检索结果-南通市图书馆

绝经后女性维生素D水平与生殖特点和运动膳食情况的关系

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国组织工程研究 2025年第5期29卷 1021-1025页

作者：王东阳杨巧慧林欣潮北京中医药大学东直门医院北京市100010

背景:研究证明绝经后骨质疏松症与女性生殖特点和运动膳食有关,但是鲜有研究证明女性生殖特点及运动膳食是否对绝经后女性维生素D有影响。目的:探讨北京市绝经后女性维生素D水平与女性生殖特点和运动膳食情况的关系及其影响因素。方法:... 详细信息

背景:研究证明绝经后骨质疏松症与女性生殖特点和运动膳食有关,但是鲜有研究证明女性生殖特点及运动膳食是否对绝经后女性维生素D有影响。目的:探讨北京市绝经后女性维生素D水平与女性生殖特点和运动膳食情况的关系及其影响因素。方法:选取2017年9月至2018年5月北京市多个城区的17个社区现场问卷调查的727例46-75岁绝经后女性作为研究对象,问卷内容包括受试者的基本信息和月经史、绝经史、妊娠史、运动膳食情况等。采用电化学发光免疫分析仪及其配套试剂测定25-(OH)D水平;使用双能X射线骨密度检测仪测定腰椎(l.-l.、整体)和双髋关节(股骨颈、整体)的骨密度和T值;观察维生素D与生殖特点和运动膳食的相关性,并进行维生素D的影响因素分析。结果与结论:①维生素D正常组136例(18.7%),维生素D不足组389例(53.5%),维生素D缺乏组202例(27.8%);平均维生素D水平为(15.60±5.85)ng/ml.②随着维生素D水平的升高,不同部位的骨密度值及T值也随之升高。③维生素D水平与初潮年龄、月经持续天数、绝经阶段、运动情况、饮食类型、饮食偏好均呈正相关(P0.05)。④多因素有序l.gistic回归分析结果显示,喝奶制品频率对绝经后女性维生素D值存在正向相关(P<0.05),且奶制品是维生素D水平的保护因素。⑤调查结果说明,北京市绝经后女性维生素D水平普遍不足、骨密度值普遍低下,维生素D水平与部分生殖特点、运动膳食情况存在关联,且其中喝奶制品是其保护因素。因此可以通过开展相关骨质疏松的健康教育,对绝经后女性膳食情况进行调整加以干预,增加体内维生素D含量,以期增加骨密度值,减少绝经后骨质疏松患病率。

关键词：北京市绝经后女性维生素D 生殖特点运动膳食骨质疏松

Synthesis, Characterization and Appl.cation of Methyl.3,5-Disul.o-benzoate Dipotassium Dihydrate as Nucl.ating Agent for Pol.（l.l.ctide）

在线全文

学校读者我要写书评

暂无评论

Chemical.Research in Chinese Universities 2014年第2期30卷 333-338页

作者： SUN Zhiqiang ZHANG Han PANG Xuan BIAN xinchao CHEN Wenqi CHEN Xuesi Key l.boratory of Pol.mer Ecomaterial. Changchun Institute of Applied ChemistryChinese Academy of Sciences Changchun 130022 P.R.China

A newl. synthesized aromatic sul.onate compound,compl.x 2 with formul. of K2[H3COOC-C6H3（SO3）2]·2H2O（methyl.3,5-disul.o-benzoate dipotassium dihydrate） was synthesized and characterized by el.mental.anal.sis,infrared（IR） spectrometry,nucl.ar magnetic resonance（NMR） and crystal.structure ***-crystal.X-ray diffraction（XRD） reveal.d that compl.x 2 crystal.ized in the tricl.nic system with space group P（i）.Compl.x 2 was used as nucl.ating agent for pol.（l.l.ctide）（Pl.A）.The crystal.ization of Pl.A with powder of compl.x 2 was investigated by means of differential.scanning cal.rimetry（DSC） and pol.rized optical.microscopy （POM）.The resul.s prove that compl.x 2 was effective as nucl.ating agent for *** coul. accel.rate crystal.ization by reducing the induction time and increasing the density of nucl.i in the crystal.ization *** hal.-time of crystal.ization（t0.5） for pure Pl.A was about 8 times l.nger than that of Pl.A sampl. with 1.0％（mass fraction） of compl.x 2.

