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Medium-and long-term efficacy of ligustrazine plus conventional medication on ischemic stroke: a systematic review and meta-analysis

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Journal of Traditional Chinese Medicine 2013年第6期33卷 715-720页

作者： Xiaojia Ni Shaonan Liu xinfeng guo Research and Development Department of New Drugs Guangdong Provincial Hospital of Chinese Medicine Key Unit of Methodology in Clinical Research Guangdong Provincial Hospital of Chinese Medicine

OBJECTIVE： To evaluate the medium- to long-term efficacy of ligustrazine plus conventional medicine treating ischemic stroke. METHODS： Randomized controlled trials （RCTs） testing ligustrazine in the treatment of acute isch- emic stroke were retrieved from Cochrane Library, PubMed, Excerpta Medica Database, Chinese Medi- cal Journal Database, Chinese Biomedical Data- base, China National Knowledge Infrastructure Da- tabase, and Chinese Clinical Trial Register, and then identified by the inclusive and exclusive criteria. The quality of trials was assessed with the Co- chrane Handbook 5.1, a risk of bias assessment toot. RevMan 5.1 was used for ***： Three RCTs involving 643 patients were included. Compared to conventional medicine treatment alone, ligustrazine plus conventional medicine treatment showed significant difference in reduction of stroke recurrence either at the end of 1-year follow-up [RR=0.42, 95% CI （0.18, 0.94）, P〈 0.05] or 3-years observation [RR=0.48, 95% C/（0.27, 0.83）, P〈0.05]. The ligustrazine group also showed higher survival rate [RR=1.67, 95% CI （1.02, 0.2.71）, P〈0.05] and significantly better effective rate [RR= 1.28, 95% CI（1.10, 1.50）, P〈0.05] than that of the control group at the end of 1 year visit. Only one tri- al conducted safety assessment and no adverse events were reported. The methodological quality of all the trials included was generally poor. CONCLUSION： The findings provided evidence that the combination of ligustrazine and conven- tional medication was medium- and long-term ben- eficial to the patients suffering ischemic stroke. But more RCTs of high quality are needed to further prove the efficacy and safety of using ligustrazine for ischemic stroke.

关键词： Tetramethylpyrazine Stroke Time Sec-ondary prevention Review Meta-analysis

噪声作业人员代谢综合征与听力损失的相关性分析

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职业卫生与应急救援 2024年第1期42卷 53-57页

作者：张超郭新峰赵树卫淄博市职业病防治院山东淄博255000

目的探讨噪声作业人员代谢综合征(metabolic syndrome,MS)与噪声性听力损失(noise-included hearing loss,NIHL)的相关性。方法采用方便抽样法,选取某汽车制造企业850名男性噪声作业人员为研究对象,采用问卷调查和职业健康检查相结合... 详细信息

目的探讨噪声作业人员代谢综合征(metabolic syndrome,MS)与噪声性听力损失(noise-included hearing loss,NIHL)的相关性。方法采用方便抽样法,选取某汽车制造企业850名男性噪声作业人员为研究对象,采用问卷调查和职业健康检查相结合的方法,收集研究对象一般人口学资料、体检资料等各类信息,按照高频听力损失情况,将噪声作业人员分为听力损失组(326人)和听力正常组(524人),采用单因素分析比较两组人员上述资料差异情况,采用二分类多因素logistic回归模型分析噪声作业人员发生NIHL的影响因素。结果该企业噪声岗位超标率为39.47%(15/38),主要集中在焊装工和涂装工岗位。听力损失检出率为38.35%(326/850),MS检出率为27.53%(234/850)。听力损失组肥胖、高水平三酰甘油、高水平空腹血糖、高血压、MS的检出率、接触的噪声声级均高于听力正常组(P 15年组发生NIHL的风险分别升高至1.553、1.727倍(P <0.001);相比无MS组,MS组发生NIHL的风险升高至1.863倍(P <0.001)。噪声声级每增加1dB(A),发生NIHL的风险升高至1.567倍(P <0.001)。结论 MS与NIHL存在相关性。除了要重视控制工作环境中的噪声声级,还要注意采取低糖、低盐、低钠饮食,降低饱和脂肪酸的摄入量,加强体育锻炼等方式,有效控制作业人员的血压、血糖、血脂水平,从而减少NIHL发病风险。

关键词：代谢综合征噪声听力损失高血压三酰甘油高脂血症肥胖汽车制造

Comparative analysis of frictional behavior and mechanism of molybdenum ditelluride with different structures

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Friction 2024年第1期12卷 110-119页

作者： Lina ZHANG xinfeng TAN Jianguo JIAO Dan guo Jianbin LUO State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China

Two-dimensional(2D)transition metal dichalcogenides(TMDCs)have layered structures with excellent tribological *** the energy difference between hexagonal-molybdenum ditelluride(2H-MoTe_(2))and distorted octahedral-molybdenum ditelluride(1T′-MoTe_(2))is very small among the transition metal dichalcogenides(TMDCs),MoTe_(2) becomes one of the most promising candidates for phase *** our experiment,we found that the friction force and friction coefficient(COF)of 2H-MoTe_(2) were an order of magnitude smaller than those of 1T′-MoTe_(2) by the atomic force microscope(AFM)*** friction difference between 1T′-MoTe_(2) and 2H-MoTe_(2) was further verified in molecular dynamics(MD)*** density functional theory(DFT)calculations suggest that the friction contrast is related to the difference in sliding energy barrier of the potential energy surface(PES)for a tip sliding across the *** PES obtained from the DFT calculation indicates that the maximum energy barrier and the minimum energy path(MEP)energy barrier of 2H-MoTe_(2) are both smaller than those of 1T′-MoTe_(2),which means that less energy needs to be dissipated during the sliding *** difference in energy barrier of the PES could be ascribed to its larger interlayer spacing and weaker Mo–Te interatomic interactions within the layers of 2H-MoTe_(2) than those of 1T′-MoTe_(2).The obvious friction difference between 1T′-MoTe_(2) and 2H-MoTe_(2) not only provides a new non-destructive means to detect the phase transition by the AFM,but also provides a possibility to tune friction by controlling the phase transition,which has the potential to be applied in extreme environments such as space lubrication.

关键词： friction two-dimensional(2D)materials distorted octahedral-molybdenum ditelluride(1T′-MoTe_(2)) hexagonal-molybdenum ditelluride(2H-MoTe_(2)) phase transition

基于“痿病治宜导引”的导引适应症的现代思考

维普期刊数据库评论

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中医杂志 2024年第11期65卷 1170-1173页

作者：余艳陈雪吟杨丽虹刘少南陈裕刘理想岳萍吴金鹏郭新峰广州中医药大学第二临床医学院广东省广州市510405 广东省中医院中国中医科学院中医基础理论研究所天津中医药大学中国医学科学院生物医学工程研究所

《素问·异法方宜论篇》提出导引适应症“痿病治宜导引”,并明确导引适应症是指湿、食杂、不劳等导致的与脾和湿相关,以肢体困重、倦怠乏力为主症的病症,类似于现代医学糖脂代谢病早期代谢失衡状态。现代临床和基础研究证据表明,导引可... 详细信息

《素问·异法方宜论篇》提出导引适应症“痿病治宜导引”,并明确导引适应症是指湿、食杂、不劳等导致的与脾和湿相关,以肢体困重、倦怠乏力为主症的病症,类似于现代医学糖脂代谢病早期代谢失衡状态。现代临床和基础研究证据表明,导引可以通过抑制炎症反应、缓解氧化应激、调节肠道菌群、调控基因表达,进而改善代谢异常状态,为导引适应症的研究提供思路。

关键词：导引痿糖代谢脂代谢

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少数民族医药循证能力现状及发展需求调查

中医杂志 2024年第15期65卷 1559-1564页

作者：喻瑞芳陈耿杭陈雪吟赖佳琪黄仟杨丽虹刘玉玮郭新峰刘少南广州中医药大学第二临床医学院广东省广州市510405 广州中医药大学第二附属医院/广东省中医院中国民族医药学会

目的调查少数民族医药循证能力现状及发展需求,探讨提升少数民族医药循证能力的有效策略。方法在少数民族医药医疗单位及研究机构进行问卷调查。问卷内容包括3个维度:对循证医学的认知和态度、少数民族医药发展的优势及推进循证医学... 详细信息

