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Genetic Polymorphism in the Second Exon of HLA-DRB1 in Cervical Cancer

Clinical oncology and cancer researeh 2010年第1期7卷 27-32页

作者： yan-yun LI Gui-fang yanG yan-ju JIA Jun xing yan-ni LI wei-ming ZHANG Department of Biochemistry and MolecularBiology Basic Medical College Tianjin Medical University Tianjin 300070 China.

OBJECTIVE The aim of this investigation was to assess the association between single nucleotide polymorphisms （SNPs） in HLA-DRB1 and the risk of developing cervical cancer. Our study focused on the second exon of the HLA-DRB1 alleles, which have most of the SNP sites on HLA-DRB1. METHODS We examined 30 cervical cancer patients and 66 control patients using the sequence-based typing polymerase chain reaction technique （PCR-SBT） to type 55 single nucleotide polymorphisms （SNPs） and haplotypes in the second exon of HLA-DRB1. The Chi-square test and the Bonferroni correction method were utilized for the statistical analysis of the data. An association between the alleles and cervical cancer was examined by the linkage disequilibrium test and the odds ratio （OR）. RESULTS Compared with the control group, among the 55 SNPs we studied in the second exon of HLA-DRB1, 4 showed an evident association with cervical cancer. Rs17880292 （P = 0.033, OR = 0.322） and rs1059586 （P = 0.029, OR = 2.657） had positive significance for the risk of developing cervical cancer, while rs17879702 （P = 0.016, OR = 0.222） and rs17882525 （P = 0.025, OR = 0.128） were negative. The difference in frequency of the 5582A-5592A-5667T haplotype between cervical cancer patients and the controls was significant （P = 0.043, OR = 2.735）. CONCLUSION The rs17880292 G/A genotype and the rs1059586 A/A genotype could be linked to an increased risk of cervical cancer. Rs17879702 and rs17882525 might be haplotype-tag SNPs （htSNPs） or belong to some other haplotypes, which might exert a protective effect against cervical cancer in combination. The 582A-5592A-5667T haplotype was shown to be a marker for susceptibility to cervical carcinogenesis.

关键词： HLA-DRB1 susceptibility SNPs. cervical cancer genetic

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Laser Wire Additive Manufacturing of Ti-6Al-4V Alloy and Its Machine Learning Study for Parameters Optimization(Invited)

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中国激光 2024年第4期51卷 182-198页

作者： Wu Junyi Zhang Bo Wang weihua Li weipeng Yao Xiyu Wang Dawei xing wei yan Ming Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055GuangdongChina Songshan Lake Materials Laboratory Dongguan 523830GuangdongChina Institute of Physics Chinese Academy of SciencesBeijing 100190China Jiaxing Research Institute Southern University of Science and TechnologyShenzhen 518055GuangdongChina High Performance Computing Department National Supercomputing CenterShenzhen 518055GuangdongChina

Ti-6Al-4V is a benchmark Ti alloy. Laser wire additive manufacturing(LWAM) offers advanced manufacturing capability to the alloy for applications possibly including exploration of outer space. As a typical multiple-variable process, LWAM is complex, which, however, can be analyzed, predicated or even optimized by artificial intelligence(AI) methods such as machine learning(ML). In this study, printing parameters of the Ti-6Al-4V is firstly optimized using single-track-single-layer experiments, and then single-track-multiple-layer samples are printed, whose properties in terms of hardness and compressive strength are analyzed subsequently by both experiments and ML. The two ML approaches, artificial neural network(ANN) and support vector machine(SVM), are employed to predict the experimental results, whose coefficients of determination R2 show good values. Further optimized properties are realized by adopting genetic algorithm(GA) and simulated annealing(SA) approaches, which contribute to high mechanical properties achieved, for instance, an engineering compressive strength of about 1694 MPa. The results here indicate that important mechanical properties of the LWAM-prepared Ti alloys can be well predicted and enhanced using suitable ML approaches.

