检索结果-南通市图书馆

Relationship between the Plasma Fibulin-1 Levels,Pulse Wave Velocity,and Vascular Age in Asymptomatic Hyperuricemia

Current Medical Science 2021年第1期41卷 94-99页

作者： Yu SANG Kai-min MAO Yi HUANG Xiao-fen WU xing-fen wang Lei RUAN Cun-tai ZHANG Department of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pulmonary and Critical Care Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Geriatrics Beijing Aerospace General HospitalBeijing 100076China

Fibulin-1(FBLN-1),an elastin-associated extracellular matrix protein,has been found in blood and may play a role in the pathophysiological processes leading to cardiovascular disease(CVD).We aimed to investigate the relationship between fibulin-1 levels and the risk of CVD by evaluating vascular age derived from the Framingham Heart Study and brachial-ankle Pulse Wave Velocity(baPWV)in patients with asymptomatic hyperuricemia(AHU).In total,66 patients with AHU and 66 gender-and age-matched healthy individuals were *** plasma fibulin-1 levels were measured by *** with AHU presented significantly higher vascular age[median(interquartile range):54(22)vs.48(14)years,P=0.01]and baPWV[mean±SD:1373±223 vs.1291±177 cm/s,P=0.02]than the healthy subjects;however,no significant difference was observed in the plasma fibulin-1 level between the patients with AHU and healthy subjects[median(interquartile range):4018(3838)vs.3099(3405)ng/mL,P=0.31].A correlation between fibulin-1 levels and baPWV was observed only in patients with AHU(r=0.29,P=0.02);and there was also a suggestively statistically significant correlation between fibulin-1 levels and vascular age(r=0.22,P=0.08).However,these associations were rendered insignificant after adjustments for potential *** healthy subjects,no correlation was observed between fibulin-1 levels and CVD *** study reveals that plasma fibulin-1 levels may reflect the CVD risk in patients with AHU,but the relationship is not robust.

关键词： fibulin-1 cardiovascular risk vascular age brachial-ankle pulse wave velocity asymptomatic hyperuricemia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Autophagy Enhances the Aggressiveness of Human Colorectal Cancer Cells and Their Ability to Adapt to Apoptotic Stimulus

引用

Clinical oncology and cancer researeh 2012年第2期9卷 105-110页

作者： Hai-yang Zheng Xiao-yang Zhang xing-fen wang Bao-cun Sun Department of Pathology The Second Hospital of Tianiin Medical University Department of Pathology Tianjin Medical University Cancer Institute and Hospital

Objective To investigate LC3B-Ⅱand active caspase-3 expression in human colorectal cancer to elucidate the role of autophagy and to explore the relationship of autophagy with apoptosis in human colorectal cancer. Methods LC3B expression was detected by immunohistochemistry in 53 human colorectal cancer tissues and 20 normal colon *** protein levels of LC3B-Ⅱand active caspase-3 were also determined by Western blot analysis in 23 human colorectal cancer tissues and 10 normal colon tissues. Results LC3B was expressed both in cancer cells and normal epithelial ***3B expression in the peripheral area of cancer tissues was correlated with several clinicopathological factors,including tumor differentiation(P=0.002),growth pattern of the tumor margin (P=0.028),pN(P=0.002),pStage(P=0.032),as well as vessel and nerve plexus invasion(P=0.002).The protein level of LC3B-Ⅱin cancer tissue was significantly higher than in normal tissue(P=0.038),but the expression of active forms of procaspase-3 in cancer tissue was lower(P=0.041).There was a statistically significant positive correlation between the expression levels of LC3B-Ⅱand the active forms of procaspase-3(r=0.537,P=0.008). Conclusions Autophagy has a prosurvival role in human colorectal *** enhances the aggressiveness of colorectal cancer cells and their ability to adapt to apoptotic stimulus.

