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Preventive Effect of Perioperative Management Using Oral Clopidogrel on Postoperative Rebleeding in Patients with Spontaneous Intracerebral Hemorrhage

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Journal of Cerebrovascular Disease 2019年第1期2卷 11-14页

作者： Tao Yang zhong-Xiao Lin Xi-Lin Zhang xing-ming zhong Department of Neurosurgery Huzhou First People’s HospitalHuzhou 313000China Department of Neurosurgery The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325027China Central Laboratory Huzhou First People’s HospitalHuzhou 313000China

Background: With the aging society in China and the increasing incidence of cardiovascular and cerebrovascular diseases,spontaneous cerebral hemorrhage with the use of oral clopidogrel has become common in patients. Owing to its inhibition of platelet aggregation,oral clopidogrel results in a high incidence of postoperative intracranial rebleeding,and the prognosis is poor. The purpose of this study is to determine the effect of perioperative management of spontaneous intracerebral hemorrhage (SICH) using oral clopidogrel on postoperative rebleeding. Methods: From January 2010 to June 2018,64 patients with SICH who took clopidogrel orally and finally received surgical treatment were selected from Huzhou First People’s Hospital and the Second Affiliated Hospital of Wenzhou Medical University. The influencing factors of postoperative rebleeding were analyzed via a case-control study. Results: All patients with SICH were divided into two groups according to the standard time of drug withdrawal before surgery: drug withdrawal at < 3 days and ≥ 3 days. The incidence of postoperative rebleeding after drug withdrawal at ≥ 3 days was significantly lower than that after drug withdrawal at < 3 days. Thereafter,all patients were divided into two groups according to the adenosine diphosphate (ADP) inhibition rate detected using a thromboelastography monitor: ADP inhibition rate of < 60% and ≥ 60%. The incidence of postoperative rebleeding in the ADP inhibition rate of < 60% group was significantly lower than that in the ADP inhibition rate of ≥ 60% group. In addition,drug withdrawal at ≥ 3 days and ADP inhibition rate of < 60% had a synergistic effect on the prevention of postoperative rebleeding. Conclusions: Patients with drug withdrawal at ≥ 3 days can undergo active early surgery. The ADP inhibition rate of ≥ 60% can be used as the predictive index of high-risk postoperative rebleeding in patients with SICH taking oral clopidogrel. By reducing the ADP inhibition rate to < 6

关键词： Spontaneous intracerebral hemorrhage Clopidogrel Adenosine diphosphate Perioperative management

A temporary-sustainable team:A new multidisciplinary team model for severe trauma

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Chinese Journal of Traumatology 2020年第6期23卷 363-366页

作者： xing-ming zhong Xiao-Hong Wen Chao-Hui Ji xing-Zhen Fei Xiao-Gang Zhao Department of Emergency and Department of Neurosurgery The First People's Hospital of HuzhouFirst Affiliated Hospital of Huzhou Normal UniversityHuzhou 313000Zhejiang ProvinceChina Department of Emergency The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina

The treatment of severe trauma,especially multiple injuries,requires multidisciplinary *** current study aims to highlight the challenges of consultation mode for severe trauma in general hospitals and emphasizes the need to create a new temporary-sustainable *** suggests developing an information consultation mode and enforcing the fine management to improve the quality and safety of the medical *** management mode of a temporary-sustainable team will reduce the cost and improve the treatment ***,a temporary-sustainable team has significant advantages over a traditional multidisciplinary team for severe trauma treatment.

关键词： Trauma Temporary-sustainable team Multidisciplinary team

Brainstem auditory evoked potential combined with high resolution cranial base CT can optimize the diagnosis of auditory nerve injury

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Chinese Journal of Traumatology 2022年第3期25卷 156-160页

作者： Hua Gu xing-ming zhong Yi-Qi Wang Jian-Guo Yang Yong Cai Department of Emergency and Department of Neurosurgery The First People's Hospital of HuzhouFirst Affiliated Hospital of Huzhou Normal UniversityHuzhou313000Zhejiang ProvinceChina

