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Hair regrowth following fecal microbiota transplantation in an elderly patient with alopecia areata: A case report and review of the literature

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World Journal of Clinical Cases 2019年第19期7卷 3074-3081页

作者： Wen-Rui Xie Xiao-Ya Yang Harry Hua-xiang Xia Li-Hao Wu xing-xiang he Department of Gastroenterology the First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Physiology Guangzhou Health Sciences CollegeGuangzhou 510180Guangdong ProvinceChina

BACKGROUND Alopecia areata is a hair loss disease associated with genetics,autoimmunity,and other *** is an intriguing link between alopecia areata and gut *** microbiota transplantation(FMT)has been recommended to treat Clostridium difficile(previously known as Clostridioides difficile)infection,and has also shown potentials in the treatment of inflammatory bowel disease,irritable bowel syndrome,and non-alcohol fatty liver *** SUMMARY An 86-year-old man,with a history of sigmoid colon carcinoma,suffered from recurrent abdominal pain and distension,and diarrhea for six months,with *** admission,he was also diagnosed with *** physical examination,the patient presented with a 1.5 cm×2.0 cm alopecia areata on his right *** to the negative results of laboratory testing,capsule endoscopy,and colonoscopy,the patient was diagnosed with noninfectious diarrhea,depressive disorder,and patchy alopecia *** that noninfectious diarrhea in the elderly patient was mainly caused by gut dysbiosis,he was given six rounds of *** diarrhea improved remarkably one month after FMT,with improved appetite and disappearance of abdominal pain,distension,and depressive ***,he reported new hair growth on the affected region of his scalp,with some of his white hair gradually turning to black,without taking any other therapies for alopecia areata before and after *** FMT might act as a potential therapy for patients who suffer from alopecia *** and well-designed studies are required to confirm the role of FMT in alopecia areata.

关键词： Fecal microbiota transplantation Alopecia areata Gut microbiota Autoimmune disease Psychopathogenesis Case report

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Efficacy and Safety of Washed Microbiota Transplantation to Treat Patients with Mild-to-Severe COVID-19 and Suspected of Having Gut Microbiota Dysbiosis: Study Protocol for a Randomized Controlled Trial

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Current Medical Science 2021年第6期41卷 1087-1095页

作者： Li-hao WU Zhi-ning YE Ping PENG Wen-rui XIE Jia-ting XU Xue-yuan ZHANG Harry Hua-xiang XIA xing-xiang he Department of Gastroenterology the First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510080China Research Center for Engineering Techniques of Microbiota-Targeted Therapies of Guangdong Province the First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510080China Guangzhou Eighth People's Hospital Guangzhou 510060China

Objective:Coronavirus disease 2019(COVTD-19)is often accompanied by gastrointestinal symptoms,which are related to gut microbiota dysbiosis(GMD).Whether washed microbiota transplantation(WMT)is an effective treatment for COV1D-19 patients suspected of having GMD by restoring the gut microbiota is *** study is designed to explore the efficacy and safety of WMT in COVID-19 patients suspected of having ***:This is a randomized,multicenter,single-blind prospective ***-19 patients suspected of having GMD will be randomly divided to receive routine treatment only or to receive routine treatment and *** frequency of WMT will be once a day for three consecutive *** and imaging examinations will be performed at admission,1 and 2 weeks after treatment,and on the day of *** a telephone follow-up will be conducted at 1st week,2nd week,and 6th month after *** clinical efficacy and safety of WMT in COVD-19 patients suspected of having GMD and the effects of WMT on the organ function,homeostasis,inflammatory response,intestinal mucosal barrier function,and immunity of the patients will be ***:By following the proposed protocol,WMT is expected to be efficacious and safe for the treatment of COVID-19 patients suspected of having GMD,and the therapeutic effect is expected to be associated with improvement of the intestinal mucosal barrier function,inflammatory response,and ***:The findings from this study may offer a new approach for the prevention and treatment of COVID-19 patients suspected of having GMD.

关键词： COVID-19 SARS-Cov-2 virus gut microbiota microbiome dysbiosis washed microbiota transplantation

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Long-term efficacy and safety of cap-assisted endoscopic sclerotherapy with long injection needle for internal hemorrhoids

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World Journal of Gastrointestinal Surgery 2022年第10期14卷 1120-1130页

作者： Ya-Ting Xie Yu Yuan Hui-Min Zhou Tao Liu Li-Hao Wu xing-xiang he Department of Gastroenterology The First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510080Guangdong ProvinceChina

BACKGROUND hemorrhoids are a common anal condition and can afflict an individual at any *** survey results in China show that the prevalence of anorectal diseases is as high as 50.1%among which 98.08%of patients have hemorrhoid *** To assess long-term efficacy and safety of cap-assisted endoscopic sclerotherapy(CAES)with long injection needle for internal *** This study was *** from patients with symptomatic internal hemorrhoids treated with CAES using endoscopic long injection needle from April 2016 to December 2019 were *** were telephoned and followed at two time points,December 2020 and 2021,to evaluate the improvements in symptoms,complications,recurrence,and *** Two hundreds and one patients with internal hemorrhoids underwent CAES with the long *** first median follow-up was performed 33 mo *** improved in 87.5%of patients after the first *** did not decrease with treatment time ***-four patients underwent colonoscopy after the first CAES treatment of which 21 underwent CAES again,and 4 underwent *** the first follow-up,62.7%of patients had both improved hemorrhoid grades and symptoms,and 27.4%had a significant improvement in both *** the second follow-up,61.7%of the patients showed satisfactory improvement in their hemorrhoid grade and symptoms when compared with pre-surgery values.90%of patients reported CAES was painless,and 85%were satisfied/very satisfied with CAES treatment *** The present study based on the largest sample size reported the long-term follow-up of the treatment for internal hemorrhoid with the CAES using endoscopic long injection *** findings demonstrate that CAES should be a micro-invasive endoscopic technology yields satisfactory long-term efficacy and safety.

关键词： hemorrhoids Cap-assisted endoscopic sclerotherapy Long injection needle Efficacy Prolapse

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Washed microbiota transplantation reduces proton pump inhibitor dependency in nonerosive reflux disease

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World Journal of Gastroenterology 2021年第6期27卷 513-522页

作者： Ya-Mei Zheng Xian-Yun Chen Jie-Yi Cai Yu Yuan Wen-Rui Xie Jia-Ting Xu Harry Hua-xiang Xia Min Zhang xing-xiang he Li-Hao Wu Department of Gastroenterology The First Affiliated Hospital of Guangdong Pharmaceutical UniversityResearch Center for Engineering Techniques of Microbiota-Targeted Therapies of Guangdong ProvinceGuangzhou 510030Guangdong ProvinceChina Department of Science and Education The First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510030Guangdong ProvinceChina Department of Epidemiology and health Statistics Guangdong Pharmaceutical UniversityGuangzhou 510220Guangdong ProvinceChina

BACKGROUND The pathogenesis of gastroesophageal reflux disease(GERD)is closely associated with the intestinal bacteria composition and their *** To investigate whether washed microbiota transplantation(WMT)improves symptoms of nonerosive reflux disease(NERD)with proton pump inhibitor(PPI)*** Patients with recurrent NERD and PPI dependency at the First Affiliated Hospital of Guangdong Pharmaceutical University from 2017 to 2018 were included and divided into a WMT or PPI group treated with PPI with/without *** endpoint was NERD symptom frequency evaluated 1 mo after WMT using reflux disease questionnaire(RDQ)and GERD questionnaire(GERDQ)scores,remission time,PPI dose,and the examination of intestinal mucosal barrier *** In the WMT(n=15)and PPI(n=12)groups,the total remission rate at 1 mo after treatment was 93.3%vs 41.7%.Compared with the PPI group,the WMT group showed better results in GERDQ(P=0.004)and RDQ(P=0.003)and in remission months(8 vs 2,P=0.002).The PPI dose was reduced to some extent for 80%of patients in the WMT group and 33.3%in the PPI *** 24 patients,intestinal mucosal barrier function was examined before treatment,and changes in the degree of damage were observed in 13 of these patients after *** one of the 15 patients had minor side effects,including a mushy stool two or three times a day,which resolved on their own after 1 *** This study is the first to demonstrate that WMT may be safe and effective for relieving NERD symptoms and reducing PPI dependency and recurrence.

关键词： Nonerosive reflux disease Washed microbiota transplantation Proton pump inhibitor dependency Intestinal bacteria Lipopolysaccharide Small intestinal bacterial overgrowth

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Ability of lactulose breath test results to accurately identify colorectal polyps through the measurement of small intestine bacterial overgrowth

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1138-1148页

作者： Lan Li Xue-Yuan Zhang Jin-Sheng Yu Hui-Min Zhou Yan Qin Wen-Rui Xie Wen-Jing Ding xing-xiang he Department of Gastroenterology The First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510080Guangdong ProvinceChina Washing Microbiota Transplantation Engineering Techniques of Microbiota-Targeted Therapies of Guangdong ProvinceGuangzhou 510080Guangdong ProvinceChina Department of Gastroenterology People's Hospital of Nanxiong CountyNanxiong 512400Guangdong ProvinceChina Department of Genetics Washington University School of MedicineSaint LouisMO 63110United States North America Medical Education Foundation CaliforniaCA 91710United States

