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World Journal of Pediatrics 2021年第4期17卷 341-354页

作者： Wasim Shuib xin-yin wu Fang Xiao Xiangya School of Public Health Central South UniversityChangsha410078China

Background Off-label and unlicensed prescriptions pose a severe safety concern among the pediatric *** aimed to summarize the up-to-date evidence on the extent,reasons,and consequences of off-label and unlicensed drugs in hospitalized pediatric *** We systematically searched PubMed,EMBASE,SCOPUS,Web of Science and Google Scholar between 1990 and 2020 in which the last search was conducted on 12 February *** included studies with the following inclusion criteria:(1)observational studies in design;(2)target population was hospitalized pediatric patients whether admitted in the intensive care unit or in the general ward;(3)study reporting the prevalence of off-label,unlicensed prescriptions or both;and(4)published in *** A total of 47 studies were eligible for *** proportion of off-label and unlicensed prescriptions ranged from 7.4%to 99.5%and 0.1%to 74.4%,*** most frequent category of off-label prescriptions was prescription outside the age range,with the most commonly reported reason for off-label prescriptions being the lack of information specifically for pediatrics on the drug information *** consequences of off-label and unlicensed prescriptions ranged from minor and bearable skin reactions to debilitating renal failure,risking *** Off-label and unlicensed prescriptions are extensive and require progressively meditative ***,the pediatric population is currently a“therapeutic orphan”.Unless adequate pediatric clinical trials and licensed drugs become available,off-label and unlicensed drug prescription should not entirely be banned but rather promoted in an organized manner.

关键词： Licensed medicines Off-label prescribing Pediatrics Unlicensed prescribing

Impact of mTOR gene polymorphisms and gene-tea interaction on susceptibility to tuberculosis

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World Journal of Clinical Cases 2020年第19期8卷 4320-4330页

作者： Mian Wang Shu-Juan Ma xin-yin wu Xian Zhang Julius Abesig Zheng-Hui Xiao xin Huang Hai-Peng Yan Jing Wang Meng-Shi Chen Hong-Zhuan Tan Hunan Provincial Key Laboratory of Clinical Epidemiology Xiangya School of Public HealthCentral South UniversityChangsha 410078Hunan ProvinceChina Department of Epidemiology and Health Statistics Xiangya School of Public HealthCentral South UniversityChangsha 410078Hunan ProvinceChina Department of Occupational and Environmental Hygiene Xiangya School of Public HealthCentral South UniversityChangsha 410078Hunan ProvinceChina Hunan Provincial Key Laboratory of Pediatric Emergency Hunan Children's HospitalChangsha 410007Hunan ProvinceChina Department of Epidemiology and Health Statistics Hunan Normal UniversityChangsha 410008Hunan ProvinceChina

BACKGROUND mTOR gene is a key component of the PI3K/Akt/mTOR signaling pathway,and its dysregulation is associated with various *** studies have demonstrated that tea drinking is a protective factor against tuberculosis(TB).This study was designed to explore five single nucleotide polymorphisms(SNPs)of mTOR in the Han population of China to determine how their interactions with tea drinking affect susceptibility to *** To investigate if the polymorphisms of mTOR gene and the gene-tea interaction are associated with susceptibility to *** In this case-control study,503 patients with TB and 494 healthy controls were enrolled by a stratified sampling *** cases were newly registered TB patients from the county-level centers for disease control and prevention,and the healthy controls were permanent residents from xin'ansi Community,Changsha *** data and environmental exposure information including tea drinking were obtained from the study *** genotyped five potentially functional SNP sites(rs2295080,rs2024627,rs1057079,rs12137958,and rs7525957)of mTOR gene and assessed their associations with the risk of TB using logistic regression analysis,and marginal structural linear odds models were used to estimate the gene-environment *** The frequencies of four SNPs(rs2295080,rs2024627,rs1057079,and rs7525957)were found to be associated with susceptibility to TB(P<0.05).Genotypes GT(OR 1.334),GG(OR 2.224),and GT+GG(OR 1.403)at rs2295080;genotypes CT(OR 1.562)and CT+TT(OR 1.578)at rs2024627,genotypes CT(OR 1.597),CC(OR 2.858),and CT+CC(OR 1.682)at rs1057079;and genotypes CT(OR 1.559)and CT+CC(OR 1.568)at rs7525957 of mTOR gene were significantly more prevalent in TB patients than in healthy *** relative excess risk of interaction between the four SNPs(rs2295080,rs2024627,rs1057079,and rs7525957)of mTOR genes and tea drinking were found to be-1.5187(95%CI:-1.9826,-1.0547,P<0.05),-1.8270(95%CI:-2.3587,-

