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Esophageal ulcer and multisystem inflammatory syndrome after COVID-19:A case report

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World Journal of Gastrointestinal Endoscopy 2024年第8期16卷 483-488页

作者： Ni Yang zhen.Liu Tong Jin Hai-Wei xin Li Gu Yue zhen. Hui-xing Zhou Ning Li xin-Juan Liu Department of Gastroenterology Beijing Chao-Yang HospitalCapital University of Medical ScienceBeijing 100020China Department of Infectious Diseases and Clinical Microbiology Beijing Chao-Yang HospitalCapital University of Medical ScienceBeijing 100020China Department of Surgical Intensive Care Unit Beijing Chao-Yang HospitalCapital University of Medical ScienceBeijing 100020China Department of Hematology Beijing Chao-Yang HospitalCapital University of Medical ScienceBeijing 100020China

BACKGROUND Multisystem inflammatory syndrome in adults(MIS-A)is a rare but severe disease occurring several weeks after severe acute respiratory syndrome coronavirus 2 *** develops in adults with inflammation of different organs including the gastrointestinal tract,heart,kidneys,skin and hematopoietic *** SUMMARY We present a 58-year-old Chinese man diagnosed with *** chief complaints were fever,generalized fatigue and anorexia,accompanied with rashes on his *** examination showed cardiac,renal and liver *** had melena and gastroscopy indicated esophageal ulcer and severe *** blood and sputum culture did not show growth of bacteria or *** treatment was stopped due to unsatisfactory *** condition improved after prednisone and other supportive *** Gastrointestinal involvement in MIS-A is not *** involvement predominates,and esophageal involvement is rarely *** ulcer with bleeding could also be a manifestation of MIS-A.

关键词： Multisystem inflammatory syndrome Esophageal ulcer SARS-CoV-2 Gastrointestinal bleeding Case report

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锰负载炭化土壤对重金属的吸附性能及机理

中国环境科学 2024年第7期44卷 3900-3909页

作者：于珍珍杨一帆高航王明新常州大学环境科学与工程学院江苏常州213164

采用高锰酸钾预处理和限氧热解相结合的方法处理石油污染土壤(PCS),并将其转化为负载锰氧化物的炭化土壤(Mn-CS).与单独热解处理获得的炭化土壤相比,Mn-CS粗糙多孔,具有更高的比表面积、微孔体积和更低的可溶有机物浸出风险.Langmuir等... 详细信息

采用高锰酸钾预处理和限氧热解相结合的方法处理石油污染土壤(PCS),并将其转化为负载锰氧化物的炭化土壤(Mn-CS).与单独热解处理获得的炭化土壤相比,Mn-CS粗糙多孔,具有更高的比表面积、微孔体积和更低的可溶有机物浸出风险.Langmuir等温线模型和拟二阶动力学模型可以很好地拟合Mn-CS对重金属的吸附特性.Mn-CS对Pb^(2+)、Cu^(2+)、Zn^(2+)和Cd^(2+)的最大理论吸附量分别为420.54,81.19,79.73,26.40mg/***-CS吸附的重金属主要与Fe/Mn氧化物结合,其次与碳酸盐和有机物结合.吸附过程以单层化学吸附为主,主要机理包括表面络合、共沉淀和矿物束缚/沉淀.高锰酸钾预处理增加了土壤表面的碳酸盐、锰氧化物和无定形碳含量,从而协同提升了Mn-CS对重金属的吸附性能.本研究提供了实现PCS增值转化的新方法,助推PCS治理从达标修复走向资源化利用.

关键词：石油污染土壤热解高锰酸钾重金属吸附剂

Polysulfide regulation by defect-modulated Ta_(3)N_(5-x) electrocatalyst toward superior room-temperature sodium-sulfur batteries

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Science Bulletin 2024年第2期69卷 197-208页

作者： zhen.Zhang Dan Luo Jun Chen Chuyin Ma Matthew Li Haoze Zhang Renfei Feng Rui Gao Haozhen.Dou aiping Yu xin Wang Zhongwei Chen Department of Chemical Engineering Waterloo Institute for NanotechnologyUniversity of WaterlooWaterloo N2L 3G1Canada Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023China South China Academy of Advanced Optoelectronics&International Academy of Optoelectronics at Zhaoqing South China Normal UniversityGuangzhou 510006China Chemical Sciences and Engineering Division Argonne National LaboratoryLemont 60439USA Canadian Light Source Saskatoon S7N 2V3Canada

