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Effective corrosion protection of magnetic microwave absorber with designed macromolecular network barrier

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Rare Metals 2023年第2期42卷 558-571页

作者： Qing-Qing Hu Liang Chai Ke Liang yan-xin jiang Guang yang Lin-Bo Zhang Liang-Jun Yin xin Wang Tao Liu Hai-Peng Lu Long-jiang Deng School of Electronic Science and Engineering and National Engineering Research Center of Electromagnetic Radiation Control Materials University of Electronic Science and Technology of ChinaChengdu611731China

Carbonyl iron(CI)particles as magnetic microwave absorption material often suffer from serious corrosion under corrosive environment which leads to performance *** this study,fluorin-containing acrylate type polymer network layers with thickness ranging from tens of nanometers to around one hundred nanometers were formed continuously around *** crosslinked coating layer(named FT)effectively increases CI’s thermal decomposition temperature by at least 34%.The FT-coated CI(named CI-FT)was able to resist both inorganic and organic corrosive media attacking efficiently compared with bare *** surface polymer network could also help CI withstand organic medium dissolution which proved the firmness of *** voltammetry(CV)test revealed that the coating layer could significantly reduce maximum oxidation current density of CI by more than 45 *** polarization study during CV tests also confirmed that thicker FT coating layer could help CI sample stabilize corrosion current ***,the surface coating also enhanced the impedance matching properties of CI as microwave absorber and the CI-FT samples demonstrated improved microwave absorption properties which degenerated little after corrosive medium soaking compared with that of CI.

关键词： Carbonyl iron(CI) Corrosion protection Microwave absorption Fluorin-containing acrylate Cyclic voltammetry Corrosion process

Rh(111)表面NO分子对多层膜的原子结构

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物理学报 2017年第2期66卷 298-306页

作者：汪辰超吴太权王新燕江影中国计量大学应用物理系杭州310018

利用第一性原理研究了NO分子对[(NO)_2]分子链、分子单层膜,Rh(111)表面上的(NO)_2分子单层膜和多层膜的原子结构.(NO)_2分子单体在虚拟Rh(111)表面自组装成两个稳定的分子链,(NO)_2分子平行有序排列,氧原子和氮原子都呈现(100)和(111)... 详细信息

利用第一性原理研究了NO分子对[(NO)_2]分子链、分子单层膜,Rh(111)表面上的(NO)_2分子单层膜和多层膜的原子结构.(NO)_2分子单体在虚拟Rh(111)表面自组装成两个稳定的分子链,(NO)_2分子平行有序排列,氧原子和氮原子都呈现(100)和(111)结构.在虚拟Rh(111)-(1×3^(1/2))上,1.00 ML(molecular layer)覆盖度时,(NO)_2分子自组装成两个稳定的分子单层膜(M1和M2),分子膜M1中N-N键与衬底的夹角为70°-90°;分子膜M2中N-N键平行衬底.在M2/Rh(111)中,(NO)_2分子可吸附于顶位、fcc空心位和hcp空心位,通过电荷转移可解释两个空心位的稳定性强于顶位.Rh(111)表面(NO)_2分子多层膜系统中,(NO)_2分子垂直吸附于两个空心位,第一层是分子膜M2,N-N键平行于衬底,第二层及以上都是分子膜M1,N-N键与衬底夹角为70°-90°,分子膜真空层为0.31 nm±0.02 nm.

关键词：一氧化氮分子对单层膜多层膜自组装

Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige jiang Dexiang Liu Tingting Li Chengcheng Gai Danqing xin Yijing Zhao yan Song Yahong Cheng Tong Li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

Thyroid function of twin-pregnant women in early pregnancy

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Chinese Medical Journal 2019年第17期132卷 2033-2038页

作者： yan-xin jiang Wei-Jie Sun yang Zhang Yu Huang You-Yuan Huang Gui-Zhi Lu Jun-Qing Zhang Ying Gao Hui-Xia yang Xiao-Hui Guo Department of Endocrinology Peking University First Hospital Beijing 100034 China Department of Obstetrics and Gynecology Peking University First Hospital Beijing 100034 China National Engineering Research Center of Software Engineering Peking University Beijing 100871 China

