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Predictive value of the Chinese group on the study of severe hepatitis B-acute-on-chronic liver failure score in the short-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure

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Chinese Medical Journal 2019年第13期132卷 1541-1549页

作者： Jing-Jing Tong Wei Zhao Xiu-Ying Mu Xiang Xu Hai-Bin Su Xiao-Yan Liu Jing Chen xing-ran zhai Yu Wang Jin-Hua Hu Liver Failure Treatment and Research Center The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Clinical Laboratory China-Japan Friendship HospitalBeijing 100029China Peking University 302 Clinical Medical School Beijing 100039China Medical School of Chinese PLA Beijing 100853China

Background:As a large,prospective,multicenter study-based prognostic score for hepatitis B virus-related acute-on-chronic liver failure(HBV-ACLF),the Chinese group on the study of severe hepatitis B-acute-on-chronic liver failure score(COSSH-ACLFs),has been approved by some foreign scholars;however,its predictive value needs to be *** study investigated the predictive value of COSSH-ACLFs for short-term prognosis in Chinese patients with ***:This retrospective cohort study included 751 patients with HBV-ACLF admitted to the Fifth Medical Center of Chinese PLA General Hospital between January 2011 and December *** method was used to assess the correlation of COSSHACLFs with classical *** COX multivariate regression models were used to confirm the relationship between COSSHACLFs and short-term prognosis in patients with HBV-ACLF,and stratified analysis was used to further verify the stability of this *** compared the predictive powers of COSSH-ACLFs and other classical scores using area under the receiver operating characteristic curve(AUROC)and ***:A total of 975 patients with HBV-ACLF were screened,and 751 were analyzed(623 male and 128 female).COSSH-ACLFs was the highest in patients with end-stage ACLF,followed by those with middle-and early-stage ACLF(H=211.8,P<0.001).In the fully adjusted model,COX multivariate regression analysis revealed that COSSH-ACLFs(as a continuous variable)was independently and positively correlated with mortality risk in patients with HBV-ACLF at 28 days(hazard ratio[HR]:1.37[1.22,1.53],P<0.001)and 90 days(HR:1.43[1.29,1.58],P<0.001).The same trend could be observed in the crude model and minimally adjusted *** AUROCs of COSSH-ACLFs for 28-day and 90-day prognoses in patients with HBV-ACLF were 0.807 and 0.792,respectively,indicating a stronger predictive accuracy than those of classic ***:COSSH-ACLFs,with a superior predictive accuracy compared wit

关键词： Hepatitis B virus-related acute-on-chronic liver failure COSSH-ACLF score Predictive value Prognosis

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Spontaneous Orientation Polarization of Anisotropic Equivalent Dipoles Harnessed by Entropy Engineering for Ultra‑Thin Electromagnetic Wave Absorber

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Nano-Micro Letters 2025年第1期17卷 424-438页

作者： Honghan Wang Xinyu Xiao Shangru zhai Chuang Xue Guangping Zheng Deqing Zhang Renchao Che Junye Cheng Liaoning Key Lab of Lignocellulose Chemistry and BioMaterials Liaoning Collaborative Innovation Center for Lignocellulosic BiorefinerySchool of Light Industry and Chemical EngineeringDalian Polytechnic UniversityDalian 116034People’s Republic of China School of Life Science and Biotechnology Dalian University of TechnologyDalian 116024People’s Republic of China Department of Mechanical Engineering Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077People’s Republic of China School of Materials Science and Engineering Qiqihar UniversityQiqihar 161006People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering&TechnologyFudan UniversityShanghai 200438People’s Republic of China Department of Materials Science Shenzhen MSU-BIT UniversityShenzhen 517182People’s Republic of China

