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Bayesian Lasso with Neighborhood Regression Method for Gaussian Graphical Model

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Acta Mathematicae Applicatae Sinica 2017年第2期33卷 485-496页

作者： Fan-qun LI xin-sheng ZHANG Department of Statistics School of Management Fudan University Institute of Statistics and Applied Mathematics Anhui University of Finance and Economics

In this paper, we consider the problem of estimating a high dimensional precision matrix of Gaussian graphical model. Taking advantage of the connection between multivariate linear regression and entries of the precision matrix, we propose Bayesian Lasso together with neighborhood regression estimate for Gaussian graphical model. This method can obtain parameter estimation and model selection simultaneously. Moreover, the proposed method can provide symmetric confidence intervals of all entries of the precision matrix.

关键词： gaussian graphical model regression precision matrix Bayesian Lasso Frobenius loss

Bayesian Estimation of Large Precision Matrix Based on Cholesky Decomposition

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Acta Mathematica Sinica,English Series 2019年第5期35卷 619-631页

作者： Fan Qun LI xin sheng ZHANG Institute of Statistics and Applied Mathematics Anhui University of Finance and Economics School of Management Fudan University

In this paper, we consider the estimation of a high dimensional precision matrix of Gaussian graphical model. Based on the re-parameterized likelihood, we obtain the full conditional distribution of all parameters in Cholesky factor. Furthermore, by imposing the prior information, we obtain the shrinkage Bayesian estimator of large precision matrix, and establish the asymptotic distribution of all parameters in the Cholesky factor. At last, we demonstrate our method through the simulation study and an application to telephone call center data.

关键词： Bayesian estimation Cholesky decomposition graphical model shrinkage

Genetic and clinical markers for predicting treatment responsiveness in rheumatoid arthritis

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Frontiers of Medicine 2019年第4期13卷 411-419页

作者： xin Wu Xiaobao sheng Rong sheng Hongjuan Lu Huji Xu Department of Rheumatology and Immunology Shanghai Changzheng Hospital the Second Military Medical University Shanghai 200003 China School ofEconomics and Management Tongji University Shanghai 200092 China The Third Research Institute of the Ministry of Public Security Shanghai 200031 China Beijing Tsinghua Changgung Hospital School of Clinical Medicine Tsinghua University Beijing 100084 China Peking-Tsingh ua Center for Life Sciences Tsinghua University Beijing 100084 China

Although many drugs and therapeutic strategies have been developed for rheumatoid arthritis (RA) treatment, numerous patients with RA fail to respond to currently available agents. In this review, we provide an overview of the complexity of this autoimmune disease by showing the rapidly increasing number of genes associated with RA. We then systematically review various factors that have a predictive value (predictors) for the response to different drugs in RA treatment, especially recent advances. These predictors include but are certainly not limited to genetic variations, clinical factors, and demographic factors. However, no clinical application is currently available. This review also describes the challenges in treating patients with RA and the need for personalized medicine. At the end of this review, we discuss possible strategies to enhance the prediction of drug responsiveness in patients with RA.

关键词： rheumatoid arthritis gene clinical markers therapy

First Enantioselective Synthesis of Isoamericanol A and Isoamericanin A

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Chinese Chemical Letters 2001年第6期12卷 485-486页

作者： Wen xin gu An xin WU Xue Gong SHE xin Fu PAN Department of Chemistry National Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhou 730000

The first enantioselective synthesis approach to two chiral 1,4-benzodioxane neolignans isoamericanol A and isoamericanin A was reported.

关键词： Enantioselective synthesis 1 4-benzodioxane neolignans

Multiple Jacobi Elliptic Function Solutions to Integrable Higher Order Broer-Kaup Equation in （2＋1）-Dimensional Spaces

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Communications in Theoretical Physics 2006年第2X期46卷 193-198页

作者： LI De-sheng LUO Cheng-xin College of Mathematics and Systems Science Shenyang Normal University Shenyang 110034 China

In this paper, we improve the method for deriving Jacobi elliptic function solutions of nonlinear evolution equations given in Ref. [12] and apply it to the integrable higher-order Broer-Kaup system in （2＋1）-dimens... 详细信息

关键词： Jacobi elliptic function projective Riccati equation higher-order Broer-Kaup system exact solutions

Toxic effect of acrylamide on the development of hippocampal neurons of weaning rats

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Neural Regeneration Research 2017年第10期12卷 1648-1654页

作者： sheng-min Lai Zi-ting gu Meng-meng Zhao Xi-xia Li Yu-xin Ma Li Luo Jing Liu Department of Human Anatomy and Histoembryology School of Basic CoursesGuangdong Pharmaceutical UniversityGuangzhouGuangdong ProvinceChina

Although numerous studies have examined the neurotoxicity of acrylamide in adult animals,the effects on neuronal development in the embryonic and lactational periods are largely ***,we examined the toxicity of acrylamide on neuronal development in the hippocampus of fetal rats during ***-Dawley rats were mated with male rats at a 1：1 *** were administered 0,5,10 or 20 mg/kg acrylamide intragastrically from embryonic days 6–*** gait scores were examined in pregnant rats in each group to analyze maternal *** weaning rats from each group were also euthanized on postnatal day 21 for follow-up *** staining was used to observe histological change in the *** was conducted to observe the condition of neurites,including dendrites and *** blot assay was used to measure the expression levels of the specific nerve axon membrane protein,growth associated protein 43,and the presynaptic vesicle membrane specific protein,*** gait scores of gravid rats significantly increased,suggesting that acrylamide induced maternal motor *** number of neurons,as well as expression of growth associated protein 43 and synaptophysin,was reduced with increasing acrylamide dose in postnatal day 21 weaning *** data suggest that acrylamide exerts dose-dependent toxic effects on the growth and development of hippocampal neurons of weaning rats.

关键词： nerve regeneration acrylamide hippocampus neurons developmental toxicity growth associated protein 43 synaptophysin weaning rats dentate gyrus protein developmental neurobiology neural regeneration

Physical modification of polyetheretherketone for orthopedic implants

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Frontiers of Materials Science 2014年第4期8卷 313-324页

作者： Ya-Wei DU Li-Nan ZHANG Zeng-Tao HOU xin YE Hong-sheng gu guo-Ping YAN Peng SHANG School of Materials Science and Engineering Wuhan Institute of Technology Wuhan 430073 China Center for Translational Medicine Research and Development Shenzhen Instituies of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 China Department of Spine Surgery Shenzhen Second People's Hospital Shenzhen 518035 China

Polyetheretherketone （PEEK） is regarded as one of the most potential candidates for replacing current implant applications. To obtain good bone-implant interfaces, many modification methods have been developed to enable PEEK and PEEK- based composites from bio-inert to bioactive. Among them, physical methods have aroused significant attention and been widely used to modify PEEK for orthopedic implants. This review summarizes current physical modification techniques of PEEK for orthopedic applications, which include composite strategies, surface coating methods and irradiation treatments. The positive consequences of those modification methods will encourage continuing investigations and stimulate the wide range of applications of PEEK-based implants in orthopedics.

关键词： polyetheretherketone (PEEK) modification bioactivity bone-implantinterface

Optimized use of MgO flux in the agglomeration of high-chromium vanadium–titanium magnetite

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International Journal of Minerals,Metallurgy and Materials 2015年第4期22卷 371-380页

作者： Jue Tang Man-sheng Chu Xiang-xin Xue School of Material and Metallurgy Northeastern University

The optimized use of MgO flux in the agglomeration of high-chromium vanadium-titanium magnetite was investigated system- atically through sinter and pellet experiments. MgO was added in the form of magnesite. When the content of MgO in the sinter was in- creased from 1.95wt% to 2.63wt%, the low-temperature reduction degradation index increased from 80.57% to 82.71%. When the content of MgO in the pellet was increased from 1.14wt% to 2.40wt%, the reduction swelling index decreased from 15.2% to 8.6%; however, the com- pressive strength of the oxidized pellet decreased dramatically and it was 1985 N with an MgO content of 1.14wt%. This compressive strength does not satisfy the requirements for blast-furnace production. When all of the aforementioned results were taken into account, the sinter with a high MgO content （2.63wt%） matching the pellet with a low MgO content （less than 1.14wt%） was the rational burden structure for smelting high-chromium vanadium-titanium magnetite in blast furnaces.

关键词： magnetite ore pellets magnesia agglomeration burden sintering

Preparation of Al_(72)Ni_8Ti_8Zr_6Nb_3Y_3 amorphous powders and bulk materials

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International Journal of Minerals,Metallurgy and Materials 2016年第10期23卷 1187-1195页

作者： Yu Wu xin-fu Wang Fu-sheng Han Key Laboratory of Materials Physics Institute of Solid State Physics Chinese Academy of Sciences

Amorphous Al_（72）Ni_8Ti_8Zr_6Nb_3Y_3 powders were successfully fabricated by mechanical alloying. The microstructure, glass-forming ability, and crystallization behavior of amorphous Al_（72）Ni_8Ti_8Zr_6Nb_3Y_3 powders were investigated by X-ray diffraction（XRD）, transmission electron microscopy（TEM）, and differential scanning calorimetry（DSC）. The isothermal crystallization kinetics was analyzed by the Johnson-Mehl-Avrami equation. In the results, the supercooled liquid region of the amorphous alloy is as high as 81 K, as determined by-non-isothermal DSC curves. The activation energy for crystallization is as high as 312.6 kJ ·mol1 obtained by Kissinger and Ozawa analyses. The values of Avrami exponent（n） imply that the crystallization is dominated by interface-controlled three-dimensional growth in the early stage and the end stage and by diffusion-controlled two- or three-dimensional growth in the middle stage. In addition, the amorphous Al_（72）Ni_8Ti_8Zr_6Nb_3Y_3 powders were sintered under 2 GPa at temperatures of 673 K and 723 K. The results show that the Vickers hardness of the compacted powders is as high as Hv 1215.

关键词： amorphous alloys mechanical alloying thermal stability pressing Vickers hardness