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Expression of YB-1 enhances production of murine leukemia virus vectors by stabilizing genomic viral RNA

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Protein & Cell 2012年第12期3卷 943-949页

作者： Wei Li xinlu Wang Guangxia Gao Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Murine leukemia virus(MLV)-based retroviral vectors is widely used for gene transfer and basic research,and production of high-titer retroviral vectors is very *** we report that expression of the Y-box binding protein 1(YB-1)enhanced the production of infectious MLV ***-1 specifically increased the stability of viral genomic RNA in virus-producing cells,and thus increasing viral RNA levels in both producer cells and virion *** viral element responsive to YB-1 was mapped to the repeat sequence(R region)in MLV genomic *** results identified YB-1 as a MLV mRNA stabilizer,which can be used for improving production of MLV vectors.

关键词： Y-box binding protein 1 retroviral vector RNA stability

Inelastic partial cross sections for scattering of HF by neon

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Science China(Physics,Mechanics & Astronomy) 2009年第4期52卷 574-579页

作者： YU ChunRi YANG XiangDong CHENG xinlu School of Physics&Electric Engineering Anqing Teachers CollegeAnqing 246133China Institute of Atomic and Molecular Physics Sichuan UniversityChengdu 610065China

An analytic expression of the potential energy surface(PES) of the ground state of the Ne-HF complex is obtained by utilizing nonlinear least square method to fit the intermolecular interaction energies [Zhang Y. Guizhou Science,2003,21(3):9-13(in Chinese)],which have been computed using the augmented correlation-consistent polarized quadruple zeta basis set aug-cc-pVQZ at the theoretical level of CCSD(T). On the basis of the PES,the partial cross sections(PCSs) at the incident energies of 60,75,100 and 150 meV for collisions between Ne atoms and HF molecules are calculated using the quantum close coupling approach. The effects of the long-range attractive and the short-range anisotropic interactions on the inelastic PCSs are discussed in detail. The results show:(1) The long-range attractive well of the EPS makes the significant contribution to the lower excitation PCSs,especially the tail maximum for j = 0→j′ = 1 transitions,whereas no contribution is to the j′≥3 inelastic transitions.(2) The short-range(the repulsive and attractive) interaction makes the significant contri-bution to the lower excitation PCSs,especially the main peak for j = 0→j′ = 1,2. As for the transitions of j′≥3,the short-range interaction plays a key role in the inelastic excitation.(3) Although the positions of the maximums and minimums of the inelastic PCSs are different at the collision energies,they correspond to almost the same impact parameter.

关键词： potential energy surface inelastic partial cross section close coupling approach

A novel preheating method for the Li-ion battery using supercooled phase change materials

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Science China(Technological Sciences) 2023年第1期66卷 193-203页

作者： FANG XuanYi NONG xinlu LIAO ZhiRong XU Chao Key Laboratory of Power Station Energy Transfer Conversion and System of Ministry of Education School of EnergyPower and Mechanical EngineeringNorth China Electric Power UniversityBeijing 102206China

The Li-ion battery is widely used in power tools, energy storage systems, and electric vehicles. In reality, battery thermal management is essential to control the battery temperature within a specific temperature range. Although research has shown that preheating the battery at low temperatures on cold days can improve output performance significantly, few efforts have been made to study the preheating method in-depth. As a result, this research proposes two preheating designs for cylindrical batteries with supercooled phase change materials: Single-and dual-phase change material(PCM) designs. A mathematical model is developed to analyze the effect of the PCM layer’s height, thickness, and mass on the preheating effect for seven candidate PCMs with high supercooling degrees. Furthermore, the economic efficiency of the single-PCM design with different PCMs is compared. In addition, the optimal ratio of the PCMs’ height for the dual-PCM design is investigated. Eventually, the improvement of the battery’s output performance is discussed. The results reveal that the proposed designs can effectively preheat the battery with a temperature rise higher than 10°C. The single-PCM design using Li NO3·3H2O shows the best preheating ability, while CH3COONa·3H2O is the most economical. Although the dual-PCM design cannot outperform the single-PCM design, it can preheat the battery twice and show better flexibility. Compared with the battery without preheating, a 26650-format battery with the single-PCM design can prolong the operating time by 38.8 min and save the electric quantity by 2.1 A h;while they are by 42.8 min and 2.3 A h with the dual-PCM design.

