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Fermented Lentinus edodes extract containingα-glucan ameliorates concanavalin A-induced autoimmune hepatitis in mice

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Food Science and Human Wellness 2024年第4期13卷 2102-2115页

作者： xin Hu Dan Cheng Yingxia Zhang Po li Xiaoping Wu Junsheng Fu College of life Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002China Mycological Research Center Fujian Agriculture and Forestry UniversityFuzhou 350002China Shanghai lithy One-Health Group Technology Co. Ltd.Shanghai 200235China

Autoimmune hepatitis(AIH)is a chronic inflammatory liver disease that threatens human health *** aim of this study was to detect the protective effect of a fermented Lentinus edodes extract containingα-glucan(FLA),in a concanavalin A(Con A)-induced AIH mouse model and to determine the underlying liver-protective *** results showed that compared with the model group,the level of proinflammatory cytokines in serum of FLA pretreated mice was significantly decreased,and the degree of inflammatory cell infiltration in liver,thymus and spleen was significantly *** polymerase chain reaction,immunohistochemistry,and Western blotting showed that FLA pre-treatment inhibited the Con A-induced apoptosis of hepatocytes by down-regulating the expression of BAX and up-regulating the expression of *** research found that FLA may improve liver injury in mice by activating NRF2 signaling pathway and inhibiting TRAF6/NF-κB signaling ***,FLA may improve liver injury in mice by shifting gut microbial composition to reduce the release of inflammatory cytokines in the serum and prevent the necrosis of ***-regulation of NRF2 signaling pathway,down-regulation of TRAF6/NF-κB signaling pathway,and an increase in the relative abundance of Lactobacillus_johnsonii and ligilactobacillus_murinus play a protective role in liver.

关键词： Autoimmune hepatitis Concanavalin A Lentinus edodes TRAF6/NF-κB NRF2

Energy Transfer Dynamics between Carbon Quantum Dots and Molybdenum Disulfide Revealed by Transient Absorption Spectroscopy

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Chinese Journal of Chemical Physics 2023年第5期36卷 503-508,I0001页

作者： Ruixiang Wu xin liu Xiaoshuai Wang Jingjing Luo Bin li Shengzhi Wang xiangyang Miao Key Laboratory of Spectral Measurement and Analysis of Shanxi Province College of Physics and Information EngineeringShanxi Normal UniversityTaiyuan 030031China

Zero-dimensional environmentally friendly carbon quantum dots(CQDs)combined with two-di-mensional materials have a wide range of applications in optoelec-tronic *** combined steady-state and transient absorp-tion spectroscopies to study the energy transfer dynamics between CQDs and molybdenum disulfide(MoS_(2)).Transient absorption plots showed photoinduced absorption and stimulated emission features,which involved the intrinsic and defect states of *** MoS_(2)to CQDs solution,the lowest unoccupied molecular orbital of CQDs transferred energy to MoS_(2),which quenched the intrinsic emission at 390 *** addition of MoS_(2),CQD-MoS_(2)composites quenched defect emission at 490 nm and upward absorption,which originated from another energy transfer from the defect *** energy transfer paths between CQDs and MoS_(2)were efficiently manipulated by changing the concentration of MoS_(2),which laid a foundation for improving device performance.

关键词： Energy transfer Transient absorption spectroscopy Carbon quantum dot Molybdenum disulfide

Deep Learning in Medical Ultrasound Analysis: A Review

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Engineering 2019年第2期5卷 261-275页

作者： Shengfeng liu Yi Wang xin Yang Baiying Lei li liu Shawn xiang li Dong Ni Tianfu Wang National-Regional Key Technology Engineering Laboratory for Medical Ultrasound & Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging & School of Biomedical Engineering Health Science Center Shenzhen University Shenzhen 518060 China Department of Computer Science and Engineering The Chinese University of Hong Kong Hong Kong China

Ultrasound (US) has become one of the most commonly performed imaging modalities in clinical practice. It is a rapidly evolving technology with certain advantages and with unique challenges that include low imaging quality and high variability. From the perspective of image analysis, it is essential to develop advanced automatic US image analysis methods to assist in US diagnosis and/or to make such assessment more objective and accurate. Deep learning has recently emerged as the leading machine learning tool in various research fields, and especially in general imaging analysis and computer vision. Deep learning also shows huge potential for various automatic US image analysis tasks. This review first briefly introduces several popular deep learning architectures, and then summarizes and thoroughly discusses their applications in various specific tasks in US image analysis, such as classification, detection, and segmentation. Finally, the open challenges and potential trends of the future application of deep learning in medical US image analysis are discussed.