Resolving low sulfur reaction activity and severe polysulfide dissolution remains challenging in metalsulfur *** by a theoretical prediction,herein,we strategically propose nitrogenvacancy tantalum nitride(Ta3N5-x)impregnated inside the interconnected nanopores of nitrogendecorated carbon matrix as a new electrocatalyst for regulating sulfur redox reactions in roomtemperature sodium-sulfur *** a pore-constriction mechanism,the nitrogen vacancies are controllably constructed during the nucleation of *** defect manipulation on the local environment enables well-regulated Ta 5d-orbital energy level,not only modulating band structure toward enhanced intrinsic conductivity of Ta-based materials,but also promoting polysulfide stabilization and achieving bifunctional catalytic capability toward completely reversible polysulfide ***,the interconnected continuous Ta3N5-x-in-pore structure facilitates electron and sodium-ion transport and accommodates volume expansion of sulfur species while suppressing their shuttle *** to these attributes,the as-developed Ta3N5-x-based electrode achieves superior rate capability of 730 mAh g-1 at 3.35 A g-1,long-term cycling stability over 2000 cycles,and high areal capacity over 6 mAh cm-2 under high sulfur loading of 6.2 mg *** work not only presents a new sulfur electrocatalyst candidate for metal-sulfur batteries,but also sheds light on the controllable material design of defect structure in hopes of inspiring new ideas and directions for future research.

关键词： Tantalum nitride Nitrogen defects Sodium-sulfur batteries Electrocatalysts Polysulfide conversion

X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway

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World Journal of Diabetes 2024年第6期15卷 1299-1316页

作者： Ming-Wei Du xin-Lin Zhu Dong-xing Zhang Xian-zhen.Chen Li-Hua Yang Jin-Zhou Xiao Wen-Jie Fang Xiao-Chun Xue Wei-Hua Pan Wan-Qing Liao Tao Yang Institute of Cardiovascular Disease Shanghai Key Laboratory of Traditional Chinese Clinical MedicineShanghai University of Traditional Chinese MedicineShanghai 200120China Department of Dermatology Shanghai Key Laboratory of Molecular Medical MycologySecond Affiliated Hospital of Naval Medical UniversityShanghai 200003China Department of Dermatology Dongshan HospitalMeizhou 514000Guangdong ProvinceChina Department of Dermatology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250000Shandong ProvinceChina Department of Emergency Naval Hospital of Eastern TheaterZhoushan 316000Zhejiang ProvinceChina Department of Pharmacy 905th Hospital of People’s Liberation Army of China(PLA)NavyShanghai 200052China

BACKGROUND Diabetic foot ulcers(DFU),as severe complications of diabetes mellitus(DM),significantly compromise patient health and carry risks of amputation and *** To offer new insights into the occurrence and development of DFU,focusing on the therapeutic mechanisms of X-Paste(XP)of wound healing in diabetic *** Employing traditional Chinese medicine ointment preparation methods,XP combines various medicinal ***-performance liquid chromatography(HPLC)identified XP’s main *** streptozotocin(STZ)-induced diabetic,we aimed to investigate whether XP participated in the process of diabetic wound ***-sequencing analyzed gene expression differences between XP-treated and control *** docking clarified XP’s treatment mechanisms for diabetic wound *** umbilical vein endothelial cells(HUVECs)were used to investigate the effects of Andrographolide(Andro)on cell viability,reactive oxygen species generation,apoptosis,proliferation,and metastasis in vitro following exposure to high glucose(HG),while NF-E2-related factor-2(Nrf2)knockdown elucidated Andro’s molecular *** XP notably enhanced wound healing in mice,expediting the healing ***-sequencing revealed Nrf2 upregulation in DM tissues following XP *** identified 21 primary XP components,with Andro exhibiting strong Nrf2 *** mitigated HG-induced HUVECs proliferation,metastasis,angiogenic injury,and inflammation *** alleviates HG-induced HUVECs damage through Nrf2/HO-1 pathway activation,with Nrf2 knockdown reducing Andro’s proliferative and endothelial protective *** XP significantly promotes wound healing in STZ-induced diabetic *** XP’s key component,Andro activates the Nrf2/HO-1 signaling pathway,enhancing cell proliferation,tubule formation,and inflammation reduction.

关键词： Words:Diabetes mellitus Wound healing NF-E2-related factor-2/HO-1 signaling pathway Andrographolide

基于物理信息神经网络的气膜冷却湍流模型反演学习

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动力工程学报 2024年第9期44卷 1459-1465页

作者：张振苏欣荣袁新清华大学能源与动力工程系北京100084

由于气膜冷却问题中湍流的复杂特性,传统雷诺平均(RANS)方法会低估湍流的热扩散强度,导致冷却效果计算不准确。对此提出了一套基于物理信息神经网络(PINN)的湍流建模框架,基于RANS流场和大涡模拟(LES)温度场,建立了数据驱动的湍流普朗... 详细信息

由于气膜冷却问题中湍流的复杂特性,传统雷诺平均(RANS)方法会低估湍流的热扩散强度,导致冷却效果计算不准确。对此提出了一套基于物理信息神经网络(PINN)的湍流建模框架,基于RANS流场和大涡模拟(LES)温度场,建立了数据驱动的湍流普朗特数神经网络模型,在RANS求解器中嵌入该模型,可以动态调整湍流的热扩散强度,获得了与LES高度一致的温度场。结果表明:PINN是构建数据驱动湍流模型的良好方法,对于湍流普朗特数的建模可以有效提升RANS方法对温度预测的准确性。

关键词：气膜冷却物理信息神经网络湍流普朗特数机器学习湍流模型

Combined ATAC-seq,RNA-seq,and GWAS analysis reveals glycogen metabolism regulatory network in Jinjiang oyster(Crassostrea ariakensis)

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Zoological Research 2024年第1期45卷 201-214页

作者： Biao Wu Xi Chen Jie Hu zhen.Yuan Wang Yan Wang Da-You Xu Hao-Bing Guo Chang-Wei Shao Li-Qing Zhou Xiu-Jun Sun Tao Yu Xiao-Mei Wang Yan-xin zhen. Guang-Yi Fan Zhi-Hong Liu State Key Laboratory of Mariculture Biobreeding and Sustainable Goods Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdaoShandong 266071China Laboratory for Marine Fisheries Science and Food Production Processes Laoshan LaboratoryQingdaoShandong 266071China BGI-Qingdao BGI-ShenzhenQingdaoShandong 266426China National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean UniversityShanghai 201306China Changdao Enhancement and Experiment Station Chinese Academy of Fishery SciencesYantaiShandong 265800China State Key Laboratory of Agricultural Genomics BGI-ShenzhenShenzhenGuangdong 518083China

Glycogen serves as the principal energy reserve for metabolic processes in aquatic shellfish and substantially contributes to the flavor and quality of *** Jinjiang oyster(Crassostrea ariakensis)is an economically and ecologically important species in *** the present study,RNA sequencing(RNA-seq)and assay for transposase-accessible chromatin using sequencing(ATAC-seq)were performed to investigate gene expression and chromatin accessibility variations in oysters with different glycogen *** identified 9483 differentially expressed genes(DEGs)and 7215 genes with significantly differential chromatin accessibility(DCAGs)were obtained,with an overlap of 2600 genes between ***,a significant proportion of these genes were enriched in pathways related to glycogen metabolism,including“Glycogen metabolic process”and“Starch and sucrose metabolism”.In addition,genome-wide association study(GWAS)identified 526 single nucleotide polymorphism(SNP)loci associated with glycogen *** loci corresponded to 241 genes,63 of which were categorized as both DEGs and *** study enriches basic research data and provides insights into the molecular mechanisms underlying the regulation of glycogen metabolism in ***.

关键词： Crassostrea ariakensis Glycogen Transcriptome ATAC GWAS

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天山北坡经济带植被覆盖度动态变化研究

中国环境科学 2024年第2期44卷 1020-1031页

作者：郝鑫怡张喆郑浩高宁真新疆大学地理与遥感科学学院新疆乌鲁木齐830046 新疆绿洲生态自治区重点实验室新疆乌鲁木齐830046 智慧城市与环境建模自治区普通高校重点实验室新疆乌鲁木齐830046

为探明天山北坡经济带植被覆盖度时空变化及其原因,本研究基于MODIS13Q1NDVI数据、气象数据、地形数据、人文数据,基于Google Earth Engine(GEE)平台,利用Theil-Sen Median趋势分析、Mann-Kendall显著性检验和稳定性分析方法,探究2000-2... 详细信息

为探明天山北坡经济带植被覆盖度时空变化及其原因,本研究基于MODIS13Q1NDVI数据、气象数据、地形数据、人文数据,基于Google Earth Engine(GEE)平台,利用Theil-Sen Median趋势分析、Mann-Kendall显著性检验和稳定性分析方法,探究2000-2020年天山北坡经济带植被覆盖度(FVC)时空变化特征及其影响因子.结果表明:天山北坡经济带的FVC表现为两条平行的高覆盖度带.其中中部地区具有较高的植被覆盖度,而边缘地区的植被覆盖度相对较低.2000~2020年间,天山北坡经济带的FVC在时空上呈轻度变化,约占总变化的70%.植被改善区域主要呈现带状分布,集中在研究区的中部,而植被减少区域主要分布在研究区的南缘.整体上,天山北坡的植被覆盖度呈现出西北至东南的相间分布趋势,并且有逐渐上升的趋势.与东部地区相比,西部地区的植被改善更为明显.2000~2020年间,天山北坡经济带的FVC整体上表现出较高的稳定性和较小的波动,其变异程度介于弱变异和中等变异之间.但是,在克拉玛依市北部、乌鲁木齐市西南部以及研究区南缘的零星地区,FVC存在较强的变异.通过地理探测器模型对天山北坡经济带FVC影响因素的研究表明,人类活动(人口密度、夜间灯光和土地利用类型)是FVC空间分异的主要解释因素.从驱动因素来看,人口密度P值为0.283,对FVC影响最大,夜间灯光P值为0.125,土地利用类型P值为0.179.

