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Chinese Chemical Letters 2017年第2期28卷 362-366页

作者： Liang Deng Wen-Hui Yang xing lyu Shu-Feng Wei Zheng Wang Hui-Xian Wang Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular Engineering Peking University Institute of Electrical Engineering Chinese Academy of Sciences

In situ NMR measurements of the diffusion coefficients,including an estimate of signal strength,of lithium ion conductor using diffusion-weighting pulse sequence are performed in this study.A cascade bilinear model is proposed to estimate the diffusion sensitivity factors of pulsed-field gradient using prior information of the electrochemical performance and Arrhenius *** model postulates that the active lithium nuclei participating electrochemical reaction are relevant to the NMR signal intensity,when discharge rate or temperature condition is *** electrochemical data and the NMR signal strength show a highly fit with the proposed model according our simulation and ***,the diffusion time is constrained by temperature based on Arrhenius equation of reaction rates *** experimental calculation of Li_4Ti_5O_（12）（LTO）/carbon nanotubes（CNTs） with the electrolyte evaluating at 20 ℃ is presented,which the b factor is estimated by the discharge rate.

关键词： Lithium ion conductor Diffusion coefficient Nuclear magnetic resonance Pulsed-field gradient Electrochemical priors

Multi-protective effects of wheat embryo globulin on D-gal-induced aging mice

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Food Science and Human Wellness 2023年第4期12卷 1300-1308页

作者： Aimei Liao xing lyu Jiarui Ma Yinchen Hou Ming Hui Na Liu Yi Zhao Yixiang Cui Jihong Huang College of Biological Engineering Henan University of TechnologyLuoyang 471000China Henan Provincial Key Laboratory of Biological Processing and Nutritional Function of Wheat Luoyang 471000China Zhengzhou Synear Food Co. Ltd.Zhengzhou 450000China School of Food and Pharmacy Xuchang UniversityXuchang 461000China

Wheat embryo globulin(WEG)has been proven to possess multiple biological activities,including antioxidative properties,immunomodulatory,and so *** mouse model were established by subcutaneous injection of D-galactose(D-gal),and the effects of WEG on learning,memory,and antioxidant capacity in aging mice were explored through behavioural tests and antioxidant enzyme activities *** with the Model group,WEG improved the percentage of the platform quadrant,increased the number of crossing platforms,and enhanced the identification *** also increased total antioxidant capacity(T-AOC),superoxide dismutase(SOD),and glutathione peroxidase(GSH-Px)activities in the liver and brains of aging mice,and reduced malondialdehyde(MDA)*** observations indicated that WEG protected against damage to brain in D-gal-induced aging *** results effectively revealed that WEG not only improved the abilities of learning and memory,and the cognitive impairment,but also delayed the aging process of the D-gal-induced mice.

关键词： Wheat embryo globulin Antioxidant activity D-galactose Superoxide dismutase Glutathione peroxidase

A New Index About the Walker Circulation

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Journal of Tropical Meteorology 2020年第3期26卷 311-320页

作者： SHI Dan-dan RONG Yan-shu lyu xing-yue WU Fu-ting College of Hydrology and Water Resources Hohai UniversityNanjing 210098 China The Experimental Teaching Center of Water Conservancy Projects of Hohai University Nanjing 210098 China

The Walker circulation(WC)has always been an important issue in atmospheric science research due to the association between the WC and tropical Pacific sea surface temperature(SST),and between the WC and ENSO *** this paper,a new index-Omega index(OMGI)-is constructed for WC characterization based on the NCEP/NCAR reanalysis data of monthly mean vertical velocity in recent 70 years(1948-2017).Results show that the OMGI can accurately depict the variation characteristics of WC on seasonal,annual and decadal *** is a significant inverse correlation between the OMGI and equatorial eastern and central Pacific ***,the peak of the OMGI appears ahead of the ENSO peak,and therefore is able to reflect the SST in the equatorial ***,in 35 ENSO events,the peak of the OMGI appears earlier than Ni?o 3.4 index for 19 times with 2.6 months ahead on *** 16 El Ni?o events,the peak of the OMGI occurs ahead of the El Ni?o for 9 times with 4 months ahead on ***19 La Ni?a events,the OMGI peak arises 10 times earlier than the La Ni?a peak,with an average of 1.4 months *** shows obvious leading effect and stability over ENSO events with different strengths and types of single peak and multi peaks:the peak of the OMGI keeps about 2-3 months ahead of the *** with other WC indexes such as UWI and SPLI,OMGI has some advantages in the ability to describe WC changes and present the probability and the time of prediction of ENSO event peaks.

关键词： Walker circulation OMGI Nino 3.4 UWI SLPI

Saikosaponin-b regulates the proliferation and apoptosis of HepG2 cells by targeting the MACC1/c-Met/Akt signaling pathway

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中国药理学与毒理学杂志 2017年第10期31卷 965-966页

作者： xing-zhi lyu Rui-fang LI Zi-han GAO Hong-wei WANG Sang-qiang LI Jian-gang WANG Laboratory of Pharmacology and Molecular Biology Medical CollegeHenan University of Science and Technology School of Nursing Henan University of Science and Technology

OBJECTIVE Metastasis-associated in colon cancer-1(MACC1)is an oncogene that has been newly *** promotes tumor proliferation and invasion via the MET *** study investigated the effects of Saikosaponin-b(SS-b)on the proliferation and apoptosis of HepG2 cells and its regulation on MACC1/c-Met/Akt signaling *** HepG2 cells were treated with SS-b(10-800 g·L^(-1))for 48 h in *** CCK-8 assay was used to assess cell proliferation,and cell apoptosis was determined by Hoechst33258 staining,AnnexinⅤ/PI staining and caspase 3 ***-PCR was used to examine the expression of MACC1,c-MET and hepatocyte growth factor(HGF)mR ***1 protein was detected by Western blot and *** protein expressions of p-cMET,c-MET,p-AKT,AKT,p-BAD,BAD were measured by Western *** SS-b inhibited the growth of HepG2 cells in dose-dependent way and induced cell apoptosis ***2 cells showed karyopyknosis,fragmentation and fluorescence highlight in SS-b treatment *** results showed that apoptosis rate of HepG2 cells increased with SS-b *** immunofluorescence results showed that the MACC1 expression decreased significantly in HepG2 cells treated with *** expression levels of MACC1,c-MET and HGF mR NA in HepG2 cells were significantly inhibited by ***-b also significantly decreased the protein expressions of MACC1,p-c-MET and p-AKT while increased the expression of p-BAD and caspase 3 in HepG2 cells(P<0.05).CONCLUSION SS-b inhibited the proliferation and induced the apoptosis of HepG2 cells by targeting the MACC1/c-Met/Akt signaling pathway.

关键词： saikosaponin-b metastasis-associated in colon cancer-1 c-Met signaling hepatocel ular carcinoma

Saikosaponins-b suppresses tumor growth and angiogenesis of hepatocellular carcinoma by regulating VEGF/ERK/HIF-1α signal pathway

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中国药理学与毒理学杂志 2017年第10期31卷 962-963页

作者： Rui-fang LI Jun-min FU xing-zhi lyu Zi-han GAO Hong-wei WANG Jian-gang WANG Laboratory of Pharmacology and Molecular Biology Medical CollegeHenan University of Science and Technology School of Nursing Henan University of Science and Technology

OBJECTIVE Angiogenesis therapy has attracted interest as a potential treatment for hepatocellular carcinoma(HCC).In this study,we investigated the anti-proliferative activities and antiangiogenesis effects of saikosaponins(SS)-b on hepatocellular carcinoma(HCC)and its regulation on VEGF/ERK/HIF-1 αsignal *** H22 hepatoma-bearing mice model and HepG-2 cells were used to study the anti-tumor and anti-angiogenesis effects of SS-b in vivo and in *** change of tumor tissue was observed by HE staining,the microvascular changes were detected by immunohistochemical *** effects of SS-b on angiogenesis were examined by using the chick embryo chorioallantoic membrane(CAM)*** effects of SS-b on proliferation,migration and invasion were investigated by MTT assay,scratch wound healing assay and transwell assay inhuman umbilical vein endothelial cell(HUVEC)and HepG2 cells in *** endothelial growth factor(VEGF),matrix metalloproteinase-2/9(MMP-2/9),hypoxia-inducible factor-1α(HIF-1α)expression and the phosphorylation of extracellular regulated kinase(ERK)were analyzed using RT-PCR and *** SS-b effectively inhibited the tumor growth of H22 mice in *** inhibitory rate of tumor was 49.1%,50.7%,66.1%in SS-b 5,10 and 20 mg·kg-1group *** staining results showed that SS-b induced tumor necrosis and nuclear dissolution in H22 ***,SS-b also reduced the number of microvessels of tumor tissue in H22 mice significantly and suppressed the angiogenesis of CAM induced by ***-b had an obvious inhibitory effect on cell proliferation,migration and invasion of HUVEC cells and HepG-2 *** effects were associated with downregulation of the expression of MMP2/9 and suppression of VEGF/ERK/HIF-1αsignaling in H22 mice and Hep-G2 *** Our findings showed that SS-b exerts anti-tumor effects by inhibiting tumor angiogenesis via regulating VEGF/ERK/HIF-1α signal pathway in vivo and in vitro.

关键词： saikosaponins-b angiogenesis hepatocellular carcinoma chorioallantoic membrane HUVEC cells

Integrated strategies for chemotherapy cycles in nasopharyngeal carcinoma patients: Real-world data from two epidemic centers guiding decision-making

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Chinese Journal of Cancer Research 2023年第2期35卷 126-139页

作者： Zejiang Zhan Yingying Huang Jiayu Zhou Zhuochen Cai Haoyang Huang Ying Deng Wenze Qiu Xun Cao Xi Chen Chixiong Liang Lulu Zhang Xiang Guo Taize Yuan xing lyu Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Centerthe State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhou 510060China Department of Radiation Oncology Affiliated Cancer Hospital and Institute of Guangzhou Medical UniversityGuangzhou 510095China Department of Critical Care Medicine Sun Yat-sen University Cancer Centerthe State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Radiation Oncology Guangzhou Concord Cancer CenterGuangzhou 510045China

objective:Two cycles of induction chemotherapy(IC)followed by 2 cycles of platinum-based concurrent chemoradiotherapy(CCRT)(2IC+2CCRT)for locoregionally advanced nasopharyngeal carcinoma(LA-NPC)is widely adopted but not *** study aimed to determine the clinical value of 2IC+2CCRT regarding efficacy,toxicity and ***:This real-world study from two epidemic centers used propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)*** enrolled patients were divided into three groups based on treatment modality:Group A(2IC+2CCRT),Group B(3IC+2CCRT or 2IC+3CCRT)and Group C(3IC+3CCRT).Long-term survival,acute toxicities and cost-effectiveness were compared among the *** developed a prognostic model dividing the population into high-and low-risk cohorts,and survivals including overall survival(OS),progression-free survival(PFS),distant metastasis-free survival(DMFS)and locoregional relapse-free survival(LRRFS)were compared among the three groups according to certain risk ***:Of 4,042 patients,1,175 were enrolled,with 660,419,and 96 included in Groups A,B and C,***-year survivals were similar among the three groups after PSM and confirmed by *** 3-4 neutropenia and leukocytopenia were significantly higher in Groups C and B than in Group A(52.1%vs.41.5%vs.25.2%;41.7%vs.32.7%vs.25.0%)as were grade 3-4 nausea/vomiting and oral mucositis(29.2%vs.15.0%vs.6.1%;32.3%vs.25.3%vs.18.0%).Cost-effective analysis suggested that 2IC+2CCRT was the least expensive,while the health benefits were similar to those of the other *** exploration showed that 2IC+2CCRT tended to be associated with a shorter PFS in high-risk patients,while 3IC+3CCRT potentially contributed to poor PFS in low-risk individuals,mainly reflected by ***:In LA-NPC patients,2IC+2CCRT was the optimal choice regarding efficacy,toxicity and costeffectiveness;however,2IC+2CCRT and 3IC

关键词： Nasopharyngeal carcinoma treatment modality chemotherapy cycle survival toxicity costeffectiveness real world

Solving Large-scale Discrete-time Algebraic Riccati Equations by Doubling

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Solving Large-scale Discrete-time Algebraic Riccati Equation...

Numerical Simulation of the Hydrodynamic Characteristics of the Porous I-type Composite Breakwater

第32届中国控制与决策会议

作者： xing-Long lyu Tiexiang Li Eric King-wah Chu School of Mathematics Southeast University School of Mathematics 9 Rainforest WalkMonash University

This paper aims to the solution of large-scale discrete-time algebraic Riccati equation D(X) ≡-X + AX(I + GX)A + H = 0 with numerically low-ranked *** on the original structure-preserving doubling algorithm(SDA),we develop the large-scale doubling algorithm by applying Sherman-Morrison-Woodbury formula,using QR decomposition,SVD to compress and truncate the approximate solutions *** resulting large-scale doubling algorithm has an O(n) computational complexity and memory requirement per iteration and converges essentially quadratically.A detailed error analysis is given.