Purpose:Auditory nerve injury is one of the most common nerve injury complications of skull base ***,there is currently a lack of auxiliary examination methods for its direct *** purpose of this study was to find a more efficient and accurate means of diagnosis for auditory nerve ***:Through retrospectively analyzing the results of brainstem auditory evoked potential(BAEP)and high-resolution CT(HRCT)in 37 patients with hearing impairment following trauma from January 1,2018 to July 31,2020,the role of the two inspection methods in the diagnosis of auditory nerve injury was *** criteria were patient had a clear history of trauma and unilateral hearing impairment after trauma;while exclusion criteria were:(1)severe patient with a Glasgow coma scale score<5 because these patients were classified as severe head injury and admitted to the intensive care unit,(2)patient in the subacute stage admitted 72 h after trauma,and(3)patient with prior hearing impairment before *** to Goodman's classification of hearing impairment,the patients were divided into low/medium/severe injury *** addition,patients were divided into HRCT-positive and negative groups for further investigation with their BAEP *** positive rates of BEAP for each group were observed,and the results were analyzed by Chi-square test(p<0.05,regarded as statistical difference).Results:A total of 37 patients were included,including 21 males and 16 *** of them were hospitalized patients with GCS score of 6-15 at the time of *** BAEP positive rate in the medium and severe injury group was 100%,which was significantly higher than that in the low injury group(27.27%)(p<0.01).The rate of BEAP positivity was significantly higher in the HRCT-positive group(20/30,66.7%)than in the HRCT-negative group(1/7,14.3%)(p<0.05).Twenty patients(54.05%)were both positive for BEAP and HRCT test,and considered to have auditory nerve ***

关键词： Auditory nerve injury Skull base fracture Brainstem auditory evoked potential(BAEP) High-resolution CT(HRCT)

Effect of Predictive Nursing on Limb Rehabilitation in Patients with Cerebral Haemorrhage:A Randomized Controlled Study

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Journal of Cerebrovascular Disease 2022年第2期5卷 6-10页

作者： Qing Li Li-Juan Shen xing-ming zhong Wan-Yi He Jie Song Li-Ying Shen School of Nursing Huzhou UniversityHuzhou 313000China Department of Nursing Huzhou First People's Hospital(the First Affiliated Hospital of Huzhou University)Huzhou 313000China Department of Neurosurgery Huzhou First People's Hospital(the First Affiliated Hospital of Huzhou University)Huzhou 313000China Department of Rehabilitation Huzhou First People's Hospital(the First Affiliated Hospital of Huzhou University)Huzhou 313000China Department of Radiation Huzhou First People's Hospital(the First Affiliated Hospital of Huzhou University)Huzhou 313000China

Objective:To explore the effect of predictive nursing on limb rehabilitation in patients with spontaneous hypertensive cerebral haemorrhage in the basal ganglia region based on diffusion tensor imaging(DTI)***:From January 2020 to January 2021,55 patients with spontaneous hypertensive cerebral haemorrhage in the basal ganglia were selected from the Department of Neurosurgery,Huzhou First People's *** were randomly divided into a control group and an experimental *** control group was given routine nursing measures,and the experimental group was assigned predictive nursing based on *** three weeks of intervention,the two groups'nursing effects were *** Fugl-Meyer motor assessment(FMA)and modified Barthel index(MBI)scoring scale were used to evaluate patients'motor function and daily living ***:After three weeks of intervention,motor function scores improved in both groups compared with before treatment(P<0.05).There was a statistically significant difference in FMA scores between the experimental and control groups before and after the intervention(P<0.001).The MBI scores of the two groups before and after the intervention were statistically significant(P<0.001).From the mean point of view,the MBI score of the experimental group after the intervention was significantly higher than that before the ***:Predictive nursing based on DTI can improve the limb motor function of patients with basal ganglia haemorrhage and enhance the patient's ability to live daily.

关键词： Diffusion tensor imaging Basal ganglia haemorrhage Foreseeable care Limb function Rehabilitation

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： ming‑Yuan Yu Jing Wu Guang Yin Fan‑Zhen Jiao zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

Study on Transplanting Germ Like Cells Differentiated from Embryonic Stem Cell into Mouse Seminiferous Tubules

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Journal of Reproduction and Contraception 2011年第2期22卷 95-105页

作者： Wei-wei ZHENG Guang-hui CUI Xi-gu CHEN Xiang-cai WEI xing-ming zhong Family Planning Research institute of Guangdong Province Guangzhou Guangdong 510600 China Experimental Animal Center Sun Yat-sen University Guangzhou Guangdong 510080 China

