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中国大城市跨国绅士化的机制与效应解析——以广州远景路韩国人聚居区为例

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经济地理 2024年第4期44卷 64-74页

作者：黄幸刘圳吴婷婷华南理工大学建筑学院广东广州5510641 广州市规划和自然资源局南沙区分局广东广州510199 华南理工大学建筑设计研究院有限公司广东广州510641

跨国绅士化是由高端跨国移民所引起的社会空间重构现象,强调跨国高端移民与原住低收入居民之间的互动、演替和博弈,具有较强的阶层性、社会性和政治性。文章选取广州远景路韩国人聚居区作为研究案例,对跨国绅士化的发展特征、形成机制... 详细信息

跨国绅士化是由高端跨国移民所引起的社会空间重构现象,强调跨国高端移民与原住低收入居民之间的互动、演替和博弈,具有较强的阶层性、社会性和政治性。文章选取广州远景路韩国人聚居区作为研究案例,对跨国绅士化的发展特征、形成机制和社会效应进行了深入分析。研究发现:(1)跨国绅士化的发展经历了萌芽、发育、发展和延续4个阶段,每个阶段在人口构成、空间形态、资本来源上都有显著变化;(2)跨国绅士化是由地方政府、开发商、跨国绅士化群体以及当地居民形成的复杂协同机制共同推动发生的,但地方政府占据了绝对主导地位;(3)跨国绅士化带来了诸如阶层与族裔的演替、生活方式改变、文化割裂与社会区隔等显著社会空间效应,但其结果的积极性和消极性显示出多元性和复杂性特征。

关键词：跨国绅士化政府主导跨国高端移民原住居民韩国人聚居区族裔社会区隔

“益髓醒神”法对卒中后失语工作记忆影响的思路探析

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中华中医药杂志 2024年第6期39卷 2973-2977页

作者：黄幸常静玲北京中医药大学东直门医院北京100700 北京中医药大学第三附属医院北京100029

语言和记忆是人类大脑核心的认知功能,脑卒中的高致残率及复发率增加了卒中后语言、记忆等认知障碍的风险。卒中的发生多伴有语言、工作记忆相关的神经功能网络异常。文章从“益髓醒神”法阐述卒中后失语(PSA)记忆障碍病机与治疗中的“... 详细信息

语言和记忆是人类大脑核心的认知功能,脑卒中的高致残率及复发率增加了卒中后语言、记忆等认知障碍的风险。卒中的发生多伴有语言、工作记忆相关的神经功能网络异常。文章从“益髓醒神”法阐述卒中后失语(PSA)记忆障碍病机与治疗中的“髓”“神”,以及益髓、醒神的关联,强调PSA记忆障碍与“脑髓空虚、窍闭不利、神失其守”及脑肾等脏腑功能协调关系密切。以“益髓醒神”法改善PSA患者的工作记忆为指标,结合现代研究,论述了EEG/ERP技术的工作记忆任务实验范式与神经心理测评相结合用于“益髓醒神”法对PSA干预效果的机制与评价应用,为PSA记忆障碍等非语言认知功能损伤提供理论指导,并为研究PSA的疗效机制提供新思路。

关键词：卒中后失语益髓醒神工作记忆事件相关电位脑电技术视觉工作记忆任务

Pancreatic tumor initiation: the potential role of IL-33

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1636-1637页

作者： xing huang Gang Zhang Tingbo Liang Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Zhejiang Provincial Key Laboratory of Pancreatic Disease the First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina

A recent report published in Nature by Alonso-Curbelo et al.1 revealed epigenetic reprogramming in pancreatic cancer initiation caused by the cooperative effects of KRAS mutation and environmental damage.

关键词： al. damage KRAS

Distribution dependent stochastic differential equations

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Frontiers of Mathematics in China 2021年第2期16卷 257-301页

作者： xing huang Panpan REN Feng-Yu WANG Center for Applied Mathematics Tianjin UniversityTianjin 300072China Department of Mathematics City University of Hong KongHong KongChina

Due to their intrinsic link with nonlinear Fokker-Planck equations and many other applications,distribution dependent stochastic differential equations(DDSDEs)have been intensively investigated.In this paper,we summarize some recent progresses in the study of DDSDEs,which include the correspondence of weak solutions and nonlinear Fokker-Planck equations,the well-posedness,regularity estimates,exponential ergodicity,long time large deviations,and comparison theorems.

关键词： Distribution dependent stochastic differential equation(DDSDE) nonlinear Fokker-Planck equation Bismut formula Wasserstein distance gradient estimate

Artificial cavernosa-like tissue based on multibubble Matrigel and a human corpus cavernous fibroblast scaffold

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Asian Journal of Andrology 2024年第3期26卷 260-267页

作者： Yu-Zhuo Chen Yi-Hong Zhou Min-Bo Yan Ming Xiao Biao Liu Ying-Hao Yin Xiao-Li Tan Yong-Quan huang Yu-Hong Lin Ting Xie Jia-Li Tian Qi Wang Jian-Ying Li Zi-Zhou Meng Zheng Li Emily xing Yu-Xin Tang Ya-Wei Li Zhong-Zhen Su Liang-Yu Zhao Department of Ultrasound The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Interventional Medicine Guangdong ProvincialKey Laboratory of Biomedical ImagingThe Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Urology The Fifth Affiliated HospitalSun Yat-sen UniversityZhuhai 519000China Department of Andrology the Center for Men’s HealthUrologic Medical CenterShanghai Key Laboratory of ReproductiveMedicineShanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Cedars-Sinai Medical Center Los AngelesCA 90024USA

Ex vivo tissue culture of the human corpus cavernosum(cc)can be used to explore the tissue structural changes and complex signaling networks.At present,artificial Cc-like tissues based on acellular or three-dimensional(3D)-printed scaffolds are used to solve the scarcity of primary penis tissue samples.However,inconvenience and high costs limit the wide application of such methods.Here,we describe a simple,fast,and economical method of constructing artificial CC-like tissue.Human Cc fibroblasts(FBs),endothelial cells(ECs),and smooth muscle cells(SMCs)were expanded in vitro and mixed with Matrigel in specific proportions.A large number of bubbles were formed in the mixture by vortexing combined with pipette blowing,creating a porous,spongy,and spatial structure.The Cc FBs produced a variety of signaling factors,showed multidirectional differentiation potential,and grew in a 3D grid in Matrigel,which is necessary for CC-like tissue to maintain a porous structure as a cell scaffold.Within the C-like tissue,ECs covered the surface of the lumen,and SMCs were located inside the trabeculae,similar to the structure of the primary Cc.Various cell components remained stable for 3 days in vitro,but the EC content decreased on the 7th day.Wingless/integrated(WNT)signaling activation led to lumen atrophy and increased tissue fibrosis in CC-like tissue,inducing the same changes in characteristics as in the primary Cc.This study describes a preparation method for human artificial cC-like tissue that may provide an improved experimental platform for exploring the function and structure of the cC and conducting drug screening for erectile dysfunction therapy.

关键词： artificial tissue corpus cavernosum ex vivo fibroblasts|

IPv6中一种基于卷积的DDoS攻击两阶段防御机制

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软件学报 2024年第5期35卷 2522-2542页

作者：王郁夫王兴伟易波黄敏东北大学计算机科学与工程学院辽宁沈阳110819 东北大学信息科学与工程学院辽宁沈阳110819

针对IPv6快速普及背景下分布式拒绝服务(DDoS)攻击威胁不断增长的现状,提出一种两阶段的DDoS攻击防御机制,包括初期实时监控DDoS攻击发生的预检测阶段,以及告警后精准过滤DDoS攻击流量的深度检测阶段.首先,分析IPv6报文格式并解析PCAP... 详细信息

针对IPv6快速普及背景下分布式拒绝服务(DDoS)攻击威胁不断增长的现状,提出一种两阶段的DDoS攻击防御机制,包括初期实时监控DDoS攻击发生的预检测阶段,以及告警后精准过滤DDoS攻击流量的深度检测阶段.首先,分析IPv6报文格式并解析PCAP流量捕获文件中的16进制头部字段作为样本元素.其次,在预检测阶段,引入轻量化二值卷积神经网络(BCNN),设计一种二维流量矩阵作为模型输入,整体感知网络在混杂DDoS流量后出现的恶意态势作为告警DDoS发生的证据.告警后,深度检测阶段介入,引入一维卷积神经网络(1DCNN)具体区分混杂的DDoS报文,从而下发阻断策略.在实验中,自建IPv6-LAN拓扑并基于NAT 4to6技术重放CIC-DDoS2019公开集生成纯IPv6-DDoS流量源测试.结果证明,所提机制提升针对DDoS攻击的响应速度、准确度和攻击流量过滤效率,当DDoS流量出现仅占总网络6%和10%时,BCNN就能以90.9%和96.4%的准确度感知到DDoS攻击的发生,同时1DCNN能够以99.4%准确率区分DDoS报文并过滤.

关键词： DDoS防御两阶段 DDoS攻击监控 DDoS流量过滤 BCNN和1DCNN IPv6

Frozen bean curd-inspired xenogeneic acellular dermal matrix with triple pretreatment approach of freeze–thaw,laser drilling and ADSCs pre-culture for promoting early vascularization and integration

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Regenerative Biomaterials 2022年第1期9卷 687-703页

作者： xing huang Zhu Zhu Lin Lu Rui Jin Di Sun Xusong Luo Department of Plastic and Reconstructive Surgery Shanghai 9th People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011PR China Shanghai Key Lab of Tissue Engineering Shanghai 9th People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011PR China

Xenogeneic acellular dermal matrix(ADM)is widely used in clinical practice given its good biocompatibility and biomechanical properties.Yet,its dense structure remains a hindrance.Incorporation of laser drilling and pre-culture with Adipose-derived stem cells(ADSCs)have been attempted to promote early vascularization and integration,but the results were not ideal.Inspired by the manufacturing procedure of frozen bean curd,we proposed a freeze–thaw treatment to enhance the porosity of ADM.We found that the ADM treated with-80℃3Rt-30℃3R had the largest disorder of stratified plane arrangement(deviation angle 28.6%)and the largest porosity(96%),making it an optimal approach.Human umbilical vein endothelial cells on freeze–thaw treated ADM demonstrated increased expression in Tie-2 and CD105 genes,proliferation,and tube formation in vitro compared with those on ADM.Combining freeze–thaw with laser drilling and pre-culture with ADSCs,such tri-treatment improved the gene expression of proangiogenic factors including IGF-1,EGF and vascular endothelial growth factor,promoted tube formation,increased cell infiltration and accelerated vascularization soon after implantation.Overall,freeze–thaw is an effective method for optimizing the internal structure of ADM,and tri-treatments may yield clinical significance by promoting early cell infiltration,vascularization and integration with surrounding tissues.

关键词： freeze-thaw xenogeneic acellular dermal matrix vascularization early integration

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生物育种法规遵循度与执行效果评估方法研究

分子植物育种 2024年第2期22卷 465-471页

作者：荣幸黄玉芬北京工业职业技术学院北京100042

生物育种法规的遵循度与执行效果评估是确保食品安全、环境可持续性和生物多样性保护的重要组成部分。本研究旨在探讨生物育种法规遵循度与执行效果评估方法的重要性和方法学。研究包括生物育种法规的定义与分类、国际与国内法规概览,... 详细信息

生物育种法规的遵循度与执行效果评估是确保食品安全、环境可持续性和生物多样性保护的重要组成部分。本研究旨在探讨生物育种法规遵循度与执行效果评估方法的重要性和方法学。研究包括生物育种法规的定义与分类、国际与国内法规概览,以及法规对生物育种的影响,分析了法规遵循度评估方法、执行效果评估方法以及法规遵循度与执行效果评估所面临的挑战,如技术问题、数据可用性和国际合作等。通过综合研究和成功案例分析,为未来研究提供启示。这些研究有助于为生物育种法规制定和实施提供更全面、可持续的方法,从而促进食品供应链的安全和可持续性。

关键词：生物育种法规遵循度执行效果评估方法

Blocking PD-L1 for anti-liver cancer immunity:USP22 represents a critical cotarget

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Cellular & Molecular Immunology 2020年第7期17卷 677-679页

作者： xing huang Xiaozhen Zhang Xueli Bai Tingbo Liang Zhejiang Provincial Key Laboratory of Pancreatic Disease the First Affiliated HospitalSchool of MedicineZhejiang University79 Qingchun RoadHangzhou 310003 ZhejiangChina Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003 ZhejiangChina Innovation Center for the Study of Pancreatic Diseases Zhejiang ProvinceHangzhou 310003 ZhejiangChina

MULTIPLE LEVELS OF PD-L1 REGULATION IN CANCER IMMUNOTHERAPY To date,the PD-1/PD-L1 blockade strategy has been tested in a variety of cancer types.However,only bladder cancer,melanoma,mismatch repair-deficient colorectal cancer,and certain hematopoietic malignancies have been highly responsive in terms of clinical outcomes.1,2 It is presumed that the expression level of the PD-L1 protein largely determines the therapeutic efficacy of PD-1/PD-L1-targeted cancer immunotherapy.3,4 Previous studies have shown that several transcriptional factors are involved in the upregulation of PD-L1 by directly binding to its promoter region.5 For instance,individual activation of STAT1,NF-κB,HIF-1α,c-Myc,or MAPK increased PD-L1 transcription and immune evasion of tumor cells.On the other hand,oncogenic RAS signaling reportedly stabilizes PD-L1 mRNA to promote tumor immunoresistance.

关键词： USP22 immunity bladder