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Therapeutic effects of the extract of Sancao Formula, a Chinese herbal compound, on imiquimod-induced psoriasis via cysteine-rich protein 61

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Journal of Integrative Medicine 2022年第4期20卷 376-384页

作者： Wan-jun Guo yi Wang Yu Deng Lin-yan Cheng xin Liu Ruo-fan Xi Sheng-jie Zhu xin-yi feng Liang Hua Kan Ze Jian-yong Zhu Dong-jie Guo Fu-lun Li Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China School of Medicine Chengdu UniversityChengdu 610106Sichuan ProvinceChina Institute of Cancer Biology and Drug Discovery Chengdu UniversityChengdu 610106Sichuan ProvinceChina Clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Objective: Psoriasis is a common chronic inflammatory skin disease that is prone to recurrence, and the proinflammatory factor, cysteine-rich protein 61(Cyr61), is important in its pathophysiology. Long-term clinical practice has shown that Sancao Formula(SC), a Chinese herbal compound, is effective in the treatment of psoriasis, but the precise mechanism remains unknown. In this study, we investigate the mechanism by which SC extract alleviates imiquimod(IMQ)-induced ***: The expression of Cyr61 in psoriatic lesions and normal healthy skin was detected using immunohistochemical analysis to investigate the biological role of Cyr61 in models of psoriatic inflammation. A psoriatic mouse model was established by topical application of IMQ, and the effect of topical application of SC extract was evaluated using the psoriasis area and severity index(PASI) score,hematoxylin-eosin staining, and histopathological features of the skin. Next, a HaCaT cell inflammation model was established using interferon-γ(IFN-γ), and the effect of SC extract on the mRNA and protein levels of Cyr61 and intercellular cell adhesion molecule-1(ICAM-1) was confirmed using Western blot and quantitative real-time polymerase chain reaction ***: Immunohistochemical staining showed that the expression of Cyr61 in psoriatic lesions was higher than that in normal skin samples(78.26% vs 41.18%, P < 0.05), and the number of Cyr61-positive cells in psoriatic lesions was also significantly higher than in normal skin(18.66 ± 2.51 vs4.33 ± 1.52, P < 0.05). Treatment in mice with IMQ-induced psoriasis showed that SC extract could significantly improve the inflammatory phenotype, PASI score(10.875 ± 0.744 vs 3.875 ± 0.582, P < 0.05),and pathological features compared with those in IMQ model group;SC treatment was also associated with decreased levels of Cyr61 and ICAM-1. In the IFN-γ-induced inflammatory cell model, the mRNA and protein levels of Cyr61 and ICAM-1 were upregulated, w

关键词： Traditional Chinese medicine Sancao Formula Psoriasis Plant extracts Cysteine-rich protein 61 Intercellular cell adhesion molecule-1

Application of convolutional neural network in detecting and classifying gastric cancer

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Artificial Intelligence in Gastrointestinal Endoscopy 2021年第3期2卷 71-78页

作者： xin-yi feng Xi Xu Yun Zhang Ye-Min Xu Qiang She Bin Deng Department of Gastroenterology Affiliated Hospital of Yangzhou UniversityYangzhou 225000Jiangsu ProvinceChina

Gastric cancer(GC)is the fifth most common cancer in the world,and at present,esophagogastroduodenoscopy is recognized as an acceptable method for the screening and monitoring of *** neural networks(CNNs)are a type of deep learning model and have been widely used for image *** paper reviews the application and prospects of CNNs in detecting and classifying GC,aiming to introduce a computer-aided diagnosis system and to provide evidence for subsequent studies.

