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A Dual Ligand Targeted Nanoprobe with High MRI Sensitivity for Diagnosis of Breast Cancer

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Chinese Journal of Polymer Science 2014年第3期32卷 321-332页

作者： Fa-ming Gong Zuo-quan Zhang Xiao-dong Chen Lu Zhang xing-su yu Qi-hua Yang Xin-tao Shuai 梁碧玲程度 PCFM Lab of Ministry of Education School of Chemistry and Chemical EngineeringSun Yat-sen University Department of Radiology Sun Yat-sen Memorial HospitalSun Yat-sen University Department of Radiology The Fifth Affiliated HospitalSun Yat-sen University Center of Biomedical Engineering Zhongshan School of MedicineSun Yat-Sen University

Antibody targeted delivery is an effective strategy to improve the diagnostic imaging outcome of nanoscale imaging agents in the focal areas. Dual targeting micelles encapsulating superparamagnetic iron oxide were prepared from the amphiphilic block copolymer poly（ethylene glycol）-poly（e-caprolactone）（PEG-b-PCL） with different targeting ligands cRGD and scFv-ErbB single chain antibody conjugated to the distal ends of PEG block. The breast cancer animal model was established by subcutaneous injecting the BT474 cells into the BALB/c-nu female nude mice and then employed to assess the potential of the dual ligand targeted magnetic micelles as a novel MRI contrast agent on a 1.5 T clinical MR/scanner. The T2 signal intensity of the tumor in animals receiving the dual ligand targeted magnetic micelles via tail vein decreased more significantly than the single ligand targeted and nontargeted magnetic micelles. These results indicate that the dual ligand targeted magnetic micelles, cRGD/scFv-ErbB-PEG-PCL-SPION, have great potential to act as a new type of effective nanoscale MRI contrast agent for early diagnosis of breast cancer.

关键词： Block copolymer micelle superparamagnetic iron oxide (SPI0) Breast cancer Magnetic resonance imaging(MRI) Herceptin c(Arg-Gly-Asp-d-Phe-Lys) (cRGDfK).

Construction of Magnetic Resonance Imaging Visible Polymeric Vector for Efficient Tumor Targeted siRNA Delivery

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Chinese Journal of Polymer Science 2022年第9期40卷 1071-1079页

作者： Rong-Ze Wang Si Huang Qiao-yun Zhang xing-su yu Ke-Ze Hong Jian-Rong Cao Hong Xiao Yong Wang Xin-Tao Shuai College of Chemistry and Materials Science Jinan UniversityGuangzhou 510632China Nanomedicine Research Center The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China Department of Reproductive Medical Center Guangdong Women and Children HospitalGuangzhou 511400China

RNA interference(RNAi),known for the highly efficient targeted gene silencing,has been demonstrated to be a promising means for cancer ***,an effective approach for siRNA delivery is urgently needed to meet the needs for its clinical ***,we constructed a polymeric vector labeled with superparamagnetic iron oxide(SPIO)for magnetic resonance imaging(MRI)visible siRNA *** antibody was also modified to the surface of nanodrug to enhance the delivery *** results showed that the vector exhibited great siRNA complexation ability and mediated an increased endocytosis of siRNA without obvious ***,both in vitro and in vivo studies evidenced the vector could effectively deliver siRNA into tumor cells,exert highly interfering effect,and show potent MR imaging *** study provides a promising MRI-visible and EGFR targeting delivery system to improve RNAi efficacy for cancer therapy.

关键词： Polymeric vector siRNA delivery Magnetic resonance imaging visible Tumor targeting

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不同强度钢筋受压屈曲性能及材料本构模型

工程力学 2023年第10期40卷 112-128页

作者：杨红苏星宇赵银重庆大学土木工程学院重庆400045 山地城镇建设与新技术教育部重点实验室(重庆大学) 重庆400030

长径比和屈服强度是影响受压钢筋屈曲性能的主要参数,已有研究成果重点分析长径比的影响,关于屈服强度对钢筋屈曲后强度退化规律的系统性研究成果很少。该文完成了长径比分别为4.000、5.000、6.000、6.250、8.000、9.000、9.375、10.000... 详细信息

长径比和屈服强度是影响受压钢筋屈曲性能的主要参数,已有研究成果重点分析长径比的影响,关于屈服强度对钢筋屈曲后强度退化规律的系统性研究成果很少。该文完成了长径比分别为4.000、5.000、6.000、6.250、8.000、9.000、9.375、10.000、12.000和15.000的HRB400钢筋、HRB500钢筋试件的单调受压屈曲试验,测量了各屈曲钢筋试件的平均应力-平均应变(σ_(s)-ε_(s))曲线和跨中横向屈曲位移。结合作者已完成的HRB600钢筋的相应试验结果,分析了屈服强度、长径比和屈曲方向对屈曲钢筋受压强度退化的影响,对比了D-M模型计算的σ_(s)-ε_(s)曲线与不同强度、长径比钢筋试件的屈曲受力性能差异。通过分析各类误差产生的原因,提出了可合理考虑长径比、屈服强度对屈曲效应影响的修正D-M模型。研究结果表明:由于不同强度钢筋的ε_(u)、ε_(sh)、f_(y)、f_(u)等力学性能参数不同,钢筋试件屈曲受力性能存在差异;较小长径比的钢筋受压屈曲后平均应力能继续提高,较大长径比的钢筋受压屈曲后无法达到屈服强度;不同长径比或屈服强度的钢筋试件屈曲方向存在差异;D-M模型的计算结果与三种强度钢筋的屈曲受力性能试验结果相比有明显误差;修正D-M模型可直接用于不同屈服强度钢筋,且能合理考虑长径比和屈服强度对屈曲钢筋σ_(s)-ε_(s)曲线的影响。

关键词：钢筋屈曲受力性能 D-M材料模型长径比

Unraveling the therapeutic potential of Calculus Bovis in liver cancer:A novel step for targeted cancer treatment

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World Journal of Gastroenterology 2025年第3期31卷 127-129页

作者： xing-yu Chen Xiang Lan Department of Hepatobiliary surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

Hepatocellular carcinoma is one of the leading causes of cancer-related deaths globally,and effective treatments are urgently *** present study aimed to investigate the inhibitory effect of Calculus Bovis(CB)on liver cancer and the underlying *** inhibited M2 tumor-associated macrophage polarization and modulated the Wnt/β-catenin signaling pathway,thereby suppressing the proliferation of liver cancer *** inhibitory effect on liver cancer growth was confirmed by both in vivo and in vitro experiments(detailed by Huang et al).The present study provides a theoretical basis for the application of CB for the treatment of liver cancer,providing new avenues for liver cancer treatment.

关键词： Calculus Bovis Liver cancer M2 tumor-associated macrophage polarization Wnt/β-catenin Pathway Tumor microenvironment

Multiparameter magnetic resonance imaging-based radiomics model for the prediction of rectal cancer metachronous liver metastasis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 62-72页

作者： Zhi-Da Long Xiao yu Zhi-Xiang xing Rui Wang Department of Hepatobiliary and Pancreaticosplenic surgery Jingzhou Hospital Affiliated to Yangtze UniversityJingzhou 434100Hubei ProvinceChina

BACKGROUND The liver,as the main target organ for hematogenous metastasis of colorectal cancer,early and accurate prediction of liver metastasis is crucial for the diagnosis and treatment of ***,this study aims to investigate the application value of a combined machine learning(ML)based model based on the multiparameter magnetic resonance imaging for prediction of rectal metachronous liver metastasis(MLM).AIM To investigate the efficacy of radiomics based on multiparametric magnetic resonance imaging images of preoperative first diagnosed rectal cancer in predicting MLM from rectal *** We retrospectively analyzed 301 patients with rectal cancer confirmed by surgical pathology at Jingzhou Central Hospital from January 2017 to December *** participants were randomly assigned to the training or validation queue in a 7:3 *** first apply generalized linear regression model(GLRM)and random forest model(RFM)algorithm to construct an MLM prediction model in the training queue,and evaluate the discriminative power of the MLM prediction model using area under curve(AUC)and decision curve analysis(DCA).Then,the robustness and generalizability of the MLM prediction model were evaluated based on the internal validation set between the validation queue *** Among the 301 patients included in the study,16.28%were ultimately diagnosed with MLM through pathological *** analysis showed that carcinoembryonic antigen,and magnetic resonance imaging radiomics were independent predictors of ***,the GLRM prediction model was developed with a comprehensive nomogram to achieve satisfactory *** prediction performance of GLRM in the training and validation queue was 0.765[95%confidence interval(CI):0.710-0.820]and 0.767(95%CI:0.712-0.822),*** with GLRM,RFM achieved superior performance with AUC of 0.919(95%CI:0.868-0.970)and 0.901(95%CI:0.850-0.952)in the training and validation queue,respect

关键词： Rectal cancer Metachronous liver metastases Magnetic resonance imaging Radiomics Machine learning

基于非对称占空比调制的DAB变换器优化策略

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电力电子技术 2023年第12期57卷 117-120页

作者：章小卫苏星宇周京华北方工业大学北京市变频技术工程技术研究中心北京100144

针对双有源桥(DAB)变换器在轻载及电压不匹配时损耗大、效率低的问题,此处提出了一种基于单侧非对称占空比调制(SSADM)的电感电流峰峰值优化策略,降低了损耗并且提升了变换器的效率。首先,分析了SSADM的工作原理及两种工作模态;然后,基... 详细信息

针对双有源桥(DAB)变换器在轻载及电压不匹配时损耗大、效率低的问题,此处提出了一种基于单侧非对称占空比调制(SSADM)的电感电流峰峰值优化策略,降低了损耗并且提升了变换器的效率。首先,分析了SSADM的工作原理及两种工作模态;然后,基于时域模型,推导了两种工作模态下的传输功率特性;接着,以电感电流峰峰值为优化目标,以传输功率为约束条件,得到了最优占空比及移相角;最后,基于StarSim硬件在环平台验证了所提优化算法的有效性。

关键词：双有源桥变换器单侧非对称占空比调制电感电流

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang Wenwu Zhang Gang Li xing Cheng Peiqiang su Yong Wan Xiang Li Department of Spine surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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客车色彩设计与图案设计

客车技术与研究 2009年第4期32卷 27-29页

作者：苏星宇何蒙郑州宇通客车股份有限公司郑州450016

简述色彩设计、色彩构成理论在客车色彩和图案设计中的应用。

关键词：客车造型色彩设计图案设计

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无创检查在婴儿血管瘤诊治中的应用进展

临床皮肤科杂志 2021年第11期50卷 701-704页

作者：苏醒玉刘晓庆余铖安湘杰李延陶娟华中科技大学同济医学院附属协和医院皮肤科、皮肤疾病诊疗与健康湖北省工程研究中心湖北武汉430022

无创检查能够实时、无创和动态地对皮损进行检查,减少了误诊、漏诊及不必要的有创组织病理检查,逐渐被运用于婴儿血管瘤(IH)的诊治中,主要检查包括皮肤镜、反射式共聚焦显微镜(RCM)、超声(US)和磁共振成像(MRI)等。上述无创检查各具优势... 详细信息

无创检查能够实时、无创和动态地对皮损进行检查,减少了误诊、漏诊及不必要的有创组织病理检查,逐渐被运用于婴儿血管瘤(IH)的诊治中,主要检查包括皮肤镜、反射式共聚焦显微镜(RCM)、超声(US)和磁共振成像(MRI)等。上述无创检查各具优势,相互补充,以无创为前提,为诊断提供信息,为治疗提供指导,帮助医生对疾病进行管理和随访。现将这些技术在IH诊治中的应用现状、价值及展望进行综述。

关键词：婴儿血管瘤皮肤镜共聚焦显微镜超声磁共振成像