Background: Serum human chorionic gonadotrophin (hCG) is higher in twin than that in singleton pregnancies. As hCG stimulates the thyroid to produce more free thyroxine (FT4), which may lead to decreased thyroid-stimulating hormone (TSH) levels, the reference ranges of thyroid-related indicators may differ between singleton and twin pregnancies in the first trimester. This study aimed to establish reference ranges for thyroid-related indicators in early twin pregnancies and to compare them with singleton pregnancies. Methods: Data of 820 twin-pregnant women were extracted from the established database of all pregnant women who delivered at Peking University First Hospital from October 2013 to May 2018;160 who met National Academy of Clinical Biochemistry criteria were included to establish TSH and FT4 reference ranges. We screened 480 (3:1 paired) women with singleton pregnancies from the same database as controls. The Mann-Whitney test for TSH and FT4 levels was applied for comparisons between singleton and twin pregnancies. Results: First-trimester reference ranges (4–12 gestational weeks) for twin pregnancies were: TSH 0.69 (0.01–3.35) mIU/L and FT4 16.38 (12.45–23.34) pmol/L. Median TSH was significantly lower at 7 to 12 gestational weeks than that at 4 to 6 gestational weeks (0.62 vs. 0.96 mIU/L, Z =-1.964, P = 0.049);FT4 was not significantly different between the two groups. Compared to singleton pregnancies, median TSH was significantly lower (0.69 vs. 1.27 mIU/L, Z =-6.538, P = 0.000), and FT4 was significantly higher (16.38 vs. 14.85 pmol/L, Z =-7.399, P = 0.000) in twin pregnancies in the first trimester. Conclusions: Specific reference ranges for thyroid-related indicators for twin pregnancies are needed to avoid a misdiagnosis of thyroid dysfunction. Moreover, establishment of separate reference ranges for 4 to 6 and 7 to 12 gestational weeks in twin pregnancies may be considered.

关键词： Twin pregnancy Reference ranges Thyroid-stimulating hormone Free thyroxine

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川东气田盐岩、膏盐岩蠕变特性试验研究

岩土力学 2012年第2期33卷 444-448页

作者：李萍邓金根孙焱闫新江徐显广中国石油大学(北京)石油工程学院北京102249 中石化国际石油勘探开发有限公司北京100083 中国石油集团公司钻井工程技术研究院北京100097

对川东气田盐岩、膏盐岩进行了矿物组分测定,采用TAW-1000深水孔隙压力伺服试验系统进行了蠕变试验,分析了固有的矿物组分及偏应力、温度、围压对蠕变的影响,结合蠕变曲线和岩石参数,提出了稳态蠕变速率本构方程。研究表明:川东气田盐... 详细信息

对川东气田盐岩、膏盐岩进行了矿物组分测定,采用TAW-1000深水孔隙压力伺服试验系统进行了蠕变试验,分析了固有的矿物组分及偏应力、温度、围压对蠕变的影响,结合蠕变曲线和岩石参数,提出了稳态蠕变速率本构方程。研究表明:川东气田盐岩、膏盐岩矿物组分以NaCl、CaSO4为主,其中NaCl含量最高可达93%以上;岩石固有的矿物组分是影响岩石蠕变特性的内因,随NaCl含量增加,瞬态蠕变、稳态蠕变速率相应增大;随偏应力、温度的增加稳态蠕变速率增大,围压对其影响不大;通过试验数据拟合得出赫德(Heard)蠕变本构方程中的参数,求出不同偏应力、温度下盐岩、膏盐岩的稳态蠕变速率,为川东气田盐岩、膏盐岩地层安全钻进泥浆密度窗口计算和套管非正常变形分析提供了理论依据。

关键词：川东气田盐岩膏盐岩矿物组分蠕变试验本构方程

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin jiang Hui-Na Liu Yu-Fan yang Zhi-Cheng Zhang Qi Dai Xiao-yan Bao Lin-Jie Wu Ya-xin Qin xin Tan Xiao-yan Sun Xu-Fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

Analysis of causes for liver function deteriora-tion in patients with HIV/HCV co-infection

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Hepatobiliary & Pancreatic Diseases International 2004年第4期3卷 538-542页

作者： Yong-Hong Zhang, xin-Yue Chen, yan jiang, Yao Xiao, Zhen Liu, Xiao-Shan Long and Hao Wu Beijing, China Department of Infectious Diseases, Beijing You’an Hospital and China Center of Disease of Control and Prevention , Beijing 100054, China Department of Infectious Diseases You'an Hospital Beijing 100054 China.

BACKGROUND:Co-infection of hepatitis C virus (HCV) and human immunodeficiency virus type 1 ( HIV-1 ) is common in hemophiliacs and drug abusers. To assess the interaction between HIV and HCV disease progression, we examined 82 HIV/HCV co-infection patients and 62 HCV infection patients. METHODS: Liver function, pathological changes, infec- tion duration, immune function and qualitative HCV-RNA and HCV antibody were compared retrospectively between the two groups of patients. RESULTS: Fourty-eight patients (58.5%) in the HIV/ HCV co-infection group and 53 patients (85.5%) in the HCV infection group showed abnormal liver function. No significant difference was observed in inflammation and fi- brosis in the two groups P =0.187, 0.954). However, liver abnormality in the patients with HIV/HCV co-infection appeared 8 years earlier than in those with HCV infection alone (P<0.001). As to immune function, the counts of CD4+T and CD8+ T in the HIV/HCV group were (226.35 ± 173.49)×106/L and (914. 40 ±448. 28)×106/L, whereas in the HCV group they were (752.31±251.69)×l06/L and (529.011170.67)×106/L respectively. The difference in the two groups was highly significant (P<0.001; P<0.001). The ratio of the number of people with both HCV-RNA and HCV antibody positive to the number of HCV-RNA positive and HCV antibody negative in the HIV/HCV group was 52:9, whereas in the HCV group it was 44:1 (P = 0.043). CONCLUSION: HIV/HCV co-infection can accelerate de- terioration of hepatitis C, which may be due to the effect of HIV on cellular immunity and humoral immunity of the body.