关键词： Tuberculosis mTOR Tea drinking Gene-environment interaction The relative excess risk of interaction Single nucleotide polymorphism

Neuronal regulated cell death in aging-related neurodegenerative diseases:key pathways and therapeutic potentials

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Neural Regeneration Research 2025年第8期20卷 2245-2263页

作者： Run Song Shiyi yin Jiannan wu Junqiang Yan Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Neuromolecular Biology Laboratory The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulatory mechanism for regulating neuronal aging and ***,excessive activation of regulated cell death may lead to the progression of aging-related *** review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related ***,the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative *** forms of cell death exacerbate disease progression by promoting inflammation,oxidative stress,and pathological protein *** review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and *** instance,FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis ***,inhibiting the Xc-transport system to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to *** insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death *** conclusion,identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.

关键词： apoptosis autophagy cuproptosis disulfidptosis ferroptosis necroptosis neurodegenerative disease neurological aging diseases PANoptosis pyroptosis

Research on Site Selection Model of Distribution Center of Agricultural Products

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Asian Agricultural Research 2011年第4期3卷 132-134页

作者： LI Yong-xin,yin Chun-wu,HUI Xiao-jian Department of Basic Courses,Xijing University,Xi’an 710123,China

In the light of the practical situation of logistics distribution of agricultural products,we primarily select transportation factor,economic factor,environment factor,and other factors,to establish evaluation index system of site selection of distribution center of agricultural *** then we adopt the analytic hierarchy process method to calculate weight of site selection of distribution center of agricultural *** the circumstance that the evaluation information is interval number,we use uncertain and multiple attribute decision making method to establish site selection model of distribution center of agricultural ***,taking one city as an example,we discuss the application of this model in site selection of distribution center of agricultural *** results of empirical analysis show that the model we established fully considers the randomness and uncertainty in the process of evaluation,so as to make the results of evaluation more objective,in line with *** the effect of evaluation is better as against the former real number evaluation calibration.

关键词： Distribution center of agricultural products Model

Effects of aggregate size distribution and carbon nanotubes on the mechanical properties of cemented gangue backfill samples under true triaxial compression

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 311-324页

作者： Qian yin Fan Wen Zhigang Tao Hai Pu Tianci Deng Yaoyao Meng Qingbin Meng Hongwen Jing Bo Meng Jiangyu wu State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China Key Laboratory of xinjiang Coal Resources Green Mining Ministry of EducationXinjiang Institute of EngineeringUrumqi 830023China

The mechanical behavior of cemented gangue backfill materials(CGBMs)is closely related to particle size distribution(PSD)of aggregates and properties of cementitious ***,the true triaxial compression tests,CT scanning,SEM,and EDS tests were conducted on cemented gangue backfill samples(CGBSs)with various carbon nanotube concentrations(P_(CNT))that satisfied fractal theory for the PSD of *** mechanical properties,energy dissipations,and failure mechanisms of the CGBSs under true triaxial compression were systematically *** results indicate that appropriate carbon nanotubes(CNTs)effectively enhance the mechanical properties and energy dissipations of CGBSs through micropore filling and microcrack bridging,and the optimal effect appears at P_(CNT)of 0.08wt%.Taking PSD fractal dimension(D)of 2.500 as an example,compared to that of CGBS without CNT,the peak strength(σ_(p)),axial peak strain(ε_(1,p)),elastic strain energy(Ue),and dissipated energy(U_(d))increased by 12.76%,29.60%,19.05%,and90.39%,***,excessive CNTs can reduce the mechanical properties of CGBSs due to CNT agglomeration,manifesting a decrease inρ_(p),ε_(1,p),and the volumetric strain increment(Δε_(v))when P_(CNT)increases from 0.08wt%to 0.12wt%.Moreover,the addition of CNTs improved the integrity of CGBS after macroscopic failure,and crack extension in CGBSs appeared in two modes:detour and pass through the ***σ_(p)and U_(d)firstly increase and then decrease with increasing D,and porosity shows the opposite ***ε_(1,p)andΔε_(v)are negatively correlated with D,and CGBS with D=2.150 has the maximum deformation parameters(ε_(1,p)=0.05079,Δε_(v)=0.01990)due to the frictional slip effect caused by coarse *** increasing D,the failure modes of CGBSs are sequentially manifested as oblique shear failure,"Y-shaped"shear failure,and conjugate shear failure.

