成[DBA+Ag]+、[2DBA+Ag]+等特征离子,再结合碰撞诱导解离技术,最终实现了鲜竹沥中DBA的快速定性定量检测。实验结果表明,DBA在0.1~100μg/L质量浓度范围内线性良好,线性相关系数(r2)为0.998 0,方法检出限(LOD)为0.054μg/L,定量下限(LOQ)为0.179μg/L。该方法对鲜竹沥中DBA的加标回收率为81.5%~87.1%,相对标准偏差为1.9%~3.9%。所建方法具有无需复杂样品预处理、准确度高、可直接快速检测等优点,适用于鲜竹沥中DBA的快速筛查与直接分析,同时也为其他PAHs的检测提供了技术手段。

关键词：电喷雾萃取电离-串联质谱(EESI-MS/MS) 鲜竹沥二苯并[a,h]蒽(DBA) 直接分析

Effect of SARS-CoV-2 infection in early pregnancy on placental development

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Science China(Life Sciences) 2024年第3期67卷 622-625页

作者： Shanru Yi Liping Wang Mengting Wang Wei Hong Ben Xu Xiaoying He Mengtian Yang Zhiping Wu Beiying Wang Guang Yang Shijun Shen Xinyu Cui Ruixue Wang Kai Wang Hong Wang Xiaocui Li Shaorong gao Cizhong Jiang Jiayu Chen Clinical and Translation Research Center of Shanghai First Maternity and Infant Hospital Shanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of the Ministry of Education Orthopaedic Department of Tongji HospitalTongji UniversityShanghai 200065China Frontier Science Center for Stem cell Research Tongji UniversityShanghai 200092China Shanghai Key Laboratory of Maternal Fetal Medicine Shanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghai 201204China

Dear Editor,Since the COVID-19 pandemic, the potential risks associated with maternal SARS-CoV-2 infection and its effect on fetal development have been a subject of considerable public concern. Previous studies have ... 详细信息

关键词： pregnancy fetal Effect

典型旅游城市土壤重金属特定源生态风险评价及优先控制源分析

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环境科学 2024年第8期45卷 4837-4846页

作者：李军高占栋台喜生焦亮臧飞兰州城市学院城市环境学院兰州730070 西北师范大学甘肃省绿洲资源环境与可持续发展重点实验室兰州730070 兰州大学草地农业科技学院兰州730020

为了解西北旅游城市土壤重金属的污染现状、分布特征及污染来源,选择敦煌市主城区土壤为研究对象,采集并分析了表层土壤重金属As、Cd、Cr、Cu、Hg、Ni、Pb和Zn的含量特征.采用地累积指数法和改进内梅罗污染指数法量化土壤重金属污染水平... 详细信息

为了解西北旅游城市土壤重金属的污染现状、分布特征及污染来源,选择敦煌市主城区土壤为研究对象,采集并分析了表层土壤重金属As、Cd、Cr、Cu、Hg、Ni、Pb和Zn的含量特征.采用地累积指数法和改进内梅罗污染指数法量化土壤重金属污染水平,利用聚类分析和正定矩阵因子分解(PMF)模型定量解析重金属污染来源,并应用PMF模型和综合生态风险指数相结合的方法解析各污染源对生态风险的贡献率.结果表明,除As和Ni之外,Cd、Cr、Cu、Hg、Pb和Zn含量的均值均高于甘肃省土壤元素背景值,但所有元素的含量均低于《土壤环境质量建设用地土壤污染风险管控标准(试行)》(GB 36600-2018)中建设用地的风险筛选值,其中Cd、Pb和Hg的富集较为严重,超标率均高于90%.地累积指数评价结果显示,研究区土壤以Hg污染为主,也存在不同程度的Cd、Cr、Cu、Pb和Zn污染.改进内梅罗污染指数结果表明,土壤的综合污染程度为无污染至中度污染,总体上为轻度污染.PMF模型源解析表明,研究区土壤重金属受自然源、工业降尘源、工业源、交通源和综合源的影响,贡献率依次为29.28%、25.86%、20.13%、16.5%和8.23%.特定源-综合生态风险评价模型分析表明,工业降尘源为优先控制污染源,Hg为生态风险优先控制污染元素.

关键词：城市土壤地累积指数污染评价生态风险溯源解析