关键词： artificial printing additive

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Variation Characteristics of Root Traits of Different Alfalfa Cultivars under Saline-Alkaline Stress and their Relationship with Soil Environmental Factors

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Phyton-International Journal of Experimental Botany 2024年第1期93卷 29-43页

作者： Tian-Jiao wei Guang Li yan-Ru Cui Jiao Xie xing-Ai Gao xing Teng Xin-Ying Zhao Fa-Chun Guan Zheng-wei Liang Northeast Agricultural Research Center of China Jilin Academy of Agricultural SciencesChangchun130033China Northeast Institute of Geography and Agroecology Chinese Academy of SciencesChangchun130102China

Soil salinization is the main factor that threatens the growth and development of plants and limits the increase of *** is of great significance to study the key soil environmental factors affecting plant root traits to reveal the adaptation strategies of plants to saline-alkaline-stressed soil *** this study,the root biomass,root morphological parameters and root mineral nutrient content of two alfalfa cultivars with different sensitivities to alkaline stress were analyzed with black soil as the control group and the mixed saline-alkaline soil with a ratio of 7:3 between black soil and saline-alkaline soil as the saline-alkaline treatment *** the same time,the correlation analysis of soil salinity indexes,soil nutrient indexes and the activities of key enzymes involved in soil carbon,nitrogen and phosphorus cycles was carried *** results showed that compared with the control group,the pH,EC,and urease(URE)of the soil surrounding the roots of two alfalfa cultivars were significantly increased,while soil total nitrogen(TN),total phosphorus(TP),organic carbon(SOC),andα-glucosidase activity(AGC)were significantly decreased under saline-alkaline *** was no significant difference in root biomass and root morphological parameters of saline-alkaline tolerant cultivar GN under saline-alkaline *** number of root tips(RT),root surface area(RS)and root volume(RV)of AG were reduced by 61.16%,44.54%,and 45.31%,respectively,compared with control *** ratios of K^(+)/Na^(+),Ca^(2+)/Na^(+)and Mg^(2+)/Na^(+)of GN were significantly higher than those of AG(pweight(RFW)and dry weight(RDW),root length(RL),RV and RT of alfalfa were positively regulated by soil SOC and TN,but negatively regulated by soil pH,EC,and URE(p<0.01).Root Ca^(2+)/Na+ratio was significantly positively correlated with soil TN,TP and SOC(p<0.01).The absorption of Mg and Ca ions in roots is significantly negatively regulated by soilβ-glucosidase ac

关键词： Saline-alkaline stress alfalfa root traits soil environmental factors correlation analysis

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Bibliometric analysis of hotspots and trends of global myopia research

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 940-950页

作者： xing-yang Wu Hui-Hui Fang yan-Wu Xu yan-Ling Zhang Shao-Chong Zhang wei-Hua yang Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina School of Future Technology South China University of TechnologyGuangzhou 510641Guangdong ProvinceChina

AIM:To gain insights into the global research hotspots and trends of ***:Articles were downloaded from January 1,2013 to December 31,2022 from the Science Core Database website and were mainly statistically analyzed by bibliometrics ***:A total of 444 institutions in 87 countries published 4124 *** 2013 and 2022,China had the highest number of publications(n=1865)and the highest H-index(61).Sun Yat-sen University had the highest number of publications(n=229)and the highest H-index(33).Ophthalmology is the main category in related *** from 2020 to 2022 highlight keywords of options and reference,child health(pediatrics),myopic traction mechanism,public health,and machine learning,which represent research ***:Myopia has become a hot research *** and Chinese institutions have the strongest academic influence in the field from 2013 to *** main driver of myopic research is still medical or *** study highlights the importance of public health in addressing the global rise in myopia,especially its impact on children’s *** present,a unified theoretical system is still *** surgical and therapeutic solutions must be proposed for people with different characteristics to manage and intervene refractive *** addition,the benefits of artificial intelligence(AI)models are also reflected in disease monitoring and prediction.

关键词： bibliometric analysis myopia global trends

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Multistep Desolvation as a Fundamental Principle Governing Peptide Self-Assembly Through Liquid-Liquid Phase Separation

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CCS Chemistry 2024年第1期6卷 255-265页

作者： Chengqian Yuan Ruirui xing Jie Cui wei Fan Junbai Li Xuehai yan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190 School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049 Analysis and Test Center Institute of ChemistryChinese Academy of SciencesBeijing 100190 Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of ColloidInterface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 Center for Mesoscience Institute of Process EngineeringChinese Academy of SciencesBeijing 100190

Biomolecular self-assembly based on peptides and proteins is a general phenomenon encountered in natural and synthetic ***–liquid phase separation(LLPS)is intimately involved in biomolecular self-assembly,yet the key factors at a molecular scale activating or modulating such a process remain largely ***,we discovered in our experiments that multistep desolvation is fundamental to the formation and evolution of peptide-rich droplets:The first step was partial desolvation of peptides to form peptide clusters,and the second step was selective desolvation of hydrophobic groups within clusters to trigger LLPS and the formation of peptiderich droplets,followed by complete desolvation of droplets,initiating the nucleation of peptide *** of the degree of desolvation at different stages was an effective strategy to control the self-assembly pathways and *** study sheds light on the molecular origin of LLPS-mediated self-assembly distinct from classical one-step self-assembly and paves the way for the precise control of supramolecular self-assembly.