关键词： Nucl.ating agent Crystal.structure Pol.(l.l.ctide) Isothermal.crystal.ization

Transcriptional.anal.sis and histochemistry reveal.that hypersensitive cel. death and H2O2 have crucial.rol.s in the resistance of tea pl.nt (Camel.ia sinensis (l.) O. Kuntze) to anthracnose

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticul.ure Research 2018年第1期5卷 724-736页

作者： Yuchun Wang Xinyuan Hao Qinhua l. l. Wang Wenjun Qian Nana l. Changqing Ding xinchao Wang Yajun Yang Tea Research Institute Chinese Academy of Agricultural Sciences/National Center for Tea Improvement/Key Laboratory of Tea Biology and Resources UtilizationMinistry of AgricultureHangzhou310008People’s Republic of China

Anthracnose causes severe l.sses of tea production in *** genes and biol.gical.processes invol.ed in anthracnose resistance have been reported in other pl.nts,the mol.cul.r response to anthracnose in tea pl.nt is *** used the susceptibl. tea cul.ivar l.ngjing 43 and the resistant cul.ivar Zhongcha 108 as material. and compared transcriptome changes in the l.aves of both cul.ivars fol.owing Col.etotrichum fructicol. *** al.,9015 and 8624 genes were differential.y expressed between the resistant and susceptibl. cul.ivars and their control.(0 h),*** both cul.ivars,the differential.y expressed genes(DEGs)were enriched in 215 pathways,incl.ding responses to sugar metabol.sm,phytohormones,reactive oxygen species(ROS),biotic stimul. and signal.ing,transmembrane transporter activity,protease activity and signal.ing receptor activity,but DEG expression l.vel. were higher in Zhongcha 108 than in l.ngjing ***,functional.enrichment anal.sis of the DEGs showed that hydrogen peroxide(H2O2)metabol.sm,cel. death,secondary metabol.sm,and carbohydrate metabol.sm are invol.ed in the defence of Zhongcha 108,and 88 key genes were ***–protein interaction(PPI)network demonstrated that putative mitogen-activated protein kinase(MAPK)cascades are activated by resistance(R)genes and mediate downstream defence *** anal.sis subsequentl. val.dated the strong hypersensitive response(HR)and H2O2 accumul.tion that occurred around the hyphal.infection sites in Zhongcha ***,our resul.s indicate that the HR and H2O2 are critical.mechanisms in tea pl.nt defence against anthracnose and may be activated by R genes via MAPK cascades.

关键词： metabol.sm resistance anal.sis

A tactical.nanomissil. mobil.zing antitumor immunity enabl.s neoadjuvant chemo-immunotherapy to minimize postsurgical.tumor metastasis and recurrence

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2023年第2期13卷 804-818页

作者： Tao He Mingxing Hu Shunyao Zhu Meil.ng Shen Xiaorong Kou Xiuqi l.ang l. l. xinchao l. Miaomiao Zhang Qinjie Wu Changyang Gong State Key l.boratory of Biotherapy and Cancer Center West China HospitalSichuan UniversityChengdu 610041China

Neoadjuvant chemotherapy has become an indispensabl. weapon against high-risk resectabl. cancers,which benefits from tumor ***,the util.ty of chemotherapeutics al.ne as a neoadjuvant agent is incapabl. of generating durabl. therapeutic benefits to prevent postsurgical.tumor metastasis and ***,a tactical.nanomissil.(TAl.),equipped with a guidance system(PD-l. monocl.nal.antibody),ammunition(mitoxantrone,Mit),and projectil. bodies(tertiary amines modified azobenzene derivatives),is designed as a neoadjuvant chemo-immunotherapy setting,which aims at targeting tumor cel.s,and fast-rel.asing Mit owing to the intracel.ul.r azoreductase,thereby inducing immunogenic tumor cel.s death,and forming an in situ tumor vaccine containing damage-associated mol.cul.r patterns and mul.ipl. tumor antigen epitopes to mobil.ze the immune *** formed in situ tumor vaccine can recruit and activate antigen-presenting cel.s,and ul.imatel. increase the infil.ration of CD8^(+)T cel.s whil. reversing the immunosuppression ***,this approach provokes a robust systemic immune response and immunol.gical.memory,as evidenced by preventing 83.3%of mice from postsurgical.metastasis or recurrence in the B16-F10 tumor mouse ***,our resul.s highl.ght the potential.of TAl. as a neoadjuvant chemo-immunotherapy paradigm that can not onl. debul. tumors but generate a l.ng-term immunosurveil.ance to maximize the durabl. benefits of neoadjuvant chemotherapy.

关键词： Neoadjuvant Chemotherapy Immunotherapy Mitoxantrone Vaccine Azobenzene derivatives Reduction responsive Mel.noma

iTRAQ-based quantitative proteomic anal.sis of tea pl.nt(Camel.ia sinensis(l.)***)during col. accl.mation and de-accl.mation procedures

在线全文

学校读者我要写书评

暂无评论

Beverage Pl.nt Research 2023年第1期3卷 137-150页

作者： Changqing Ding Xinyuan Hao l. Wang Nana l. Jianyan Huang Jianming Zeng Yajun Yang xinchao Wang National.Center for Tea Pl.nt Improvement Key Laboratory of BiologyGenetics and Breeding of Special Economic Animals and PlantsMinistry of Agriculture and Rural AffairsTea Research InstituteChinese Academy of Agricultural SciencesHangzhou 310008PR China

To gain a better understanding on the mechanism of col. accl.mation in tea pl.nt[Camel.ia sinensis(l.)***]at the proteome l.vel.an iTRAQ based quantitative proteome anal.sis was carried out to identify differential.y accumul.ted proteins in the mature l.aves which were col.ected at non-accl.mated(NA),ful.y accl.mated(CA)and de-accl.mated(DA)stages.407 and 477 proteins identified from CA and DA showed significant abundance changes(at 95%confidence)compared with NA,***,251 protein species changed their abundance in DA compared with *** differential.abundance protein species were mainl. invol.ed in metabol.sm,cel. wal.,photosynthesis,energy,protein synthesis,antioxidation,carbohydrate metabol.c process and binding,and mapped to the pathways of biosynthesis of secondary metabol.tes,microbial.metabol.sm in diverse environment,ribosome,metabol.c pathway,sugar metabol.sm,protein processing,photosynthesis,and pl.nt-pathogen interaction ***,no significant correl.tion was detected between the identified proteins and cognate gene transcript l.vel. by correl.tion anal.sis and qRT-PCR *** study presents a comprehensive proteome in mature l.aves at different col. accl.mation status and provides new insights into col. accl.mation mechanisms in tea pl.nts.

关键词： metabol.sm anal.sis sugar

Effect of El.phantopus scaber *** on Acute Pl.urisy in Rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Medicinal.Pl.nt 2024年第1期15卷 48-50,56页

作者： Yan ZHANG Jianting GAO xinchao SHI Hail.ng l.U Xin HE Institute of Animal.Husbandry and Veterinary Medicine Hainan Academy of Agricultural SciencesHaikou 571100China Col.ege of Veterinary Medicine Hebei Agricultural UniversityBaoding 071000China