Objective To investigate whether germ like cells isolated from embryoid body formed by mouse embryonic stem cells could survive and initiate spermatogenesis in seminiferous tubules of adult mice. Methods SSEA-1＋ cells were isolated from embryoid bodies prepared from mouse EGFP-ES cells, after retinoic acid treatment, the cells were detected for the expression of alkaline phosphatase, Rnh2, stella, fragilis, Tex14, Sry, Hsp90-a, Stra8 and integrin a6, and then, the cells were transplanted into seminiferous tubules of busulfan-treated adult mice. Results Six days after retinoic acid treatment, alkaline phosphatase expressing cells could still be found in embryoid body （EB） derived cells, indicating the existence of retinoic acid-resistant primordial germ cells. When the SSEA-1＋ cells isolated from embryoid bodies were stimulated with retinoic acid for 6 days, some of these cells expressed cell markers of Hsp90-a, Stra8 and integrin a6, resembling the expression profile of spermatogonial stem cells. Forty-five days after cell transplantation, a little amount of GFP-expressing cells attached to the basement membrane of seminiferous tubule and formed small colonies; Three months later, these cells started amplification in the form of cell chains with varied length, and moving towards the lumen of the seminiferous tubules. Five months after the transplantation, multilayered cell mass was found in seminiferous tubules of two, out of four recipient mice. There was no GFP-expressing cells existed in non-cell-transplanted seminiferous tubules. Conclusion In our study, although full-termed spermatogenesis was not observed in all of the recipients, the results did indicate that the embryoid body contains germ like cells, and these cells can survive and initiate amplification in seminiferous tubules of adult mouse.

关键词： germ like cells embryonic stem cell embryoid body seminiferous tubule

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固体润滑材料高纯二硫化钼生产工艺改进

现代化工 2017年第10期37卷 156-158页

作者：成兰兴谷中鸣师传兴邵国斌丁为公张碧波河南省化工研究所有限责任公司河南郑州450052 洛阳申雨钼业有限责任公司河南洛阳471000

通过对原有生产工艺进行改进,加入除铁专用的助溶剂,变原有多段除铁为一段除铁,使生产过程周期由原工艺的24 h缩短为15 h,生产效率提高50%,酸性废水减少60%。加入除铁专用的助溶剂,使铁的去除率由原工艺的78.0%提高到93.3%。通过生产连... 详细信息

通过对原有生产工艺进行改进,加入除铁专用的助溶剂,变原有多段除铁为一段除铁,使生产过程周期由原工艺的24 h缩短为15 h,生产效率提高50%,酸性废水减少60%。加入除铁专用的助溶剂,使铁的去除率由原工艺的78.0%提高到93.3%。通过生产连续运行考察,在最佳操作条件下,产品中铁质量分数降低到0.08%,收率由原工艺的88%提高到93%,经济效益显著。

关键词：二硫化钼工艺改进一段除铁

水下线型聚能切割器内外炸高对射流侵彻性能的影响

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爆破 2018年第1期35卷 130-136页

作者：谢兴博钟明寿宋歌纪冲吴建宇解放军理工大学野战工程学院南京210007

借助ANSYS/LS-DYNA程序,对线型聚能切割器在水下切割钢板的性能进行了数值模拟研究,并通过试验对数值模拟仿真结果进行了验证。通过数值模拟和试验对比,重点分析了水下聚能切割器空气内炸高和水外炸高对射流侵彻靶板的特性影响。数值模... 详细信息

借助ANSYS/LS-DYNA程序,对线型聚能切割器在水下切割钢板的性能进行了数值模拟研究,并通过试验对数值模拟仿真结果进行了验证。通过数值模拟和试验对比,重点分析了水下聚能切割器空气内炸高和水外炸高对射流侵彻靶板的特性影响。数值模拟和试验结果表明:聚能槽内的水介质会阻碍射流的形成,严重影响切割性能,设置适量的空气内炸高并减小水外炸高,可以提供射流形成的空间,大幅提高射流的侵彻能力;空气内炸高越小,射流的形成越不充分,形成射流的速度和动能越小,侵彻能力越弱。

关键词：爆炸力学聚能切割器水下切割聚能射流侵彻

Palladium installed copper-organic framework for C–C coupling reactions

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Science China Chemistry 2025年

作者： Yu-Mei Wang Mei-Xia Tao Kai-ming Mo Xu Chen Shu-Hua zhong Elena S Shubina Guo-Hong Ning Dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Supramolecular Coordination ChemistryJinan University A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences

The formation of C–C bonds is a crucial aspect of organic synthesis. Synthesists' long-term objective is to identify novel catalysts to optimize reaction systems based on traditional transition metal catalysis. This study explores the synthesis and catalytic potential of palladium-installed covalent metal-organic frameworks(CMOFs) based on copper cyclic trinuclear units(Cu-CTUs). By incorporating palladium ions into the imine-based framework JNM-7 through a straightforward immersion method, we achieved a notable enhancement in catalytic activity for critical C–C coupling reactions, including C–H arylation and Sonogashira cross-coupling. The resulting JNM-7-Pd demonstrated remarkable stability and recyclability, maintaining its efficiency over at least three cycles without any decline in efficiency.

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