关键词： peptide liquid-liquid phase separation multistep desolvation nanostructures self-assembly

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Effect of distribution of fines on evolution of cooperation in spatial public goods game

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CHINESE PHYSICS B 2024年第9期33卷 239-245页

作者： Sun, xing-Ping Bi, yan-Zheng Kang, Hong-wei Shen, Yong Chen, Qing-Yi Yunnan Univ Sch Software Kunming 650000 Peoples R China

In the realm of public goods game, punishment, as a potent tool, stands out for fostering cooperation. While it effectively addresses the first-order free-rider problem, the associated costs can be substantial. Punishers incur expenses in imposing sanctions, while defectors face fines. Unfortunately, these monetary elements seemingly vanish into thin air, representing a loss to the system itself. However, by virtue of the redistribution of fines to cooperators and punishers, not only can we mitigate this loss, but the rewards for these cooperative individuals can be enhanced. Based upon this premise, this paper introduces a fine distribution mechanism to the traditional pool punishment model. Under identical parameter settings, by conducting a comparative experiment with the conventional punishment model, the paper aims to investigate the impact of fine distribution on the evolution of cooperation in spatial public goods game. The experimental results clearly demonstrate that, in instances where the punishment cost is prohibitively high, the cooperative strategies of the traditional pool punishment model may completely collapse. However, the model enriched with fine distribution manages to sustain a considerable number of cooperative strategies, thus highlighting its effectiveness in promoting and preserving cooperation, even in the face of substantial punishment cost.

关键词： public goods game fine distribution cooperation 02.50.Le 02.50.Ng 02.60.Cb 02.70.Uu REPLICATOR DYNAMICS PUNISHMENT REWARDS INVESTMENT ALLOCATION PROVISION SANCTIONS EMERGENCE MECHANISM

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Configuration Synthesis and Grasping Performance Analysis of Multi-Loop Coupling Capture Mechanism for Launch and Recovery of Torpedo-Shaped Autonomous Underwater Vehicle

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China Ocean Engineering 2024年第3期38卷 453-466页

作者： ZHANG Guo-xing XIA Xin-lu GUO Jin-wei School of Mechanical Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Research of capture mechanisms with strong capture adaptability and stable grasp is important to solve the problem of launch and recovery of torpedo-shaped autonomous underwater vehicles(AUVs).A multi-loop coupling capture mechanism with strong adaptability and high retraction rate has been proposed for the launch and recovery of torpedo-shaped AUVs with different morphological ***,the principle of capturing motion retraction is described based on the appearance characteristics of torpedo-shaped AUVs,and the configuration synthesis of the capture mechanism is carried out using the method of constrained chain ***,the screw theory is employed to analyze the degree of freedom(DoF)of the capture ***,the 3D model of the capture mechanism is established,and the kinematics and dynamics simulations are carried *** with the capture orientation requirements of the capture mechanism,the statics and vibration characteristics analyses are carried ***,considering the capture process and the underwater working environment,the motion characteristics and hydraulics characteristics of the capture mechanism are ***,a principle prototype is developed and the torpedo-shaped AUVs capture experiment is *** work provides technical reserves for the research and development of AUV capture special equipment.

关键词： capture mechanism torpedo-shaped AUVs configuration synthesis launch and recovery grasping performance analysis

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Work-function-induced interfacial electron redistribution of MoO_(2)/WO_(2) heterostructures for high-efficiency electrocatalytic hydrogen evolution reaction

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Rare Metals 2024年第2期43卷 489-499页

作者： Tong-Fei Li Jing Li Lu-Ping Zhang Jia-wei Ke Meng-xing Fan Li-Fang Zhang Cheng-wei Deng Yi Sun Tao Qian Cheng-Lin yan School of Chemistry and Chemical Engineering Nantong UniversityNantong226019China Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Centre of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing210023China Aerospace Hydrogen Energy Technology(Shanghai)Co.Ltd. Shanghai201800China Key Laboratory of Core Technology of High Specific Energy Battery and Key Materials for Petroleum and Chemical Industry College of EnergySoochow UniversitySuzhou215006China Light Industry Institute of Electrochemical Power Sources Suzhou215006China