关键词： GEE MODIS13Q1 植被覆盖度时空变化地理探测器天山北坡

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甲基苯丙胺成瘾的表观遗传学机制

生物化学与生物物理进展 2024年第4期51卷 873-880页

作者：刘明鑫司紫珍刘昱宁波大学医学部宁波315211

苯丙胺类兴奋剂是全世界第二大滥用程度的药物,甲基苯丙胺作为苯胺类兴奋剂中的主要药物,是中国滥用的“头号毒品”。而现有的研究对甲基苯丙胺成瘾机制尚不清晰,且临床上对药物成瘾的治疗依然存在无药可医的局面。因此,发现新的成瘾机... 详细信息

苯丙胺类兴奋剂是全世界第二大滥用程度的药物,甲基苯丙胺作为苯胺类兴奋剂中的主要药物,是中国滥用的“头号毒品”。而现有的研究对甲基苯丙胺成瘾机制尚不清晰,且临床上对药物成瘾的治疗依然存在无药可医的局面。因此,发现新的成瘾机制和治疗策略尤为迫切。甲基苯丙胺成瘾与额前叶皮质(mPFC)、中脑腹侧被盖区(VTA)和伏隔核(NAc)中的多巴胺(DA)、谷氨酸(Glu)、去甲肾上腺素(NE)和血清素(SNRIS)等神经递质的异常释放有关。研究表明,这些神经递质受到表观遗传机制中组蛋白乙酰化、甲基化、泛素化和非编码RNA等调节,某些基因的表达在甲基苯丙胺的诱导过程中增强或被抑制,导致甲基苯丙胺依赖性产生。本文将针对表观遗传学对甲基苯丙胺成瘾机制的影响进行着重论述,以期推进临床开发甲基苯丙胺戒断药物的研究。

关键词：甲基苯丙胺表观遗传学组蛋白修饰非编码RNA

基于空间尺度效应的山东省PM_(2.5)浓度时空变化及空间分异地理探测

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环境科学 2024年第5期45卷 2596-2612页

作者：徐勇韦梦新邹滨郭振东李沈鑫中南大学地球科学与信息物理学院长沙410083 桂林理工大学测绘地理信息学院桂林541006

基于PM_(2.5)遥感数据,采用Theil-Sen Median趋势分析和Mann-Kendall显著性检验,分析2000~2021年山东省PM_(2.5)浓度时空变化特征,结合地理探测器,在省-市-县三级空间尺度上探测影响山东省PM_(2.5)浓度空间分异的影响因子影响力.结果表... 详细信息

基于PM_(2.5)遥感数据,采用Theil-Sen Median趋势分析和Mann-Kendall显著性检验,分析2000~2021年山东省PM_(2.5)浓度时空变化特征,结合地理探测器,在省-市-县三级空间尺度上探测影响山东省PM_(2.5)浓度空间分异的影响因子影响力.结果表明:①时间上,2000~2021年山东省ρ(PM_(2.5))均值在38.15~88.63μg·m^(−3)之间,略微高于《环境空气质量标准》中可吸入颗粒物的二级标准限值(35μg·m^(−3)).在年际尺度上,2013年是ρ(PM_(2.5))变化的峰值年,其值为83.36μg·m^(−3),据此将山东省PM_(2.5)浓度变化趋势分为两个阶段:持续上升和快速下降阶段.在季节尺度上,PM_(2.5)浓度呈现“夏低冬高,春秋居中”分布特征和先降后升的“U”型变化规律.②空间上,山东省PM_(2.5)浓度呈现出“西高东低”的空间分布格局,PM_(2.5)浓度高值区分布山东省西部地区,低值区则分布在东部半岛地区.PM_(2.5)浓度空间变化趋势呈现显著的空间异质性,极显著下降的区域主要分布在东部半岛地区.③因子探测结果表明,气候因子是影响山东省PM_(2.5)浓度空间分异的重要影响因素,平均气温对山东省PM_(2.5)浓度空间分异的影响最高,q值为0.512.省-市-县多尺度探测结果显示,影响PM_(2.5)浓度空间分异的影响因子及其影响力在不同空间尺度上具有差异性.省级尺度上,平均气温、日照时数和坡度是影响PM_(2.5)浓度空间分异的主要影响因子;市级尺度上,降水、高程和相对湿度是影响PM_(2.5)空间分异的主要影响因子;县级尺度上,降水、平均气温和日照时数是影响PM_(2.5)浓度空间分异的主要影响因子.

关键词：山东省 PM_(2.5)浓度多尺度时空变化地理探测器影响因素