关键词： Algebraic Riccati Equation Numerically Low-ranked Solution Doubling Algorithm Sherman-Morrison-Woodbury Formula

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Journal of Marine Science and Application 2022年第1期21卷 140-150页

作者： Yongzhou Cheng Zhiyuan Lin Gan Hu xing lyu School of Hydraulic and Environmental Engineering Changsha University of Science&TechnologyChangsha 410114China Key Laboratory of Water-Sediment Sciences andWater Disaster Prevention of Hunan Province Changsha 410114China

Based on the three-dimensional Reynolds-averaged Navier-Stokes equation with the closure of renormalization group k-εturbulence model and volume of fluid method,a wave-breakwater interaction numerical flume was developed to examine the wave-structure interaction of the porous I-type composite(PITC)*** transmission and reflection coefficients of the breakwater at different wave steepness H/L are quantitatively analyzed,and the wave-dissipating performance of the breakwater is *** changing the submerged depth of the breakwater,the velocity field,and vorticity field in the wave propagation process are analyzed,and the optimal working water depth of the new breakwater is *** results show that the vertical wave force on the PITC breakwater is greater than the horizontal wave *** addition,during the wave dissipation process,the transverse baffle provided by the new breakwater destroys the trajectory of the water *** the interior of the wave-breaking chamber,the water that enters from the gap of the permeable plate mixes with the water entering through the bottom *** turbulence created by this process further dissipates the wave *** relative submergence depth of h/d has a great influence on the hydrodynamic *** the relative depth is large,most of the wave energy enters the breakwater,the wave energy dissipation of the breakwater is large,and the wave-absorbing effect is *** research results provide important referential data for the study of permeable plate breakwaters.

关键词： Wave-structure interaction Plate breakwater Numerical simulation Wave force Regular wave Hydrodynamic

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肝炎后肝硬化所致脾功能亢进临床研究进展

中华肝胆外科杂志 2016年第9期22卷 642-645页

作者：吕行陈勇第四军医大学西京医院肝胆外科西安710032

【提要】肝炎后肝硬化门静脉高压所致脾功能亢进为肝胆外科常见临床问题之一。目前临床仍以血小板数目为最主要判定指标，并结合病史及临床辅助检查结果进行综合判断。治疗目的主要为改善脾功能亢进、降低门静脉压力和降低出血危险眭。... 详细信息

【提要】肝炎后肝硬化门静脉高压所致脾功能亢进为肝胆外科常见临床问题之一。目前临床仍以血小板数目为最主要判定指标，并结合病史及临床辅助检查结果进行综合判断。治疗目的主要为改善脾功能亢进、降低门静脉压力和降低出血危险眭。但是，在临床诊治方面仍未形成共识，如“保脾”还是“切脾”，在中西学者中仍存在争议。究其原因，是对脾功能亢进及其治疗的病理生理学特点和临床意义认识不足。本文对这方面的最新研究进行综述。

关键词：肝硬化脾功能亢进病理生理治疗

感染中毒性休克的液体复苏和血管活性药物应用的时机、评价标准与规范

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中华结核和呼吸杂志 2024年第10期47卷 917-920页

作者：吕行宋立强空军军医大学西京医院呼吸与危重症医学科西安710032

感染中毒性休克(SS)是感染中毒症(sepsis)的最严重并发症,一直是危重症领域救治难点和研究热点。SS属于分布性休克,液体复苏和血管活性药物应用相辅相成,已经成为临床救治SS的两个常规措施。然而,怎样基于SS动态的病理生理过程,在复苏... 详细信息

感染中毒性休克(SS)是感染中毒症(sepsis)的最严重并发症,一直是危重症领域救治难点和研究热点。SS属于分布性休克,液体复苏和血管活性药物应用相辅相成,已经成为临床救治SS的两个常规措施。然而,怎样基于SS动态的病理生理过程,在复苏、优化、稳定和撤除的管理环节中精准地监测大循环、微循环及细胞代谢指标,从而指导两个措施的统筹兼顾、个体化和动态化应用,仍没有明确答案。笔者将结合近年的国际管理指南和文献,在液体治疗和血管活性药物的应用方面提出相关建议。

关键词：血管活性药物感染中毒性休克液体复苏液体治疗临床救治管理指南危重症代谢指标