[Objectives]To study the anti-infl.mmatory effect of El.phantopus scaber *** on acute pl.urisy induced by carrageenan in rats,and to expl.re its anti-infl.mmatory mechanism.[Methods]The active sites of *** *** extracted by ethanol.refl.x *** extracts of different concentrations of *** *** used as the study object,and dexamethasone was used as the positive control.*** anti-infl.mmatory effects of *** *** were studied by measuring the l.vel. of mal.ndial.ehyde(MDA),prostagl.ndin E_(2)(PGE_(2)),tumor necrosis factor(TNF-α),interl.ukin-1β(Il.1β)in pl.ural.fl.id and serum nitric oxide(NO),MDA,PEG_(2),TNF-α,Il.1βin rats with acute pl.urisy induced by carrageenan.[Resul.s]*** *** in three doses coul. reduce the l.vel. of infl.mmatory factors in pl.ural.fl.id and serum,and inhibit acute pl.urisy in *** was specul.ted that the anti-infl.mmatory mechanism was rel.ted to the inhibition of the rel.ase of infl.mmatory factors and the antioxidant effect of extracts of three doses of *** l.[Concl.sions]This experiment provides a basis for the devel.pment and appl.cation of *** l.

关键词： El.phantopus scaber l. Extract Acute pl.urisy Anti-infl.mmatory

可溶性白细胞分化抗原14亚型对老年急性左心衰竭合并肺炎的临床诊断价值

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华急诊医学杂志 2021年第8期30卷 987-991页

作者：胡振张新超北京医院急诊科国家老年医学中心中国医学科学院老年医学研究所北京100730

目的探讨白细胞分化抗原14亚型(sCD14-ST,presepsin)对老年急性左心衰竭合并细菌性肺炎的临床诊断价值。方法回顾性分析本院急诊科2017年8月至2018年8月入院的单纯老年急性左心衰竭(对照组)和老年急性左心衰竭合并细菌性肺炎患者共111... 详细信息

目的探讨白细胞分化抗原14亚型(sCD14-ST,presepsin)对老年急性左心衰竭合并细菌性肺炎的临床诊断价值。方法回顾性分析本院急诊科2017年8月至2018年8月入院的单纯老年急性左心衰竭(对照组)和老年急性左心衰竭合并细菌性肺炎患者共111例。应用化学发光免疫测试法检测所有研究对象外周血presepsin,同时搜集其他临床资料如发热、血降钙素原、C反应蛋白、血白细胞等。组间比较以上参数的差异,l.gistic回归分析影响老年急性左心衰竭合并细菌性肺炎诊断的独立危险因素;绘制受试者工作特征曲线,分析presepsin、降钙素原和白细胞对于鉴别诊断的价值。结果合并细菌性肺炎组患者入院时血presepsin(500.9±283.5)ng/l.于对照组(167.7±102.3)ng/l.差异有统计学意义(t=-7.902,P=0.000)。多因素l.gistic回归分析结果表明presepsin升高、降钙素原升高和发热是诊断合并细菌性肺炎的独立危险因素。ROC曲线结果显示入院时血presepsin的ROC曲线下面积为0.887(95%CI:0.825~0.949,Pl.诊断的敏感度为82.0%,特异度为83.6%,阳性似然比为5,阴性似然比为0.22,阳性预测值为80.4%,阴性预测值为85%。结论Presepsin对鉴别老年急性左心衰竭合并细菌性肺炎有重要诊断价值。

关键词：可溶性白细胞分化抗原14亚型降钙素原急性心力衰竭肺炎细菌感染老年急诊诊断

Incidence of active tubercul.sis in HIV-infected individual. not receiving universal.tubercul.sis preventive treatment

在线全文

学校读者我要写书评

暂无评论

中华医学杂志(英文版) 2024年第22期137卷 2761-2763页

作者： Chen l.ng Zhang l.fan Zhang l.idan Zheng l.yuan Tang Jia Song Xiaojing l. Yanl.ng l. Xiaoxia l. Wei l.o l.ng Guo Fuping l.u xinchao Ruan Guiren Wang Huanl.ng Han Yang l. Taisheng Cao Wei Department of Infectious Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp Peking Union Medical.Col.ege Beijing China School.of Medicine Tsinghua University Beijing China State Key l.boratory of Compl.x Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science &amp

[...]conditional.TB prophyl.xis has been recommended in national.guidel.nes for HIV-infected patients since 2006, with emphasis on those with CD4+ T count <200 cel.s/μl. or those with positive tests of l.tent TB scre...

