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Programmed death-ligand 1 expression in the tumour stroma of colorectal liver oligometastases and its association with prognosis after liver resection

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Gastroenterology Report 2021年第5期9卷 443-450,I0002页

作者： Jian-Hong Peng yi Tai yi-xin zhao Bao-Jia Luo Qing-Jian Ou Zhi-Zhong Pan Lin Zhang Zhen-Hai Lu Department of Colorectal Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine GuangzhouGuangdongP.R.China Department of Clinical Laboratory Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China

Background The clinical value of programmed death-ligand 1(PD-L1)expression in colorectal liver oligometastases(CLOs)remains *** study aimed to detect PD-L1 in the microenvironment of CLOs and determine its association with patient *** We collected 126 liver-resection specimens from CLO patients who underwent curative liver resection between June 1999 and December ***(IHC)was performed to assess PD-L1 expression in paraffinembedded *** survival(OS)and recurrence-free survival(RFS)were analysed using the Kaplan–Meier method and log-rank *** PD-L1 was mainly expressed in the stroma of liver *** with high PD-L1 expression had a higher proportion of clinical-risk scores(CRSs)of 2–4(67.7%vs 40.4%;P=0.004).With a median 58-month follow-up,patients with high PD-L1 expression had a significantly lower 3-year OS rate(65.5%vs 92.7%;P=0.001)and 3-year RFS rate(34.7%vs 83.8%;P<0.001)than patients with low PD-L1 *** Cox analysis demonstrated that high PD-L1 expression(hazard ratio[HR]=3.581;95%confidence interval[CI]2.301–9.972;P=0.015),CRS 2–4(HR=6.960;95%CI 1.135–42.689;P=0.036)and increased preoperative CA19-9(HR=2.843;95%CI 1.229–6.576;P=0.015)were independent risk factors for *** PD-L1 expression(HR=4.815;95%CI 2.139–10.837;P<0.001)and lymph-node metastasis(HR=2.115;95%CI 1.041–4.297;P=0.038)were independent risk factors for *** This study found that PD-L1 was commonly expressed in the tumour stroma of CLOs and high PD-L1 expression was associated with poor prognosis.

关键词： PD-L1 colorectal liver oligometastases expression prognosis

An electron-transfer[Fe_(2)Co_(2)]square complex exhibiting unprecedented wide room-temperature hysteresis

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Science China Chemistry 2024年第4期67卷 1198-1207页

作者： xin-Hua zhao yi-Fei Deng Jia-Tao Chen Jiong Yang Yuan-Zhu Zhang Department of Chemistry Southern University of Science and Technology(SUSTech)Shenzhen 518055China

Switchable molecules with magnetic bistability that can function at standard conditions are highly desirable from the perspective of practical *** the last decade,significant progress has been made in modulating thermally induced electrontransfer-coupled spin transition(ETCST)events between diamagnetic{Fe_(LS)^(Ⅱ)(μ-CN)Co_(LS)^(Ⅲ)}and paramagnetic{Fe_(LS)^(Ⅲ)(μ-CN)-Co_(HS)^(Ⅱ)}electron configurations(named LS and HS,respectively,for short)within the Fe/Co mixed-valence cyanometallate ***,we prepared a novel[Fe_(2)Co_(2)]square complex[(pzTp)Fe(CN)_(3)Co(bnbpen)]_(2)[NO_(3)]_(2)·4CH_(3)OH·2.5H_(2)O(1·Solv)and its desolvated phase[(pzTp)Fe(CN)_(3)Co(bnbpen)]_(2)[NO_(3)]_(2)(1),obtained via single-crystal-to-single-crystal(SCSC)*** 1·Solv remaining in the diamagnetic state below room temperature exhibits an irreversible ETCST behavior accompanied by desolvation upon ***,complex 1 displays an unprecedented rate-dependent ETCST behaviour involving with two diamagnetic LS states(a dynamically favoured LS1 state and a thermodynamically favoured LS2state),between which a net one-way transition from LS1 to LS2 is accessible likely via a structural phase transition(SPT)above255 ***,two well separated transition channels(HS?LS1 at around 255 K and HS←→LS2 in the temperature range of 317-350 K)are achieved according to either fast(>20 K/min)or slow rate(<1 K/min),*** a moderate rate of 3 K/min,complex 1 shows a wide hysteresis of 66 K centered at 328 K,the largest yet reported for discrete Fe/Co cyanometallate *** 1 represents the first ETCST example coupled with dynamic SPT,providing a new strategy for manipulating bistability within this fascinating cyanometallate family.