BACKGROUND While colorectal polyps are not cancerous,some types of polyps,known as adenomas,can develop into colorectal cancer over *** can often be found and removed by colonoscopy;however,this is an invasive and expensive ***,there is a need for new methods of screening patients at high risk of developing *** To identify a potential association between colorectal polyps and small intestine bacteria overgrowth(SIBO)or other relevant factors in a patient cohort with lactulose breath test(LBT)*** A total of 382 patients who had received an LBT were classified into polyp and non-polyp groups that were confirmed by colonoscopy and *** was diagnosed by measuring LBTderived hydrogen(H)and methane(M)levels according to 2017 North American Consensus *** regression was used to assess the ability of LBT to predict colorectal *** barrier function damage(IBFD)was determined by blood *** H and M levels revealed that the prevalence of SIBO was significantly higher in the polyp group than in the non-polyp group(41%vs 23%,Phe peak H values in the adenomatous and inflammatory/hyperplastic polyp patients were significantly higher than those in the non-polyp group(Phe rate of IBFD determined by blood lipopolysaccharide levels was significantly higher among patients with polyps than those without(15%vs 5%,Phe current study made key associations among colorectal polyps,SIBO,and IBFD and demonstrated that LBT ha

关键词： Lactulose breath test Colorectal polyp Small intestine bacteria overgrowth Intestinal barrier function Retrospective study

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Supplementation with high-GABA-producing Lactobacillus plantarum L5 ameliorates essential tremor triggered by decreased gut bacteria-derived GABA

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Translational Neurodegeneration 2023年第1期12卷 31-49页

作者： Hao-Jie Zhong Si-Qi Wang Ruo-Xin Zhang Yu-Pei Zhuang Longyan Li Shuo-Zhao Yi Ying Li Lei Wu Yu Ding Jumei Zhang Xinqiang Xie xing-xiang he Qingping Wu Guangdong Provincial Key Laboratory of Microbial Safety and health State Key Laboratory of Applied Microbiology Southern ChinaInstitute of MicrobiologyGuangdong Academy of SciencesGuangzhou 510000China Department of Gastroenterology the First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510000China.

Background Theγ-aminobutyric acid(GABA)hypothesis posits a role of GABA deficiency in the central nervous system in the pathogenesis and progression of essential tremor(ET).However,the specific causative factor for GABA deficiency is not *** gut microbiota in mammals has recently been considered as a significant source of ***,the GABA-based signals originating from the intestine can be transmitted to the brain through the“enteric nervous system-vagus nerve-brain”***,the plausible contribution of gut microbiota to ET seems inspiring but remains *** Fecal samples from patients with ET and healthy controls were examined by metagenomic sequencing to compare the composition of gut microbiota and the expression of genes involved in GABA *** impact of gut microbiota on ET was explored through transplantation of fecal microbiota from patients with ET into the murine ET *** acid bacteria producing high amounts of GABA were identified through whole-genome sequencing and ultra-performance liquid chromatography-tandem mass ***,mice were treated with the high-GABA-producing strain Lactobacillus plantarum *** severity,behavioral tests,pro-inflammatory cytokines,GABA concentration,and gut microbiota composition were examined in these *** The gut microbiota of patients with ET demonstrated an impaired GABA-producing capacity and a reduced fecal GABA *** of the gut microbiota from patients with ET induced an extension of tremor duration and impaired mobility in the murine model of ET.L5 exhibited an augmented GABA-producing capacity,with the De Man-Rogosa-Sharpe culture broth containing 262 mg/l of *** addition,administration of L5 significantly decreased the tremor severity and enhanced the movement capability and grasping ability of ET *** vivo mechanistic experiments indicated that L5 reshaped the gut microbial composition,supplemented the mucosa-as

关键词： Cerebellum Essential tremor Gamma-aminobutyric acid Gut microbiota Lactobacillus plantarum

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Pan-cancer analysis of positive regulatory domain-containing 16 in human tumors

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Precision Medicine Research 2023年第3期5卷 1-10页

作者： Shi-Yi Zhang Ting-Ting Yang xiang-xing he Fang Yang Lin Zhang School of Basic Medical Sciences Hubei University of Chinese MedicineWuhan 430065China Department of Respiratory and Critical Care Medicine the Center for Biomedical ResearchNHC Key Laboratory of Respiratory DiseasesTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China College of Laboratory Medicine Hubei University of Chinese MedicineWuhan 430065China

