检索结果-南通市图书馆

Increased long-distance and homo-trans interactions related to H3K27me3 in Arabidopsis hybrids

Journal of Integrative Plant Biology 2024年第2期66卷 208-227页

作者： Zhaoxu Gao Yanning Su Le Chang Guanzhong Jiao Yang Ou Mei Yang Chao Xu Pengtao Liu Zejia wang Zewen Qi Wenwen Liu Linhua Sun Guangming He xing wang deng Hang He School of Advanced Agriculture Sciences and School of Life Sciences State Key Laboratory of Protein and Plant Gene ResearchPeking UniversityBeijing 100871China College of Grassland Science Beijing Forestry UniversityBeijing 100083China Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences in WeifangWeifang 261325China

In plants,the genome structure of hybrids changes compared with their parents,but the effects of these changes in hybrids remain elusive.Comparing reciprocal crosses between Col×C24 and C24×Col in Arabidopsis using high-throughput chromosome conformation capture assay(Hi-C)analysis,we found that hybrid three-dimensional(3D)chromatin organization had more long-distance interactions relative to parents,and this was mainly located in promoter regions and enriched in genes with heterosis-related pathways.The interactions between euchromatin and heterochromatin were increased,and the compartment strength decreased in hybrids.In compartment domain(CD)boundaries,the distal interactions were more in hybrids than their parents.In the hybrids of CURLY LEAF(clf)mutants clfCol×clfC24and clfC24×clfCol,the heterosis phenotype was damaged,and the long-distance interactions in hybrids were fewer than in their parents with lower H3K27me3.ChIP-seq data revealed higher levels of H3K27me3 in the region adjacent to the CD boundary and the same interactional homo-trans sites in the wild-type(WT)hybrids,which may have led to more long-distance interactions.In addition,the differentially expressed genes(DEGs)located in the boundaries of CDs and loop regions changed obviously in WT,and the functional enrichment for DEGs was different between WT and clf in the longdistance interactions and loop regions.Our findings may therefore propose a new epigenetic explanation of heterosis in the Arabidopsis hybrids and provide new insights into crop breeding and yield increase.

关键词： 3D chromatin organization H3K27me3 homo-trans hybrids long-distanceinteractions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of combustion temperature on the optical properties of brown carbon from biomass burning

引用

Journal of Environmental Sciences 2024年第3期137卷 302-309页

作者： Peng Gao Rule deng Song Jia Yue Li Xuefei wang Qian xing School of Chemistry Sciences University of Chinese Academy of SciencesBeijing 100049China College of Chemistry and Materials Engineering Beijing Technology and Business UniversityBeijing 100048China

Biomass burning has been known as one of main sources of Brown Carbon(BrC)in atmosphere.In this study,by controlling the combustion temperature at 250℃,350℃,and 450℃,the methanol soluble organic carbon(MSOC)and methanol insoluble carbon(MISC)from pine wood burning was collected by impinger.UV–Vis,excitation emission matrix(EEM),TEM and FTIR spectra were applied to investigate the properties of BrC collected.For MSOC at 250℃ and 350℃,all the spectral profiles of UV–Vis absorption and excitation emission matrix are almost the same,while the EEM of MSOC at 450℃ are different from that of the other two.For MISC fuorescence was observed only in the case of 450℃.In the FTIR spectra,with the temperature increasing the peaks associated to the oxygen-contained functions was weakened,indicating the formation of the fuorophores with larger conjugated system,especially aromatic hydrocarbons.Our results show that biomass combustion at low temperature produces more oxygen-riched BrC,which possesses relatively lower light absorption,while at high temperature produces more aromatics hydrocarbons with relatively strong light absorption.The results of this work are helpful to trace the source of brown carbon and optimize biomass energy utilization.

关键词： Biomass burning Combustion temperature Methanol-soluble brown carbon EEM Impinger

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

From molecular basics to agronomic benefits:Insights into noncoding RNA-mediated gene regulation in plants

引用

Journal of Integrative Plant Biology 2022年第12期64卷 2290-2308页

作者： Yuqiu wang xing wang deng Danmeng Zhu State Key Laboratory of Protein and Plant Gene Research School of Advanced Agricultural Sciences and School of Life SciencesPeking-Tsinghua Center for Lfe SciencesPeking UniversityBeiing 100871China Shandong Laboratory of Advanced Agricultural Sciences in Weifang Peking University Institute of Advanced Agricultural SciencesWeifang 261325China

The development of plants is largely dependent on their growth environment.To better adapt to a particular habitat,plants have evolved various subtle regulatory mechanisms for altering gene expression.Noncoding RNAs(ncRNAs)constitute a major portion of the transcriptomes of eukaryotes.Various ncRNAs have been recognized as important regulators of the expression of genes involved in essential biological processes throughout the whole life cycles of plants.In this review,we summarize the current understanding of the biogenesis and contributions of small nucleolar RNA(snoRNA)-and regulatory long noncoding RNA(lncRNA)-mediated gene regulation in plant development and environmental responses.Many regulatory ncRNAs appear to be associated with increased yield,quality and disease resistance of various species and cultivars.These ncRNAs may potentially be used as genetic resources for improving agronomic traits and for molecular breeding.The challenges in understanding plant ncRNA biology and the possibilities to make better use of these valuable gene resources in the future are discussed in this review.

关键词： gene expression long noncoding RNA snoRNA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comprehensive Survey of the Landscape of Digital Twin Technologies and Their Diverse Applications

引用

工程与科学中的计算机建模(英文) 2024年第1期138卷 125-165页

作者： Haiyu Chen Haijian Shao xing deng Lijuan wang Xia wang School of Computer Jiangsu University of Science and TechnologyZhenjiang212003China Department of Electrical and Computer Engineering University of Nevada Las VegasLas VegasNV89154USA Department of Electrical and Computer Engineering National University of Singapore117583Singapore

The concept of the digital twin,also known colloquially as the DT,is a fundamental principle within Industry 4.0 framework.In recent years,the concept of digital siblings has generated considerable academic and practical interest.However,academia and industry have used a variety of interpretations,and the scientific literature lacks a unified and consistent definition of this term.The purpose of this study is to systematically examine the definitional landscape of the digital twin concept as outlined in scholarly literature,beginning with its origins in the aerospace domain and extending to its contemporary interpretations in the manufacturing industry.Notably,this investigationwill focus on the research conducted on Industry 4.0 and smartmanufacturing,elucidating the diverse applications of digital twins in fields including aerospace,intelligentmanufacturing,intelligent transportation,and intelligent cities,among others.

关键词： Digital twins Industry 4.0 smart manufacturing digital thread modeling simulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

HIF-1α signaling: Essential roles in tumorigenesis and implications in targeted therapies

引用

Genes & Diseases 2024年第1期11卷 234-251页

作者： Yan Zhao Cheng xing Yating deng Can Ye Hongling Peng Department of Hematology The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Hunan Key Laboratory of Tumor Models and Individualized Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Hunan Engineering Research Center of Cell Immunotherapy for Hematopoietic Malignancies The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China

The hypoxic microenvironment is an essential characteristic of most malignant tu-mors.Notably,hypoxia-inducible factor-1 alpha(HIF-1a)is a key regulatory factor of cellular adaptation to hypoxia,and many critical pathways are correlated with the biological activity of organisms via HIF-1a.In the intra-tumoral hypoxic environment,HIF-1αis highly expressed and contributes to the malignant progression of tumors,which in turn results in a poor prog-nosis in patients.Recently,it has been indicated that HiF-1αinvolves in various critical pro-cesses of life events and tumor development via regulating the expression of HiF-1a target genes,such as cell proliferation and apoptosis,angiogenesis,glucose metabolism,immune response,therapeutic resistance,etc.Apart from solid tumors,accumulating evidence has re-vealed that HiF-1αis also closely associated with the development and progression of hemato-logical malignancies,such as leukemia,lymphoma,and multiple myeloma.Targeted inhibition of HiF-1a can facilitate an increased sensitivity of patients with malignancies to relevant ther-apeutic agents.In the review,we elaborated on the basic structure and biological functions of HIF-1a and summarized their current role in various malignancies.It is expected that they will have future potential fortargeted therapy.

