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Effect of powdery mildew on interleaf microbial communities and leaf antioxidant enzyme systems

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Journal of Forestry Research 2023年第5期34卷 1535-1547页

作者： xinbo Ma Zhanbin Wang Run Liu Yibing Jiang Northeast Forestry University Harbin 150040People’s Republic of China

Chinese peony(Paeonia lactiflora Pall.)is both medicinally and aesthetically *** mildew is a common fungal disease that seriously jeopardizes the value of numerous species,including peonies as a *** order to provide a basis for the prevention and treatment of peony powdery mildew,we examined the microbial diversity,the malondialdehyde(MDA)concentrations and antioxidant enzyme activities of peony leaves infected with three levels of powdery mildew to determine any modifications to the leaf's antioxidant enzyme systems and microbial community structure following the onset of *** results show that the MDA content rose as the degree of infection became *** enzyme activity rose and then *** the initiation of powdery mildew,fungal community diversity decreased,whereas there was not any appreciable change in bacterial communities according to microbial diversity *** relative abundance of more than half of fungal species decreased,with the bacterial genera displaying both abundant and diminished communities with less pronounced alterations in their community structure after the disease *** different taxa that were critical to the organization of each microbiome were *** analysis showed that the relative abundance of powdery mildew pathogenic fungal genus Erysiphe was correlated with those of 11 fungal genera and one bacterial *** them,Aureobasidium,Neosetophoma and Sclerostagonospora showed significant positive correlations with Erysiphe and MDA.

关键词： Powdery mildew Disease level Interleaf microbial diversity Antioxidant enzyme

生育支持与欠发达地区育龄女性的生育意愿——基于贵州省88个区县的生育意愿调查

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河南社会科学 2025年第1期33卷 91-101页

作者：周文贵州省社会科学院博士后工作站贵州贵阳550002 贵州财经大学经济学院贵州贵阳550025

生育支持已经成为强化青年生育意愿和生育行为的重要举措,然而受限于研究数据,以往的研究很少对欠发达地区各类生育支持及其效果进行研究。为了研究欠发达地区各类生育支持对育龄女性生育意愿的作用,基于贵州省88个区县的生育意愿调查数... 详细信息

生育支持已经成为强化青年生育意愿和生育行为的重要举措,然而受限于研究数据,以往的研究很少对欠发达地区各类生育支持及其效果进行研究。为了研究欠发达地区各类生育支持对育龄女性生育意愿的作用,基于贵州省88个区县的生育意愿调查数据,从政府政策支持、社会托育支持和家庭代际支持三个维度研究了生育支持对欠发达地区育龄女性生育意愿的影响。研究发现:(1)当前贵州育龄女性的生育意愿已经下降到了较低水平,未来生育水平有进一步下降的风险。(2)家庭代际支持、社会托育支持和政府政策支持对育龄女性的总体生育意愿都具有显著的促进作用,但只有政府政策支持和家庭代际支持对三孩生育意愿具有显著的影响,社会托育支持对三孩生育意愿的影响不显著。(3)异质性分析则发现各类生育支持对35岁以上的育龄女性影响较大,是对35岁以下年轻群体影响的两倍左右。各类支持对不同学历育龄女性的影响也出现了分化,总体上呈现出低学历女性受到家庭支持与政府政策支持影响较大,而高学历女性受到托育服务影响较大的特征。(4)各类生育支持方式对育龄女性生育意愿的协同效应十分显著,当各类生育支持都较强时,对育龄女性生育意愿的影响较大。基于上述结论,一方面,生育支持体系与生育支持政策既要坚持普惠性,又要兼顾不同群体差异化需求;另一方面,需要进一步完善生育支持体系,充分发挥各类生育支持的协同效应,让育龄女性在生育决策时有更多生育支持方式的选择。

关键词：生育支持体系生育意愿欠发达地区被访者驱动抽样调查

Iron-chelated hydrogel-derived bifunctional oxygen electrocatalyst for high-performance rechargeable Zn-air batteries

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Nano Research 2017年第12期10卷 4436-4447页

作者： Fanlu Meng Haixia Zhong Junmin Yan xinbo Zhang State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Key Laboratory of Automobile Materials Ministry of Education and College of Materials Science and Engineering Jilin University Changchun 130012 China University of Chinese Academy of Sciences Beijing 100049 China

Efficient oxygen electrocatalysts are the key elements of numerous energy storage and conversion devices, including fuel cells and metal-air batteries. In order to realize their practical applications, highly efficient and inexpensive non-noble metal-based oxygen electrocatalysts are urgently required. Herein, we report a novel iron-chelated urea-formaldehyde resin hydrogel for the synthesis of Fe-N-C electrocatalysts. This novel hydrogel is prepared using a new instantaneous （20 s） one-step scalable strategy, which theoretically ensures the atomic-level dispersion of Fe ions in the urea-formaldehyde resin, guaranteeing the microstructural homogeneity of the electrocatalyst. Consequentl~ the prepared electrocatalyst exhibits higher catalytic activity and durability in the oxygen reduction （ORR） and evolution （OER） reactions than the commercial Pt/C catalyst. Furthermore, the above catalyst also shows a much better performance in rechargeable Zn-air batteries, including higher power density and better cycling stability. The developed synthetic approach opens up new avenues toward the development of sustainable active electrocatalysts for electrochemical energy devices.

关键词： hydrogel iron-nitrogen-doped carbon bifunctional oxygen reduction reaction(ORR) oxygen evolution reaction(OER) Zn-air batteries

Non-isolated high step-up DC–DC converter adopting auxiliary capacitor and coupled inductor

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Journal of Modern Power Systems and Clean Energy 2018年第2期6卷 384-398页

作者： Gang WU xinbo RUAN Zhihong YE College of Automation Engineering Nanjing University of Aeronautics and Astronautics Power SBG ATD-NJ R&D Center Lite-On Technology Corp

For grid-connected power system based on photovoltaic(PV) source and fuel cells, high step-up and high-efficiency DC–DC converters are needed, due to the bus voltage of the grid-connected inverter is much higher than the output voltage of PV and fuel cells. In this paper, a novel high step-up converter is proposed. An auxiliary capacitor is introduced into the boost converter, which serves as a voltage source. It is in series with the input voltage source with the same voltage polarities. Thus, the input voltage is increased equivalently and the voltage gain is increased accordingly. To reduce the voltage stresses of the switch and the diode, multiple output capacitors are introduced. The voltage of each output capacitor is degraded leading to the reduced voltage stress. To replenish energy for the multiple output capacitors, a coupled inductor is adopted. Based on this, high step-up converter adopting auxiliary capacitor and coupled inductor is derived. The operating principles and voltage gain of the proposed converters are analyzed in this paper. In theend, experiment results are given to verify the theoretical analysis.

关键词： High voltage gain High efficiency Nonisolated Photovoltaic(PV) Fuel cell

Experimental research on the seismic behavior of CSPSWs connected to frame beams

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Earthquake Engineering and Engineering Vibration 2011年第1期10卷 65-73页

作者： Guo Lanhui Ma xinbo Li Ran Zhang Sumei School of Civil Engineering Harbin Institute of Technology Harbin 150090 China

The seismic performance of composite steel plate shear walls （CSPSWs） that consist of a steel plate shear wall （SPSW） with reinforced concrete （RC） panels attached to one or both sides by means of bolts or connectors is experimentally studied. The shear wall is connected to the frame beams but not to the columns. This arrangement restrains the possible out-of-plane buckling of the thin-walled steel plate, thus significantly increasing the bearing capacity and ductility of the overall wall, and prevents the premature overall or local buckling failure of the frame columns. From a practical viewpoint, these solutions can provide open space in a floor as this type of composite shear walls with a relatively small aspect ratio can be placed parallel along a bay. In this study, four CSPSWs and one SPSW were tested and the results showed that both CSPSWs and SPSW possessed good ductility. For SPSW alone, the buckling appeared and resulted in a decrease of bearing capacity and energy dissipation capacity. In addition, welding stiffeners at corners were shown to be an effective way to increase the energy dissipation capacity of CSPSWs.

关键词： steel plate shear wall (SPSW) composite steel plate shear wall (CSPSW) seismic behavior ductility

Analysis of jacking forces during pipe jacking in granular materials using particle methods

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Underground Space 2019年第4期4卷 277-288页

作者： xinbo Ji Pengpeng Ni Marco Barla School of Civil Engineering Sun Yat-sen UniversityZhuhai 519082China School of Civil and Environmental Engineering Nanyang Technological UniversitySingapore 639798Singapore The Fifth Engineering Co. Ltd.of ChinaTiesiju Civil Engineering GroupJiujiang 332000China Department of Structural Geotechnical and Building EngineeringPolitecnico di TorinoTurinItaly

Trenchless technology is often used in congested urban areas or river crossings to install underground pipelines to minimize disturbance to surface traffic or other *** jacking is a typical technique applied to jack pipe segments between two working ***,the design of the jacking force is usually implemented using empirical *** should be emphasized that the jacking force will change for each site,depending on the magnitude of overcut,lubricants,work stoppages,geology and misalignment.A particle method is proposed to estimate the jacking force along the *** microparameters are calibrated for sandy soils in Shenyang,so that the macroscale material behavior can be reproduced using the particle ***,the normal force around the pipe circumference can be derived in the particle model,after which the interface friction coefficient is applied to evaluate the friction resistance mobilized at the soil-pipe interface.A modified Protodyakonov’s arch model can be used to assess the magnitude of earth pressure acting on the shield *** the end,the combination of friction resistance and face pressure provides the jacking *** efficacy of the proposed particle method is demonstrated by comparing calculated jacking forces with those measured in the field for three types of jacking machines in sandy soils under the Hun River,Shenyang.

关键词： Pipe jacking Jacking force Particle methods Distinct element

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han Yan Su Yiming zhou Minhui Xu Jiyan Xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiyu Hu Yuanqing Cao Chenglin Cai Guangming Wang Min zhou Luying Peng Yantao Fan Qiong Lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji Li Tingting Liu Shiqi Huang Xiangliang Chen Shen Liu Junshan zhou Hongdong Zhao Ye Hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization