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Inhibitory effect of icariin on expression of myelin inhibitory factors in the central nervous system of rats with focal cerebral ischemia

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Neural Regeneration Research 2010年第16期5卷 1211-1215页

作者： Huaiqiang Hu Yonghong Zhou Bingzhen Cao xinlu Wang Department of Neurology General Hospital of Jinan Military Area Command of Chinese PLA Jinan 250031 Shandong Province China Department of Integrated Traditional and Western Medicine Medical College Qingdao University Qingdao 266071 Shandong Province China Department of Neurology Clinical College Shandong University of Traditional Chinese Medicine Jinan 250355 Shandong Province China

Icariin, the major active component of Chinese medicinal herb epimedium brevicornum maxim, is used widely in traditional Chinese medicine for the treatment of neurological diseases. However, the effects of icariin on myelin inhibitory factors are as yet unclear. In the present study, administration of icariin at 20 mg/kg showed a marked reduction in neurological deficit of middle cerebral artery occlusion rats. Icariin exhibited better inhibitory effects on myelin inhibitory factors： Nogo-A, myelin-associated glycoprotein and oligodendrocyte myelin glycoprotein in ischemia regions of middle cerebral artery occlusion rats compared with monosialotetrahexosylganglioside. These results indicate that icariin exhibits potent inhibitory effects on expression of myelin inhibitors after middle cerebral artery occlusion-induced focal cerebral ischemia in vivo. This effect may be mediated, at least in part, by the inhibition of both Nogo-A, myelin-associated glycopretein and oligodendrocyte myelin glycoprotein activation, followed by the enhancement of axonal sprouting and regeneration, resulting in neurological functional recovery.

关键词： icariin monosialotetrahexosylganglioside Nogo-A myelin-associated glycoprotein oligodendrocyte myelin glycoprotein ischemic cerebrovascular disease neuroplasticity single Chinese herb neural regeneration

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Increasing Anthropogenic Mercury Pollution over the Last 200 Years Revealed by Lagoonal Sediments from Hainan Island,South China

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Chinese Geographical Science 2023年第6期33卷 1127-1140页

作者： LI Yanting XUE Jibin CHEN Jingqiang LU Yi MA xinlu School of Geographical Sciences South China Normal UniversityGuangzhou510631China

The toxic heavy metal mercury(Hg)has significantly enhanced the global Hg cycle influenced by human activities over the last *** this study,we presented a high-resolution Hg deposition history between∼1780 and 2015 AD in a sediment core from Xincun Lagoon,located in the southeastern Hainan Island,South China,and analyzed it in conjunction with geochemical elements,grain-size distribution,organic matter,and HYSPLIT backward trajectory *** objective was to investigate the influencing factors affecting historical Hg deposition in relatively remote regions and assess the extent of the effects of natural background and human *** results showed that the Hg in the sediment was deposited primarily through atmospheric deposition,which was closely related to regional and even global human *** Hg contamination increased gradually from the 1830s to 1850s,possibly due to Hg emissions from Opium Wars I and II occurring in southeastern *** broad peaks of anthropogenic Hg were observed during the 1910s to 1950s and in the 1980s,likely associated with the two world wars and modern Chinese *** addition,a further sharp increase in anthropogenic Hg from the mid-1970s to the present occurred,likely originating from the intense industrial activities in China triggered by the reform and opening-up policy of China in 1978 and some countries in Southeast Asia.

关键词： Mercury deposition pollution history anthropogenic impact Xincun Lagoon Hainan,China

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Relationship Between the Formation of Clusters in Electrorheological Fluids and Their Fractal Dimension

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Chinese Physics Letters 1995年第8期12卷 501-504页

作者： WU Feng TANG xinlu YANG Yuegui WANG Xiaohong Department of Modern Mechanics University of Science and Technology of ChinaHefei 230026

In this paper,the scaling properties of aggregation of particles in electrorheological fluids(ERF)are *** is found that the cluster size is related to both the space dimension and its fractal dimension,*** structure of *** analyzing the experimental data and the results of computer simulations we have shown that the fractal dimension of the particle clusters in ERF is one for 2-dimensional space and 5/4 for 3-dimensional space.

