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Allosteric regulation of Keap1 by 8b-hydroxy-acyclocostunolide for the treatment of acute lung injury

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4174-4178页

作者： Juan Zhang Min Zhang Qi-Meng Zhu xin-Rong Xu Yan-Li Feng sheng Lin Feng Qiu cheng-Peng Sun School of Chinese Materia Medic1 Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China

To the Editor:Acute lung injury(ALI)is a debilitating lung disease characterized by pulmonary edema,diffuse alveolar damage,and uncontrolled neutrophil *** cases of ALI can potentially lead to the development of acute respiratory distress syndrome(ARDS),which can lead to impaired respiratory function,multiorgan dysfunction,and an extremely high mortality *** may be caused by various factors,including aspiration,severe pneumonia,sepsis,trauma,fatty embolism,pancreatitis,and blood *** clinical approaches to treating ALI/ARDS include mechanical ventilation,extracorporeal membrane oxygenation(ECMO),and other supportive therapies5,***,ALI/ARDS is an urgent problem that needs to be addressed in the field of respiratory critical care and innovative mechanisms and therapies6.

关键词： Macrophage overactivation Keap1 8b-Hydroxy-a-cyclocostunolide Nrf2 Acute lung injury

Super P and MoO2/MoS2 co-doped gradient nanofiber membrane as multi-functional separator for lithium–sulfur batteries

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Rare Metals 2024年第9期43卷 4263-4273页

作者： xin Liang Dong-Qing Zhao Qian-Qian Huang sheng Liang Li-Li Wang Lei Hu Ling-Li Liu Kun-Hong Hu Chong-Hai Deng sheng cheng Er-Tao Zhu Hua-Xia Deng School of Energy Materials and Chemical Engineering LIB Technology Center of Anhui ProvinceHefei University Instrumental Analysis Centre Hefei University of Technology Hefei Youngy Energy Materials Co. Ltd. Department of Modern Mechanics University of Science and Technology of China

Lithium-sulfur battery is one of the most promising battery systems for industrialization due to its high theoretical specific capacity and high energy ***,the??shuttle effect??has restrained the advancement of lithium-sulfur *** this work,a gradient-structured nanofiber membrane with pure gelatin on one side and Super P-MoO2/MoS2-gelatin on the other side was created using a multi-step electrostatic spinning technique,which was applied for multi-functional separator for lithium-sulfur *** pure gelatin layer facing the anode side primarily homogenizes the lithium flux,whereas the Super P-MoO2/MoS2-gelatin layer facing the cathode side primarily adsorbs polysulfides by physical and chemical adsorption and enhancing polysulfide conversion *** findings demonstrate that even after 150 cycles at 0.2C,the lithium-sulfur battery can still sustain a discharge-specific capacity of 572.3 mAh·*** used with Li||Li symmetric batteries,it has a cycle life of more than 1200 *** commercialization of lithium-sulfur batteries is given a fresh idea by this straightforward preparation technique.

关键词： Li–S battery Membrane MoO2/MoS2 Nanofiber

Imide-pillared covalent organic framework protective films as stable zinc ion-conducting interphases for dendrite-free Zn metal anodes

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Journal of Energy Chemistry 2024年第10期97卷 470-477页

作者： Xiaoman Ye Xuemei Xiao Zhijing Wu xin Wu Lin Gu sheng Liu School of Chemical Engineering and Technology Sun Yat-sen University The Key Lab of Low-Carbon Chemistry & Energy Conservation of Guangdong Province Sun Yat-sen University

The notorious growth of zinc dendrite and the water-induced corrosion of zinc metal anodes（ZMAs）restrict the practical development of aqueous zinc ion batteries（AZIBs）.In this work,a zinc metallized,imide-pillared covalent organic framework（ZPC） protective film has been engineered as a stable Zn2+ion-conducting interphase to modulate interfacial kinetics and suppress side reactions for *** to bare Zn,ZPC@Zn exhibits a higher Zn2+ionic conductivity,a larger Zn2+transference number,a lower electronic conductivity,a smaller desolvation activation energy and correspondingly a significant suppression of corrosion,hydrogen evolution and Zn ***,the ZPC@Zn||ZPC@Zn symmetric cell obtains a cycling lifespan over 3000 h under 5 mA cm-2for 1 mA h *** ZPC@Zn||NH4V4O10coin-type full battery delivers a specific capacity of 195.8 mA h g-1with a retention rate of78.5% at 2 A g-1after 1100 cycles,and the ZPC@Zn||NH4V4O10pouch full cell shows a retention of70.1% in reversible capacity at 3 A g-1after 1100 *** present incorporation of imide-linked covalent organic frameworks in the surface modification of ZMAs will offer fresh perspectives in the search for ideal protective films for the practicality of AZIBs.