The synthesis of carbon supporter/nanoscale high-entropy alloys(HEAs)electromagnetic response composites by carbothermal shock method has been identified as an advanced strategy for the collaborative competition engineering of conductive/dielectric *** migration modes within HEAs as manipulated by the electronegativity,valence electron configurations and molar proportions of constituent elements determine the steady state and efficiency of equivalent ***,enlightened by skin-like effect,a reformative carbothermal shock method using carbonized cellulose paper(CCP)as carbon supporter is used to preserve the oxygencontaining functional groups(O·)of carbonized cellulose fibers(CCF).Nucleation of HEAs and construction of emblematic shell-core CCF/HEAs heterointerfaces are inextricably linked to carbon metabolism induced by O·.Meanwhile,the electron migration mode of switchable electronrich sites promotes the orientation polarization of anisotropic equivalent *** virtue of the reinforcement strategy,CCP/HEAs composite prepared by 35%molar ratio of Mn element(CCP/HEAs-Mn_(2.15))achieves efficient electromagnetic wave(EMW)absorption of−51.35 dB at an ultra-thin thickness of 1.03 *** mechanisms of the resulting dielectric properties of HEAs-based EMW absorbing materials are elucidated by combining theoretical calculations with experimental characterizations,which provide theoretical bases and feasible strategies for the simulation and practical application of electromagnetic functional devices(e.g.,ultra-wideband bandpass filter).

关键词： High-entropy alloys Carbothermal shock Switchable electron migration modes Emblematic shell-core heterointerfaces Ultra-thin thickness

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THE SHIFTED-INVERSE POWER WEAK GALERKIN METHOD FOR EIGENVALUE PROBLEMS

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Journal of Computational Mathematics 2020年第4期38卷 606-623页

作者： Qilong zhai Xiaozhe Hu ran Zhang Department of Mathematics Peking UniversityBeijing 100871China Department of Mathematics Tufts UniversityMedford02155USA Department of Mathematics Jilin UniversityChangchun 130012China

This paper proposes and analyzes a new weak Galerkin method for the eigenvalue problem by using the shifted-inverse power technique.A high order lower bound can be obtained at a relatively low cost via the proposed *** error estimates for both eigenvalue and eigenfunction are provided and asymptotic lower bounds are shown as well under some *** examples are presented to validate the theoretical analysis.

关键词： Weak Galerkin finite element method Eigenvalue problem Shifted-inverse power method Lower bound

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Gradient‑Layered MXene/Hollow Lignin Nanospheres Architecture Design for Flexible and Stretchable Supercapacitors

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Nano-Micro Letters 2025年第2期17卷 447-462页

作者： Haonan Zhang Cheng Hao Tongtong Fu Dian Yu Jane Howe Kaiwen Chen Ning Yan Hao Ren Huamin zhai Jiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass Materials NanJing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering and Applied Chemistry University of Toronto200 College StreetTorontoON M5S 3E5Canada Department of Materials Science and Engineering University of Toronto184 College StreetTorontoON M5S 3E4Canada College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China

With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has *** this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable *** depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene ***,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of *** these strategies effectively enhanced the capacitive performance of the *** addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the *** electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),***,their capacitances were well preserved after 1000 times of 600%stretch-release *** study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.

关键词： Hollow lignin nanospheres MXene Gradient-layered architecture Wrinkled electrodes Stretchable supercapacitors

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The energy performance and passive survivability of high thermal insulation buildings in future climate scenarios

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Building Simulation 2022年第7期15卷 1209-1225页

作者： ran Wang Shilei Lu Xue zhai Wei Feng School of Environment Science and Engineering Tianjin University92 Weijin RoadTianjin300072China Tianjin Key Laboratory of Built Environment and Energy Application Tianjin UniversityTianjin300350China Lawrence Berkeley National Laboratory BerkeleyCA 94720USA

Given that the passive performance simulation of buildings based on typical meteorological year data and specific design schemes makes it challenging to respond to climate change and refine design requirements on time,this article established a passive performance prediction model for future buildings considering multi-dimensional variables including climate change,building design,and operational *** high thermal insulation buildings under future climates,the mild climate zone is more sensitive than the others,cooling energy demand is more sensitive than heating demand,apartments are more sensitive than office buildings,and passive survivability is more sensitive than energy performance;for buildings of the same type located in the same climate zone,thermal design solutions determine the increase rate of cooling *** potential benefits of climate warming on heating demand reduction are almost zero,but the cooling demand increases significantly,with apartments and office buildings increasing up to 22.1% and 5.0%,*** generally overheat in the future,and the increase rate of the mild zone far exceeds other zones with duration and severity being 3004.8% and 877.7%for apartments,and 884.3% and 288.9%for office buildings,respectively.

