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Fangji Fuling Decoction Alleviates Sepsis by Blocking MAPK14/FOXO3A Signaling Pathway

Chinese Journal of Integrative Medicine 2024年第3期30卷 230-242页

作者： WANG Yi CHEN Ming-qi DAI Lin-feng ZHANG Hai-dong WANG xing Department of Critical Care Medicine Changzhou Hospital of Traditional of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineChangzhouJiangsu Province213000China Department of Critical Care Medicine Jiangsu Province Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing210029China

Objective:To examine the therapeutic effect of Fangji Fuling Decoction(FFD) on sepsis through network pharmacological analysis combined with in vitro and in vivo experiments.Methods:A sepsis mouse model was constructed through intraperitoneal injection of 20 mg/kg lipopolysaccharide(LPS).RAW264.7 cells were stimulated by 250 ng/m L LPS to establish an in vitro cell model.Network pharmacology analysis identified the key molecular pathway associated with FFD in sepsis.Through ectopic expression and depletion experiments,the effect of FFD on multiple organ damage in septic mice,as well as on cell proliferation and apoptosis in relation to the mitogen-activated protein kinase 14/Forkhead Box O 3A(MAPK14/FOXO3A) signaling pathway,was analyzed.Results:FFD reduced organ damage and inflammation in LPS-induced septic mice and suppressed LPS-induced macrophage apoptosis and inflammation in vitro(P<0.05).Network pharmacology analysis showed that FFD could regulate the MAPK14/FOXO signaling pathway during sepsis.As confirmed by in vitro cell experiments,FFD inhibited the MAPK14 signaling pathway or FOXO3A expression to relieve LPS-induced macrophage apoptosis and inflammation(P<0.05).Furthermore,FFD inhibited the MAPK14/FOXO3A signaling pathway to inhibit LPS-induced macrophage apoptosis in the lung tissue of septic mice(P<0.05).Conclusion:FFD could ameliorate the LPS-induced inflammatory response in septic mice by inhibiting the MAPK14/FOXO3A signaling pathway.

关键词： sepsis Fangji Fuling Decoction mitogen-activated protein kinase 14/Forkhead Box O 3A signaling pathway inflammatory response apoptosis lung injury Chinese medicine

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Highly Differentiated Target Detection under Extremely Low-Light Conditions Based on Improved YOLOX Model

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1507-1537页

作者： Haijian Shao Suqin Lei Chenxu Yan xing Deng Yunsong qi School of Computer Jiangsu University of Science and TechnologyZhenjiang212003China Department of Electrical and Computer Engineering University of NevadaLas VegasNV89154USA Zhejiang Geely Automobile Research Institute Ningbo315336China

This paper expounds upon a novel target detection methodology distinguished by its elevated discriminatory efficacy,specifically tailored for environments characterized by markedly low luminance levels.Conventional methodologies struggle with the challenges posed by luminosity fluctuations,especially in settings characterized by diminished radiance,further exacerbated by the utilization of suboptimal imaging instrumentation.The envisioned approach mandates a departure from the conventional YOLOX model,which exhibits inadequacies in mitigating these challenges.To enhance the efficacy of this approach in low-light conditions,the dehazing algorithm undergoes refinement,effecting a discerning regulation of the transmission rate at the pixel level,reducing it to values below 0.5,thereby resulting in an augmentation of image contrast.Subsequently,the coiflet wavelet transform is employed to discern and isolate high-discriminatory attributes by dismantling low-frequency image attributes and extracting high-frequency attributes across divergent axes.The utilization of CycleGAN serves to elevate the features of low-light imagery across an array of stylistic variances.Advanced computational methodologies are then employed to amalgamate and conflate intricate attributes originating from images characterized by distinct stylistic orientations,thereby augmenting the model’s erudition potential.Empirical validation conducted on the PASCAL VOC and MS COCO 2017 datasets substantiates pronounced advancements.The refined low-light enhancement algorithm yields a discernible 5.9%augmentation in the target detection evaluation index when compared to the original imagery.Mean Average Precision(mAP)undergoes enhancements of 9.45%and 0.052%in low-light visual renditions relative to conventional YOLOX outcomes.The envisaged approach presents a myriad of advantages over prevailing benchmark methodologies in the realm of target detection within environments marked by an acute scarcity of luminosity.