关键词： preheating method Li-ion battery phase change material supercooling

Analyses of SELEX-derived ZAP-binding RNA aptamers suggest that the binding specificity is determined by both structure and sequence of the RNA

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Protein & Cell 2010年第8期1卷 752-759页

作者： Zhi Huang xinlu Wang Guangxia Gao Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing 100101China

The zinc-finger antiviral protein(ZAP)is a host factor that specifically inhibits the replication of certain viruses,including murine leukemia virus,Sindbis virus and Ebola virus,by targeting the viral mRNAs for *** directly binds to the target viral mRNA and recruits the cellular RNA degradation machinery to degrade the *** significant sequence similarity or obvious common motifs have been found in the so far identified target viral *** minimum length of the target sequence is about 500 nt *** workable ZAP-binding RNAs should facilitate further studies on the ZAP-RNA interaction and characterization of such RNAs may provide some insights into the underlying *** this study,we used the SELEX method to isolate ZAP-binding RNA *** 21 rounds of selection,ZAP-binding aptamers were *** analysis revealed that they are G-rich RNAs with predicted stem-loop structures containing conserved“GGGUGG”and“GAGGG”motifs in the loop *** of the aptamer sequence into a luciferase reporter failed to render the reporter sensitive to ***,overexpression of the aptamers modestly but significantly reduced ZAP’s antiviral *** of the conserved motifs of the aptamers significantly impaired their ZAP-binding ability and ZAP-antagonizing activity,suggesting that the RNA sequence is important for specific interaction between ZAP and the target *** aptamers identified in this report should provide useful tools to further investigate the details of the interaction between ZAP and the target RNAs.

关键词： zinc-finger antiviral protein(ZAP) SELEX RNA aptamers

Theoretical study of M_(6)X_(2) and M_(6)XX'structure(M=Au,Ag;X,X'=S,Se):Electronic and optical properties,ability of photocatalytic water splitting,and tunable properties under biaxial strain

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Chinese Physics B 2022年第9期31卷 450-459页

作者： Jiaqi Li xinlu Cheng Hong Zhang College of Physics Sichuan UniversityChengdu 610065China Key Laboratory of High Energy Density Physics and Technology(Ministry of Education) Sichuan UniversityChengdu 610065China .Institute of Atomic and Molecular Physics Sichuan UniversityChengdu 610065China

MoS_(2),a transition metal dichalcogenide(TMDC),has attracted significant amount of attention due to its direct bandgap,tunability and optical ***,a novel structure consisting of MoS_(2) and noble metal nanoclusters has been *** by this,first principle calculations are implemented to predict the structures of M_(6)X_(2) and M_(6)XX'(M=Au,Ag;X,X'=S,Se).The calculated bandgap,band edge position,and optical absorption of these structures prove that the silver compounds(Ag_(6)X_(2) and Ag_(6)XX')have great potential for catalytic water *** addition,biaxial strain(tensile strain and compressive strain)is applied to adjust the properties of these *** bandgap presents a quasi-linear trend with the increase of the applied ***,the transition between the direct and indirect bandgap is *** outstanding electronic and optical properties of these materials provide strong evidence for their application in microelectronic devices,photoelectric devices,and photocatalytic materials.

关键词： M_(6)XX'structure water spliting biaxial strain electronic properties optical absorption

YB-1 stabilizes HIV-1 genomic RNA and enhances viral production

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Protein & Cell 2013年第8期4卷 591-597页

作者： Xin Mu Wei Li xinlu Wang Guangxia Gao Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

HIV-1 utilizes cellular factors for effi cient *** viral RNA is different from cellular mRNAs in many aspects,and is prone to attacks by cellular RNA quality control *** establish effective infection,the virus has evolved multiple mechanisms to protect its ***,we show that expression of the Y-box binding protein 1(YB-1)enhanced the production of *** of endogenous YB-1 in producer cells decreased viral ***-1 increased viral protein expression by stabilizing HIV-1 *** stem loop 2 in the HIV-1 RNA packaging signal was mapped to be the YB-1-responsive *** together,these results indicate that YB-1 stabilizes HIV-1 genomic RNA and thereby enhances HIV-1 gene expression and viral production.