关键词： switchable molecules cyanometallate complexes electron transfer hysteresis structural phase transition

Unique Azolyl Acylhydrazonyl Hybridization of Aloe Emodins to Access Potential Antibacterial Agents

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Chinese Journal of Chemistry 2024年第15期42卷 1741-1758页

作者： yi-xin Wang zhao Deng Aisha Bibi Bo Fang Cheng-He Zhou Institute of Bioorganic&Medicinal Chemistry Key Laboratory of Applied Chemistry of Chongqing MunicipalitySchool of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China College of Pharmacy National&Local Joint Engineering Research Center of Targeted and Innovative TherapeuticsChongqing Key Laboratory of Kinase Modulators as Innovative MedicineChongqing University of Arts and SciencesChongqing 402160China

A type of unique azole-hybridized acylhydrazonyl aloe emodins(AAEs)were developed as new antibacterial agents for combating bacterial *** target AAEs showed strong antibacterial activities,especially,tetrazolylthioether AAE 27a exhibited broad antibacterial spectrum with 16-256 folds and 8-64 folds more active antibacterial efficacy than the reference drugs aloe emodin and norfloxacin,*** AAE 27a also gave low hemolysis and cytotoxicity,as well as favorable *** mechanism explorations revealed that tetrazolylthioether AAE 27a could cause bacterial membrane depolarization and damage the cell membrane,resulting in nucleic acid ***,compound 27a could intercalate into DNA to impede its replication and form supramolecular 27a-DNA gyrase complex to disturb the function of DNA *** findings would provide valuable insights for the further exploration of azolyl acylhydrazonyl aloe emodins as new potential antibacterial candidates.

关键词： Aloe emodin Hydrazone Heterocycle Antibacterial Membrane damage

HUMAN DRIVING MECHANISM OF REGIONAL LAND USE CHANGE:A CASE STUDY OF KARST MOUNTAIN AREAS OF SOUTHWESTERN CHINA

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Chinese Geographical Science 2000年第4期10卷 2-8页

作者： Hui-yuan Zhang xin-yi zhao Yun-long Cai Song Liu Center of Environmental Science Peking University 100871 Beijing P. R. China

Based on analysis of the change of land use and related social- economic factors in karst mountain areas of southwestern China, the index system characterizing land use change and its human driving forces in county scale is put forward. Then the relationship of land use change and the driving forces is studied by statistic analysis to identify quantitatively the contribution of human forces and their differences in driving land use change. Moreover, taking the Luodian County as the case, a model simulating the annual change of cultivated land area under the driving of human forces is built. Result of the study will supply reference for the management of the relationship of man and land in karst mountain areas of southern- western China, and accumulate research experience for further study on land use/cover change.

关键词： land use/cover change human driving forces karst mountain are

Poles Extraction Based LiDAR Localization for Autonomous Robot Systems

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Journal of Systems Science & Complexity 2024年第4期37卷 1413-1424页

作者： HONG xin DONG yi College of Electronic and Information Engineering Tongji UniversityShanghai 201800China

With the development of intelligent technology,the problem of Li DAR-based localization has played an increasingly important role in the localization of robots in unmanned *** the dense point clouds from the environment requires a large amount of memory,specific and stable structural features,such as pole-like objects in the environment,can serve as the ideal landmarks for localization in unmanned systems,which can effectively reduce the memory usage and mitigate the effects of dynamic environment *** this paper,the authors propose a pole-like objects extraction approach and then,it is applied into the localization system of mobile *** the same experimental conditions,the proposed method can extract more pole-like objects and achieve better long-term localization accuracy than some existing methods in different urban environmental datasets.

关键词： Pole-like landmark extraction robot localization

Who Takes Care of the Elderly

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The Journal of Human Rights 2007年第1期6卷 29-31页

作者： yi xin & zhao JINGJING

It is an advertisement. An old granny has prepared a tableful of dishes, waiting for her sons and daughters to come back home to enjoy. But, one after another, her sons and daughters called back, saying that they are unable to return home, because either of working overtime or dining out with friends. The old woman is so tired that she has fallen fast asleep by the table against a background of a grandmother clock ticking away.

关键词： Pr Who Takes Care of the Elderly

Arsenic contamination caused by roxarsone transformation with spatiotemporal variation of microbial community structure in a column experiment

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Journal of Groundwater Science and Engineering 2021年第4期9卷 304-316页

作者： Ya-ci Liu zhao-ji Zhang xin-yi zhao Meng-tuo Wen Sheng-wei Cao Ya-song Li Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuang 050061China Key Laboratory of Groundwater Remediation of Hebei Province and China Geological Survey Shijiazhuang 050061China Hebei Hydrology Engineering Geological Survey Institute Co.LTD Shijiazhuang 050061China China University of Geosciences Beijing 100083China.

