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Effect of Electroacupuncture on Neurological Deficit and Activity of Clock and Bmal1 in Cerebral Ischemic Rats

Current Medical Science 2020年第6期40卷 1128-1136页

作者： xin-yin xu Qi FANG Wei HUANG Bo-cun LI Xiao-hong ZHOU Zhong-yu ZHOU Jia LI Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion Hubei University of Chinese MedicineWuhan 430061China Department of Acupuncture Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Acupuncture&Moxibustion Hubei Provincial Hospital of Traditional Chinese medicineWuhan 430061China

Acute focal cerebral ischemic stroke(IS)is a leading cause of morbidity and mortality *** is an emerging alternative therapy that has been beneficial to acute brain ***,the underlying protective mechanism of its neuroprotective effect remains *** original circadian rhythm will be lost after IS,which seriously affects the quality of life and functional recovery of stroke *** hypothesize that acupuncture treats IS by regulating the balance of Clock and *** study aims to explore the effect of acupuncture at acupoints GV20 and BL23 on neuroprotection and anti-apoptosis in middle cerebral artery occlusion(MCAO)rats and expression of apoptosis and circadian rhythm related *** Sprague-Dawley(SD)rats were randomly divided into five groups:normal group(Normal),sham model group(Sham MCAO),MCAO model group(MCAO),sham electroacupuncture group(Sham EA)and electroacupuncture group(EA).The MCAO model was prepared by *** first acupuncture treatment was performed within 2 h after surgery,and then acupuncture therapy was performed on 1st day,2nd day and 3rd day *** their neurological examination at 72 h of ischemia,the rats from each group were *** chloride(TTC)staining was used to evaluate the brain infarct *** observation on cerebral ischemic cortex and serum inflammatory cytokines were *** staining was used to detect cell apoptosis of brain *** expression levels of proteins Bax,bcl-2,caspase-3,Clock and Bmal1 in the cerebral ischemic region were detected by immunofluorescence ***,we presented evidence that EA at GV20 and BL23 could significantly improve the neurological deficit score and infarct size,and alleviate the cell apoptosis of brain ***,acupuncture treatment upregulated the anti-apoptotic Bcl-2/Bax ratio and reversed the upregulation of caspase-3 following 72-h cerebral *** additio

关键词： acupuncture anti-apoptosis middle cerebral artery occlusion circadian rhythms

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Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan yin Jiahui Kang xuan Cheng Hui Gao Shujia Huo Haiwei xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

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Identification and characterization of a novel ubiquitin-related gene(TaRUB1)from wheat

Identification and characterization of a novel ubiquitin-rel...

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中国作物学会50周年庆祝会暨2011年学术年会

作者： Zhang ying,Ma xin,yin Na,xu Jinqiu,Feng Deshun~*,Wang Honggang College of Agronomy,Shandong Agricultural University,Taian 271018

Suppression subtraction hybridization(SSH) cDNA library was constructed with cDNA from SN6306 leaves inoculated with Blumeria graminis as the tester and cDNA from uninoculated SN6306 leaves as the driver. BlastX results in nr-protein database revealed that 20 ESTs were highly homologous with known proteins involved in the disease resistance and defense *** them,a 648 bp EST was *** alignments with Blast indicated that the EST revealed a high degree of similarity with other members of the plant ubiquitin related(UBR) protein genes in both nucleic and amino acid *** the genomic sequence of this gene was *** analysis showed that the gene was interrupted by two introns,one was 1450 bp and another was 111 *** cDNA contained an open reading frame(ORF) of 462 bp consisting of 153 amino *** acid Blastp indicated that the predicted protein is a fusions protein of the ubiquitin-coding region with that of *** the new gene screened belongs to wheat ubiquitin related genes and was named as TaRUB1(GenBank accession ***927719).The results of quantitative real-time PCR showed that TaRUB1 was up-regulated in leaves infected with powdery mildew in early *** TaRUB1 was induced by powdery mildew infection and might play important roles in wheat resistance to powdery *** of TaRUB1 in transgenic Arabidopsis showed that TaRUB1 ehanced plant tolerance of osmotic and salt ***1 has multiple functions in plant abiotic and biotic stress tolerance.

关键词： Suppression subtraction hybridization(SSH) powdery mildew related-to-ubiquitin(RUB) protein wheat osmotic and salt stress

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Effects of electroacupuncture pretreatment on mitochondrial energy metabolism in the rats with myocardial ischemia reperfusion

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World Journal of Acupuncture-Moxibustion 2020年第2期30卷 120-124页

作者： Yi-xuan xuE Wei HUANG Bi-jiang WAN Xiao-lei ZHANG Yi-meng LIN Li-li XIANG xin-yin xu Hubei University of Chinese Medicine Wuhan 430061China Department of Acupuncture and Moxibustion Hubei Provincial Hospital of TCMWuhan 430061China First Clinical College Hubei University of Chinese MedicineWuhan 430061China

Objective:To explore the effects of electroacupuncture pretreatment on mitochondrial energy metabolism in the rats with myocardial ischemia reperfusion injury(MIRI).Methods:A total of 60 SPF Wistar rats were randomly divided into a sham-operation group(sham group),a myocardial ischemia reperfusion injury group(MIRI group)and an electroacupuncture pretreatment group(EA group),20 rats in each *** rats in the sham group and the MIRI group were binded for 7 days,once a day,20 min each *** the 8th day,the sample was collected after the heart exposed for 50 min in thoractomy in the sham group and the sample was collected after ischemia for 20 min and reperfusion for 30 min in thoractomy in the MIRI *** the EA group,the pretreatment intervention with electroacupuncture was applied at"Neiguan(内关PC6)","Guanyuan(关元CV4)"and"Zusanli(足三里ST36)"in the rats for 7 days,once a day,20 min each *** the 8th day,after ischemia for 20 min and reperfusion for 30 min in thoractomy,the sample was collected in the EA *** changes in STⅡsegment of electroacardiogram(ECG)were observed and *** enzymelinked immunosorbent assay(ELISA),the concentrations of cardiac troponin T(cTnT)and cardiac troponin I(cTnl)were *** nitro blue tetrazolium chloride monohydrate(NBT)staining,the myocardial infarction weight percentage was *** ELISA,the concentrations of mitochondrial adenosine monophosphate(AMP),adenosine diphosphate(ADP)and adenosine triphosphate(ATP)were ***:(1)STⅡchanges:in 20 min of ligation,compared with the sham group,the STⅡsegment of electrocardiograph(ECG)was elevated significantly in the MIRI group and EA group(both P<0.01),but the elevation range in the EA group was lower than that of the MIRI group(P<0.01).After reperfusion for30 min,the STⅡsegment was fallen by over 50%in the MIRI group and the EA ***,the STⅡsegment in the EA group was lower than that of the MIRI group(P<0.01).(2)Regarding myocardial inf

关键词： Myocardial ischemia reperfusion injury(MIRI) Electrioacupunuture pretreatment Mitochondrial energy metabolism ATP ADP AMP

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关中西部地区抗污染性园林植物及其应用调查

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陕西林业科技 2009年第3期33卷 51-54页

作者：辛银绪陕西凤翔陈村镇林业技术推广站陕西凤翔721400

抗污染性园林植物能够吸收土壤中有害物质、净化空气,有效改善城市环境。本文对关中西部受污染较严重的工业区及其他污染较集中地区的绿化植物的应用及生长状况进行了调查和相关资料整理,归纳总结出关中西部地区防治环境污染的主要植物... 详细信息