关键词： Angiogenesis Hematological malignancies Hypoxia-inducible factor-1 alpha(HIF-1α) Immune escape Targeted therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pd Pt VO_(x)/CeO_(2)-ZrO_(2):Highly efficient catalysts with good sulfur dioxide-poisoning reversibility for the oxidative removal of ethylbenzene

引用

Journal of Environmental Sciences 2024年第4期138卷 153-166页

作者： Jia wang Yuxi Liu Jiguang deng Lin Jing Xiuqing Hao xing Zhang Xiaohui Yu Hongxing Dai Beijing Key Laboratory for Green Catalysis and Separation Key Laboratory of Beijing on Regional Air Pollution ControlKey Laboratory of Advanced Functional MaterialsEducation Ministry of ChinaLaboratory of Catalysis Chemistry and NanoscienceDepartment of Chemical EngineeringFaculty of Environment and LifeBeijing University of TechnologyBeijing 100124China

The PdPtVO_(x)/CeO_(2)-ZrO_(2)(PdPtVO_(x)/CZO)catalysts were obtained by using different approaches,and their physical and chemical properties were determined by various techniques.Catalytic activities of these materials in the presence of H_(2)O or SO_(2)were evaluated for the oxidation of ethylbenzene(EB).The PdPtVO_(x)/CZO sample exhibited high catalytic activity,good hydrothermal stability,and reversible sulfur dioxide-poisoning performance,over which the specific reaction rate at 160℃,turnover frequency at 160℃(TOF_(Pd or Pt)),and apparent activation energy were 72.6 mmol/(g_(Pt)·sec)or 124.2 mmol/(g_(Pd)·sec),14.2 sec^(-1)(TOF_(Pt))or 13.1 sec^(-1)(TOF_(Pd)),and 58 k J/mol,respectively.The large EB adsorption capacity,good reducibility,and strong acidity contributed to the good catalytic performance of PdPtVO_(x)/CZO.Catalytic activity of PdPtVO_(x)/CZO decreased when 50 ppm SO_(2)or(1.0 vol.%H_(2)O+50 ppm SO_(2))was added to the feedstock,but was gradually restored to its initial level after the SO_(2)was cut off.The good reversible sulfur dioxide-resistant performance of PdPtVO_(x)/CZO was associated with the facts:(i)the introduction of SO_(2)leads to an increase in surface acidity;(ii)V can adsorb and activate SO_(2),thus accelerating formation of the SO_(x)^(2-)(x=3 or 4)species at the V and CZO sites,weakening the adsorption of sulfur species at the PdPt active sites,and hence protecting the PdPt active sites to be not poisoned by SO_(2).EB oxidation over PdPtVO_(x)/CZO might take place via the route of EB→styrene→phenyl methyl ketone→benzaldehyde→benzoic acid→maleic anhydride→CO_(2)and H_(2)O.

关键词： Ceria-zirconia Supported palladium-platinum-vanadium catalyst Volatile organic compound Ethylbenzene oxidation Sulfur dioxide resistance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research progress on venous thrombosis development in patients with malignant tumors

引用

World Journal of Clinical Cases 2024年第11期12卷 1900-1908页

作者： Teng-Fei wang Qian Chen Jie deng Shi-Liang Li Yuan Xu Si-xing Ma Department of Vascular Surgery The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina Department of Organ Transplantation The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550000Guizhou ProvinceChina

The coexistence of venous thromboembolism(VTE)within patients with cancer,known as cancer-associated thrombosis(CAT),stands as a prominent cause of mortality in this population.Over recent years,the incidence of VTE has demonstrated a steady increase across diverse tumor types,influenced by several factors such as patient management,tumor-specific risks,and treatment-related aspects.Furthermore,mutations in specific genes have been identified as potential contributors to increased CAT occurrence in particular cancer subtypes.We conducted an extensive review encompassing pivotal historical and ongoing studies on CAT.This review elucidates the risks,mechanisms,reliable markers,and risk assessment methodologies that can significantly guide effective interventions in clinical practice.

关键词： Malignant tumor Venous thromboembolism Cancer-associated thrombosis Research progress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Reinforcement Learning-Based Dynamic Order Recommendation for On-Demand Food Delivery

引用

Tsinghua Science and Technology 2024年第2期29卷 356-367页

作者： xing wang Ling wang Chenxin Dong Hao Ren Ke xing Department of Automation Tsinghua UniversityBeijing 100080China School of Mechanical and Automotive Engineering Qingdao Hengxing University of Science and TechnologyQingdao 266100China Meituan Beijing 100015China

On-demand food delivery(OFD)is gaining more and more popularity in modern society.As a kernel order assignment manner in OFD scenario,order recommendation directly influences the delivery efficiency of the platform and the delivery experience of riders.This paper addresses the dynamism of the order recommendation problem and proposes a reinforcement learning solution method.An actor-critic network based on long short term memory(LSTM)unit is designed to deal with the order-grabbing conflict between different riders.Besides,three rider sequencing rules are accordingly proposed to match different time steps of the LSTM unit with different riders.To test the performance of the proposed method,extensive experiments are conducted based on real data from Meituan delivery platform.The results demonstrate that the proposed reinforcement learning based order recommendation method can significantly increase the number of grabbed orders and reduce the number of order-grabbing conflicts,resulting in better delivery efficiency and experience for the platform and riders.

关键词： on-demand food delivery order recommendation reinforcement learning actor-critic network long short term memory

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Numerical Study on Reduction in Aerodynamic Drag and Noise of High-Speed Pantograph

引用

Computer Modeling in Engineering & Sciences 2024年第5期139卷 2155-2173页

作者： deng Qin xing Du Tian Li Jiye Zhang State Key Laboratory of Rail Transit Vehicle System Southwest Jiaotong UniversityChengdu610031China School of Electrical Engineering Southwest Jiaotong UniversityChengdu610031China

Reducing the aerodynamic drag and noise levels of high-speed pantographs is important for promoting environmentally friendly,energy efficient and rapid advances in train technology.Using computational fluid dynamics theory and the K-FWH acoustic equation,a numerical simulation is conducted to investigate the aerodynamic characteristics of high-speed pantographs.A component optimization method is proposed as a possible solution to the problemof aerodynamic drag and noise in high-speed pantographs.The results of the study indicate that the panhead,base and insulator are the main contributors to aerodynamic drag and noise in high-speed pantographs.Therefore,a gradual optimization process is implemented to improve the most significant components that cause aerodynamic drag and noise.By optimizing the cross-sectional shape of the strips and insulators,the drag and noise caused by airflow separation and vortex shedding can be reduced.The aerodynamic drag of insulator with circular cross section and strips with rectangular cross section is the largest.Ellipsifying insulators and optimizing the chamfer angle and height of the windward surface of the strips can improve the aerodynamic performance of the pantograph.In addition,the streamlined fairing attached to the base can eliminate the complex flow and shield the radiated noise.In contrast to the original pantograph design,the improved pantograph shows a 21.1%reduction in aerodynamic drag and a 1.65 dBA reduction in aerodynamic noise.

关键词： High-speed pantograph aerodynamic drag aerodynamic noise reduction optimizing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High speed laser cladding as a new approach to prepare ultra-high temperature ceramic coatings

引用

Journal of Advanced Ceramics 2024年第2期13卷 143-154页

作者： Qiyao deng Pengfei He Chuan Sun Yang Li Yue xing Yujie wang Jinglong Li Xiubing Liang Xin wang Yujie Zhou Yujun Cai National-Local Joint Engineering Laboratory of Intelligent Manufacturing Oriented Automobile Die&Mould Tianjin University of Technology and EducationTianjin 300222China Defense Innovation Institute Academy of Military ScienceBeijing 100071China School of mechanical engineering Tianjin University of Technology and EducationTianjin 300222China Scientific and Technological Innovation Center Beijing 100012China

Ultra-high temperature ceramic(UHTC)coatings are used to protect the hot-end components of hypervelocity aerocrafts from thermal ablation.This study provides a new approach to fabricate UHTC coatings with high speed laser cladding(HSLC)technology,and places more emphasis on investigating the formation mechanism,phase compositions,and mechanical properties of HSLC-UHTC coatings.Results show that a well-bonded interface between the coating and the tantalum alloy substrate can be formed.The coating is mainly composed of(Zr,Ta)C ceramic solid solution phase with a content of higher than 90% by volume and Ta(W)metal solid solution phase.At a relatively high powder feeding rate,the ZrC ceramic phase appears in the coating while a dense ZrC UHTC top layer with a thickness of up to~50μm is successfully fabricated.As for the mechanical properties of the HSLC coatings,the fracture toughness of the coating decreases with the increase of powder feeding rate.The increase of carbide solid solution phase can significantly improve the high temperature microhardness(552.7±1.8 HV0.5@1000℃).The innovative design of HSLC ZrC-based coatings on refractory alloys accomplishes continuous transitions on microstructure and properties from the substrate to the UHTC top layer,which is a very promising candidate scheme for thermal protection coating.

关键词： high speed laser cladding(HSLC) ultra-high temperature ceramic(UHTC) thermal protection coating microstructure mechanical properties

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：