The engineering of the electronic configurations of active sites,together with the production of more accessible active sites through heterostructure design,has been established as a forceful methodology for boosting water electrolysis ***,a facile approach is developed to fabricate well-dispersed MoO_(2) and WO_(2) nanoparticles with abundant heterointerfaces entrapped in N,P-doped carbon nanofibers(referred to as MoO_(2)/WO_(2)@N,P-CNFs hereafter)as hydrogen evolution reaction(HER)electrocatalysts in alkaline and acidic *** spectroscopic analyses and theoretical findings manifest that the heterointerface formed by the work function modulation of MoO_(2)/WO_(2) triggers the spontaneous electron redistribution from MoO_(2)to WO_(2) and a built-in electric field,which is essential to promote water adsorption,optimize the H-intermediate adsorption energy,result in the enhanced charge transfer efficiency,and ultimately increase the intrinsic HER ***,the intimate confinement of MoO_(2)/WO_(2) heterostructures in the porous carbon substrate can restrain the active sites from unfavorable coarsening and detachment,thus ensuring facilitated HER kinetics and outstanding structural *** a result,MoO_(2)/WO_(2)@N,P-CNFs exhibit superior catalytic HER performance in acidic and basic solutions,requiring 118 and 95 mV overpotentials to achieve 10 mA·cm^(−2),respectively,surpassing a number of reported non-noble metal-based *** work provides guidelines for the rational design and construction of special metallic heterocomponents with optimized interfacial electronic structure for various electrochemical technologies.

关键词： Electrospinning MoO_(2)/WO_(2) heterostructure Work function Hydrogen evolution reaction

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Impact of Mo/Ni alloying on microstructural modulation and low-temperature toughness of high-strength low-alloy steel

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Journal of Iron and Steel Research International 2024年第7期31卷 1746-1762页

作者： wei Liu Hong-li Zhao Bing-xing Wang Yong Tian State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina

The high-strength low-alloy steel plates with varying Ni/Mo contents were manufactured using the thermos-mechanical control *** investigation was conducted to explore the effect of Ni/Mo microalloying on microstructure evolution and mechanical properties of the *** results revealed that the increase in Ni content from 1 to 2 wt.%reduced the transition temperature of ferrite and the growth range of ferritic grain was narrowed,which promoted grain *** optimized combination of grain size,high-angle grain boundaries(HAGBs),and martensite-austenite(M-A)islands parameter contributed to the excellent impact toughness of S1 steel at-100℃(impact absorbed energy of 218.2 J at-100℃).As the Mo increases from 0 to 2 wt.%,the matrix structure changes from multiphase structure to granular bainite,which increases the average effective grain size to~4.62 pm and reduces HAGBs proportion to~36.22%.With these changes,the low-temperature impact toughness of S3 steel is *** addition,based on the analysis of the characteristics of crack propagation path,it was found that M-A islands with low content(~2.21%)and small size(~1.76 pm)significantly retarded crack propagation,and the fracture model of M-A islands with different morphologies was further ***,correlation between behaviour of delamination and toughness was further analysed by observing delamination size and impact energy parameters.

关键词： High-strength low-alloy steel Microstructural regulation Ni addition Mo addition Crack propagation Low-temperature toughness

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An Adaptive Local Grid Nesting-based Genetic Algorithm for Multi-earth Observation Satellites' Area Target Observation

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Journal of Systems Science and Systems Engineering 2024年第2期33卷 232-258页

作者： Ligang xing wei Xia Xiaoxuan Hu Waiming Zhu Yi Wu School of Management Hefei University of TechnologyHefei 230009China Key Laboratory of Process Optimization and Inteligent Decision-making Ministry of EducationHefei 230009China Intelligent Interconnected Systems Laboratory of Anhui Province Hefei 230009China

The Scheduling of the Multi-EOSs Area Target Observation(SMEATO)is an EOS resource schedul-ing problem highly coupled with computational *** advances in EOS technology and the ex-pansion of wide-area remote sensing applications have increased the practical significance of *** this paper,an adaptive local grid nesting-based genetic algorithm(ALGN-GA)is proposed for developing SMEATO ***,a local grid nesting(LGN)strategy is designed to discretize the target area into parts,so as to avoid the explosive growth of calculations.A genetic algorithm(GA)framework is then used to share reserve information for the population during iterative evolution,which can generate high-quality solutions with low computational *** this basis,an adaptive technique is introduced to determine whether a local region requires nesting and whether the grid scale is *** effectiveness of the proposed model is assessed experimentally with nine randomly generated tests at different *** results show that the ALGN-GA offers advantages over several conventional algorithms in 88.9%of instances,especially in large-scale *** fully demonstrate the high efficiency and stability of the ALGN-GA.

关键词： Multi-EOSs scheduling area target observation adaptive genetic algorithm local grid nesting

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