关键词： cluster. space. dimension

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A Novel Hybrid Model for Gasoline Prices Forecasting Based on Lasso and CNN

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Journal of Social Computing 2022年第3期3卷 206-218页

作者： Hu Yang xinlu Tian Xin Jin Haijun Wang the School of Information Central University of Finance and EconomicsBeijing 100872China School of Economics Beijing Wuzi UniversityBeijing 101149China

Gasoline is the lifeblood of the national *** forecasting of gasoline prices is difficult because of frequent price fluctuations,its complex nature,diverse influencing factors,and low accuracy of prediction *** studies mainly focus on forecasting gasoline prices in a single region by single time series analysis which ignores the daily price co-movement of different series from multiple *** price co-movement may contain useful information for price forecasting,this paper proposes the LassoCNN ensemble model that combines statistical models and deep neural networks to forecast gasoline *** this model,the Least Absolute Shrinkage and Selection Operator(Lasso)screens and chooses the correlated time series to enhance the performance of forecasting and avoid overfitting,while Convolutional Neural Network(CNN)takes the selected multiple series as its input and then forecasts the gasoline prices in a certain *** results of gasoline prices at the national level and regional levels by using the new method demonstrate that the new approach provides more accurate results for the predictions of gasoline prices than those results generated by alternative ***,the relevant series can enhance the performance of forecasting and help to gain better results.

关键词： gasoline prices forecasting Lasso-CNN multiple time series

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PREPARATION OF Co50Ni50 ULTRAFINES BY CO-REDUCTION OF SOLUTION IN PRESENCE OF POLYMER

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中国有色金属学会会刊：英文版 1999年第1期9卷 3-5,7+6页

作者： Chen, Zuyao Zhang, Guochun Zhu, Yurui Jiang, Wanquan Tang, xinlu Univ of Science and Technology of China Hefei China

ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｍｅｔａｌＣｏ，ａｓｏｎｅｏｆｆｅｒｏｍａｇｎｅｔｉｃｔｒａｎｓｉｔｉｏｎｅｌｅｍｅｎｔｓ，ａｎｄｉｔｓａｌｏｙｓａｎｄｃｏｍｐｏｕｎｄｓ，ｅｓｐｅｃｉａｌｙｉｔｓｕｌｔｒａｆｉｎｅｐ... 详细信息

ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｍｅｔａｌＣｏ，ａｓｏｎｅｏｆｆｅｒｏｍａｇｎｅｔｉｃｔｒａｎｓｉｔｉｏｎｅｌｅｍｅｎｔｓ，ａｎｄｉｔｓａｌｏｙｓａｎｄｃｏｍｐｏｕｎｄｓ，ｅｓｐｅｃｉａｌｙｉｔｓｕｌｔｒａｆｉｎｅｐａｒｔｉｃｌｅｓａｎｄｐｏｗｄｅｒ...

关键词： Co50Ni50 magnetic alloy ultrafines Co reduction of solution polymer(CRSPP)

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Geochemistry, U-Pb Geochronology and Sr-Nd-Hf Isotopes of the Early Cretaceous Volcanic Rocks in the Northern Da Hinggan Mountains

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Acta Geologica Sinica(English Edition) 2015年第1期89卷 203-216页

作者： HU xinlu YAO Shuzhen HE Mouchun DING Zhenju CHEN Bin Faculty of Earth Resources China University of Geosciences Key Laboratory of Tectonics and Petroleum Resources Ministry of Education State Key Laboratory of Geological Process and Mineral Resources China University of Geosciences

Whole-rock geochemical, zircon U-Pb geochronological and Sr-Nd-Hf isotopic data are presented for the Early Cretaceous volcanic rocks from the northern Da Hinggan Mountains. The volcanic rocks generally display high SiO2 （73.19-77.68 wt%） and Na20＋K20 （6.53-8.98 wt%） contents, with enrichment in Rb, Th, U, Pb and LREE, and depletion in Nb, Ta, P and Ti. Three rhyolite samples, one rhyolite porphyry sample, and one volcanic breccia sample yield weighted mean 206pb/23SU ages of 135.1±1.2 Ma, 116.5±1.1 Ma, 121.9±1.0 Ma, 118.1±0.9 Ma and 116.9±1.4 Ma, respectively. All these rocks have moderate （STSr/S6Sr）i values of 0.704912 to 0.705896, slightly negative eNd（t） values of -1.4 to -0.1, and positive Cur（t） values of 3.7 to 8. Their zircon Hf and whole-rock Nd isotopic model ages range from 594 to 1024 Ma. These results suggest that the Early Cretaceous volcanic rocks were originated from melting of subducted oceanic crust and associated sediments during the closure of the Mongol-Okhotsk Ocean.

关键词： U-Pb geochronology Sr-Nd-Hf isotopes volcanic rocks Early Cretaceous Da HingganMountains

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Data quality evaluation and calibration of on-road remote sensing systems based on exhaust plumes

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Journal of Environmental Sciences 2023年第1期123卷 317-326页

作者： Shijie Liu xinlu Zhang Linlin Ma Liqiang He Shaojun Zhang Miaomiao Cheng State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Institute of Atmospheric Environment Chinese Research Academy of Environmental SciencesBeijing 100012China School of Environment State Key Joint Laboratory of Environment Simulation and Pollution ControlTsinghua UniversityBeijing 100084China State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex Beijing 100084China

In recent years,with rapid increases in the number of vehicles in China,the contribution of vehicle exhaust emissions to air pollution has become increasingly *** achieve the precise control of emissions,on-road remote sensing(RS)technology has been developed and applied for law enforcement and ***,data quality is still an existing issue affecting the development and application of *** this study,the RS data from a cross-road RS system used at a single site(from 2012 to 2015)were collected,the data screening process was reviewed,the issues with data quality were summarized,a new method of data screening and calibration was proposed,and the effectiveness of the improved data quality control methods was finally *** results showed that this method reduces the skewness and kurtosis of the data distribution by up to nearly 67%,which restores the actual characteristics of exhaust diffusion and is conducive to the identification of actual clean and high-emission *** annual variability of emission factors of nitric oxide decreases by 60%-on average-eliminating the annual drift of fleet emissions and improving data reliability.

关键词： On-road remote sensing(RS) Data quality Spearman rank correlation Least-square regression with a non-zero intercept Cook value

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Influence of temperature and diffusive entropy on the capture radius of fly-casting binding

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Science China(Physics,Mechanics & Astronomy) 2011年第12期54卷 2237-2242页

作者： CHANG Le GUO xinlu ZHANG Jian WANG Jun WANG Wei National Laboratory of Solid State Microstructure and Department of Physics Nanjing University Nanjing 210093 China

The recognition and binding of proteins through the "fly-casting" mechanism are important biological processes. In this paper, a physical model for fly-casting binding is described based on the capillarity theory for protein chains. It is found that the capture radius for the fly-casting binding process is maximized at the transition temperature at which the free energy of the monomeric extended state of the protein equals that of the folded state. The factors related to the folding barrier or binding affinity do not change the condition needed to realize the optimization for fly-casting processes. These results will aid in the comprehensive understanding of binding processes.