目的调查少数民族医药循证能力现状及发展需求,探讨提升少数民族医药循证能力的有效策略。方法在少数民族医药医疗单位及研究机构进行问卷调查。问卷内容包括3个维度:对循证医学的认知和态度、少数民族医药发展的优势及推进循证医学面临的困难、少数民族医药循证能力提升的需求及建议。结果共回收有效问卷501份,其中针对参与数量不足的少数民族医药地区补发问卷回收103份。问卷中少数民族医药从业者354份(70.66%),包括藏医、蒙医、维吾尔医、壮医、朝鲜医等少数民族医药。146例(29.14%)表示了解循证医学,70.86%(355例)的被调查者对循证医学“一般了解”或“不太了解,没听说过”,93.61%(469例)的被调查者认为引入循证医学能推动少数民族医药的发展。少数民族医药领域内推进循证医学面临的最大困难是缺乏循证医学专业人才,不知道如何运用循证医学推动临床实践(442例,88.22%)。关于循证能力提升的9分制重要性评分中,临床实践指南的规范制订得分(7.50±1.90)和常见临床研究的样本量估算方法得分(7.45±1.90)较高。临床科研素养提升的需求方面,选择最多的是专家学术讲座与经验分享(404例,80.64%)和相关循证方法学专著(401例,80.04%)。结论少数民族医药从业者对引入循证医学持积极态度,循证医学的教育与普及尚有较大发展空间。循证能力的提升主要可从培养或引进循证医学人才、建设临床研究循证支持平台、定期开展学术讲座及交流、加强少数民族医药理论和评价体系建设等措施具体落实,走符合少数民族医药特色的循证之路。

关键词：民族医药循证医学循证能力问卷调查

热泵蓄能光伏发电系统与配电网耦合联动运行性能研究与分析

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建筑科学 2024年第8期40卷 128-138页

作者：李瑞霞冯晓梅杨晨郭新锋李昊王天任薛汇宇崔一鸣中石化新星(北京)新能源研究院有限公司北京100000 建科环能科技有限公司北京100013 中国建筑科学研究院有限公司北京100013

随着建筑低碳发展,热泵和光伏等可再生能源技术在建筑能源系统中逐步得到规模化应用,然而其无序应用会给电网配电和承载带来较大压力。本文提出了1种“热泵+蓄能+光伏”冷热电耦合建筑能源系统,采用源网荷储联动运行方法,通过有序调节... 详细信息

随着建筑低碳发展,热泵和光伏等可再生能源技术在建筑能源系统中逐步得到规模化应用,然而其无序应用会给电网配电和承载带来较大压力。本文提出了1种“热泵+蓄能+光伏”冷热电耦合建筑能源系统,采用源网荷储联动运行方法,通过有序调节光伏、配电网、热泵、蓄能运行状态,实现建筑低成本供冷供热,促进可再生能源发电本地消纳和电网调度平衡。同时,本文通过模拟平台验证了源网荷储联动运行方法的应用效果,结果表明,采用源荷储联动运行方法较热泵直供运行方法,在冬季部分负荷典型日,可再生能源本地消纳提升24.13%,系统全天运行费用降低34.10%,电力移峰量提高27.60%;在夏季部分负荷典型日,可再生能源本地消纳提升21.47%,系统全天运行费用降低33.20%,电力移峰量提高21.11%。全年能源系统可再生能源本地消纳提升22.47%,运行费用降低33.59%,电力移峰量提高15.95%,系统静态投资回收周期为4.67 a。本文表明了“热泵+蓄能+光伏”系统采用源网荷储联动运行方法在很大程度上节省了系统运行费用,促进了本地可再生能源消纳,平衡了电网,研究结果可用于指导工程应用。

关键词：热泵蓄能光伏源网荷储联动运行费用可再生能源本地消纳移峰量

Reporting quality and effect size comparison in randomized controlled trials of bo's abdominal acupuncture using CONSORT statement and STRICTA

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Journal of Traditional Chinese Medicine 2016年第3期36卷 382-391页

作者： Wen Wanxin Yang Lihong Liu Shaonan Zhong Ying Hu Xiaoyi Huang Xiaowan guo xinfeng Department of General Internal Medicine Guangdong Provincial Hospital of Chinese Medicine (The Second Clinical College of Guangzhou University of Chinese Medicine) Evidence-based Medicine & Clinical Research Service Group Guangdong Provincial Hospital of Chinese Medicine (the Second Clinical College of Guangzhou University of Chinese Medicine Guangdong Provincial Academy of Chinese Medical Sciences) Department of Respiratory Medicine Guangdong Provincial Hospital of Chinese Medicine (the Second Clinical College of Guangzhou University of Chinese Medicine)

OBJECTIVE: To evaluate the reporting quality of randomized controlled trials(RCT) that compared Bo's abdominal acupuncture with conventional body acupuncture, and compare the efficacy and safetybetweenthembyperforminga ***: All RCTs comparing Bo's abdominalacupuncture with conventional body acupuncture were included. English and Chinese databases were searched from their respective inceptions to March 2014. The reporting quality was assessed according to the "Consolidated Standards of Reporting Trials"(CONSORT) checklist for parallel RCTs and the revised "Standards for Reporting Interventions in Clinical Trials of Acupuncture"(STRICTA). A Meta-analysis was conducted to synthesize the effect sizes,and publication bias was evaluated by the Egger linear regression test using ***: Ninety-seven studies were included, of which most lacked adequate reporting information, and 80.4% showed that the efficacy of abdominal acupuncture is superior to conventional body acupuncture, especially for the following diseases:lumbar disc herniation, cervical spondylosis, omarthritis and cervical vertigo, except simple ***-sizes were controversial when evaluating different ***: The international standard CONSORT statement and STRICTA guidelines should be strictly applied when reporting acupuncture RCTs in the future. Abdominal acupuncture appears to be more effective compared with conventional body acupuncture for some diseases. However, further high quality blind RCTs using validated outcomeindexesandstandardreportingarewarranted.

关键词： Bo's abdominal acupuncture Randomized controlled trials CONSORT STRICTA Reporting quality Meta-analysis

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对外讲好中国故事的困难挑战与对策建议

党的文献 2020年第1期 28-30页

作者：郭信峰新华社对外部中国国际传播研究中心

党的十八大以来,习近平多次就“讲好中国故事,传播好中国声音,增强在国际上的话语权”作出重要指示。党的十九大进一步强调,要“推进国际传播能力建设,讲好中国故事,展现真实、立体、全面的中国”。近年来,我国国际传播事业取得了巨大进... 详细信息

党的十八大以来,习近平多次就“讲好中国故事,传播好中国声音,增强在国际上的话语权”作出重要指示。党的十九大进一步强调,要“推进国际传播能力建设,讲好中国故事,展现真实、立体、全面的中国”。近年来,我国国际传播事业取得了巨大进展,中国故事的国际吸引力、影响力不断增强。但仍要看到,我们讲述中国故事的实际效果与预期仍存在着一定差距,其中既有其客观因素,也有主观方面的问题。

关键词：国际传播能力传播事业挑战与对策党的十九大讲好中国故事党的十八大以来话语权主观方面

Letters for "Prospects for the future of clinical efficacy evaluation of traditional Chinese Medicine—Emphasis on original theory and clinical practice"

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TMR Modern Herbal Medicine 2020年第1期3卷 50-54页

作者： Yaolong Chen Kehu Yang xinfeng guo Darong Wu Ling Zhao Bo Li Evidence Based Medicine Centre of Lanzhou University GansuChina Beijing Hospital of Traditional Chinese Medicine Capital Medical UniversityBeijing Institute of Traditional Chinese MedicineBeijingChina 不详

Editorial Note:On January 1,2020,we published an online comment,titled“Prospects for the future of clinical efficacy evaluation of traditional Chinese medicine——Emphasis on original theory and clinical practice”,which focuses on the evaluation of traditional Chinese *** the article was published,it attracted the attention of some scholars,who discussed with the editorial department by *** relevant letters are organized as follows for further communication and discussion by readers.

关键词： theory letters clinical