关键词： Deep learning Medical ultrasound analysis Classification Segmentation Detection

The Epidemiology, Diagnosis and Prognosis of Long-COVID

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Biomedical and Environmental Sciences 2022年第12期35卷 1133-1139页

作者： DU Ying ZHANG Jie WU li Juan ZHANG Qun WANG You xin Beijing Key Laboratory of Clinical Epidemiology School of Public HealthCapital Medical UniversityBeijing 100069China Chinese Center for Disease Control and Prevention Beijing 102206China Centre for Precision Medicine Edith Cowan UniversityPerth WA6027Australia

INTRODUCTION As of October 26, 2022, more than 625 million confirmed cases of COVID-19 and more than 6.56 million deaths have been reported to the World Health Organization(WHO), and the natural history,clinical course, and long-term consequences of this new disease are still not completely *** more than two years of fighting against the SARS-CoV-2 pandemic, the number of patients with long-term persistent COVID-19 symptoms after acute infection is noteworthy.

关键词： Epidemiology acute clinical

Evolution of nuclear charge radii in copper and indium isotopes

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Chinese Physics C 2022年第6期46卷 138-146页

作者： Rong An xiang Jiang li-Gang Cao Feng-Shou Zhang Key Laboratory of Beam Technology of Ministry of Education Institute of Radiation TechnologyBeijing Academy of Science and TechnologyBeijing 100875China Key Laboratory of Beam Technology of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Acceleator of LanzhouLanzhou 730000China

Systematic trends in nuclear charge radii are of great interest due to universal shell effects and odd-even staggering(OES).The modified root mean square(rms)charge radius formula,which phenomenologically accounts for the formation of neutron-proton(np)correlations,is here applied for the first time to the study of odd-Z copper and indium *** results obtained by the relativistic mean field(RMF)model with NL3,PK1 and NL3^(*)parameter sets are compared with experimental *** results show that both OES and the abrupt changes across N=50 and 82 shell closures are clearly reproduced in nuclear charge *** inverted parabolic-like behaviors of rms charge radii can also be described remarkably well between two neutron magic numbers,namely N=28 to 50 for copper isotopes and N=50 to 82 for indium *** implies that the np-correlations play an indispensable role in quantitatively determining the fine structures of nuclear charge radii along odd-Z isotopic ***,our conclusions have almost no dependence on the effective forces.

关键词： nuclear charge radii neutron-proton correlations relativistic mean field theory odd-even staggering shell closure

Ultrasonic preparation of nano-nickel/activated carbon composite using spent electroless nickel plating bath and application in degradation of 2,6-dichlorophenol

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Journal of Environmental Sciences 2014年第11期26卷 2355-2361页

作者： Jingyu Su Guanping Jin Changyong li Xiaohui Zhu Yan Dou Yong li xin Wang Kunwei Wang Qianqian Gu Department of Application Chemistry of School of Chemical Engineering Hefei University of Technology

Ni was effectively recovered from spent electroless nickel （EN） plating baths by forming a nano-nickel coated activated carbon composite. With the aid of ultrasonication, melamine- formaldehyde-tetraoxalyl-ethylenediamine chelating resins were grafted on activated carbon （MFT/AG）. PdC12 sol was adsorbed on MFT/AC, which was then immersed in spent electroless nickel plating bath; then nano-nickel could be reduced by ascorbic acid to form a nano-nickel coating on the activated carbon composite （Ni/AC） in situ. The materials present were carefully examined by Fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy, X-ray photoelectron spectroscopy and electro- chemistry techniques. The resins were well distributed on the inside and outside surfaces of activated carbon with a size of 120 ± 30 nm in MFT/AC, and a great deal of nano-nickel particles were evenly deposited with a size of 3.8 ± 1.1 nm in Ni/MFT. Moreover, Ni/AC was successfully used as a catalyst for ultrasonic degradation of 2.6-dichloronhenol.

