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Syntheses of Binuclear Copper(I) Complexes Containing Benzimidazole

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Chinese Journal of Structural Chemistry 2005年第8期24卷 895-900页

作者： KANG Bei-sheng ZHAO Dong GUO li-bing ZHENG xin SUN Yu-An School of Material and Chem. Eng. Zhengzhou Institute of Light Industry Zhengzhou 450002 China Henan Institute of Chemistry Zhengzhou 450002 China

A binuclear copper（I） complex [Cu2（dppm）2（C7H6N2）2]（NO3）2 （C7H6N2 = benzimidazole, dppm = Ph2PCH2PPh2） has been synthesized and characterized by X-ray *** crystal belongs to monoclinic, space group C2/c with a = 14.167（3）, b = 21.209（4）, c =20.680（4）A°, β = 103.93（3）°, C32H28CuN3O3P2, Mr = 628.05, Z = 8, μ = 0.868 mm^-1, V = 6031 （2） ,A°^3,F（000） = 2592, De= 1.383 g/cm^3, R = 0.0593 and wR = 0.1736. A total of 5297 independent reflections were collected, of which 3503 were observed with 1 〉 2σ（/）. The central copper atom is tri-coordinated by phosphorus atoms from bridging dppm and nitrogen atom from benzimidazole. In the coordination sphere, the bond lengths of Cu-P（1） and Cu-P（2） are 2.2607（17） and 2.2503（16） A°,respectively and the P-Cu-P bond angle is 127.26（6）°.

关键词： copper dppm benzimidazole complex binuclear

Multiscale observation of li plating for lithium-ion batteries

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Rare Metals 2021年第11期40卷 3038-3048页

作者： xin-Lei Gao xin-Hua liu Wen-Long xie li-sheng Zhang Shi-Chun Yang School of Transportation Science and Engineering Beihang UniversityBeijing 100191China

As the most hazardous side reaction,li plating poses high risks of undermining electrochemical performance of li-ion batteries by accelerating *** some extreme abuse conditions,li plating can even jeopardize safety performance and induce catastrophic results like thermal ***,multiscale observation of li plating is of great significance for understanding the internal mechanisms and early detection of li *** this mini-review,the recent progress of formation mechanisms of plated metallic lithium was ***,the in situ and ex situ observation methods of macroscopic,microscopic and atomic level were *** electrode provides a promising tool for real-time monitoring of anode potential,which is the critical factor of li plating,showing great potentials in cloudbased battery management ***,some perspectives for future researches on li plating observation and corresponding utilizations in developing li plating free control strategies were proposed.

关键词： lithium-ion battery li plating Multiscale observation Reference electrodes

DMH1(4-[6-(4-isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline) inhibits chemotherapeutic drug-induced autophagy

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Acta Pharmaceutica Sinica B 2015年第4期5卷 330-336页

作者： Yue sheng Bo Sun xin xie Na li Deli Dong The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratory of Cardiovascular Research Ministry of Education Department of PharmacologyHarbin Medical University

Our previous work found that DMH1(4-[6-(4-isopropoxyphenyl)pyrazolo [1,5-a]pyrimidin-3-yl]quinoline) was a novel autophagy inhibitor. Here, we aimed to investigate the effects of DMH1 on chemotherapeutic drug-induced autophagy as well as the efficacy of chemotherapeutic drugs in different cancer cells. We found that DMH1 inhibited tamoxifen- and cispcis-diaminedichloroplatinum(II)(CDDP)-induced autophagy responses in MCF-7 and HeLa cells, and potentiated the anti-tumor activity of tamoxifen and CDDP for both cells. DMH1 inhibited 5-fluorouracil(5-FU)-induced autophagy responses in MCF-7 and HeLa cells, but did not affect the anti-tumor activity of 5-FU for these two cell lines. DMH1 itself did not induce cell death in MCF-7 and HeLa cells, but inhibited the proliferation of these cells. In conclusion, DMH1 inhibits chemotherapeutic drug-induced autophagy response and the enhancement of efficacy of chemotherapeutic drugs by DMH1 is dependent on the cell sensitivity to drugs.

关键词： Autophagy Tamoxifen 5-Fluorouracil Cancer cells

Type 2 Diabetes and Hyperlipidemia Caused by AKT2 Gene Combined with PliN1 Gene Mutation:A Case Report

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Biomedical and Environmental Sciences 2023年第4期36卷 371-375页

作者： liU Jing li sheng bing LUO xie YUAN Lei LAI Ye Rui ZHANG li li Department of Endocrinology the Second Affiliated HospitalChongqing Medical UniversityChongqing 400010China

Type 2 diabetes(T2DM)is a common metabolic disorder associated with environmental and genetic factors characterized by both insulin resistance and relative insufficiency of insulin secretion.T2DM has a high genetic *** is reported that 40% of first-degree relatives of patients with T2DM may develop diabetes;however,the incidence rate is only 6% in the general population[1].

关键词： T2DM AKT2 insufficiency

Effects of Temperature and Alloying Elements on γ Phase Fraction of Grain-oriented Silicon Steel

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Journal of Iron and Steel Research International 2016年第6期23卷 573-579页

作者： bing FU Hai-jun WANG Jian-xin YAN li XIANG sheng-tao QIU Guo-guang CHENG National Engineering Research Center of Continuous Casting Technology China Iron and Steel Research Institute Group School of Metallurgical and Ecological Engineering University of Science and Technology Beijing State Key Laboratory of Advanced Steel Processes and Products Central Iron and Steel Research Institute Valin LY Steel Co. Ltd.

The effects of temperature and alloying elements on γ phase fraction of grain-oriented silicon steel,which contained 2.97-3.42mass% Si and 0.028-0.058mass% C,were studied by microstructure observation and ***,the quantitative relationships of temperature as well as C,Si,and Mn contents to γ phase fraction were obtained by numerical *** experimental results show that γ phase fraction firstly increases with increasing temperature,reaches a maximum and then decreases in the temperature range of 900-1 250 ℃.The temperature corresponding to the maximum γ phase fraction is about 1 150-1 200℃.Meanwhile,the γ phase fractions in steels at the same temperature have some differences because of different contents of various alloying *** verification results show that the values of γ phase fractions to C,Si,and Mn contents at the specific temperatures,which were obtained by multiple linear regression method,agree well with the measured *** addition,the values of γ phase fractions to C,Si,and Mn contents in the temperature range of 900-1 250℃,which were obtained by binomial regression method,agree with the measured values when the contents of Mn and soluble Al are not more than 0.320mass% and 0.034mass%,*** obtained equations can carry out the approximate prediction of γ phase fractions of grain-oriented silicon steels during the hot rolling process.

关键词： fitting Grain steels approximate alloying carry agree reaches contained utilizing

Mesoscopic measurement of damage and shear bands of granite residual soil using Micro-CT and digital volume correlation

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Journal of Mountain Science 2023年第11期20卷 3423-3436页

作者： li Cheng-sheng ZHANG bing-xin liU Zhi-jun KONG ling-wei SHU Rong-jun Department of Civil and Environmental Engineering Shantou UniversityShantou 515000China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChineseAcademy of SciencesWuhan 430000China College of Civil and Architecture Engineering Chuzhou UniversityChuzhou 239000China

The mesomechanics of geotechnical materials are closely related to the macromechanical properties,especially the mesoscale evolution of shear bands,which is helpful for understanding the failure mechanism of geotechnical ***,there is lack of effective quantitative analysis method for the complex evolution mechanism of threedimensional shear *** this work,we used X-ray computed tomography(CT)to reconstruct volume images and used the digital volume correlation(DVC)method to calculate the three-dimensional strain fields of granite residual soil samples at different loading *** trend of the failure surface of the shear bands was obtained by the planar fitting method,and the connectivity index was constructed according to the projection characteristics of the shear bands on the failure trend *** results support the following findings:the connectivity index of the shear band increases rapidly and then slowly with increasing axial strain,which is characterized by a near'S'*** the stress reaches the peak value,the connectivity index of the shear bands almost exceeds *** contribution of the new shear band volume to the connectivity of the shear bands becomes increasingly small with increasing axial *** by quartz grains and stress at the initial stage,the dip angle gradually and finally approaches the included angle of the maximum shear stress from the discrete state with increasing axial *** tendency and dip angle of the resulting shear bands are dynamic,and the tendency slightly deflects with increasing loading.

关键词： Damage Shear band Digital volume correlation Micro-CT Granite residual soil

Clinical study on the surgical treatment of atypical lisfranc joint complex injury

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World Journal of Clinical Cases 2020年第19期8卷 4388-4399页

作者： Xu li Le-sheng Jia Ang li xin xie Jun Cui Guo-liang li Department of Foot and Ankle Surgery Central Hospital Affiliated to Shenyang Medical CollegeShenyang 110024Liaoning ProvinceChina Department of Functional Experiment Center Liaoning University of Traditional Chinese MedicineShenyang 110847Liaoning ProvinceChina

BACKGROUND lisfranc injuries have not received much attention by orthopedic doctors in the past,and there is little related research on the diagnosis and treatment of these *** recent years with the rise in foot and ankle surgery,doctors are now paying more attention to this type of ***,there is still a high rate of missed diagnosis due to insufficient attention causing treatment delays or inadequate treatments,which eventually result in greater sequelae;including long-term pain,arthritis,foot deformity *** particular,for cases with a mild lisfranc joint complex injury,the incidence of sequelae is *** To select an active surgical treatment for an atypical lisfranc joint complex injury and to evaluate the clinical efficacy of the surgical *** The clinical data of 18 patients,including 10 males and 8 females aged 20-64 years with lisfranc injuries treated in our department from January 2017 to September 2019 were retrospectively *** patients were treated with an open reduction and internal fixation method using locking titanium mini-plates and hollow screws or Kirschner wires.X-ray images were taken and follow-up was performed monthly after the operation;the internal fixation was then removed 4-5 mo after the operation;and the American Orthopedic Foot and Ankle Society(AOFAS)score was used for evaluation on the last *** All patients were followed up for 6-12 mo.A good/excellent AOFAS score was observed in 88.9%of *** For atypical lisfranc joint complex injuries,active open reduction and internal fixation can be performed to enable patients to obtain a good prognosis and satisfactory functional recovery.

关键词： lisfranc joint complex injury Avulsion fracture Open reduction and internal fixation Atypical lisfranc injury Stress test Computed tomography

Polarized few-layer g-C3N4 as metal-free electrocatalyst for highly efficient reduction of CO2

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Nano Research 2018年第5期11卷 2450-2459页

作者： bing Zhang Tian-Jian Zhao Wei-Jie Feng Yong-xing liu Hong-Hui Wang Hui Su li-bing Lv xin-Hao li Jie-sheng Chen School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 China

The greenhouse effect and global warming are serious problems because the increasing global demand for fossil fuels has led to a rapid rise in greenhouse gas exhaust emissions in the atmosphere and disruptive changes in climate. As a major contributor, CO2 has attracted much attention from scientists, who have attempted to convert it into useful products by electrochemical or photoelectrochemical reduction methods. Facile design of efficient but inexpensive and abundant catalysts to convert CO2 into fuels or valuable chemical products is essential for materials chemistry and catalysis in addressing global climate change as well as the energy crisis. Herein, we show that two-dimensional fewlayer graphitic carbon nitride （g-C3N4） can function as an efficient metal-free electrocatalyst for selective reduction of CO2 to CO at low overpotentials with a high Faradaic efficiency of - 80%. The polarized surface of ultrathin g-C3N4 layers （thickness： -1 nm）, with a more reductive conduction band, yields excellent electrochemical activity for CO2 reduction.

关键词： CO2 reduction two-dimensional (2D) materials metal-free electrocatalyst electrochemistry nanostructures

Current status and progress in laparoscopic surgery for gallbladder carcinoma

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World Journal of Gastroenterology 2023年第16期29卷 2369-2379页

作者： Jia Sun Tian-Ge xie Zu-Yi Ma xin Wu bing-Lu li Department of General Surgery State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China

Gallbladder carcinoma(GBC)is the most common biliary tract malignancy associated with a concealed onset,high invasiveness and poor *** surgery remains the only curative treatment for GBC,and the optimal extent of surgery depends on the tumor *** resection can be achieved by simple cholecystectomy for Tis and T1a ***,whether simple cholecystectomy or extended cholecystectomy,including regional lymph node dissection and hepatectomy,is the standard surgical extent for T1b GBC remains *** cholecystectomy should be performed for T2 and some T3 GBC without distant *** radical surgery is essential for incidental gallbladder cancer diagnosed after *** locally advanced GBC,hepatopancreatoduodenectomy may achieve R0 resection and improve long-term survival outcomes,but the extremely high risk of the surgery limits its *** surgery has been widely used in the treatment of gastrointestinal *** was once regarded as a contraindication of laparoscopic ***,with improvements in surgical instruments and skills,studies have shown that laparoscopic surgery will not result in a poorer prognosis for selected patients with GBC compared with open ***,laparoscopic surgery is associated with enhanced recovery after surgery since it is minimally invasive.

关键词： gallbladder metastasis curative treatment