关键词： cemented gangue backfill materials particle size distribution true triaxial compression test carbon nanotubes mechanical properties failure modes

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鲍鱼肌肉胶原蛋白的提取与性质研究

现代食品科技 2017年第2期33卷 29-34页

作者：马少抗陈俊郝更新翁武银集美大学食品与生物工程学院福建厦门361021 厦门市海洋功能食品重点实验室福建厦门361021

提取了鲍鱼肌肉酸溶性胶原蛋白(ASC)和不同胃蛋白酶质量浓度下的酶溶性胶原蛋白(PSC),并对它们的理化性质进行研究和比较。结果发现,ASC的提取率只有0.63%,低于任一PSC。氨基酸组成结果显示,ASC和PSC的Gly含量都没有达到氨基酸总量的1/3... 详细信息

提取了鲍鱼肌肉酸溶性胶原蛋白(ASC)和不同胃蛋白酶质量浓度下的酶溶性胶原蛋白(PSC),并对它们的理化性质进行研究和比较。结果发现,ASC的提取率只有0.63%,低于任一PSC。氨基酸组成结果显示,ASC和PSC的Gly含量都没有达到氨基酸总量的1/3,但都含有12.03~16.30个Cys残基和9.75~14.68个Tyr残基。根据SDS-PAGE图谱,发现鲍鱼肌肉ASC的α亚基是由160ku的α_1、140 ku的α_2和130 ku的α_3肽链组成,而PSC则是由3条α_1肽链组成。ASC的最大紫外吸收峰出现在224 nm,而PSC却偏移至228 nm。ASC与PSC在粘度特性上存在明显的差异,结果表现为ASC的热变性温度高于任一PSC。Zeta电位测定结果表明,无论是ASC还是PSC,其等电点均在pH 4.90附近。pH和NaCl对ASC的溶解性影响趋势与PSC基本一致,但在同一pH或NaCl浓度下,PSC的溶解度高于ASC,且随着胃蛋白酶添加量的增加出现一定程度的上升。综上所述,鲍鱼肌肉ASC与PSC在理化性质上具有明显的区别。

关键词：鲍鱼肌肉酸溶性胶原酶溶性胶原胃蛋白酶浓度理化性质

Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

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Nano-Micro Letters 2025年第1期17卷 46-97页

作者： Xueyan Zhang Shichao Cheng Chuankai Fu Geping yin Liguang Wang Yongmin wu Hua Huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑Yuan Yu Jing wu Guang yin Fan‑Zhen Jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

舒芬太尼联合地佐辛镇痛在剖宫产术后产妇中的应用效果

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中国当代医药 2019年第32期26卷 155-157页

作者：尹新武罗新萍江西省吉安市妇幼保健院麻醉科

目的探讨舒芬太尼联合地佐辛镇痛在剖宫产术后产妇中的应用效果。方法选择2017年6月~2019年2月在我院的剖宫产术后产妇120例,按照随机数字表法分成对照组和观察组,每组各60例。对照组采取枸橼酸舒芬太尼注射液联合枸橼酸托烷司琼注射液... 详细信息

目的探讨舒芬太尼联合地佐辛镇痛在剖宫产术后产妇中的应用效果。方法选择2017年6月~2019年2月在我院的剖宫产术后产妇120例,按照随机数字表法分成对照组和观察组,每组各60例。对照组采取枸橼酸舒芬太尼注射液联合枸橼酸托烷司琼注射液镇痛,观察组采取枸橼酸舒芬太尼注射液联合地佐辛注射液镇痛,比较两组治疗后的血清泌乳素水平、视觉模拟量表(VAS)、初次泌乳时间、泌乳充足时间及不良反应的发生率。结果两组干预24、48 h后的血清泌乳素水平显著高于干预前,差异有统计学意义(P<0.05);观察组干预24、48 h后的血清泌乳素水平明显高于对照组,差异有统计学意义(P<0.05);观察组干预后初次泌乳时间、泌乳充足时间明显短于对照组,差异有统计学意义(P<0.05);观察组在干预2、4、12、24 h的VAS评分显著低于对照组,差异有统计学意义(P<0.05);观察组嗜睡、头晕、呕吐及恶心的发生率低于对照组,差异有统计学意义(P<0.05)。结论舒芬太尼联合地佐辛镇痛在剖宫产术后产妇中应用效果显著,能有效提高产妇泌乳素分泌,减少不良反应的发生,值得临床推广应用。

关键词：舒芬太尼地佐辛剖宫产术血清泌乳素

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu xin Shao Qinqin Wang xin Dong Bin Duan Feiyang xing Jun wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening