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儿童重症肺炎病原学及PCT和IL-8及CRP水平变化的临床意义

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中华医院感染学杂志 2024年第8期34卷 1232-1236页

作者：茅慧萍徐小娟俞红粉徐红余新亮董彩侠绍兴市中心医院儿科浙江绍兴312030

目的了解重症肺炎(SP)患儿病原菌分布及耐药性,并分析患儿降钙素原清除率(PCTc)、白细胞介素-8(IL-8)、C-反应蛋白(CRP)水平变化及临床意义。方法选取2022年1月-2023年6月绍兴市中心医院收治的142例SP患儿(SP组)及90例普通肺炎患儿(普... 详细信息

目的了解重症肺炎(SP)患儿病原菌分布及耐药性,并分析患儿降钙素原清除率(PCTc)、白细胞介素-8(IL-8)、C-反应蛋白(CRP)水平变化及临床意义。方法选取2022年1月-2023年6月绍兴市中心医院收治的142例SP患儿(SP组)及90例普通肺炎患儿(普通肺炎组)为研究对象,采集SP患儿呼吸道痰液,进行细菌培养及药敏分析;检测所有患儿入院时IL-8、CRP水平及治疗24h的PCTc;SP组患儿根据治疗10d后临床效果,分为好转组和恶化组,比较两组临床资料及PCTc、IL-8、CRP水平,采用多因素Logistic回归分析法探究患儿预后影响因素。结果142例SP患儿痰培养共分离病原菌163株,其中革兰阴性菌以肺炎克雷伯菌、铜绿假单胞菌为主;肺炎克雷伯菌对氨苄西林、头孢唑林耐药率>80%;铜绿假单胞菌对氨苄西林、头孢唑林绝对耐药,对磺胺甲噁唑/甲氧苄啶、头孢西丁耐药率>80%;SP组PCTc低于普通肺炎组,IL-8、CRP高于普通肺炎组(P<0.05);好转组小儿危重病例评分(PCIS)较恶化组高(P<0.05),致病菌种类2种、机械通气、伴并发症占比较恶化组低(P<0.05);好转组PCTc高于恶化组,IL-8、CRP低于恶化组(P<0.05);PCIS评分、PCTc、IL-8、CRP均是SP患儿预后的影响因素(P<0.05)。结论SP患儿以革兰阴性菌感染为主,常见病原菌对青霉素类、头孢菌素类抗菌药物耐药性普遍较高,临床应根据病原菌种类及耐药性合理使用抗生素;SP患儿PCTc水平较低,IL-8、CRP升高,且与患儿不良预后有关。

关键词：重症肺炎儿童病原学耐药性降钙素原清除率白细胞介素-8 C-反应蛋白预后

Regularity of Invariant Sets in Variable Internal Damped Wave Equations

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Acta Mathematicae Applicatae Sinica 2020年第4期36卷 952-974页

作者： Gao-cheng yuE yu-xin liang Jia-jia YANG Department of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 211106China

In this paper we prove that every compact invariant subset■associated with the semigroup{Sn,k(t)}t≥0 generated by wave equations with variable damping,either in the interior or on the boundary of the domainΩwhereΩ■R^3 is a smooth bounded domain,in H^10(Ω)×L^2(Ω)is in fact bounded in D(B0)×H^10(Ω)As an application of our results,we obtain the upper-semicontinuity for global attractor of the weakly damped semilinear wave equation in the norm of H^1(Ω)×L^2(Ω)when the interior variable damping converges to theboundary damping in the sense of distributions.

关键词： Damped wave equation boundary damping invariant set regularity

Quantitative Structure-activity Relationship Models of Monomer Reactivity

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Chinese Journal of Structural Chemistry 2019年第11期38卷 1867-1873页

作者： yu xin-liang YI Xiang YANG Hui-Qiong Hunan Provincial Key Laboratory of Environmental Catalysis & Waste Regeneration College of Chemistry and Chemical Engineering Hunan Institute of Engineering

The reactivity parameters,Q and e,in the Q-e scheme reflect the reactivities of a monomer(or a radical)in free-radical *** applying multiple linear regression(MLR)analysis,the optimal quantitative structure-activity relationship(QSAR)model for the reactivity parameter lnQ was developed based on five descriptors(NAF,NOF,EαLUMO,EβHOMO,and EβLUMO)and 69 monomers with the root mean square(rms)error of *** optimal MLR model of the parameter e obtained from five descriptors(TOcl,NpN,NSO,EαHOMO and DH)and 68 monomers produced rms error of *** with previous models,the two optimal MLR models in this paper show satisfactory statistical *** feasibility of combining 2D descriptors obtained from the monomers and 3D descriptors calculated from the radical structures(formed from monomers+H )to predict parameters Q and e has been demonstrated.

关键词： density functional theory molecular descriptors multiple linear regression quantum chemical descriptors quantitative structure-activity relationship

医校联动推进志愿服务融入医学人文教育的策略探讨

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医院管理论坛 2024年第9期41卷 75-77,86页

作者：曹炜康佳立于新亮王明亮北京大学医学人文学院北京大学口腔医院

面对当前医患关系的困境和挑战,志愿服务在发挥自身独特优势,加强医学人文教育方面具有十分重要的作用。本文以一项医学院校和医院联合开展的志愿服务项目为例,分析探究志愿服务融入医学人文教育的实现路径,包括坚持学科优势和临床需求... 详细信息

面对当前医患关系的困境和挑战,志愿服务在发挥自身独特优势,加强医学人文教育方面具有十分重要的作用。本文以一项医学院校和医院联合开展的志愿服务项目为例,分析探究志愿服务融入医学人文教育的实现路径,包括坚持学科优势和临床需求相结合、知识传授和价值塑造相统一、志愿服务和劳动教育相融合、组织引领和个人主动相促进等,以提升医学生、医务人员等人文素养,推动医学人文回归,为建立良好医患关系提供参考。

关键词：志愿服务人文关怀医患关系文化建设

Enhancement of glass-forming ability and thermal stability of a soft magnetic Co_(75)B_(25)metallic glass by micro-alloying Y and Nb

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Journal of Iron and Steel Research International 2021年第5期28卷 597-603页

作者： Feng Bao Yan-hui Li Zheng-wang Zhu xin-yu liang Yan Zhang Wei Zhang Key Laboratory of Materials Modification by Laser Ionand Electron Beams(Ministry of Education)School of Materials Science and EngineeringDalian University of TechnologyDalian 116024LiaoningChina Institute of Metal Research Chinese Academy of SciencesShenyang 110016LiaoningChina Institute for Materials Research Tohoku UniversitySendai 980-8577MiyagiJapan

Soft magnetic Co-based Co-Y-Nb-B bulk metallic glasses(BMGs)without Fe have been developed by micro-alloying Y and Nb into a C075B25 ***,addition of 3^at.%Y promotes the occurrence of glass transition and increases the supercooled liquid stability and magnetic softness.C0_(71.5)Y_(35)B_(25) metallic glass possesses a large supercooled liquid region(△T_(x))of 33 K and low coercivity(H_(c))of l.5 A/*** alloying 2-4 at.% Nb into C0_(71.5)Y_(35)B_(25) alloy further enlarges △T_(x) to 50 K,lowers H_(c) to 0.9 A/m,and enables the formation of BMGs with a critical sample diameter up to 2.0 *** alloying Nb causes the formation of complex(Co,Nb,Y)_(23)B_(6) competing phase during crystallization and widens the melt undercooling during solidification,which improves the supercooled liquid stability and glass-forming ability,***-Y-Nb-B BMGs also exhibit good soft magnetic and mechanical properties,i.e.,lowH_(c)of 0.9-1.2 A/m,relatively high saturation magnetic flux density of 0.36-0.57 T,high yielding strength of 3877-3930 MPa with plastic strain of 0.2%-0.3%,and high Vickers hardness of *** developed soft magnetic Co-based BMGs are promising for applications as structural and functional materials.

关键词： Co-based bulk metallic glass Glass-forming ability Thermal stability Soft magnetic property Micro-alloying

Atypical imaging features of the primary spinal cord glioblastoma:A case report

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World Journal of Clinical Cases 2022年第22期10卷 7950-7959页

作者： xin-yu liang Yao-Ping Chen Qiao Li Ze-Wang Zhou Department of Radiology The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Radiology The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Endocrinology The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina

BACKGROUND Primary spinal cord(PSC)glioblastoma(GB)is an extremely rare but fatal primary tumor of the central nervous system and associated with a poor *** typical tumor imaging features are generally easy to recognize,glioblastoma multiforme can have a wide range of imaging *** GB is often misdiagnosed,which usually delays the optimal time for *** this article,we discuss a clinical case of pathologically confirmed PSC GB under the guise of benign tumor imaging findings,as well as the most recent literature pertaining to PSC *** SUMMARY A 70-year-old female complained of limb weakness lasting more than 20 *** masses were observed inside and outside the left foramina of the spinal canal at C7-T1 on medical *** on the imaging features,radiologists diagnosed the patient with *** resection was performed under general *** final histopathological findings revealed a final diagnosis of PSC GB,world health organization Grade *** patient subsequently underwent a 4-wk course of radiotherapy(60 Gy in 20 fractions)combined with temozolomide *** patient was alive at the time of submission of this *** Atypical GB presented unusual imaging findings,which led to ***,a complete recognition of imaging signs may facilitate early accurate diagnosis.