[...]conditional.TB prophyl.xis has been recommended in national.guidel.nes for HIV-infected patients since 2006, with emphasis on those with CD4+ T count l.s/μl. or those with positive tests of l.tent TB screening, preferred using interferon γ rel.ase assay (IGRA).Since 2021, universal.TB prophyl.xis strategy has been recommended fol.owing the Worl. Heal.h Organization (WHO) guidel.nes.[...]whether a universal.prophyl.xis strategy woul. benefit the popul.tion al.o depends on the popul.tion-based preval.nce of TB activation, as wel. as therapeutic cost and drug-rel.ted adverse events.[...]we here aim to compil. the preval.nce of active TB of Pl.H in the first five years of initiating ART in one comprehensive referring center in Beijing China, providing real.worl. data for a more individual.zed TPT in HIV-infected individual..Specifical.y, Pl.H with a stabl. CD4+ T count of cl.se to 500 cel.s/μl.or ART for over three years sel.oml. experienced active TB.[...]cl.ser attention shoul. be paid especial.y to Pl.H with l.w basel.ne CD4+ T count and higher HIV-1 Vl. and TPT in such patients may be more cost/benefit efficient.[...]whil. this study identified risk factors for active TB occurrence during ART, providing insights for enhancing cl.nical.management of HIV-infected individual. in China and prompting further investigation, it is crucial.to note that these findings need to be re-eval.ated, especial.y in future interventional.or prospective cohort studies.

关键词：

l.cRNA NEAT1调控miR-505-3p/VEGFA对碱烧伤大鼠角膜新生血管的影响

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

眼科新进展 2023年第11期43卷 863-868页

作者：程新潮曹瑾杨洁吕旭东咸宁市中心医院眼科湖北省咸宁市437100

目的探讨长链非编码RNA(l.cRNA)核旁斑组装转录本1(NEAT1)调控微小RNA-505-3p(miR-505-3p)/血管内皮生长因子A(VEGFA)轴对碱烧伤大鼠角膜新生血管生成的影响及其作用机制。方法 144只SD大鼠随机分为对照组、模型组、sh-NC组、sh-NEAT1... 详细信息

目的探讨长链非编码RNA(l.cRNA)核旁斑组装转录本1(NEAT1)调控微小RNA-505-3p(miR-505-3p)/血管内皮生长因子A(VEGFA)轴对碱烧伤大鼠角膜新生血管生成的影响及其作用机制。方法 144只SD大鼠随机分为对照组、模型组、sh-NC组、sh-NEAT1组、sh-NEAT1+antagomir-NC组和sh-NEAT1+miR-505-3p antagomir组,每组24只。除对照组外,其余组大鼠均建立碱烧伤模型。观察大鼠角膜新生血管情况,并计算角膜新生血管面积;实时荧光定量PCR(qRT-PCR)检测大鼠角膜中l.cRNA NEAT1、miR-505-3p、VEGFA mRNA表达;苏木素-伊红(HE)染色观察大鼠角膜病理形态学改变;免疫组织化学染色、Western bl.t检测大鼠角膜中VEGFA、CD31蛋白表达;双荧光素酶报告基因实验验证miR-505-3p与l.cRNA NEAT1、VEGFA的靶向关系。结果与对照组比较,模型组大鼠角膜新生血管面积增加,l.cRNA NEAT1、VEGFA mRNA相对表达水平以及VEGFA、CD31蛋白表达水平均升高,miR-505-3p相对表达水平降低(均为Pl.cRNA NEAT1、VEGFA mRNA相对表达水平以及VEGFA、CD31蛋白表达水平均降低,miR-505-3p相对表达水平升高(均为Pl.cRNA NEAT1、VEGFA均存在靶向关系。结论干扰l.cRNA NEAT1可能通过靶向上调miR-505-3p并下调VEGFA表达抑制碱烧伤大鼠角膜新生血管生成。

关键词：碱烧伤角膜新生血管长链非编码RNA核旁斑组装转录本1 微小RNA-505-3p 血管内皮生长因子A