关键词： Nickel recovery Ultrasonic Activated carbon 2 6 -Dichlorophenol Degradation

Potent in vitro Interference of Fleroxacin in DNA-binding,Unwinding and ATPase Activities of Bloom Helicase

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Biomedical and Environmental Sciences 2013年第4期26卷 231-242页

作者： LUO Heng XU Hou Qiang CHEN xiang DING Mei YANG Qi xin li Kun Key Laboratory of Animal Genetics Breeding and Reproduction in Plateau Mountainous RegionMinistry of EducationCollege of Animal ScienceGuizhou University Guizhou Key Laboratory of Animal Genetics Breeding and ReproductionCollege of Animal ScienceGuizhou University Provincial Key Laboratory for Agricultural Pest Management of Mountainous Region Guizhou University

Objective To study the effect of fleroxacin （FLRX） on biological properties of Bloom （BLM） helicase catalytic core （BLM 642-2290 helicase） in vitro and the molecular mechanism of interaction between the two molecules. Methods DNA-binding and unwinding activities of BLM 642-1290 helicase were assayed by fluorescence polarization and gel retardation assay under conditions that the helicase was subjected to different concentrations of FLRX. Effect of FLRX on helicase ATPase activity was analyzed by phosphorus-free assay based on a colorimetric estimation of ATP hydrolysis-produced inorganic phosphate. Molecular mechanism of interaction between the two molecules was assayed by ultraviolet and fluorescence spectra. Results The DNA unwinding and ATPase activities of BLM 642-1290 helicase were inhibited whereas the DNA-binding activity was promoted in vitro. A BLM-FLRX complex was formed through one binding site, electrostatic and hydrophobic interaction force. Moreover, the intrinsic fluorescence of the helicase was quenched by FLRX as a result of non-radioactive energy transfer. The biological activity of helicase was affected by FLRX, which may be through an allosteric mechanism and stabilization of enzyme conformation in low helicase activity state, disruption of the coupling of ATP hydrolysis to unwinding, and blocking helicase translocation on DNA strands. Conclusion FLRX may affect the biological activities and conformation of BLM 642-1290 helicase, and DNA helicase may be used as a promising drug target for some diseases.

关键词： Biological activity BLM helicase Fleroxacin Interaction mechanism

Generation and characterization of customized Laguerre–Gaussian beams with arbitrary profiles

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Frontiers of physics 2024年第4期19卷 235-241页

作者： Chengyuan Wang Yun Chen Jinwen Wang xin Yang Hong Gao Fuli li Ministry of Education Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter Shaanxi Province Key Laboratory of Quantum Information and Quantum Optoelectronic DevicesSchool of PhysicsXi’an Jiaotong UniversityXi’an 710049China Department of Physics Huzhou UniversityHuzhou 313000China

We experimentally demonstrate the generation of customized Laguerre–Gaussian(LG)beams whose intensity maxima are localized around any desired *** principle is to act with appropriate algebraic functions on the angular spectra of LG *** characterize the propagation properties of these beams and compare them with non-diffraction caustic beams possessing the same intensity *** results manifest that the customized-LG beams can maintain their profiles during propagation and suffer less energy loss than the non-diffraction caustic beams,and hence are able to propagate a longer ***,the customized-LG beam exhibits self-healing ability when parts of their bodies are *** new structure beam has potential applications in areas such as optical communication,soliton routing and steering,and optical tweezing.

关键词： light manipulation wave propagation invariant optical fields

Tipping Point Detection Using Reservoir Computing

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Research 2024年第1期2023卷 779-790页

作者： xin li Qunxi Zhu Chengli Zhao Xuzhe Qian Xue Zhang Xiaojun Duan Wei lin College of Science National University of Defense TechnologyChangshaHunan 410073China Research Institute of Intelligent Complex Systems and MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200433China Shanghai Artificial Intelligence Laboratory Shanghai 200232China School of Mathematical Sciences SCMSSCAMand CCSBFudan UniversityShanghai 200433China

Detection in high fidelity of tipping points,the emergence of which is often induced by invisible changes in internal structures or/and external interferences,is paramountly beneficial to understanding and predicting complex dynamical systems(CDSs).Detection approaches,which have been fruitfully developed from several perspectives(e.g.,statistics,dynamics,and machine learning),have their own advantages but still encounter difficulties in the face of high-dimensional,fluctuating ***,using the reservoir computing(RC),a recently notable,resource-conserving machine learning method for reconstructing and predicting CDSs,we articulate a model-free framework to accomplish the detection only using the time series observationally recorded from the underlying unknown CDSs.

关键词： computing record ping