关键词： Artificial intelligence Convolutional neural network Endoscopy Gastric cancer Deep learning

Association between late gadolinium enhancement and outcome in dilated cardiomyopathy:A meta-analysis

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World Journal of Radiology 2023年第11期15卷 324-337页

作者： xin-yi feng Wen-feng He Tian-Yue Zhang Ling-Li Wang Fan Yang Yu-Ling feng Chun-Ping Li Rui Li Department of Radiology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Cardiology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND The prognostic value of late gadolinium enhancement(LGE)derived from cardiovascular magnetic resonance(CMR)is well studied,and several new metrics of LGE have ***,some controversies remain;therefore,further discussion is needed,and more precise risk stratification should be *** To investigate the associations between the positivity,extent,location,and pattern of LGE and multiple outcomes in dilated cardiomyopathy(DCM).METHODS PubMed,Ovid MEDLINE,and Cochrane Library were searched for studies that investigated the prognostic value of LGE in patients with *** hazard ratios(HRs)and 95%confidence intervals were calculated to assess the role of LGE in the risk stratification of *** Nineteen studies involving 7330 patients with DCM were included in this metaanalysis and covered a wide spectrum of DCM,with a mean left ventricular ejection fraction between 21%and 50%.The meta-analysis revealed that the presence of LGE was associated with an increased risk of multiple adverse outcomes(all-cause mortality,HR:2.14;arrhythmic events,HR:5.12;and composite endpoints,HR:2.38;all P<0.001).Furthermore,every 1%increment in the extent of LGE was associated with an increased risk of all-cause *** of a subgroup revealed that the prognostic value varied based on different location and pattern of ***,we found that LGE was a stronger predictor of arrhythmic events in patients with greater left ventricular ejection *** LGE by CMR in patients with DCM exhibited a substantial value in predicting adverse outcomes,and the extent,location,and pattern of LGE could provide additional information for risk stratification.

关键词： Cardiac magnetic resonance Dilated cardiomyopathy Late gadolinium enhancement Meta-analysis Myocardial fibrosis Prognosis

Application of Improved PSO Algorithm in Hydraulic Pressing System Identification

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Journal of Iron and Steel Research International 2012年第9期19卷 29-35页

作者： YU Yu-zhen 1 , 2 , REN xin-yi 2 , DU feng-shan 2 , SHI Jun-jie 2 ( 1.Institute of Mechanical Engineering , Hebei United University , Tangshan 063009 , Hebei , China 2.Institute of Mechanical Engineering , Yanshan University , Qinhuangdao 066004 , Hebei , China ) [a] Institute of Mechanical Engineering Hebei United University Tangshan 063009 Hebei China [b] Institute of Mechanical Engineering Yanshan University Qinhuangdao 066004 Hebei China

In view of characteristics of particle swarm optimization ( PSO ) algorithm of fast convergence but easily falling into local optimum value , a novel improved particle swarm optimization algorithm is put forward , and it is applicable to identify parameters of hydraulic pressure system model in strip rolling *** order to maintain population diversity and enhance global optimization capability , the algorithm is firstly improved by means of decreasing its inertia weight linearly from the maximum to the minimum and then combined with chaotic characteristics of ergodicity , randomness and sensitivity to initial *** the improved algorithm is used to identify parameters of hydraulic pressure system , the comparison of simulation curves and measured curves indicates that the identification results are reliable and close to actual situation.A new method was provided for hydraulic AGC system model identification.

关键词： hydraulic pressing system PSO algorithm chaos self-adaptive parameter identification

高剂量双联疗法作为幽门螺杆菌感染根除方案的研究进展

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世界华人消化杂志 2020年第17期28卷 847-851页

作者：冯心怡张云邓彬扬州大学附属医院消化内科江苏省扬州市225000

随着抗生素耐药率不断的提高,幽门螺杆菌(Helicobacter pylori,***)根除方案也在不断更新,目前含铋剂的四联疗法是主要的经验治疗根除方案.但长期使用多种抗生素,会增强其耐药性.我们需要一种能够根除***并减少所用抗生素的新方法,以防... 详细信息

随着抗生素耐药率不断的提高,幽门螺杆菌(Helicobacter pylori,***)根除方案也在不断更新,目前含铋剂的四联疗法是主要的经验治疗根除方案.但长期使用多种抗生素,会增强其耐药性.我们需要一种能够根除***并减少所用抗生素的新方法,以防止将来***产生抗药性,而含质子泵抑制剂和阿莫西林的高剂量双联疗法(high-dose dual therapy,HDDT)可能是根除***的突破.目前研究表明,HDDT作为一线治疗或者补救治疗,其根除率与四联疗法相当,不良事件发生率低,而且使用单种抗生素大大减少了抗药性.

关键词：幽门螺杆菌高剂量双联疗法一线治疗补救治疗

Designing Electronic Structures of Multiscale Helical Converters for Tailored Ultrabroad Electromagnetic Absorption

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Nano-Micro Letters 2025年第1期17卷 439-455页

作者： Zhaobo feng Chongbo Liu xin Li Guangsheng Luo Naixin Zhai Ruizhe Hu Jing Lin Jinbin Peng Yuhui Peng Renchao Che Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle School of Environmental and Chemical EngineeringNanchang Hangkong UniversityNanchang 330063People’s Republic of China School of Physics and Materials Nanchang UniversityNanchang 330031People’s Republic of China Key Laboratory of Nondestructive Testing Ministry of EducationNanchang Hangkong UniversityNanchang 330063People’s Republic of China Laboratory of Advanced Materials Shanghai Key Lab of Molecular Catalysis and Innovative MaterialsAcademy for Engineering and TechnologyFudan UniversityShanghai 200438People’s Republic of China

Atomic-scale doping strategies and structure design play pivotal roles in tailoring the electronic structure and physicochemical property of electromagnetic wave absorption(EMWA)***,the relationship between configuration and electromagnetic(EM)loss mechanism has remained ***,drawing inspiration from the DNA transcription process,we report the successful synthesis of novel in situ Mn/N co-doped helical carbon nanotubes with ultrabroad EMWA *** calculation and EM simulation confirm that the orbital coupling and spin polarization of the Mn–N4–C configuration,along with cross polarization generated by the helical structure,endow the helical converters with enhanced EM *** a result,HMC-8 demonstrates outstanding EMWA performance,achieving a minimum reflection loss of−63.13 dB at an ultralow thickness of 1.29 *** precise tuning of the graphite domain size,HMC-7 achieves an effective absorption bandwidth(EAB)of 6.08 GHz at 2.02 mm ***,constructing macroscale gradient metamaterials enables an ultrabroadband EAB of 12.16 GHz at a thickness of only 5.00 mm,with the maximum radar cross section reduction value reaching 36.4 dB *** innovative approach not only advances the understanding of metal–nonmetal co-doping but also realizes broadband EMWA,thus contributing to the development of EMWA mechanisms and applications.

关键词： Metal-nonmetal co-doping 3d-2p orbital coupling Spin polarization Helical structure Broadband EM wave absorption

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三峡库区面源污染防控BMPs框架体系研究

水生态学杂志 2017年第1期38卷 54-60页

作者：孙平周源伟华新柏益尧冯琳污染控制与资源化研究国家重点实验室南京大学环境学院江苏南京210023 中国人民大学环境学院北京100872

三峡库区面源污染具有地域范围大、随机性强、成因复杂的特点,形成过程受地理、气候、土壤等多种因素影响,监测、控制、处理和管理难度较大。构建三峡库区面源污染防控最佳管理措施框架体系,从源头控制、迁移途径阻截、末端治理三方面... 详细信息

三峡库区面源污染具有地域范围大、随机性强、成因复杂的特点,形成过程受地理、气候、土壤等多种因素影响,监测、控制、处理和管理难度较大。构建三峡库区面源污染防控最佳管理措施框架体系,从源头控制、迁移途径阻截、末端治理三方面控制三峡库区面源污染。基于源头控制的最佳管理措施:根据区域现场条件,选择"坡改梯"或"大横坡+小顺坡"坡耕地有限顺坡耕作技术模式;进一步推广植物篱种植模式;大范围推广粮食作物的平衡施肥技术,推广使用高效低毒低残留非水溶性农药。基于迁移途径阻截的最佳管理措施:在适生植物筛选及淹没实验研究基础上,进行消落带湿地生态系统培育;开展库岸植被缓冲带工程建设和水塘-湿地工程建设,拦截、净化入库污染物,兼以改善景观;实施植被过滤带防护性工程,控制N、P等养分流失,保护生态环境。基于末端治理的最佳管理措施:按照成本低廉、效果稳定、技术操作简单的原则,可考虑生物处理+人工湿地的组合工艺处理典型农村的生活污水;在前置水库周边建设沿岸生态防护林、湿地及多塘系统、敞水区动植物措施等生态工程;遵循减量化、资源化、无害化原则,对畜禽养殖业进行科学规划,合理布局;发展养殖业和种植业相结合,既可消除畜禽养殖业产生的负面效应,又可减少化肥施用量。

关键词：最佳管理措施面源污染控制三峡库区

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建筑室内环境艺术设计的人才培养探讨

高等建筑教育 2008年第3期17卷 24-27页

作者：辛艺峰华中科技大学建筑与城市规划学院湖北武汉430074

文章通过对建筑室内环境艺术行业中设计人才培养现状的分析与问题的思考,结合中国经济建设给建筑装饰及室内环境艺术设计教育带来的发展契机,提出了面对未来挑战的对策与措施,并对走向未来的建筑室内环境艺术设计教育的发展取向进行了探... 详细信息

文章通过对建筑室内环境艺术行业中设计人才培养现状的分析与问题的思考,结合中国经济建设给建筑装饰及室内环境艺术设计教育带来的发展契机,提出了面对未来挑战的对策与措施,并对走向未来的建筑室内环境艺术设计教育的发展取向进行了探索,以期对建筑室内环境艺术设计人才的培养能有所推动和促进。

关键词：建筑室内环境艺术设计人才培养

右胸前外侧小切口心脏不停跳房间隔缺损修补术

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复旦学报（医学版） 2003年第3期30卷 277-278,284页

作者：乔晨晖蔡萍卫洪超郅兴义赵高峰张新郑州大学第一附属医院胸心外科郑州450052

目的总结右胸前外侧小切口心脏不停跳下房间隔缺损修补术的治疗经验。方法手术在常温深度血液稀释体外循环下施行,沿右侧第5肋间切开皮肤,经第3或第4肋间入胸,距右膈神经前2.0cm纵向切开心包,主动脉及上、下腔静脉插管常规建立体外循... 详细信息

目的总结右胸前外侧小切口心脏不停跳下房间隔缺损修补术的治疗经验。方法手术在常温深度血液稀释体外循环下施行,沿右侧第5肋间切开皮肤,经第3或第4肋间入胸,距右膈神经前2.0cm纵向切开心包,主动脉及上、下腔静脉插管常规建立体外循环时间为(36.0±14.4)min。心脏跳动下切开右心房,直接缝合和自体心包片或涤纶片修补缺损。结果 57例患者均痊愈出院。术后气管插管呼吸机辅助时间(6.3±2.8)h,监护时间(35.3±16.4)h,术后住院(7.5±1.2)d。术后胸腔引流量(250.8±175.3)mL。54例(94.7％)未输库血。术后随访3个月～4年,心功能较术前改善。结论采用右胸前外侧小切口心脏不停跳技术修补房间隔缺损,微创美观,安全可靠,手术操作简单,库血用量小,疗效满意。房间隔缺损及合并部分型肺静脉畸形引流患者的手术治疗均可采用此技术。

关键词：右胸前外侧小切口心脏不停跳房间隔缺损修补术切开术后库血体外循环施行立体直接