抗污染性园林植物能够吸收土壤中有害物质、净化空气,有效改善城市环境。本文对关中西部受污染较严重的工业区及其他污染较集中地区的绿化植物的应用及生长状况进行了调查和相关资料整理,归纳总结出关中西部地区防治环境污染的主要植物种类及其在城市绿化中的应用。以便更好地为城区、工矿区及其他环境条件相似的工业城市的绿化植物选择提供依据。

关键词：抗污染性园林植物关中西部

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Complete response of gallbladder cancer treated with gemcitabine and cisplatin chemotherapy combined with durvalumab:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 226-232页

作者： Kai Chen xu Feng Yuan Shi xin-Lin Li Zheng-Rong Shi Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Gallbladder cancer(GBC)is the most common and aggressive subtype of biliary tract cancer(BTC)and has a poor prognosis.A newly developed regimen of gemcitabine,cisplatin,and durvalumab shows promise for the treatment of advanced ***,the efficacy of this treatment for GBC remains *** SUMMARY In this report,we present a case in which the triple-drug regimen exhibited marked effectiveness in treating locally advanced GBC,thus leading to a long-term survival benefit.A 68-year-old man was diagnosed with locally advanced GBC,which rendered him ineligible for curative *** three cycles of therapy,a partial response was *** one year of combined therapy,a clinical complete response was successfully *** maintenance therapy with durvalumab monotherapy resulted in a disease-free survival of 9 months for the *** patient experienced tolerable toxicities of reversible grade 2 nausea and *** adverse events were observed in the patient throughout the entirety of the *** The combination of gemcitabine and cisplatin chemotherapy with durvalumab was proven to be an effective treatment approach for advanced GBC,with manageable adverse *** research is warranted to substantiate the effectiveness of the combined regimen in the context of GBC.

关键词： Gallbladder cancer Chemotherapy Immunotherapy Durvalumab Complete response Case report

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin yin Yalan xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram

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World Journal of Gastroenterology 2025年第2期31卷 71-84页

作者： Yu-Qin Li Wen-Tao Kuai Lin Chen Ming-Hui Zeng xue-Mei Tao Jia-xin Han Yue-Kui Wang Lian-xin xu Li-ying Ge Yong-Gang Liu Shuang Li Liang xu Yu-Qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Pathology Clinical School of the Second People’s HospitalTianjin 300110China Endoscopy Center Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.

关键词： Metabolic dysfunction associated steatotic liver disease Fatty liver Chronic liver disease Colorectal adenomas Hepatitis Risk factors

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Pretreatment red blood cell distribution width as a predictive marker for postoperative complications after laparoscopic pancreatoduodenectomy

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 143-157页

作者： Xian-Rang Cao yin-Long xu Jia-Wei Chai Kai Zheng Jun-Jie Kong Jun Liu Shun-Zhen Zheng Department of Liver Transplantation and Hepatobiliary Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Breast and Thyroid Surgery Shandong Provincial Maternal and Child Health Care HospitalJinan 250014Shandong ProvinceChina

BACKGROUND Red blood cell distribution width(RDW)is associated with the development and progression of various *** To explore the association between pretreatment RDW and short-term outcomes after laparoscopic pancreatoduodenectomy(LPD).METHODS A total of 804 consecutive patients who underwent LPD at our hospital between March 2017 and November 2021 were retrospectively *** between pretreatment RDW and clinicopathological characteristics and short-term outcomes were *** Patients with higher pretreatment RDW were older,had higher Eastern Cooperative Oncology Group scores and were associated with poorer short-term outcomes than those with normal *** pretreatment RDW was an independent risk factor for postoperative complications(POCs)(hazard ratio=2.973,95%confidence interval:2.032-4.350,Pying patients who were at high risk of developing POCs after LPD.

关键词： Biomarker Laparoscopic pancreatoduodenectomy Postoperative complication Red blood cell distribution width Short-term outcomes

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Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting Xiang Xiangxin xing xuyun Hua Yuwen Zhang xin xue Jiajia Wu Mouxiong Zheng He Wang Jianguang xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

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