Arsenic contamination from roxarsone in livestock manure is common,and livestock manure continuously accumulates in the open *** of the environmental processes of As mobilization and transformation are critical for predicting the fate of As compounds after roxarsone *** this study,spatiotemporal variations in As species and microbial community structure were characterized using laboratory column experiments with background soil collected from Yanggu County(northern Shandong Plain,China),a region of intense poultry *** and inorganic arsenic were detected by high-performance liquid chromatography(HPLC)and HPLC with hydride generation atomic fluorescence spectrometry(HPLC-HG-AFS),***-throughput sequencing technology was used to describe microbial *** showed that roxarsone was transformed completely within 7 days,and A_(s)(Ⅲ)and As(Ⅴ)were the major degradation *** concentration of A_(s)(Ⅲ)was much lower than that of As(Ⅴ).The A_(s)(Ⅲ)concentration increased significantly after Day 14,whereas the A_(s)(Ⅴ)concentration increased significantly after Day 84,indicating that A_(s)(Ⅲ)was initially *** microbial community structure changed significantly as roxarsone transformed into various As compounds.A critical and dominant bacterial strain,norank_f__Family_XVⅢ,was found to be related to the degradation of roxarsone into As(Ⅲ).This study improves our understanding of the fate of As species released from poultry litter to soil and groundwater,which is a threat to human health and environment.

关键词： Arsenic Roxarsone Spatiotemporal variation Microbial community

Microstructure and elevated-temperature tensile properties of differential pressure sand cast Mg-4Y-3Nd-0.5Zr alloy

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China Foundry 2016年第1期13卷 30-35页

作者： Hong-hui Liu Zhi-liang Ning Hai-chao Sun Fu-yang Cao Hao Wang xin-yi zhao Jian-fei Sun School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China Harbin Dongan Engine (Group) Co. Ltd. Harbin 150066 China National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of Technology Harbin 150001 China

The microstructures of an Mg-4Y-3Nd-0.5Zr alloy by differential pressure casting were investigated using scanning electron microscopy （SEM） and transmission electron microscopy （TEM）, and its tensile deformation behavior was measured using a Gleeble1500D themo-simulation machine in the temperature range of 200 to 400 ℃ at initial strain rates of 5×10^-4 to 10^-1 s^-1. Results show that the as-cast microstructure consists of primary α-Mg phase and bone-shaped Mg5RE eutectic phase distributed along the grain boundary. The eutectic phase is dissolved into the matrix after solution treatment and subsequently precipitates during peak aging. Tensile deformation tests show that the strain rate has little effect on stress under 300 ℃. Tensile stress decreases with an increase in temperature and the higher strain rate leads to an increase in stress above 300 ℃. The fracture mechanism exhibits a mixed quasi-cleavage fracture at 200 ℃, while the fracture above 300 ℃ is a ductile fracture. The dimples are melted at 400 ℃ with the lowest strain rate of 10^-4 s^-1.

关键词： Mg-4Y-3Nd-0.5Zr alloy microstructure mechanical property at elevated temperature fracture

Ethanol extract of Abelmoschus manihot suppresses endoplasmic reticulum stress in contrast-induced nephropathy

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Asian Pacific Journal of Tropical Biomedicine 2024年第1期14卷 17-27,I0002,I0003页

作者： xin Lin xin Lu Yun-He zhao yi-Bei Wang Ru-Ge Niu Xiao-Hu Chen Department of Cardiology Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Chinese MedicineNanjingJiangsu 210004China

Objective:To explore the efficacy and potential mechanisms of the ethanol extract of Abelmoschus manihot(L.)Medic in contrast-induced nephropathy(CIN).Methods:CIN rat models and human renal proximal tubular cells(HK-2)with iopromide-induced injury were employed to mimic CIN *** effect of Abelmoschus manihot extract on the rat models and HK-2 cells was *** rat models,kidney function,histology,oxidative stress and apoptosis were *** HK-2 cells,cell viability,apoptosis,mitochondrial membrane potential,and endoplasmic reticulum stress were ***:Abelmoschus manihot extract significantly improved structural and functional impairments in the kidneys of CIN ***,the extract effectively mitigated the decline in cellular viability and reduced iopromide-induced oxidative stress and lipid *** investigations revealed that Abelmoschus manihot extract prominently attenuated acute endoplasmic reticulum stress-mediated apoptosis by downregulating GRP78 and CHOP protein ***:Abelmoschus manihot extract can be used as a promising therapeutic and preventive agent in the treatment of CIN.

关键词： Contrast-induced nephropathy Abelmoschus manihot extract ER stress Apoptosis GRP78 CHOP