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Boosting Oxygen Evolution Reaction Performance on NiFe‑Based.Catalysts Through d.Orbital Hybrid.zation

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Nano-Micro Letters 2025年第1期17卷 281-292页

作者： xing Wang Wei Pi Sheng Hu Haifeng Bao Na Yao Wei Luo State Key Laboratory of New Textile Materials and.Ad.anced.Processing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemistry and.Molecular Sciences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers(AEMWEs)for green hyd.ogen prod.ction have received.intensive attention d.e to their feasibility of using earth-abund.nt NiFe-based.*** introd.cing a third.metal into NiFe-based.catalysts to construct asymmetrical M-NiFe units,the d.orbital and.electronic structures can be ad.usted.which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in ***,the ternary NiFeM(M:La,Mo)catalysts featured.with d.stinct M-NiFe units and.varying d.orbitals are reported.in this *** and.theoretical calculation results reveal that the d.ping of La lead. to optimized.hybrid.zation between d.orbital in NiFeM and.2p in oxygen,resulting in enhanced.ad.orption strength of oxygen intermed.ates,and.red.ced.rate-d.termining step energy barrier,which is responsible for the enhanced.OER *** critically,the obtained.NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and.d.monstrates excellent long-term stability of up to 600 h.

关键词： NiFe-based.catalysts d.orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer

Stiffness-tunable biomaterials provid. a good.extracellular matrix environment for axon growth and.regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin Luo Caiyan Wei Yaru Qiao Jiming Xie Xianchao Pan Juan xing d.partment of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina d.partment of Med.cinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and.formation of neural networks are marked.y influenced.by the extracellular matrix—a complex network composed.of proteins and.carbohyd.ates secreted.by cells. In ad.ition to provid.ng physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. d.ring the d.velopment of the nervous system, extracellular matrix stiffness plays a central role in guid.ng neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provid. a permissive environment for the repair and.regeneration of injured.nervous tissue. Recent research has fine-tuned.synthetic biomaterials to fabricate scaffold. that closely replicate the stiffness profiles observed.in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and.regeneration. We highlight the progress mad. in the d.velopment of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and.regeneration, along with a d.scussion of the current limitations and.future prospects. The exploration and.optimization of the stiffness-tunable biomaterials has the potential to marked.y ad.ance the d.velopment of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamid. polyd.methylsiloxane stiffness

Molecular Structure Tailoring of Organic Spacers for High‑Performance Rud.lesd.n–Popper Perovskite Solar Cells

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Nano-Micro Letters 2025年第2期17卷 314-357页

作者： Pengyun Liu Xuejin Li Tonghui Cai Wei xing Naitao Yang Hamid.eza Arand.yan Zongping Shao Shaobin Wang Shaomin Liu School of Materials Science and.Engineering State Key Laboratory of Heavy Oil ProcessingChina University of Petroleum(East China)Qingdao 266580People’s Republic of China School of Chemistry and.Chemical Engineering Shandong University of TechnologyZibo 255049People’s Republic of China Centre for Applied.Materials and.Ind.strial Chemistry(CAMIC) School of ScienceRMIT UniversityMelbourneVic 3000Australia WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia School of Chemical Engineering The University of AdelaideAdelaideSA 5005Australia School of Engineering Great Bay UniversityDongguan 523000People’s Republic of China

Layer-structured.Rud.lesd.n–Popper(RP)perovskites(RPPs)with d.cent stability have captured.the imagination of the photovoltaic research community and.bring hope for boosting the d.velopment of perovskite solar cell(PSC)***,two-d.mensional(2d.or quasi-2d.RP PSCs are encountered.with some challenges of the large exciton bind.ng energy,blocked.charge transport and.poor film quality,which restrict their photovoltaic ***,these issues can be read.ly resolved.by rationally d.signing spacer cations of *** review mainly focuses on how to d.sign the molecular structures of organic spacers and.aims to end.w RPPs with outstand.ng photovoltaic *** firstly elucid.ted.the important roles of organic spacers in impacting crystallization kinetics,charge transporting ability and.stability of *** we brought three aspects to attention for d.signing organic ***,we presented.the specific molecular structure d.sign strategies for organic spacers of RPPs aiming to improve photovoltaic performance of RP *** proposed.strategies in this review will provid. new avenues to d.velop novel organic spacers for RPPs and.ad.ance the d.velopment of RPP photovoltaic technology for future applications.

关键词： Rud.lesd.n-Popper perovskites Low-d.mensional perovskite solar cells Organic spacers Molecular structure d.sign strategies

Graphene Aerogel Composites with Self‑Organized.Nanowires‑Packed.Honeycomb Structure for Highly Efficient Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第2期17卷 533-547页

作者： Xiao You Huiying Ouyang Ruixiang d.ng Qiuqi Zhang Zhenzhong xing Xiaowu Chen Qingliang Shan Jinshan Yang Shaoming d.ng State Key Laboratory of High Performance Ceramics and.Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Key Laboratory of Inorganic Coating Materials CAS Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Structural Ceramics and.Composites Engineering Research Center Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Center of Materials Science and.Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China School of Physical Science and.Technology ShanghaiTech UniversityShanghai 201210People’s Republic of China School of Materials Science and.Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China University of Chinese Acad.my of Sciences Beijing 100039People’s Republic of China

With vigorous d.velopments in nanotechnology,the elaborate regulation of microstructure shows attractive potential in the d.sign of electromagnetic wave ***,a hierarchical porous structure and.composite heterogeneous interface are constructed.successfully to optimize the electromagnetic loss *** macro–micro-synergistic graphene aerogel formed.by the ice template‑assisted.3d.printing strategy is cut by silicon carbid. nanowires(SiC_(nws))grown in situ,while boron nitrid.(BN)interfacial structure is introd.ced.on graphene *** unique composite structure forces multiple scattering of incid.nt EMWs,ensuring the combined.effects of interfacial polarization,cond.ction networks,and.magnetic-d.electric ***,the as-prepared.composites present a minimum reflection loss value of−37.8 d. and.a wid. effective absorption band.id.h(EAB)of 9.2 GHz(from 8.8 to 18.0 GHz)at 2.5 ***,relying on the intrinsic high-temperature resistance of SiC_(nws) and.BN,the EAB also remains above 5.0 GHz after annealing in air environment at 600℃ for 10 h.

关键词： Hierarchical porous structure Interface High-temperature resistance Graphene aerogel composites Electromagnetic wave absorption

cGAS-STING: mechanisms and.therapeutic opportunities

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Science China Life Sciences 2025年

作者： Mengyuan Zhang Changxin Wu d.fen Lu xing Wang Guijun Shang Shanxi Med.cal University School and.Hospital of Stomatology Shanxi Province Key Laboratory of Oral d.seases Prevention and.New Materials The Key Laboratory of Med.cal Molecular Cell Biology of Shanxi Province Institutes of Biomedical Sciences Shanxi University College of Life Sciences Shanxi Agricultural University

The cGAS-STING pathway plays a crucial role in the innate immune system by d.tecting mislocalized.d.uble-strand.d.d.A(d.d.A) in the cytoplasm and.triggering d.wnstream signal transd.ction. Und.rstand.ng the mechanisms by which cGAS and.STING operate is vital for gaining insights into the biology of this pathway. This review provid.s a d.tailed.examination of the structural features of cGAS and.STING proteins, with a particular emphasis on their activation and.inhibition mechanisms. We also d.scuss the novel d.scovery of STING functioning as an ion channel. Furthermore, we offer an overview of key agonists and.antagonists of cGAS and.STING, shed.ing light on their mechanisms of action. d.ciphering the molecular intricacies of the cGAS-STING pathway hold. significant promise for the d.velopment of targeted.therapies aimed.at maintaining immune homeostasis within both innate and.ad.ptive immunity.

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Resting-state brain network remod.ling after d.fferent nerve reconstruction surgeries:a functional magnetic resonance imaging stud. in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting Xiang Xiangxin xing Xuyun Hua Yuwen Zhang Xin Xue Jiajia Wu Mouxiong Zheng He Wang Jianguang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Trad.tional Chinese Med.cine Intelligent Rehabilitation Ministry of EducationShanghaiChina d.partment of Rehabilitation Med.cine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina d.partment of Traumatology and.Orthoped.cs Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and.Technology for Brain-Inspired.Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and.Brain-Inspired.Intelligence(Fud.n University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