关键词： Aqueous zinc ion batteries Covalent organic frameworks Imide linkage Surface modification Zinc metal anodes

Reconstruction of biomimetic ionic channels within covalent organic frameworks for ultrafast and selective uranyl capture

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Science China Chemistry 2024年第10期67卷 3423-3431页

作者： cheng-Rong Zhang Xiao-Juan Chen cheng-Peng Niu cheng Meng Shun-Mo Yi xin Liu Jia-xin Qi Qiu-Xia Luo Ru-Ping Liang Jian-Ding Qiu State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China College of Chemistry and Chemical Engineering Nanchang UniversityNanchang 330031China

The efficient extraction of uranium,as the primary component of nuclear energy,holds significant *** inspiration from the charge interaction observed in biological ion channels,we encapsulated negatively charged polystyrene sulfonate(PSS)or sodium polystyrene carboxylate(PVBA)into the nanochannels of amidoxime functionalized covalent organic framework(COF-AO)in-situ to alter the cavity environment of *** synthesized COF-AO-PSS and COF-AO-PVBA are used for ultra-fast and highly selective uranium *** negatively charged PSS/PVBA was confined in the COF-AO channel providing the driving force for uranium transport and blocking other ions,thus creating a highly selective“uranium highway”.Additionally,introducing sulfonate groups or carboxyl groups into COF-AO offers supplementary coordination environments and weak interactions with *** to charge-assisted migration and various interaction mechanisms,both COF-AO-PSS and COF-AO-PVBA exhibit faster adsorption kinetics and higher selectivity compared to COF-AO *** adsorption capacities are 3.8 times and 2.4 times that of COF-AO alone respectively which highlights the necessity for constructing biomimetic ion channels in uranium adsorption *** work presents a bionic adsorbent based on covalent organic frameworks(COFs)for the first time,overcoming environmental and equipment limitations associated with traditional photocatalysis and electrocatalysis methods for uranium capture,opening up new avenues for designing multifunctional materials that mimic biological systems.

关键词： covalent organic frameworks Uranium biomimetic ion-channels adsorption

Numerical analysis of the correlation between fluid dynamic modes and hydrodynamic noise in flows around a three-dimensional circular cylinder

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Journal of Hydrodynamics 2024年第1期36卷 119-129页

作者： Jia-jia Qin Ming-xin Zou Yuan Zhuang De-cheng Wan Computational Marine Hydrodynamics Lab(CMHL) School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Wuhan Second Ship Design and Research Institute Wuhan430205China

The flow around a circular cylinder for Re=1000 is characterized by flow separation and Karman vortex *** typical flow features can be captured to study the correlation between fluid fields and sound *** this paper,the three-dimensional circular cylinder is taken as the research object,and the probes of surface fluctuating pressure and far field sound pressure are arranged every 10°.The directional diagram and the coherence of fluctuating pressure and sound pressure are *** relationship between the flow mode and hydrodynamic noise is studied by using dynamic mode decomposition(DMD).The characteristics of the dipole and quadrupole sound source term of a long span cylinder are *** results show that at the angles between 30°–120°and 190°–350°,the fluctuating pressure contributes more to the generation of dipole *** quadrupole sound source shows three-dimensional effects,which is more obvious in a cylinder with large spanwise length.

关键词： Pressure coherence dynamic mode decomposition flow-sound correlation circular cylinder

Single-structure 3-axis Lorentz force magnetometer based on an AlN-on-Si MEMS resonator

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Microsystems & Nanoengineering 2024年第3期10卷 75-86页

作者： cheng Tu Xu-heng Ou-Yang Ying-jie Wu Xiao-sheng Zhang School of Integrated Circuit Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

This work presents a single-structure 3-axis Lorentz force magnetometer(LFM)based on an AlN-on-Si MEMS *** operation of the proposed LFM relies on the flexible manipulation of applied excitation currents in different directions and frequencies,enabling the effective actuation of two mechanical vibration modes in a single device for magnetic field measurements in three ***,the excited out-of-plane drum-like mode at 277 kHz is used for measuring the x-and y-axis magnetic fields,while the in-plane square-extensional mode at 5.4 MHz is used for measuring the z-axis magnetic *** different configurations of applied excitation currents ensure good crossinterference immunity among the three *** to conventional capacitive LFMs,the proposed piezoelectric LFM utilizes strong electromechanical coupling from the AlN layer,which allows it to operate at ambient pressure with a high *** understand and analyze the measured results,a novel equivalent circuit model for the proposed LFM is also reported in this work,which serves to separate the effect of Lorentz force from the unwanted capacitive *** demonstrated 3-axis LFM exhibits measured magnetic responsivities of 1.74 ppm/mT,1.83 ppm/mT and 6.75 ppm/mT in the x-,y-and z-axes,respectively,which are comparable to their capacitive counterparts.

关键词： resonator Lorentz structure

Feasibility Study on Recovering Human-Occupied Vehicle with An Offshore Crane

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China Ocean Engineering 2024年第4期38卷 648-662页

作者： HAN Ming-yue XIE Peng XIAN Hao-yi ZHONG xin-xin CHEN sheng-lin SUN Tie-rui SUN Feng-lei School of Ocean Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China Key Laboratory of Comprehensive Observation of Polar Environment(Sun Yat-sen University) Ministry of EducationZhuhai 519082China Guangzhou Marine Engineering Corporation Guangzhou 510250China

Launching and recovering human-occupied vehicles(HOVs)has always been a challenging *** current recovery process requires staff to manually complete the tethering task,which is inefficient and endangers the lives of *** paper suggests moving the recovery position from the surface to underwater at approximately half the wavelength of the water depth(30−50 m underwater),where the HOV experiences less environmental *** ROV equipped with a ultra-short baseline beacon(USBL)and a manipulator was used to complete the tethering ***,a shackle customized to the shape of the manipulator’s gripper is fitted to the end of the cable to simplify the tethering *** investigate the dynamic response of recovering the HOV using this suggested method,a comprehensive numerical model is developed in this *** effects of wind,surface waves,ocean currents,and nonlinear interaction between the installation vessel and the HOV are quantitatively *** results show that the proposed recovery method can reduce the motion amplitude of the HOV and that the wave has the greatest influence on the dynamic response of the HOV during the recovery *** model provides better insight into the proposed HOV recovery method and confirms the effectiveness of the heave compensation *** proposed approach aims to enhance safety and operational efficiency by reducing direct human involvement in the recovery process and mitigating potential *** finding holds particular significance,especially in environmentally sensitive areas,where reducing the impact on the surrounding ecosystem is crucial.

关键词： human-occupied vehicle recovery dynamic response active heave compensation

Microphase Separation of Semiflexible Ring Diblock Copolymers

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Chinese Journal of Polymer Science 2024年第2期42卷 267-276,I0011页

作者： Dan-Yan Qin sheng-Da Zhao Zhi-xin Liu Jing Zhang xing-Hua Zhang School of Physical Science and Engineering Beijing Jiaotong UniversityBeijing100044China

Aiming at the difficult problem of solving the conformation statistics of complex polymers, this study presents a novel and concise conformation statistics theoretical approach based on Monte Carlo and Neural Network method. This method offers a new research idea for investigating the conformation statistics of complex polymers, characterized by its simplicity and practicality. It can be applied to more complex topological structure, more higher degree of freedom polymer systems with higher dimensions, theory research on dynamic self-consistent field theory and polymer field theory, as well as the analysis of scattering experimental data. The conformation statistics of complex polymers determine the structure and response properties of the system. Using the new method proposed in this study, taking the semiflexible ring diblock copolymer as an example, Monte Carlo simulation is used to sample this ring conformation to construct the dataset of polymer. The structure factor describing conformation statistics are expressed as continuous functions of structure parameters by neural network supervised learning. This is the innovation of this work. As an application, the structure factors represented by neural networks were introduced into the random phase approximation theory to study the microphase separation of semiflexible ring diblock copolymers. The influence of the ring's topological properties on the phase transition behavior was pointed out.

关键词： Ring copolymer Diblock copolymers Semiflexible The order-disorder transition

A Comparative Study on the Post-Buckling Behavior of Reinforced Thermoplastic Pipes(RTPs)Under External Pressure Considering Progressive Failure

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China Ocean Engineering 2024年第2期38卷 233-246页

作者： DING xin-dong WANG Shu-qing LIU Wen-cheng YE Xiao-han College of Engineering Ocean University of ChinaQingdao 266100China Shandong Provincial Key Laboratory of Ocean Engineering Ocean University of ChinaQingdao 266100China Department of Marine Technology Norwegian University of Science and Technology(NTNU)Trondheim NO-7491Norway

The collapse pressure is a key parameter when RTPs are applied in harsh deep-water *** investigate the collapse of RTPs,numerical simulations and hydrostatic pressure tests are *** the numerical simulations,the eigenvalue analysis and Riks analysis are combined,in which the Hashin failure criterion and fracture energy stiffness degradation model are used to simulate the progressive failure of composites,and the“infinite”boundary conditions are applied to eliminate the boundary *** for the hydrostatic pressure tests,RTP specimens were placed in a hydrostatic chamber after filled with *** has been observed that the cross-section of the middle part collapses when it reaches the maximum *** collapse pressure obtained from the numerical simulations agrees well with that in the ***,the applicability of NASA SP-8007 formula on the collapse pressure prediction was also *** has a relatively greater difference because of the ignorance of the progressive failure of *** the parametric study,it is found that RTPs have much higher first-ply-failure pressure when the winding angles are between 50°and 70°.Besides,the effect of debonding and initial ovality,and the contribution of the liner and coating are also discussed.

关键词： reinforced thermoplastic pipes post-buckling behavior progressive failure of composites debonding initial ovality