Background:Positive regulatory domain-containing 16(PRDM16)plays a key role in brown adipose transcription,but its function in cancer is *** research to investigate the potential roles of PRDM16 across multiple types of cancer by pan cancer ***:UALCAN and TIMER2 database were utilized to evaluate PRDM16 expression in cancer *** Expression Profiling Interactive Analysis was employed to analyze the overall survival and disease-free survival across all The Cancer Genome Atlas Program *** the cBioPortal tool,we analyzed the mutation features of PRDM16 for the The Cancer Genome Atlas Program tumors,then utilized the Encyclopedia of RNA Interactomes database to predict the miRNA-mRNA relationships associated with the PRDM16 for all ***:The expression level of PRDM16 in the tumor tissues is lower than that in the normal ***,the high expression of PRDM16 has a positive effect on the prognosis of kidney clear cell carcinoma and lung adenocarcinoma,but not conducive to the prognosis of most *** multiple cancer types,the expression of PRDM16 was significantly positively correlated with immune infiltration of cancer-associated *** Encyclopedia of Genes and Genomes and Gene Ontology analysis indicated that PRDM16 may be related to transcriptional misregulation pathway in *** identified potential miRNAs that play regulatory roles of PRDM16 in kidney clear cell carcinoma and lung ***:PRDM16 is expressed in different cancers,it can be used as a biomarker for prognosis of pan-cancer and is associated with immune infiltration.

关键词： positive regulatory domain-containing 16 pan-cancer prognosis immune infiltration

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Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting xiang xiangxin xing Xuyun Hua Yuwen Zhang Xin Xue Jiajia Wu Mouxiong Zheng he Wang Jianguang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

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Rationale,new anus positioning methods,and updated protocols:Expert recommendations on cap-assisted endoscopic sclerotherapy for hemorrhoids from China Gut Conference

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Chinese Medical Journal 2021年第22期134卷 2675-2677页

作者： Fa-Ming Zhang Kai-Chun Wu Jing-Nan Li Xin Wang xing-xiang he Rong Wan Shi-Yao Chen CAES-LPRA Study Group Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210011China National Clinical Research Center for Digestive Diseases Xijing HospitalFourth Military Medical UniversityXi’anShaanxi 710032China Department of Gastroenterology Peking Union Medical College HospitalBeijing 100730China Department of Gastroenterology The First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhouGuangdong 510080China Department of Gastroenterology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201620China Department of Gastroenterology and hepatology Zhongshan HospitalFudan UniversityShanghai 200032China. 不详

Injection sclerotherapy is most effective for internal hemorrhoids,especially for patients with ***-er,traditional sclerotherapy via anoscope may cause iatrogenic risk and complications due to misplaced injections.[1]The flexible endoscopic sclerotherapy for internal hemorrhoids using a short needle without cap assistant was first reported in 1991 in the United States.[2]The flexible endoscopic injection using a short needle with cap assistant was reported in 2014 in Japan.[3]Cap-assisted endoscopic sclerotherapy(CAES)primarily using a long needle was reported in 2015[4]as an emerging flexible endoscopic therapy,and has been widely used for internal hemorrhoids and some prolapse in China.A panel of experts aimed to develop expert recommendations for CAES and derived guidelines on the key issues in hemorrhoidal disease,including rationale,new positioning methods for anus,indications,contraindications,techniques,post-procedure management,and core outcome set for evaluation[Figure 1].

关键词： needle hemorrhoids Rational

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中国三大城市群知识密集型制造业的空间集聚特征及形成机制——基于科技型企业大数据分析

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人文地理 2024年第4期39卷 57-65,105页

作者：于英杰杜德斌李祺祥邢和祥华东师范大学地理科学学院上海200241 全球创新与发展研究院上海200062 华东师范大学产业技术研究院上海200062

探究不同尺度下知识密集型制造业的集聚特征及其形成机制。结果显示:(1)计算机行业的集聚强度最高,京津冀各行业集聚强度高于长三角和珠三角地区;(2)城市群尺度各行业多集中在100 km范围内,京津冀呈现“核心—边缘”结构,长三角为“扇... 详细信息

探究不同尺度下知识密集型制造业的集聚特征及其形成机制。结果显示:(1)计算机行业的集聚强度最高,京津冀各行业集聚强度高于长三角和珠三角地区;(2)城市群尺度各行业多集中在100 km范围内,京津冀呈现“核心—边缘”结构,长三角为“扇形”结构,珠三角具有“多核心”特点;(3)城市尺度大部分行业集中在40 km范围内,少数行业在边缘区集聚,京津冀表现为“蔓延型”集聚,长三角为“局部型”和“多中心型”,珠三角为“多中心型”;(4)城市群尺度上的集聚特征依据地区资源禀赋和比较优势,城市尺度上的集聚特征则依生产成本上的空间差异、产业政策和地方保护主义等因素二有所不同。

关键词：知识密集型制造业产业集聚 DO指数城市群科技型企业

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