关键词： climate change overheating risk cooling demand heating demand scenarios thermal insulation

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Blocking of the PD-1/PD-L1 interaction by a novel cyclic peptide inhibitor for cancer immunotherapy

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Science China(Life Sciences) 2021年第4期64卷 548-562页

作者： Wenjie zhai Xiuman Zhou Mingxia zhai Wanqiong Li Yunhui ran Yixuan Sun Jiangfeng Du Wenshan Zhao Lingxiao xing Yuanming Qi Yanfeng Gao School of Life Sciences Zhengzhou UniversingZhengzhou 450001China School of Pharmacenutical Sciences(Shenzhen) Sun Yar-sen UniversiyShenzhen 518107.China Deparment of Pathology Hebei Medical University Shijazhuang 050017China

The interaction of PD-1/PD-L1 allows tumor cells to escape from immune *** success of the antibody drugs has proven that blockade of PD-1/PD-L1 pathway is a promising strategy for cancer ***,we developed a cyclic peptide C8 by using Ph.D.-C7 C phage display technology.C8 showed high binding affinity with h PD-1 and could effectively interfere the interaction of PD-1/***,C8 could stimulate CD8^(+)T cell activation in human peripheral blood mononuclear cells(PBMCs).We also observed that C8 could suppress tumor growth in CT26 and B16-OVA,as well as anti-PD-1 antibody resistant B16 mouse ***8^(+)T cells infiltration significantly increased in tumor microenvironment,and IFN-γsecretion by CD8^(+)T cells in draining lymph nodes also ***,we exploited T cells depletion models and confirmed that C8 exerted anti-tumor effects via activating CD8^(+)T cells dependent *** interaction model of C8 with h PD-1 was simulated and confirmed by alanine *** conclusion,C8 shows anti-tumor capability by blockade of PD-1/PD-L1 interaction,and C8 may provide an alternative candidate for cancer immunotherapy.

关键词： PD-1/PD-L1 cancer immunotherapy immune checkpoint blockade cyclic peptide phage display CD8~+T cell

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A hybridized weak Galerkin finite element scheme for the Stokes equations

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Science China Mathematics 2015年第11期58卷 2455-2472页

作者： zhai QiLong ZHANG ran WANG XiaoShen Department of Mathematics Jilin University Department of Mathematics University of Arkansas at Little Rock

In this paper a hybridized weak Galerkin(HWG) finite element method for solving the Stokes equations in the primary velocity-pressure formulation is *** WG method uses weak functions and their weak derivatives which are defined as *** functions and weak derivatives can be approximated by piecewise polynomials with various *** combination of polynomial spaces leads to different WG finite element methods,which makes WG methods highly flexible and efficient in practical computation.A Lagrange multiplier is introduced to provide a numerical approximation for certain derivatives of the exact *** this new feature,the HWG method can be used to deal with jumps of the functions and their flux *** order error estimates are established for the corresponding HWG finite element approximations for both primal variables and the Lagrange multiplier.A Schur complement formulation of the HWG method is derived for implementation *** validity of the theoretical results is demonstrated in numerical tests.

关键词： hybridized weak Galerkin finite element methods weak gradient weak divergence Stokes equation

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Designing Electronic Structures of Multiscale Helical Converters for Tailored Ultrabroad Electromagnetic Absorption

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Nano-Micro Letters 2025年第1期17卷 439-455页

作者： Zhaobo Feng Chongbo Liu Xin Li Guangsheng Luo Naixin zhai Ruizhe Hu Jing Lin Jinbin Peng Yuhui Peng Renchao Che Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle School of Environmental and Chemical EngineeringNanchang Hangkong UniversityNanchang 330063People’s Republic of China School of Physics and Materials Nanchang UniversityNanchang 330031People’s Republic of China Key Laboratory of Nondestructive Testing Ministry of EducationNanchang Hangkong UniversityNanchang 330063People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering and TechnologyFudan UniversityShanghai 200438People’s Republic of China

Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)***,the relationship between configuration and electromagnetic(EM)loss mechanism has remained ***,drawing inspiration from the DNA transcription process,we report the successful synthesis of novel in situ Mn/N co-doped helical carbon nanotubes with ultrabroad EMWA *** calculation and EM simulation confirm that the orbital coupling and spin polarization of the Mn–N4–C configuration,along with cross polarization generated by the helical structure,endow the helical converters with enhanced EM *** a result,HMC-8 demonstrates outstanding EMWA performance,achieving a minimum reflection loss of−63.13 dB at an ultralow thickness of 1.29 *** precise tuning of the graphite domain size,HMC-7 achieves an effective absorption bandwidth(EAB)of 6.08 GHz at 2.02 mm ***,constructing macroscale gradient metamaterials enables an ultrabroadband EAB of 12.16 GHz at a thickness of only 5.00 mm,with the maximum radar cross section reduction value reaching 36.4 dB *** innovative approach not only advances the understanding of metal–nonmetal co-doping but also realizes broadband EMWA,thus contributing to the development of EMWA mechanisms and applications.