关键词： protein binding fly-casting mechanism protein folding

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From Laboratory to Field:Unsupervised Domain Adaptation for Plant Disease Recognition in the Wild

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Plant Phenomics 2023年第2期5卷 195-208页

作者： xinlu Wu Xijian Fan Peng Luo Sruti Das Choudhury Tardi Tjahjadi Chunhua Hu College of Information Science and Technology Nanjing Forestry UniversityNanjing 210037China Institute of Forest Resource Information Techniques Chinese Academy of ForestryBeijing 100091China Key Laboratory of Forestry Remote Sensing and Information System National Forestry and Grassland AdministrationBeijing 100091China Department of Computer Science and Engineering University of Nebraska-LincolnLincolnNE 68588USA School of Engineering University of WarwickCoventry CV47ALUK

Plant disease recognition is of vital importance to monitor plant development and predicting crop ***,due to data degradation caused by different conditions of image acquisition,e.g.,laboratory *** environment,machine learning-based recognition models generated within a specific dataset(source domain)tend to lose their validity when generalized to a novel dataset(target domain).To this end,domain adaptation methods can be leveraged for the recognition by learning invariant representations across *** this paper,we aim at addressing the issues of domain shift existing in plant disease recognition and propose a novel unsupervised domain adaptation method via uncertainty regularization,namely,Multi-Representation Subdomain Adaptation Network with Uncertainty Regularization for Cross-Species Plant Disease Classification(MSUN).Our simple but effective MSUN makes a breakthrough in plant disease recognition in the wild by using a large amount of unlabeled data and via nonadversarial ***,MSUN comprises multirepresentation,subdomain adaptation modules and auxiliary uncertainty *** multirepresentation module enables MSUN to learn the overall structure of features and also focus on capturing more details by using the multiple representations of the source *** effectively alleviates the problem of large interdomain *** adaptation is used to capture discriminative properties by addressing the issue of higher interclass similarity and lower intraclass ***,the auxiliary uncertainty regularization effectively suppresses the uncertainty problem due to domain *** was experimentally validated to achieve optimal results on the PlantDoc,Plant-Pathology,Corn-Leaf-Diseases,and Tomato-Leaf-Diseases datasets,with accuracies of 56.06%,72.31%,96.78%,and 50.58%,respectively,surpassing other state-of-the-art domain adaptation techniques considerably.

关键词： Plant breakthrough details

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Selective hydrocracking of light cycle oil into high-octane gasoline over bi-functional catalysts

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Journal of Energy Chemistry 2021年第1期30卷 41-50,I0002页

作者： Zhengkai Cao Xia Zhang Chunming Xu xinlu Huang Ziming Wu Chong Peng Aijun Duan State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing 102249China Dalian Research Institute of Petroleum and Petrochemicals SINOPECDalian 116041LiaoningChina

Light cycle oil(LCO) with high content of poly-aromatics was difficult to upgrade and convert,which had hindered upgrading fuel quality to meet with the standard of automotive diesel for the purpose of sustainable *** hydrocracking behaviors of typical aromatics in LCO of naphthalene and tetralin were investigated over NiMo and CoMo *** characterization methods including N2-adsoprtion and desorption,ammonia temperature-programmed desorption(NH3-TPD),Pyridine infrared spectroscopy(Py-IR),CO infrared spectroscopy(CO-IR),Raman and X-ray photoelectron spectroscopy(XPS) were applied to determine the properties of different *** results showed that CoMo catalyst with high concentration of S-edges could hydrosaturate more naphthalene to tetralin but exhibit lower yield of high-value light aromatics(carbon numbers less than 10) than NiMo *** catalyst with high concentration of Mo-edges also presented a higher selectivity of converting naphthalene into cyclanes than CoMo ***,the naphthalene and LCO hydrocracking performances were also investigated over different catalysts *** activity evaluation and kinetic analysis results showed that the naphthalene hydrocracking conversion and the yield of light aromatics for CoMo-AY/NiMo-AY grading catalysts were higher than NiMo-AY/CoMo-AY grading catalysts at same condition.A stepwise reaction principle was proposed to explain the high efficiency of CoMo-AY/NiMoAY grading ***,the LCO hydrocracking evaluation results confirmed that CoMo-AY/NiMoAY catalysts grading system with low carbon deposition and high stability could remain high percentage of active phases,which was more efficient to convert LCO to high-octane gasoline.

关键词： Hydrocracking Conversion Selectivity Catalysts grading High-octane gasoline

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