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全基因组关联分析的扩展方法及其在畜禽中应用的研究进展

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中国畜牧兽医 2024年第4期51卷 1382-1389页

作者：谢鑫峰王子轶钟梓奇潘德优倪世恒肖倩海南大学热带农林学院海口570228 海南省畜牧技术推广总站海口571100

全基因组关联分析(GWAS)是一种通过对大规模样本集合进行基因型和表型数据的比较分析,寻找与特定性状相关的遗传变异的方法。随着高通量测序技术、生物信息学技术和统计学方法的不断发展,一些频率更小的遗传变异或小分子物质能够被更加... 详细信息

全基因组关联分析(GWAS)是一种通过对大规模样本集合进行基因型和表型数据的比较分析,寻找与特定性状相关的遗传变异的方法。随着高通量测序技术、生物信息学技术和统计学方法的不断发展,一些频率更小的遗传变异或小分子物质能够被更加精准和经济的方式检测。基于技术进步衍生出GWAS的扩展方法,为畜禽精准育种和遗传改良提供了新的思路,其中包括基于拷贝数变异(copy number variation,CNV)、结构变异(structural variation,SV)和串联重复序列(tandem repeats,TR)的GWAS和基于单倍型、基因表达和代谢组的GWAS。研究人员期望利用不同分子标记以提供更全面和详细的遗传变异信息来增加GWAS的解释性和准确性,或通过结合其他类型的数据来进一步解释和深化GWAS的结果,从而深入研究遗传变异与性状之间联系并确定影响复杂性状的关键基因。作者介绍了基于不同分子标记的GWAS在畜禽研究当中的应用并对其结果进行讨论,分析了不同方法的优势与可行性,为进一步推动GWAS在畜禽研究中的应用,精准育种和遗传改良提供更多的思路和支持。

关键词：全基因组关联分析(GWAS) 畜禽分子标记

基于全基因组关联分析研究文昌鸡初生重性状相关的候选基因

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畜牧与兽医 2024年第7期56卷 1-5页

作者：谢鑫峰钟梓奇王子轶程文豪郎艺严涛覃尧肖倩海南大学热带农林学院海南海口570228

为筛选文昌鸡初生重相关联的候选基因,本研究采集235只文昌鸡初生重表型值,结合全基因组重测序获得的12 085 689个高质量单核苷酸多态性位点(SNP),利用GEMMA软件进行全基因组关联分析(GWAS)。结果显示:与初生重相关的潜在SNP位点共有11... 详细信息

为筛选文昌鸡初生重相关联的候选基因,本研究采集235只文昌鸡初生重表型值,结合全基因组重测序获得的12 085 689个高质量单核苷酸多态性位点(SNP),利用GEMMA软件进行全基因组关联分析(GWAS)。结果显示:与初生重相关的潜在SNP位点共有11个;通过基因功能注释,确定了6个可能影响初生重的候选基因,分别为cAMP响应元件结合蛋白5(CREB5)、锯齿状Notch配体1(JAG1)、蓝带WH2重复蛋白(COBL)、WD重复结构域11(WDR11)、FIG4磷酸肌酸5-磷酸酶(FIG4)和跨膜结构域蛋白(VSTM2A);进一步富集分析发现,ATP和钙离子结合、钙离子信号通路和MAPK信号通路在初生重中发挥重要作用。本研究结果为文昌鸡初生重相关性状提供了重要的候选分析标记,为进一步选育优良品种提供理论支持。

关键词：全基因组关联分析单核苷酸多态性文昌鸡初生重生长性状

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Pore-pressure and stress-coupled creep behavior in deep coal:Insights from real-time NMR analysis

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International Journal of Mining Science and Technology 2024年第1期34卷 77-90页

作者： Wenhao Jia Hongwei Zhou Senlin xie Yimeng Wang xinfeng Hu Lei Zhang School of Mechanics and Civil Engineering China University of Mining and Technology-BeijingBeijing 100083China School of Energy and Mining Engineering China University of Mining and Technology-BeijingBeijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology-BeijingBeijing 100083China College of Safety and Emergency Management Engineering Taiyuan University of TechnologyTaiyuan 030024China

Understanding the variations in microscopic pore-fracture structures(MPFS) during coal creep under pore pressure and stress coupling is crucial for coal mining and effective gas treatment. In this manuscript, a triaxial creep test on deep coal at various pore pressures using a test system that combines in-situ mechanical loading with real-time nuclear magnetic resonance(NMR) detection was ***-scale quantitative characterization, online real-time detection, and visualization of MPFS during coal creep influenced by pore pressure and stress coupling were performed using NMR and NMR imaging(NMRI) techniques. The results revealed that seepage pores and microfractures(SPM) undergo the most significant changes during coal creep, with creep failure gradually expanding from dense primary pore fractures. Pore pressure presence promotes MPFS development primarily by inhibiting SPM compression and encouraging adsorption pores(AP) to evolve into SPM. Coal enters the accelerated creep stage earlier at lower stress levels, resulting in more pronounced creep deformation. The connection between the micro and macro values was established, demonstrating that increased porosity at different pore pressures leads to a negative exponential decay of the viscosity coefficient. The Newton dashpot in the ideal viscoplastic body and the Burgers model was improved using NMR experimental results, and a creep model that considers pore pressure and stress coupling using variable-order fractional operators was developed. The model’s reasonableness was confirmed using creep experimental data. The damagestate adjustment factors ω and β were identified through a parameter sensitivity analysis to characterize the effect of pore pressure and stress coupling on the creep damage characteristics(size and degree of difficulty) of coal.

关键词： Real-time monitoring Pore pressure-stress coupling Microscopic pore-fracture structure Variable-order fractional creep model Deep coal

水稻新品种“粤禾丝苗”在汕头市的示范表现及栽培技术

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南方农业 2024年第14期18卷 57-59页

作者：谢欣锋张建林王新廖学群张泽佳许岱谢沛丽汕头市农业科学研究所广东汕头515041

筛选适宜机插秧的水稻品种是实现水稻高产的重要基础。2023年,广东省汕头市开展了常规水稻品种粤禾丝苗的机插秧示范栽培,该品种在示范种植中表现出适宜机插、适宜当地推广、耐肥抗倒性较好、耐寒性较好、生育期适中、穗长粒多及高产稳... 详细信息

筛选适宜机插秧的水稻品种是实现水稻高产的重要基础。2023年,广东省汕头市开展了常规水稻品种粤禾丝苗的机插秧示范栽培,该品种在示范种植中表现出适宜机插、适宜当地推广、耐肥抗倒性较好、耐寒性较好、生育期适中、穗长粒多及高产稳产等特点。为了提高粤禾丝苗在汕头市的推广应用率,结合该品种的示范种植表现,从播种、移栽、田间管理等方面介绍该品种水稻的栽培技术。

关键词：水稻机插秧栽培广东省汕头市

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Paving continuous heat dissipation pathways for quantum dots in polymer with orangeinspired radially aligned UHMWPE fibers

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Opto-Electronic Advances 2024年第7期7卷 27-38页

作者： Xuan Yang xinfeng Zhang Tianxu Zhang Linyi Xiang Bin xie Xiaobing Luo School of Energy and Power Engineering Huazhong University of Science and TechnologyWuhan 430074China School of Mechanical Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China

Thermal management of nanoscale quantum dots(QDs)in light-emitting devices is a long-lasting *** existing heat transfer reinforcement solutions for QDs-polymer composite mainly rely on thermal-conductive ***,this strategy failed to deliver the QDs’heat generation across a long distance,and the accumulated heat still causes considerable temperature rise of QDs-polymer composite,which eventually menaces the performance and reliability of lightemitting *** by the radially aligned fruit fibers in oranges,we proposed to eliminate this heat dissipation challenge by establishing long-range ordered heat transfer pathways within the QDs-polymer *** molecular weight polyethylene fibers(UPEF)were radially aligned throughout the polymer matrix,thus facilitating massive efficient heat dissipation of the *** a UPEF filling fraction of 24.46 vol%,the in-plane thermal conductivity of QDs-radially aligned UPEF composite(QDs-RAPE)could reach 10.45 W m^(−1) K^(−1),which is the highest value of QDs-polymer composite reported so *** a proof of concept,the QDs’working temperature can be reduced by 342.5℃ when illuminated by a highly concentrated laser diode(LD)under driving current of 1000 mA,thus improving their optical *** work may pave a new way for next generation high-power QDs lighting applications.

关键词： quantum dots UHMWPE fibers radial alignment heat dissipation light-emitting devices

Engineering Thermoelectric Performance of α-GeTe by Ferroelectric Distortion

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Energy & Environmental Materials 2024年第2期7卷 171-179页

作者： Yuting Fan Chenghao xie Jun Li Xiangyu Meng Jinchang Sun Jinsong Wu xinfeng Tang Gangjian Tan State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China International School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China

The rhombohedralα-GeTe can be approximated as a slightly distorted rock-salt structure along its[111]direction and possesses superb thermoelectric ***,the role of such a ferroelectric-like structural distortion on its transport properties remains ***,we performed a systematic study on the crystal structure and electronic band structure evolutions of Ge_(1-x)Sn_(x)Te alloys where the degree of ferroelectric distortion is continuously *** is revealed that the band gap is maximized while multiple valence bands are converged at x=0.6,where the ferroelectric distortion is the least but still *** undistorted,the band gap is considerably reduced,and the valence bands are largely separated ***,near the ferro-to-paraelectric phase transition Curie temperature,the lattice thermal conductivity reaches its minima because of significant lattice softening enabled by ferroelectric *** predict a peak ZT value of 2.6 at 673 K inα-GeTe by use of proper dopants which are powerful in suppressing the excess hole concentrations but meanwhile exert little influence on the ferroelectric distortion.

关键词： electronic band structures ferroelectric distortion lattice softening thermoelectric α-GeTe

Effective enrichment of Zn from smelting wastewater via an integrated Fe coagulation and hematite precipitation method

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Frontiers of Environmental Science & Engineering 2019年第6期13卷 147-155页

作者： Zhan Qu Ting Su Yu Chen Xue Lin Yang Yu Suiyi Zhu xinfeng xie Mingxin Huo Science and Technology Innovation Centre for Municipal Wastewater Treatment and Water Quality Protection Northeast Normal UniversityChangchun 130117China Jilin Institute of Forestry Survey and Design Changchun 130022China Guangdong Shouhui Lantian Engineering and Technology Co.Ltd. Guangzhou 510075China Michigan Technological University School of Forest Resources and Environmental ScienceHoughtonMI 49932USA

Coagulation is commonly applied to treat Zn-bearing wastewater from smelting industries(smelting wastewater),and thus the Zn-bearing sludge was considerably produced,which should be solidified before safety ***,we demonstrated a novel approach to recycle Zn effectively from smelting wastewater via an integrated Fe coagulation and hematite precipitation ***,smelting wastewater was coagulated by adding ferric chloride to generate Fe/Zn-bearing sludge(sludge for short).Secondly,the sludge was dissolved to generate an acid solution containing 2.2 g/L of Zn and 39.2 g/L of ***,the Fe/Zn-bearing solution was hydrothermally treated,and 89%of Fe was eliminated to highly purified hematite block,whereas the percentage of Zn lost was below 1.1%.Finally,the hematite precipitates were collected,and the supernatant was hydrothermally treated again with the addition of *** the molar ratio of glucose to Fe in the supernatant was 1.5,over 99.5%of Fe was precipitated in hematite nanoparticles with a diameter of 10-100 nm,and the residual Fe was 21.5 mg/*** loss of Zn was below 0.4%,and the residual Zn in the solution was 2169 mg/L,290 times of that in the smelting *** major mechanism for Fe removal was the hydrolysis of ferric nitrate into hematite,which was promoted by nitrate consumption in glucose *** paper is the first report of an environment-friendly method for enriching Zn without generating any waste.

关键词： Smelting wastewater Hydrothermal Hematite precipitation Heavy metals

Intrinsically large effective mass and multi-valley band characteristics of n-type Bi_(2)eBi_(2)Te_(3)superlattice-like films

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Journal of Materiomics 2024年第3期10卷 716-724页

作者： Yujie Ouyang Min Zhang Fangyang Zhan Chunxia Li Xianda Li Fan Yan Sen xie Qiwei Tong Haoran Ge Yong Liu Rui Wang Wei Liu xinfeng Tang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan430070China International School of Materials Science and Engineering Wuhan University of TechnologyWuhan430070China Institute for Structure and Function&Department of Physics Chongqing UniversityChongqing400044China School of Physics and Technology and the Key Laboratory of Artificial Micro/Nano Structures of Ministry of Education Wuhan UniversityWuhan430072China

Thermoelectric superlattices are expected to decouple the strong correlation between various thermo-electric parameters,and are an important strategy for excellent thermoelectric *** superlattices of(Bi_(2))m(Bi_(2)Te_(3))n homologous series are well-known for low lattice thermal conductivity and intriguing topological surface ***,the impacts of electronic structure on the thermo-electric performance were still not well-understood in(Bi_(2))m(Bi_(2)Te_(3))*** cope with this issue,Bi_(2)eBi_(2)Te_(3)superlattice-like films with adjustable Bi_(2)/(Bi_(2)+Bi_(2)Te_(3))molar ratio(R)were successfully fabricated by the molecular beam epitaxy ***-resolved photoemission spectroscopy measurements com-bined with theoretical calculations revealed the conduction band evolution from single-valley to multi-valley as R≥0.30,leading to intrinsically high carrier effective mass and improved thermoelectric power ***,the superlattice film(R=0.46)with the structure close to Bi_(4)Te_(3)possesses the topological surface state feature around the high symmetry *** a result of the high effective mass of 3.9 m0 and very high electron density of_(2).31×10^(21)cm^(-3),the film with R=0.46 acquired the highest power factor of 1.49 mW·m^(-1)·K^(-2)at 420 K,outperforming that of other(Bi_(2))m(Bi_(2)Te_(3))n *** work lays an essential foundation on understanding the electronic structure and further improving thermoelectric performances of(Bi_(2))m(Bi_(2)Te_(3))n homologous series.

关键词： Bi_(2)eBi_(2)Te_(3)superlattice Molecular beam epitaxy Band structure Thermoelectric performance

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面向深度学习加速器的安全加密方法

计算机研究与发展 2019年第6期56卷 1161-1169页

作者：左鹏飞华宇谢新锋胡杏谢源冯丹武汉光电国家研究中心(华中科技大学) 武汉430074 华中科技大学计算机学院武汉430074 加州大学圣芭芭拉分校加利福利亚圣芭芭拉美国93106

随着机器学习特别是深度学习技术的飞速发展,其应用场景也越来越广,并逐渐从云计算向边缘计算上扩展.在深度学习中,深度学习模型作为模型提供商的知识产权是非常重要的数据.发现部署在边缘计算设备上的深度学习加速器有泄露在其上存储... 详细信息

随着机器学习特别是深度学习技术的飞速发展,其应用场景也越来越广,并逐渐从云计算向边缘计算上扩展.在深度学习中,深度学习模型作为模型提供商的知识产权是非常重要的数据.发现部署在边缘计算设备上的深度学习加速器有泄露在其上存储的深度学习模型的风险.攻击者通过监听深度学习加速器和设备内存之间的总线就能很容易地截获到深度学习模型数据,所以加密该内存总线上的数据传输是非常重要的.但是,直接地在加速器上使用内存加密会极大地降低加速器的性能.为了解决这个问题,提出了一个有效的安全深度学习加速器架构称作***通过利用计数器模式加密不仅提高了加速器的安全性,而且能够把解密操作从内存访问的关键路径中移走来极大地提高加速器性能.在GPGPU-Sim上实现了提出的COSA架构,并使用神经网络负载测试了其性能.实验结果显示COSA相对于直接加密的架构提升了3倍以上的性能,相对于一个不加密的加速器性能只下降了13%左右.

关键词：机器学习加速器边缘设备安全总线监听攻击