关键词： autophagy apoptosis colorectal neoplasms LC3B caspase-3

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Navigating the complex landscape of crawling-type gastric adenocarcinomas:Insights and implications for clinical practice

引用

World Journal of Gastrointestinal Oncology 2024年第11期16卷 4309-4314页

作者： Hai-Bo Yu Ke-feng Jia xing-fen wang Bao-Yu Li Qi Xin Laboratory The Second Hospital of Tianjin Medical UniversityTianjin 300211China Department of Radiology Tianjin Third Central HospitalTianjin 300170China Department of Pathology The Second Hospital of Tianjin Medical UniversityTianjin 300211China Department of Gastrointestinal Surgery The Second Hospital of Tianjin Medical UniversityTianjin 300211China Department of Pathology The Third Central Hospital of TianjinTianjin 300170China

In this editorial,we comment on an article by Xu et *** article describes a case of crawling-type gastric adenocarcinoma(CRA)distinguished by its rare occurrence and diagnostic *** reviewed the detailed case-report findings showcasing clinical,pathological,and molecular characteristics of CRA that shed light on its elusive nature and challenges for early detection and *** case underscored the significance of advanced diagnostic tools such as endoscopic submucosal *** was placed on the molecular peculiarities of CRA,including the higher mutation rates of genes such as TP53 and RHOA and the notable absence of HER2 amplification,differentiating it from more conventional forms of gastric *** this editorial,we advocate for a multidisciplinary approach to effectively manage this rare subtype and highlight the necessity for precision in both diagnostic and therapeutic ***,a heightened awareness urging the adoption of advanced diagnostic techniques and collaborative approaches is necessary among clinicians and *** aim to contribute to the ongoing discourse in gastrointestinal oncology,emphasizing the importance of recognizing and addressing the complexities associated with rare cancer subtypes such as CRA.

关键词： Crawling-type gastric adenocarcinoma Diagnosis Pathology Endoscopy Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Harnack inequality and gradient estimate for G-SDEs with degenerate noise

引用

Science China Mathematics 2022年第4期65卷 813-826页

作者： xing Huang fen-fen Yang Center for Applied Mathematics Tianjin UniversityTianjin300072China

In this paper,the Harnack inequality for G-SDEs with degenerate noise is derived by the method of coupling by change of the ***,for any bounded and continuous function f,the gradient estimate∣∇P_(t)f∣≤c(p,t)(Pt|f|p)^(1/p),p>1,t>0 is obtained for the associated nonlinear semigroup P¯*** an application of the Harnack inequality,we prove the existence of the weak solution to degenerate G-SDEs under some integrable ***,an example is *** of the above results extend the existing ones in the linear expectation setting.

关键词： Harnack inequality degenerate noise G-SDE gradient estimate weak solution invariant expectation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

低酚棉种质资源耐盐性鉴定

引用

植物遗传资源学报 2016年第6期17卷 1099-1105页

作者：李函利王省芬王国宁李志坤吴立强张艳吴金华张桂寅马峙英华北作物种质资源教育部重点实验室/河北省作物种质资源重点实验室/河北农业大学保定071001

为了解决粮棉争地矛盾,棉花向更加盐碱干旱区域发展是大势所趋。因此进行耐盐鉴定筛选抗性种质意义重大。本研究在培养室条件下,利用发芽盒和石英砂对179份来源不同的低酚棉种质资源的耐盐性进行了评价。结果表明,179份低酚棉资源材料中... 详细信息

为了解决粮棉争地矛盾,棉花向更加盐碱干旱区域发展是大势所趋。因此进行耐盐鉴定筛选抗性种质意义重大。本研究在培养室条件下,利用发芽盒和石英砂对179份来源不同的低酚棉种质资源的耐盐性进行了评价。结果表明,179份低酚棉资源材料中,没有高抗材料;抗盐材料4份,占所鉴定材料的2.2%;耐盐材料54份,占30.2%;盐敏感材料121份,占67.6%。筛选出8份耐盐性突出的材料,其耐盐性达到了耐盐或抗盐的水平,包括豫无424、衡无87-306、中无1651、中无3385、多毛101、中无374-G、中无1038和中无642,这些材料在盐胁迫下的相对成活苗率均在70%以上。国内材料耐盐性好于国外材料,国内材料中河北省、山东省、河南省的材料耐盐性明显好于其他省份。本研究筛选出了耐盐性好的低酚棉材料,为低酚棉育种提供了优异的种质资源。

关键词：低酚棉种质资源苗期耐盐性鉴定

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Protective mechanisms of micro RNA-27a against oxygen-glucose deprivation-induced injuries in hippocampal neurons

引用

Neural Regeneration Research 2016年第8期11卷 1285-1292页

作者： Qun Cai Ting wang Wen-jie Yang xing fen Department of Neonatology Children's Hospital of Soochow University Suzhou Jiangsu Province China Department of Emergency Affiliated Hospital of Nantong University Nantong Jiangsu Province China Medical College of Nantong University Nantong Jiangsu Province China

Hypoxic injuries during fetal distress have been shown to cause reduced expression of micro RNA-27a（mi R-27a）,which regulates sensitivity of cortical neurons to *** hypothesized that miR-27 a overexpression attenuates hypoxia- and ischemia-induced neuronal apoptosis by regulating FOXO1,an important transcription factor for regulating the oxidative stress ***-27 a mimic was transfected into hippocampal neurons to overexpress miR-27 *** showed increased hippocampal neuronal viability and decreased caspase-3 *** luciferase reporter gene system demonstrated that mi R-27 a directly binded to FOXO1 3′UTR in hippocampal neurons and inhibited FOXO1 expression,suggesting that FOXO1 was the target gene for mi R-27 *** findings confirm that mi R-27 a protects hippocampal neurons against oxygen-glucose deprivation-induced *** mechanism might be mediated by modulation of FOXO1 and apoptosis-related gene caspase-3 expression.

关键词： nerve regeneration brain injury miR-27a hypoxic-ischemic hippocampal neurons oxygen-glucose deprivation cell survival apoptosis caspase 3 FOX01 luciferase reporter gene system neuroprotection neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The flow characteristics around bridge piers under the impact of a ship

引用

Journal of Hydrodynamics 2020年第6期32卷 1165-1177页

作者： Yan-fen Geng Hua-qiang Guo xing Ke School of Transportation Southeast UniversityNanjing211189China

The complicated flow structure around the pier threatens the safe navigation of *** paper studies the mechanism of the flow with a ship around the pier,passing or not passing and with consideration of the interval between the ship and the *** flow field model and the moving ship model are constructed by the six degrees of freedom(6DOF)solver combined with the virtual unit immersed boundary method and the level set method,both of which are based on the three-dimensional Navier-Stokes *** simulation results show that the ship significantly influences the flow around the pier,increasing the flow velocity by 50%to 140%.Away from the bridge pier,the cross-flow velocity *** cross-flow velocity near the side of the pier also increases but in the opposite *** ship is affected by the negative yaw moment because of the reverse cross-flow between the pier and the *** size of the ship has an important impact on the extent of the affected flow areas but the velocity distribution is roughly in the same *** results show double impacts of ship and pier should be considered when determining the safe area of navigation.

关键词： Bridge pier flow around cylinder moving ship model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Ca modification on the elemental composition, microstructure and tensile properties of Al?7Si?0.3Mg alloy

引用

International Journal of Minerals,Metallurgy and Materials 2019年第11期26卷 1457-1466页

作者： Jia-hong Zhang Shu-ming xing Xiao-hui Ao Peng Sun Ru-fen wang School of Mechanical and Electronic Control Engineering Beijing Jiaotong UniversityBeijing 100044China Tianjin Lizhong Alloy Group Company Limited Tianjin 300457China

The effect of Ca addition on the elemental composition,microstructure,Brinell hardness and tensile properties of Al-7 Si-0.3 Mg alloy were *** residual content of Ca in the alloy linearly increased with the amount of Ca added to the *** optimal microstructure and properties were obtained by adding 0.06 wt%Ca to Al-7 Si-0.3 Mg *** secondary dendrite arm spacing(SDAS)of the primaryαphase decreased from 44.41μm to 19.4μm,and the eutectic Si changed from coarse plates to fine *** length of the Fe-rich phase(β-Al5 Fe Si)decreased from 30.2μm to 3.8μm,and the Brinell hardness can reach to *** ultimate tensile strength,yield strength,and elongation of the resulting alloy increased from 159.5 MPa,79 MPa,and 2.5%to 212 MPa,86.5 MPa,and 4.5%,*** addition of Ca can effectively refine the primaryαphase and modify the eutectic Si phase,likely because Ca enrichment at the front of the solid-liquid interface led to undercooling of the alloy,reduced the growth rate of the primaryαphase,and refined the grain ***,it could increase the latent heat of crystallization,undercooling,and the nucleation rate of eutectic Si,which was beneficial to the improvement of the morphology of eutectic Si.

关键词： Ca Al–Si–Mg alloy microstructure mechanical properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Association between plasma immunoproteasome and 90-day prognosis after first-ever ischemic stroke

引用

Neural Regeneration Research 2021年第4期16卷 795-800页

作者： xing-Yong Chen Ming Fu Shao-fen Wan Xu Zhang Yin-Zhou wang Department of Neurology Fujian Provincial HospitalShengli Clinical Medical College of Fujian Medical UniversityFuzhouFujian ProvinceChina

Many blood biomarkers are reportedly helpful for predicting post-stroke cognitive impairment(PSCI),but no biomarkers are widely used in clinical *** purpose of this study was to investigate the association between the plasma immunoproteasome and patients’90-day prognosis after first-ever acute ischemic *** our prospective,single-center study,259 patients with first-ever acute ischemic stroke were enrolled from the Department of Neurology,Fujian Provincial Hospital,China,from March to September *** these,27 patients(10.4%)had unfavorable outcomes as assessed by the Modified Rankin Scale(scores of 3–6).The National Institutes of Health Stroke Scale score on admission,plasma N-terminal pro-B-type natriuretic peptide(NT-pro-BNP)levels,and immunopro-teasome subunit(low molecular mass peptide[LMP]2,LMP5,and LMP7)levels were significantly higher in the unfavorable outcome group than in the favorable outcome *** predict unfavorable outcomes,the optimal cutoff points were National Institutes of Health Stroke Scale score>12,NT-pro-BNP level>1883.5 pg/mL,and LMP2 level>841.4 pg/*** the 193 patients that were able to complete the Mini-Mental State Examination at 90 days poststroke,66 patients(34.2%)had *** levels of NT-pro-BNP and LMP2 were higher in patients with PSCI than in those without *** predict PSCI,the optimal cutoff values were age>70.5 years and LMP2 level>630.5 pg/*** findings indicate that plasma LMP2 may serve as a new prognostic biomarker of poor outcome and PSCI at 90 days after *** study was approved by the Ethics Committee of Fujian Provincial Hospital,Provincial Clinical Medical College of Fujian Medical University(approval No.K2014-01-003)on January 15,2014.

关键词： behavior biomarker brain clinical trial cognitive impairment immune function neurological function protein stroke

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simulation experiment of AE-based localization damage and deformation characteristic on covering rock in mined-out area

引用

International Journal of Minerals,Metallurgy and Materials 2009年第3期16卷 255-260页

作者： Sheng-jun Miao xing-ping Lai xing-guang Zhao fen-hua Ren School of Civil ＆ Environmental Engineering University of Science and Technology Beijing Beijing 100083 China School of Energy Engineering Xi＇an University of Science and Technology Xi＇an 710054 China

The localization damage and deformation characteristics of multiple rock in mined-out area under thick soil layer were investigated by acoustic emission （AE）-based physical similar simulation experiment and damage test combined with the AE theory on rock damage. During different mining courses, the degree of wall rock suffered from mining disturbed process in mined-out area was different, so did the AE density of initial damage and fracture. Some characteristic parameters, including large events, total events, and energy rate, presented fluctuations with temporal and spatial change and take on a certain extent statistic relation. Subsequently, the percent of damage degree was defined and divided into 4 stages, and the localization damage and deformation characteristics of surrounding rock in mined-out area and coal pillars were analyzed quantitatively.

关键词： acoustic emission soil layer underground mine rock damage in-site monitoring

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：