关键词： Primary spinal cord glioblastoma Atypical imaging features Benign-looking Misdiagnosis Pathology confirmed Case report

THREE-DIMENSIONAL NUMERICAL MODELLING OF SUBMERGED DIKE ALIGNMENT IN CURVED ESTUARINE CHANNEL

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Journal of Hydrodynamics 2005年第5期17卷 601-606页

作者： ZHENG Jin-hai LIU Ying-qi YAN Yi-xin ZHU yu-liang Research Institute of Coastal and Ocean Engineering Hohai University Nanjing 210098 China

Submerged dikes were frequently built in curved estuarine channels to improve navigational conditions. A three-dimensional numerical model of tidal motions was developed to simulate flows through the submerged dike alignment in curved estuarine reach of complex bathymetry on the basis of satisfactory calibrations. Through the analysis of the morphological characteristics of the curved channel of the Huangpu River mouth in the Yangtze River Delta, a submerged dike alignment project was examined. The effect of the navigation channel improvement project and its influence on the flow regimes, the navigational conditions, the flood control and the operating conditions of harbours within the adjacent water area were evaluated, and the technical feasibility of the navigation channel improvement scheme was demonstrated.

关键词： submerged dike alignment three-dimensional numerical model curved estuarine channel morphological analysis

Understanding and improving Yangtze River Basin summer precipitation prediction using an optimal multi-Physics ensemble

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Frontiers of Earth Science 2024年第1期18卷 256-277页

作者： Yang ZHAO Fengxue QIAO xin-Zhong liang Jinhua yu Climate Environment and Sustainability CenterNanjing University of Information Science and TechnologyNanjing 210044China Key Laboratory of Geographic Information Science(Ministry of Education) East China Normal UniversityShanghai 200241China School of Geographic Sciences East China Normal UniversityShanghai 200241China Department of Atmospheric and Oceanic Science University of MarylandCollege Park MD 20740USA Earth System Science Interdisciplinary Center University of MarylandCollege Park MD 20740USA Key Laboratory of Meteorological Disaster(KLME)(Ministry of Education)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Nanjing University of Information Science and TechnologyNanjing 210044China

This study employs the regional Climate-Weather Research and Forecasting model(CWRF)to first investigate the primary physical mechanisms causing biases in simulating summer precipitation over the Yangtze River Basin(YRB),and then enhance its predictive ability through an optimal multi-physics ensemble *** CWRF 30-km simulations in China are compared among 28 combinations of varying physics parameterizations during 1980−***-term average summer biases in YRB precipitation are remotely correlated with those of large-scale *** teleconnections of biases are highly consistent with the observed correlation patterns between interannual variations of precipitation and circulations,despite minor shifts in their primary action *** YRB precipitation aligns with a southward shifted East Asian westerly jet,an intensified low-level southerly flow south of YRB,and a south-eastward shifted South Asian high,alongside higher moisture availability over ***,decreased YRB precipitation corresponds to an opposite circulation *** CWRF control configuration using the ensemble cumulus parameterization(ECP),compared to other cumulus schemes,best captures the observed YRB precipitation characteristics and associated circulation *** ECP with the Morrison or Morrison-aerosol microphysics and the CCCMA or CAML radiation schemes enhances the overall CWRF *** to the control CWRF,the ensemble average of these skill-enhanced physics configurations more accurately reproduces YRB summer precipitation’s spatial distributions,interannual anomalies,and associated circulation *** Bayesian Joint Probability calibration to these configurations improves the ensemble’s spatial distributions but compromises its interannual anomalies and teleconnection *** findings highlight substantial potential for refining the representation of climate system physics to improve YRB precipitation *** is notabl

关键词： physics parameterization regional climate model downscaling skill enhancement multi-physics ensemble teleconnection bias reduction

Controllable Ring-opening Polymerization ofδ-Valerolactone Catalyzed by Quinolinyl-Urea/MTBD Systems

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Chinese Journal of Polymer Science 2024年第8期42卷 1103-1110页

作者： xin-yu Liu liang Zhu Su-yun Jie Bo-Geng Li State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310058China

Due to their excellent biocompatibility and biodegradability,aliphatic polyesters are widely used in the biomedical,packaging and agricultural fields,which are usually accessed by the ring-opening polymerization(ROP)of lactones and the catalysts particularly play an important *** a series of quinolinyl-urea catalysts have been synthesized via the reaction between isocyanate and aminoquinoline with an amino group at different substitution positions and *** combination with 7-methyl-1,5,7-triazabicyclo[4,4,0]dec-5-ene(MTBD)as a cocatalyst and benzyl alcohol(BnOH)as an initiator,1-(3,5-bis(trifluoromethyl)phenyl)-3-(quinolin-3-yl)urea(3-QU)was observed to be most active for the ROP ofδ-valerolactone(δ-VL).The polymerization conditions were optimized by varying the type of organic base,catalyst concentration and reaction *** changing the ratio of[M]_0/[I],linear polyvalerolactones(PVLs)with different molecular weights and narrow molecular weight distribution were *** kinetic and chain extension experiments were carried out to prove the"living"/controllable *** the NMR experiments were used to support the proposal of possible mechanism.

关键词： Quinolinyl-urea Ring-opening polymerization PVL