关键词： Target detection extremely low-light wavelet transformation highly differentiated features YOLOX

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LncRNA HCP5-encoded protein contributes to adriamycin resistance through ERK/mTOR pathway-mediated autophagy in breast cancer cells

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Genes & Diseases 2024年第4期11卷 69-72页

作者： Jia-Ni xing Yi-Ni Shang Zheng-Ling Yu shun-Heng Zhou Wang-Yang Chen Li-Hong Wang Department of Pathophysiology Medical College of Southeast UniversityNanjingJiangsu 210009China Department of Biomedical Engineering Nanjing University of Aeronautics and AstronauticsNanjingJiangsu 211106China School of Medicine Taizhou UniversityTaizhouZhejiang 318000China Jiangsu Provincial Key Laboratory of Critical Care Medicine NanjingJiangsu 210009China

Adriamycin(ADR),also known as doxorubicin,is an anthracycline anticancer drug and a chemotherapeutic drug commonly used in breast cancer treatments.1 However,breast cancer patients can gradually become tolerant to chemotherapy.Therefore,improving the curative effect of ADR remains an urgent problem to be solved.Autophagy is a complex catabolic process;normal living cells break down damaged organelles or aggregated molecules and absorb energy to maintain homeostasis through autophagy.

关键词： breast cancer homeostasis

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Detecting fake reviewers in heterogeneous networks of buyers and sellers:a collaborative training-based spammer group algorithm

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Cybersecurity 2024年第2期7卷 44-67页

作者： qi Zhang Zhixiang Liang Shujuan Ji Benyong xing Dickson K.W.Chiu Shandong Provincial Key Laboratory of Wisdom Mine Information Technology Shandong University of Science and TechnologyQingdao 266590ShandongChina Zhejang University-University of linois at Urbana-Champaign Institute Haining 314499ZhejiangChina School of Civil Engineering Beijing Jiaotong UniversityBeijing 100044China Faculty of Education The University of Hong KongPok Fu LamHong KongChina

It is not uncommon for malicious sellers to collude with fake reviewers(also called spammers)to write fake reviews for multiple products to either demote competitors or promote their products'reputations,forming a gray industry chain.To detect spammer groups in a heterogeneous network with rich semantic information from both buyers and sellers,researchers have conducted extensive research using Frequent Item Mining-based and graph-based meth-ods.However,these methods cannot detect spammer groups with cross-product attacks and do not jointly consider structural and attribute features,and structure-attribute correlation,resulting in poorer detection performance.There-fore,we propose a collaborative training-based spammer group detection algorithm by constructing a heterogene-ous induced sub-network based on the target product set to detect cross-product attack spammer groups.To jointly consider all available features,we use the collaborative training method to learn the feature representations of nodes.In addition,we use the DBSCAN clustering method to generate candidate groups,exclude innocent ones,and rank them to obtain spammer groups.The experimental results on real-world datasets indicate that the overall detection performance of the proposed method is better than that of the baseline methods.

关键词： Spammer group Heterogeneous network Collaborative training DBSCAN

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MicroRNA-630 alleviates inflammatory reactions in rats with diabetic kidney disease by targeting toll-like receptor 4

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World Journal of Diabetes 2024年第3期15卷 488-501页

作者： qi-shun Wu Dan-Na Zheng Cheng Ji Hui qian Juan Jin qiang He Graduate School Medical College of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Nephrology Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou 314408Zhejiang ProvinceChina Department of Nephrology Affiliated Hospital of Jiangsu UniversityZhenjiang 212001Jiangsu ProvinceChina Department of Nephrology Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 314408Zhejiang ProvinceChina Molecular Inspection Laboratory School of MedicineJiangsu UniversityZhenjiang 212000Jiangsu ProvinceChina Department of Nephrology The First Affiliated Hospital of Zhejiang Chinese Medical UniversityZhejiang Provincial Hospital of Traditional Chinese MedicineHangzhou 310060Zhejiang ProvinceChina

BACKGROUND Diabetic kidney disease(DKD)is a major complication of diabetes mellitus.Renal tubular epithelial cell(TEC)damage,which is strongly associated with the inflammatory response and mesenchymal trans-differentiation,plays a significant role in DKD;However,the precise molecular mechanism is unknown.The recently identified microRNA-630(miR-630)has been hypothesized to be closely associated with cell migration,apoptosis,and autophagy.However,the association between miR-630 and DKD and the underlying mechanism remain unknown.AIM To investigate how miR-630 affects TEC injury and the inflammatory response in DKD rats.METHODS Streptozotocin was administered to six-week-old male rats to create a hypergly cemic diabetic model.In the second week of modeling,the rats were divided into control,DKD,negative control of lentivirus,and miR-630 overexpression groups.After 8 wk,urine and blood samples were collected for the kidney injury assays,and renal tissues were removed for further molecular assays.The target gene for miR-630 was predicted using bioinformatics,and the association between miR-630 and toll-like receptor 4(TLR4)was confirmed using in vitro investigations and double luciferase reporter gene assays.Overexpression of miR-630 in DKD rats led to changes in body weight,renal weight index,basic blood parameters and histopathological changes.RESULTS The expression level of miR-630 was reduced in the kidney tissue of rats with DKD(P<0.05).The miR-630 and TLR4 expressions in rat renal TECs(NRK-52E)were measured using quantitative reverse transcription polymerase chain reaction.The mRNA expression level of miR-630 was significantly lower in the high-glucose(HG)and HG+mimic negative control(NC)groups than in the normal glucose(NG)group(P<0.05).In contrast,the mRNA expression level of TLR4 was significantly higher in these groups(P<0.05).However,miR-630 mRNA expression increased and TLR4 mRNA expression significantly decreased in the HG+miR-630 mimic group than in the HG+mimic NC group(P<0.05).Furthermore,the levels o

关键词： Diabetic kidney disease MicroRNA-630 Toll-like receptor 4 Mouse model Renal tubular epithelial cells damage Hyperglycemic model

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Multifunctional role of oral bacteria in the progression of nonalcoholic fatty liver disease

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World Journal of Hepatology 2024年第5期16卷 688-702页

作者： En-Hua Mei Chao Yao Yi-Nan Chen shun-Xue Nan Sheng-Cai qi Shanghai Medical College Fudan UniversityShanghai 200000China Department of Prothodontics Shanghai Stomatological HospitalFudan UniversityShanghai 200000China Shanghai Key Laboratory of Craniomaxiofacial Development and Diseases Fudan UniversityShanghai 200000China

Non-alcoholic fatty liver disease(NAFLD)encompasses a spectrum of liver disorders of varying severity,ultimately leading to fibrosis.This spectrum primarily consists of NAFL and non-alcoholic steatohepatitis.The pathogenesis of NAFLD is closely associated with disturbances in the gut micr-obiota and impairment of the intestinal barrier.Non-gut commensal flora,particularly bacteria,play a pivotal role in the progression of NAFLD.Notably,Porphyromonas gingivalis,a principal bacterium involved in periodontitis,is known to facilitate lipid accumulation,augment immune responses,and induce insulin resistance,thereby exacerbating fibrosis in cases of periodontitis-associated NAFLD.The influence of oral microbiota on NAFLD via the“oral-gut-liver”axis is gaining recognition,offering a novel perspective for NAFLD management through microbial imbalance correction.This review endeavors to encapsulate the intricate roles of oral bacteria in NAFLD and explore underlying mechanisms,emphasizing microbial control strategies as a viable therapeutic avenue for NAFLD.

关键词： Non-alcoholic fatty liver disease Oral bacteria Gut bacteria Periodontitis Non-alcoholic steatohepatitis

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Engineered interface of three-dimensional coralliform NiS/FeS_(2)heterostructures for robust electrocatalytic water cleavage

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Nano Research 2024年第6期17卷 4693-4701页

作者： Xin Yu Jing Mei Yeshuang Du Xiaohong Cheng xing Wang qi Wu State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430073China Hubei Key Laboratory of Pollutant Analysis&Reuse Technology College of Chemistry and Chemical EngineeringHubei Normal UniversityHuangshi 435002China Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices Hubei University of Arts and ScienceXiangyang 441053China

Heterojunction structures improve the intrinsic activity of electrocatalysts by enhancing the charge transfer between the catalyst and the electrode.In this paper,the NiS/FeS_(2)heterostructured electrocatalyst is fabricated by a simple sulfidation method using an interface engineering strategy to adjust the surface electron density of the electrocatalyst.As expected,NiS/FeS_(2)electrocatalyst exhibits superior activity and durable oxygen evolution reaction(OER)stability,requiring only a low overpotential of 183 mV to achieve a current density of 10 mA·cm^(−2)and can be stable for more than 80 h,superior to NiS,FeS_(2)electrocatalyst individually,and precious RuO_(2).Notably,NiS/FeS_(2)is also a good bifunctional electrocatalyst with good overall water splitting performance,and it only requires a voltage 1.56 V to obtain a current density of 10 mA·cm^(−2)for more than 12 h.Remarkably,the NiS/FeS_(2)hybridization facilitates the formation of coral-like structures,increasing the electrochemical surface area(ECSA)and enhancing the charge transfer efficiency,thus leading to excellent electrocatalytic performance.This work proposes a constructive strategy for designing efficient electrocatalysts based on interface engineering,and lays a foundation for designing a new class of electrocatalysts.

关键词： NiS/FeS_(2) interface engineering nanorods bifunctional water splitting

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The Orthogonal Bases of Exponential Functions Based on Moran–Sierpinski Measures

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Acta Mathematica Sinica,English Series 2024年第7期40卷 1804-1824页

作者： qi Rong DENG xing Gang HE Ming Tian LI Yuan Ling YE School of Mathematics and Statistics Center for Applied Mathematics of Fujian Province & Key Laboratory of Analytical Mathematics and Applications (Ministry of Education)Fujian Normal University School of Mathematics and Statistics Key Lab NAA-MOE and Hubei Key Lab-Math.Sci.Central China Normal University School of Mathematical Sciences & South China Research Center for Applied Mathematics and Interdisciplinary Studies South China Normal University

Let A_n ∈ M2（Z） be integral matrices such that the infinite convolution of Dirac measures with equal weights ■ is a probability measure with compact support, where D = {（0, 0）~t,（1, 0）~t,（0, 1）~t} is the Sierpinski digit.We prove that there exists a set Λ ? R2such that the family ■ is an orthonormal basis of L2(μ{An,n≥1}) if and only if 1/3（1,-1）A_n ∈ Z2for n ≥ 2 under some metric conditions on A_n.

关键词： Moran-Sierpinski measures orthonormal basis of exponential functions self-affine measures spectral measures 28A33 42C05 28A80 42C30

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Degradation analysis and doping modification optimization for high-voltage P-type layered cathode in sodium-ion batteries

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Journal of Energy Chemistry 2024年第2期89卷 1-9,I0002页

作者： Bao Zhang Yi Zhao Minghuang Li qi Wang Lei Cheng Lei Ming xing Ou Xiaowei Wang National Engineering Laboratory for High-Efficiency Recovery of Refractory Nonferrous Metals School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083HunanChina Zhejiang Power New Energy Co. LTDZhuji 311800ZhejiangChina

Advancing high-voltage stability of layered sodium-ion oxides represents a pivotal avenue for their progress in energy storage applications.Despite this,a comprehensive understanding of the mechanisms underpinning their structural deterioration at elevated voltages remains insufficiently explored.In this study,we unveil a layer delamination phenomenon of Na_(0.67)Ni_(0.3)Mn_(0.7)O_(2)(NNM)within the 2.0-4.3 V voltage,attributed to considerable volumetric fluctuations along the c-axis and lattice oxygen reactions induced by the simultaneous Ni^(3+)/Ni^(4+)and anion redox reactions.By introducing Mg doping to diminished Ni-O antibonding,the anion oxidation-reduction reactions are effectively mitigated,and the structural integrity of the P2 phase remains firmly intact,safeguarding active sites and precluding the formation of novel interfaces.The Na_(0.67)Mg_(0.05)Ni_(0.25)Mn_(0.7)O_(2)(NMNM-5)exhibits a specific capacity of100.7 mA h g^(-1),signifying an 83%improvement compared to the NNM material within the voltage of2.0-4.3 V.This investigation underscores the intricate interplay between high-voltage stability and structural degradation mechanisms in layered sodium-ion oxides.

关键词： Soidum ion batteries Layer cathode materials P-type High-voltage performance Degradation analysis

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The First Verification Test of Space-Ground Collaborative Intelligence via Cloud-Native Satellites

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China Communications 2024年第4期21卷 208-217页

作者： Wang Shangguang Zhang qiyang xing Ruolin qi Fei Xu Mengwei State Key Laboratory of Networking and Switching Beijing University of Posts and TelecommunicationsBeijing 100876China Star Network and Intelligent Computing Laboratory Beiyou Shenzhen InstituteShenzhen 518000China Huawei Technologies Co. LtdShenzhen 518129China

Recent advancements in satellite technologies and the declining cost of access to space have led to the emergence of large satellite constellations in Low Earth Orbit(LEO).However,these constellations often rely on bent-pipe architecture,resulting in high communication costs.Existing onboard inference architectures suffer from limitations in terms of low accuracy and inflexibility in the deployment and management of in-orbit applications.To address these challenges,we propose a cloud-native-based satellite design specifically tailored for Earth Observation tasks,enabling diverse computing paradigms.In this work,we present a case study of a satellite-ground collaborative inference system deployed in the Tiansuan constellation,demonstrating a remarkable 50%accuracy improvement and a substantial 90%data reduction.Our work sheds light on in-orbit energy,where in-orbit computing accounts for 17%of the total onboard energy consumption.Our approach represents a significant advancement of cloud-native satellite,aiming to enhance the accuracy of in-orbit computing while simultaneously reducing communication cost.

关键词： cloud-native satellite orbital edge computing satellite inference verification test

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