关键词： Y-box binding protein 1 HIV-1 RNA stability

Stability,electronic structure,and optical properties of lead-free perovskite monolayer Cs3B2X9(B=Sb,Bi;X=Cl,Br,I)and bilayer vertical heterostructure Cs_(3)B_(2)X_(9)/Cs3B’2X9(B,B’=Sb,Bi;X=Cl,Br,I)

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Chinese Physics B 2022年第2期31卷 538-546页

作者： Yaowen Long Hong Zhang xinlu Cheng College of Physics Sichuan UniversityChengdu 610065China Key Laboratory of High Energy Density Physics and Technology(Ministry of Education) Sichuan UniversityChengdu 610065China Institute of Atomic and Molecular Physics Sichuan UniversityChengdu 610065China

The lead-free perovskites Cs_(3)B_(2)X_(9)(B=Sb,Bi;X=Cl,Br,I)as the popular photoelectric materials have excellent optical properties with lower *** this study,we systematically investigate the stable monolayer Cs_(3)B_(2)X_(9)and bilayer vertical heterostructure Cs_(3)B_(2)X_(9)/Cs3B02X9(B,B0=Sb,Bi;X=Cl,Br,I)via first-principles *** exploring the electrical structures and band edge positions,we find the band gap reduction and the band type transition in the heterostructure Cs_(3)B_(2)X_(9)/Cs3B02X9 due to the charge transfer between ***,the results of optical properties reveal light absorption from the visible light to UV region,especially monolayer Cs3Sb2I9 and heterostructure Cs3Sb2I9/Cs3Bi2I9,which have absorption peaks in the visible light region,leading to the possibility of photocatalytic water *** results provide insights for more two-dimensional semiconductors applied in the optoelectronic and photocatalytic fields.

关键词： first principles simulations lead-free perovskite monolayer Cs_(3)B_(2)X_(9) vertical heterostructure Cs_(3)B_(2)X_(9)/Cs_(3)B’_(2)X_(9) photoelectric materials

Indoor evacuation model based on visual-guidance artificial bee colony algorithm

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Building Simulation 2022年第4期15卷 645-658页

作者： xinlu Zong Aiping Liu Chunzhi Wang Zhiwei Ye Jiayuan Du College of Computer Science and Technology Hubei University of TechnologyNo.28Nanli RoadHong-shan DistrictWuchangWuhanHubei ProvinceChina

Research on evacuation simulation and modeling is an important and urgent issue for emergency *** paper presents an evacuation model based on cellular automata and social force to simulate the evacuation *** force of target position,repulsive forces of individuals and obstacles,as well as congestion are considered in order to simulate the interaction among evacuees and the changing environment.A visual-guidance-based artificial bee colony algorithm is proposed to optimize the evacuation *** evacuee moves toward exits with the guidance of leading bee in his/her visual *** leading bee is selected according to comprehensive factors including distance from the current individual,the number of obstacles and congestion,which avoids the randomness of roulette mechanism used by basic artificial bee colony *** experimental results indicate that the proposed model and algorithm can achieve effective performances for indoor evacuation problems with a large number of evacuees and obstacles,which accords with the actual evacuation situation.

关键词： evacuation model artificial bee colony algorithm visual guidance cellular automata social force

Automatic Navigation for Rat-Robots with Modeling of the Human Guidance

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Journal of Bionic Engineering 2013年第1期10卷 46-56页

作者： Chao Sun Nenggan Zheng xinlu Zhang Weidong Chen Xiaoxiang Zheng Qiushi Academy for Advanced Studies (QAAS) Zhejiang University Hangzhou 310027 P. R. China College of Computer Science and Technology Zhejiang University Hangzhou 310027 P. R. China Department of Biomedical Engineering Zhejiang University Hangzhou 310027 P. R. China

A bio-robot system refers to an animal equipped with Brain-Computer Interface （BCI）, through which the outer stimulation is delivered directly into the animal＇s brain to control its behaviors. The development ofbio-robots suffers from the dependency on real-time guidance by human operators. Because of its inherent difficulties, there is no feasible method for automatic con- trolling of bio-robots yet. In this paper, we propose a new method to realize the automatic navigation for bio-robots. A General Regression Neural Network （GRNN） is adopted to analyze and model the controlling procedure of human operations. Com- paring to the traditional approaches with explicit controlling rules, our algorithm learns the controlling process and imitates the decision-making of human-beings to steer the rat-robot automatically. In real-time navigation experiments, our method suc- cessfully controls bio-robots to follow given paths automatically and precisely. This work would be significant for future ap- plications of bio-robots and provide a new way to realize hybrid intelligent systems with artificial intelligence and natural biological intelligence combined together.

关键词： bio-robot rat-robots brain-computer interface automatic navigation