关键词： Metal-nonmetal co-doping 3d-2p orbital coupling Spin polarization Helical structure Broadband EM wave absorption

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区域医疗系统抗震韧性综述

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哈尔滨工业大学学报 2025年第1期57卷 1-12页

作者：裴顺顺翟长海胡杰结构工程灾变与控制教育部重点实验室(哈尔滨工业大学) 哈尔滨150090 土木工程智能防灾减灾工业和信息化部重点实验室(哈尔滨工业大学) 哈尔滨150090

韧性作为一种新的灾害风险管理理念,已成为防灾减灾领域的研究热点,考虑到医疗系统在城市运行和灾后救援中的重要作用,在地震期间和之后,区域医疗系统应该具有足够的韧性,并提供连续的医疗服务。如何综合考虑区域范围内多家医院和交通... 详细信息

韧性作为一种新的灾害风险管理理念,已成为防灾减灾领域的研究热点,考虑到医疗系统在城市运行和灾后救援中的重要作用,在地震期间和之后,区域医疗系统应该具有足够的韧性,并提供连续的医疗服务。如何综合考虑区域范围内多家医院和交通系统的安全性、应急响应能力、多系统的整合与协作,有效评估区域医疗系统的抗震韧性水平,并提出科学的改进建议,对建设韧性城乡具有重要的理论意义。本文通过梳理国内外文献,阐明了区域医疗系统韧性的概念和内涵,总结了地震后短期应急和长期修复两个阶段韧性评估的重点,归纳了现有区域医疗系统韧性的评估框架,从医院集群系统、面向医疗的交通系统、应急医疗服务系统和医疗-交通耦合系统4个方面阐述了现有评估方法。区域医疗系统韧性的研究旨在提高其面对灾害时的抵抗性、短期适应性和长期恢复性,这些研究对于满足紧急和日常的医疗需求以及指导灾后恢复具有重要意义。目前区域医疗系统抗震韧性的研究取得了一些进展,但仍然存在一些挑战,本文最后展望了未来的研究方向。

关键词：区域医疗系统单体医院交通系统抗震韧性功能评估恢复时间

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Effects of soybean oil exposure on the survival,reproduction,biochemical responses,and gut microbiome of the earthworm Eisenia fetida

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Journal of Environmental Sciences 2023年第11期133卷 23-36页

作者： Yating Du Guangshen Shang Junjie zhai xing Wang College of Resources and Environmental Sciences China Agricultural UniversityBeijing 100193China Beijing Key Laboratory of Biodiversity and Organic Farming Beijing 100193China Organic Recycling Research Institute(Suzhou) China Agricultural UniversitySuzhou 215100China

With increasing production of kitchen waste,cooking oil gradually enters the soil,where it can negatively affect soil *** this study,we explored the effects of soybean oil on the survival,growth,reproduction,tissue structure,biochemical responses,mRNA expression,and gut microbiome of earthworms(Eisenia fetida).The median lethal concentration of soybean oil was found to be 15.59%.Earthworm growth and reproduction were significantly inhibited following exposure to a sublethal concentration of soybean oil(1/3 LC50,5.2%).The activity of the antioxidant enzymes total superoxide dismutase(T-SOD),peroxidase(POD),and catalase(CAT)were affected under soybean oil *** glutathione(GSH)content decreased significantly,whereas that of the lipid peroxide malondialdehyde(MDA)increased significantly after soybean oil *** expression levels of the SOD,metallothionein(MT),lysenin and lysozyme were significantly *** abundance of Bacteroides species,which are related to mineral oil repair,and Muribaculaceae species,which are related to immune regulation,increased within the earthworm *** results indicate that soybean oil waste is toxic to ***,earthworms deployed defense mechanisms involving antioxidant system and gut microbiota for protection against soybean oil exposure-induced stress.

关键词： Gene expression Gut microbiota Eisenia fetida Soybean oil Reproduction

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