关键词： HIV virus hepatitis C virus CD4+T cell HCV-RNA

Cascade degradation and electrocatalytic upcycling of waste poly(ethylene terephthalate)to valued products

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Nano Research 2025年第1期18卷 76-93页

作者： xin Li Zirui jiang Zongkui Kou John Wang Shiyou Zheng School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China Department of Materials Science and Engineering National University of SingaporeSingapore 117574Singapore

The global annual production of poly(ethylene terephthalate)(PET)has reached 82 million tons,yet only a small fraction(less than 20%)is *** ultra-slow degradation rate of PET results in the accumulation of PET waste in the environment,causing serious plastic pollution and posing severe challenges to *** response,great efforts have been directed toward developing a cascade degradation and electrocatalytic upcycling strategy,which serves as a“waste-towealth”*** strategy involves electro-reforming PEThydrolyzed intermediates or using PET pyrolyzed products as electrocatalysts to generate high-value *** review provides an overview of the state-of-the-art strategies for the“degradation-electrocatalytic upcycling(De-eUp)”of PET ***,an introduction to the strategy is provided,categorizing it into two main frameworks:“pyrolysis-electrocatalytic upcycling”and“hydrolysis-electrocatalytic upcycling”.The section on“pyrolysis-electrocatalytic upcycling”delves into the degradation methods for designing derived carbon nanomaterials and their utilization as high-performance ***“hydrolysis-electrocatalytic upcycling”section discusses recent advancements in electro-reforming of PET hydrolyzed intermediates for the production of C_(1) and C_(2) *** review concludes by examining the challenges and future prospects in developing an efficient and economical PET upcycling *** is anticipated that this review will stimulate further progress in plastic waste valorization.

关键词： poly(ethylene terephthalate)waste electrocatalytic upcycling pyrolysis hydrolysis ethylene glycol oxidation reaction

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堆载作用下桥梁桩基偏移及处治分析

公路交通科技 2024年第6期41卷 148-155,198页

作者：严新江张华杰谢柯新疆交通规划勘察设计研究院有限公司新疆乌鲁木齐830006

针对桥梁桩基偏移问题,以一座受非对称堆载影响的公路桥梁为例,对桩基础偏移和偏移成因进行分析。通过建立有限元模型,分析该公路桥梁桩基础受堆载影响前、堆载影响后、堆载高度、卸载纠偏处治后等多个工况下的力学特性。根据现场桥梁... 详细信息

针对桥梁桩基偏移问题,以一座受非对称堆载影响的公路桥梁为例,对桩基础偏移和偏移成因进行分析。通过建立有限元模型,分析该公路桥梁桩基础受堆载影响前、堆载影响后、堆载高度、卸载纠偏处治后等多个工况下的力学特性。根据现场桥梁上下部检测情况、土体处治监控情况和有限元数值分析,结果表明:非对称堆载是桩基础产生偏移的主要原因,桥梁周边的非对称堆载对桩基础周边的土体产生一定的扰动,使土体对桩基础产生水平的推力,从而引起桩基础的偏移。对堆载土体进行卸载直至土体变形趋于稳定,可在一定程度上改善既有桩基础的受力状态,起到一定的纠偏作用。通过增设反力锚直接作用外力于桥墩结构,控制纠偏方向,来提供对桥梁桩基的纠偏力,并在桩基顺桥向和横桥向布置应力释放孔,有效释放土体侧向挤压应力,减小土体侧向变形对桩基的影响。同时对偏移的桩基础,采用在原桩基础位置两侧进行对称性群桩加固后,桩基础的横桥向位移、弯矩和轴力大幅度降低,纠偏作用效果明显,使桥墩恢复到正常使用状态。以实际桥梁工程为例,对受非对称堆载影响的桩基础采用钻孔卸压、开挖卸载、桥梁横向加强、桥墩纵向复位和加桩加固等综合纠偏方案,结果表明纠偏方案效果良好。

关键词：桥梁工程偏移处治有限元分析桩基础桩基偏移非对称堆载