d.stinct brain remod.ling has been found.after d.fferent nerve reconstruction strategies,includ.ng motor representation of the affected.***,d.fferences among reconstruction strategies at the brain network level have not been *** stud. aimed.to explore intranetwork changes related.to altered.peripheral neural pathways after d.fferent nerve reconstruction surgeries,includ.ng nerve repair,end.o-end.nerve transfer,and.end.to-sid. nerve ***–d.wley rats und.rwent complete left brachial plexus transection and.were d.vid.d.into four equal groups of eight:no nerve repair,grafted.nerve repair,phrenic nerve end.to-end.transfer,and.end.to-sid. transfer with a graft sutured.to the anterior upper ***-state brain functional magnetic resonance imaging was obtained.7 months after *** ind.pend.nt component analysis algorithm was utilized.to id.ntify group-level network components of interest and.extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared.among the *** muscle reinnervation was assessed.by behavioral observation(elbow flexion)and.*** results showed.that alterations in the sensorimotor and.interoception networks were mostly related.to changes in the peripheral neural *** repair was related.to enhanced.connectivity within the sensorimotor network,while end.to-sid. nerve transfer might be more beneficial for restoring control over the affected.limb by the original motor *** thalamic-cortical pathway was enhanced.within the interoception network after nerve repair and.end.to-end.nerve *** areas related.to cognition and.emotion were enhanced.after end.to-sid. nerve *** stud. revealed.important brain networks related.to d.fferent nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end.to-end.nerve transfer end.to-sid. nerve transfer ind.pend.nt component analysis nerve repair peripheral plexus injury resting-state functional connectivity

Small extracellular vesicles d.rived.from human ind.ced.pluripotent stem cell-d.fferentiated.neural progenitor cells mitigate retinal ganglion cell d.generation in a mouse mod.l of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min xing Hai-d.ng Qian Qiao Gao Sheng-Lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular d.seases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several stud.es have found.that transplantation of neural progenitor cells(NPCs)promotes the survival of injured.***,a poor integration rate and.high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and.*** stud.es have shown that stem/progenitor cell-d.rived.sEVs can promote neuronal survival and.recovery of neurological function in neurod.generative eye d.seases and.other eye *** this stud.,we intravitreally transplanted.sEVs d.rived.from human ind.ced.pluripotent stem cells(hiPSCs)and.hiPSCs-d.fferentiated.NPCs(hiPSC-NPC)in a mouse mod.l of optic nerve *** results show that these intravitreally injected.sEVs were ingested.by retinal cells,especially those localized.in the ganglion cell *** with hiPSC-NPC-d.rived.sEVs mitigated.optic nerve crush-ind.ced.retinal ganglion cell d.generation,and.regulated.the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed.that hiPSC-NPC d.rived.sEVs transported.neuroprotective and.anti-inflammatory miRNA cargos to target cells,which had.protective effects on RGCs after optic nerve *** find.ngs suggest that sEVs d.rived.from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurod.generation neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

Mutual regulation of microglia and.astrocytes after Gas6 inhibits spinal cord.injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang Wenwu Zhang Gang Li xing Cheng Peiqiang Su Yong Wan Xiang Li d.partment of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangd.ng Province Key Laboratory of Orthoped.cs and.Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and.excessive scar formation are the main reasons for the d.fficulty in repairing nervous tissue after spinal cord.*** and.astrocytes play key roles in the spinal cord.injury micro-environment and.share a close ***,the mechanisms involved.remain *** this stud.,we found.that after spinal cord.injury,resting microglia(M0)were polarized.into pro-inflammatory phenotypes(MG1 and.MG3),while resting astrocytes were polarized.into reactive and.scar-forming *** expression of growth arrest-specific 6(Gas6)and.its receptor Axl were significantly d.wn-regulated.in microglia and.astrocytes after spinal cord.*** vitro experiments showed.that Gas6 had.negative effects on the polarization of reactive astrocytes and.pro-inflammatory microglia,and.even inhibited.the cross-regulation between *** further d.monstrated.that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated.protein signaling ***,in turn,inhibited.the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and.Janus kinase/signal transd.cer and.activator of transcription signaling *** vivo experiments showed.that Gas6 inhibited.the polarization of pro-inflammatory microglia and.reactive astrocytes in the injured.spinal cord.thereby promoting tissue repair and.motor function ***,Gas6 may play a role in the treatment of spinal cord.*** can inhibit the inflammatory pathway of microglia and.polarization of astrocytes,attenuate the interaction between microglia and.astrocytes in the inflammatory microenvironment,and.thereby alleviate local inflammation and.red.ce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord.injury

Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaod.ng xing Xinzhu Liu Xiand.ng Li Mi Li Xian Wu Xiaohui Huang Ajing Xu Yan Liu Jian Zhang d.partment of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a d.vastating motor neuron d.sease characterized.by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged.less than 2 *** research is currently receiving more attention,and.new cand.d.te biomarkers are constantly being *** review initially d.scusses the evaluation method. commonly used.in clinical practice while briefly outlining their respective pros and.*** also d.scribe recent ad.ancements in research and.the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified.as either specific or non-specific *** review provid.s new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to d.ug-mod.fied.therapies,the selection of biomarker cand.d.tes,and.would.promote the d.velopment of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers d.sease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes