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Prognostic prediction model of colorectal cancer based on preoperative serum tumor markers

World Journal of Gastrointestinal Surgery 2024年第5期16卷 1344-1353页

作者： Yu-Hang Diao Si-Qi rao xin-Peng Shu Yong Cheng Can Tan Li-Juan Wang Dong Peng Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Preoperative serum tumor markers not only play a role in the auxiliary diagnosis and postoperative monitoring in colorectal cancer(CRC),but also have been found to have potential prognostic *** To analyze whether preoperative serum tumor markers,including carcinoembryonic antigen(CEA)and carbohydrate antigen 19-9(CA19-9),affect the prognosis of *** This was a retrospective study conducted in a single *** with nonmetastatic CRC who underwent initial surgery between January 2011 and January 2020 were enrolled and divided into development site and validation site groups at a ratio of 7:*** independent prognostic factors were screened by Cox regression analysis,and finally,a prognostic nomogram model was *** newly developed model was tested by internal *** Eventually,3526 postoperative patients with nonmetastatic CRC were included in the *** were 2473 patients at the development site and 1056 patients at the validation ***(P<0.01,HR=1.042,95%CI=1.033-1.051),tumor node metastasis(TNM)classification(P<0.01,HR=1.938,95%CI=1.665-2.255),preoperative CEA(P=0.001,HR=1.393,95%CI=1.137-1.707)and CA19-9(P<0.01,HR=1.948,95%CI=1.614-2.438)levels were considered independent prognostic factors for patients with nonmetastatic CRC and were used as variables in the nomogram *** areas under the curve of the development and validation sites were 0.655 and 0.658,*** calibration plot also showed the significant performance of the newly established *** We successfully constructed a nomogram model based on age,TNM stage,preoperative CEA,and CA19-9 levels to evaluate the overall survival of patients with nonmetastatic CRC.

关键词： Colorectal cancer Prognosis Carcinoembryonic antigen Carbohydrate antigen 19-9 Nomogram

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Generating synthetic as-built additive manufacturing surface topography using progressive growing generative adversarial networks

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Friction 2024年第6期12卷 1283-1298页

作者： Junhyeon SEO Prahalada rao Bart RAEYMAEKERS Department of Mechanical Engineering Virginia TechBlacksburgVA 24061USA Grado Department of Industrial and Systems Engineering Virginia TechBlacksburgVA 24061USA

Numerically generating synthetic surface topography that closely resembles the features and characteristics of experimental surface topography measurements reduces the need to perform these intricate and costly ***,existing algorithms to numerically generated surface topography are not well-suited to create the specific characteristics and geometric features of as-built surfaces that result from laser powder bed fusion(LPBF),such as partially melted metal particles,porosity,laser scan lines,and ***,we present a method to generate synthetic as-built LPBF surface topography maps using a progressively growing generative adversarial *** qualitatively and quantitatively demonstrate good agreement between synthetic and experimental as-built LPBF surface topography maps using areal and deterministic surface topography parameters,radially averaged power spectral density,and material ratio *** ability to accurately generate synthetic as-built LPBF surface topography maps reduces the experimental burden of performing a large number of surface topography ***,it facilitates combining experimental measurements with synthetic surface topography maps to create large data-sets that facilitate,*** as-built surface topography to LPBF process parameters,or implementing digital surface twins to monitor complex end-use LPBF parts,amongst other applications.

关键词： additive manufacturing surface topography synthetic surface topography generative adversarial networks

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Enhancing lithium-sulfur battery performance with In_(2)O_(3)-In_(2)S_(3)@NSC heterostructures:Synergistic effects of double barrier and catalytic transformation

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Journal of Materials Science & Technology 2024年第2期169卷 105-114页

作者： Deqing He Chunyu Zhu Yutao Huo Zhonghao rao School of Energy and Environmental Engineering Hebei University of TechnologyTianjin 300401China Hebei Key Laboratory of Thermal Science and Energy Clean Utilization Hebei University of TechnologyTianjin 300401China School of Low-carbon Energy and Power Engineering China University of Mining and TechnologyXuzhou 221116China

The sluggish redox reaction kinetics of lithium polysulfides(LiPSs)are considered the main obstacle to the commercial application of lithium-sulfur(Li-S)*** accelerate the conversion by catalysis and inhibit the shuttling of soluble LiPSs in Li-S batteries,a solution is proposed in this *** solution involves fabrication of N,S co-doped carbon coated In_(2)O_(3)/In_(2)S_(3)heterostructure(In_(2)O_(3)-In_(2)S_(3)@NSC)as a multifunctional host material for the *** In_(2)O_(3)-In_(2)S_(3)@NSC composite can reduce the Gibbs free energy for the conversion reactions of LiPSs,which results in superior *** synergy between different components in In_(2)O_(3)-In_(2)S_(3)@NSC and the unique 3D structure facilitate ion and electron transport in Li-S *** In_(2)O_(3)-In_(2)S_(3)@NSC/Li 2 S 6 cathode exhibits excellent rate capacity,with a capacity of 599 mAh g−1 at 5.5 C,and good cycle stability,with a capacity of 436 mAh g^(−1)after 1000 cycles at 1 ***,this study proposes a promising solution to improve the energy storage properties of Li-S batteries,which could potentially facilitate the commercialization of Li-S batteries.

关键词： Li-S battery Multifunctional host material Synergy Heterostructures Energy storage properties

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Allogenic microglia replacement:A novel therapeutic strategy for neurological disorders

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Fundamental Research 2024年第2期4卷 237-245页

作者： Yanxia rao Bo Peng Department of Laboratory Animal Science MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200032China Department of Neurosurgery Huashan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical NeurobiologyMOE Frontiers Center for Brain ScienceMOE Innovative Center for New Drug Development of Immune Inflammatory DiseasesFudan UniversityShanghai 200000China Co-Innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu 226001China

Microglia are resident immune cells in the central nervous system(CNS)that play vital roles in CNS development,homeostasis and disease *** defects in microglia lead to microglial dysfunction,which in turn leads to neurological *** correction of the specific genetic defects in microglia in these disorders can lead to therapeutic *** genetic defect correction approaches are dependent on viral vectorbased genetic defect ***,the viruses used in these approaches,including adeno-associated viruses,lentiviruses and retroviruses,do not primarily target microglia;therefore,viral vector-based genetic defect corrections are ineffective in *** replacement is a novel approach to correct microglial genetic defects via replacing microglia of genetic defects with allogenic healthy *** this paper,we systematically review the history,rationale and therapeutic perspectives of microglia replacement,which would be a novel strategy for treating CNS disorders.

关键词： Microglia Replacement Microglia replacement Microglia depletion Microglia-free niche CSF1R

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Hierarchical V_(3)S_(4)/C nanofibers with fast kinetics for superior alkali metal batteries

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Rare Metals 2024年第4期43卷 1836-1844页

作者： Li Chen Zhi-xin rao Zhi Chen Zhao-Hui Wu Shuai Yang Zhi-Jun Feng Hui-Yong Yang Fan-Yan Zeng Xi-Bao Li Jin-Yang Hu Jun-Tong Huang School of Materials Science and Engineering Nanchang Hangkong UniversityNanchang330063China School of Aeronautical Manufacturing Engineering Nanchang Hangkong UniversityNanchang330063China

Owing to the numerous benefits,including low cost and great theoretical capacity,V3S4 has been a research hotspot for Li^(+)/Na^(+)/K^(+) ***,the V_(3)S_(4) electrode with long cycling stability and high specific capacities continues to pose significant *** this work,vacuum vulcanization is combined with electrospinning to synthesize V_(3)S_(4)/C composite nanofibers(V_(3)S_(4)@CNF).

关键词： composite fibers kinetics

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Cretaceous integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 1229-1289页

作者： Dangpeng XI Guobiao LI Shijun JIANG xin rao Tian JIANG Tianyang WANG Zuohuan QIN Yasu WANG Jianzhong JIA Muhammad KAMRAN Zhongye SHI Yuyang WU Panxi WANG Lixin SUN Qinggao ZENG Xiaoqiao WAN State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesBeijing 100083China College of Oceanography Hohai UniversityNanjing 213200China Key Laboratory of Palaeobiology and Petroleum Stratigraphy Nanjing Institute of Geology and PaleontologyChinese Academy of SciencesNanjing 210008China State Key Laboratory of Tibetan Plateau Earth System Environmentand Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China China National Offshore Oil Corporation Limited Beijing 100028China Shanghai Science and Technology Museum Shanghai 200120China Xizang Bureau of Geological and Mineral Exploration and Development Lhasa 850000China Tianjin Geological Survey Center of China Geological Survey Tianjin 300170China

The Cretaceous Period is a vital time interval in deciphering the evolutionary history of the Neo-Tethys Ocean and the convergence of different plates and blocks across the Qinghai-Tibetan Plateau.A detailed stratigraphic framework and paleogeographic patterns are the basis for understanding the evolution of the Neo-Tethys Ocean and the formation of the QinghaiTibetan ***,the Cretaceous stratigraphy,biota,paleogeography,and major geological events in the Qinghai-Tibetan Plateau are analyzed to establish an integrative stratigraphic framework,reconstruct the paleogeography during the Cretaceous Period,and decode the history of the major geological *** Cretaceous rocks of the Qinghai-Tibetan Plateau and its surrounding area are predominantly marine deposits,with a small amount of interbedded marine-terrestrial and terrestrial *** Indus-Yarlung Tsangpo Suture Zone was responsible for the deposition of deep marine sediments dominated by ophiolite suites and radiolarian *** the south,the Tethys Himalayas and Indus Basin received marine sediments of varying depths and lithology;to the north,the Xigaze and Ladakh forearc basins are also filled with marine *** Lhasa Block,Karakorum Block,western Tarim Basin,and West Burma block consist of shallow marine,interbedded marine-terrestrial,and terrestrial *** Qiangtang Basin and other areas are dominated by terrestrial *** Cretaceous strata of the Qinghai-Tibetan Plateau and its surrounding areas are widely distributed and diversified,with abundant foraminifera,calcareous nannofossils,radiolarians,ammonites,bivalves,and *** the basis of integrated lithostratigraphic,biostratigraphic,geochronologic,and chemostratigraphic analyses,we proposed herein a comprehensive stratigraphic framework for the Cretaceous Period of the eastern *** analyzing the Cretaceous biota of different biogeographic zones from eastern Neo-Tethys and its surrounding a

关键词： Qinghai-Tibetan Plateau Tethys Cretaceous Stratigraphy Biota Paleogeography

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Clinical application of COVID-19 vaccine in liver transplant recipients

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 339-343页

作者： Feng-Chao Liu Man Xie Wei rao Division of Hepatology Liver Disease CenterThe Affiliated Hospital of Qingdao UniversityQingdao 266000China Organ Transplantation Center The Affiliated Hospital of Qingdao UniversityQingdao 266000China Institute of Organ Donation and Transplantation of Qingdao University Qingdao 266000China Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdao 266000China

Background:Solid organ transplant(SOT)activities,such as liver transplant,have been greatly influenced by the pandemic of coronavirus disease 2019(COVID-19),a disease caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Immunosuppressed individuals of liver transplant recipients(LTRs)tend to have a high risk of COVID-19 infection and related ***,COVID-19 vaccination has been recommended to be administered as early as possible in *** sources:The keywords“liver transplant”,“SARS-CoV-2”,and“vaccine”were used to retrieve articles published in ***:The antibody response following the 1st and 2nd doses of vaccination was disappointingly low,and the immune responses among LTRs remarkably improved after the 3rd or 4th dose of *** the 3rd or 4th dose of COVID-19 vaccine increased the antibody titer,a proportion of patients remained ***,recent studies showed that SARS-CoV-2 vaccine could trigger adverse events in LTRs,including allograft rejection and liver ***:This review provides the recently reported data on the antibody response of LTRs following various doses of vaccine,risk factors for poor serological response and adverse events after vaccination.

关键词： Liver transplant COVID-19 SARS-CoV-2 Vaccine Antibody response

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Recent progress of MgO-based materials in CO_(2) adsorption and conversion:Modification methods,reaction condition,and CO_(2) hydrogenation

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Chinese Chemical Letters 2024年第5期35卷 57-65页

作者： Zixuan Zhu Xianjin Shi Yongfang rao Yu Huang Key Laboratory of Aerosol Chemistry&Physics State Key Laboratory of Loess and Quaternary Geology(SKLLQG)Institute of Earth EnvironmentChinese Academy of Sciences(CAS)Xi’an 710061China Center for Excellence in Quaternary Science and Global Change Chinese Academy of SciencesXi’an 710061China University of Chinese Academy of Sciences Beijing 100049China Department of Environmental Science and Engineering Xi’an Jiaotong UniversityXi’an 710049China

Integrated CO_(2) capture and conversion of(ICCC)is one of the most effective solutions to reduce anthropogenic CO_(2) emissions,which has attracted extensive public *** functional materials(DFMs),including adsorbent and catalyst,are the key components to achieve *** oxide(MgO)is an ideal adsorbent for ICCC,since it is characterized by high theoretical adsorption capacity,low cost,low energy consumption and extensive *** can also be used as DFMs in combination with the Ni *** not only can act as an adsorbent in DFMs but also enhance the catalytic performance of *** review summarizes the advantages and modification methods of MgO as adsorbent and the influence of its adsorption conditions on the adsorption ***,the important role of MgO in facilitating the catalytic conversion of CO_(2) is *** research focuses are proposed for the development of MgO based DFMs with high adsorption capacity,high stability,conversion,and selectivity as well as low cost and energy consumption.

关键词： CO_(2) ICCC MgO Adsorption Conversion

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Stroke Risk Assessment Decision-Making Using a Machine Learning Model:Logistic-AdaBoost

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 699-724页

作者： Congjun rao Mengxi Li Tingting Huang Feiyu Li School of Science Wuhan University of TechnologyWuhan430070China Wuhan University of Technology Hospital Wuhan University of TechnologyWuhan430070China

Stroke is a chronic cerebrovascular disease that carries a high *** risk assessment is of great significance in preventing,reversing and reducing the spread and the health hazards caused by *** to objectively predict and identify strokes,this paper proposes a new stroke risk assessment decision-making model named Logistic-AdaBoost(Logistic-AB)based on machine ***,the categorical boosting(CatBoost)method is used to perform feature selection for all features of stroke,and 8 main features are selected to form a new index evaluation system to predict the risk of ***,the borderline synthetic minority oversampling technique(SMOTE)algorithm is applied to transform the unbalanced stroke dataset into a balanced ***,the stroke risk assessment decision-makingmodel Logistic-AB is constructed,and the overall prediction performance of this new model is evaluated by comparing it with ten other similar *** comparison results show that the new model proposed in this paper performs better than the two single algorithms(logistic regression and AdaBoost)on the four indicators of recall,precision,F1 score,and accuracy,and the overall performance of the proposed model is better than that of common machine learning *** Logistic-AB model presented in this paper can more accurately predict patients’stroke risk.

关键词： Stroke risk assessment decision-making CatBoost feature selection borderline SMOTE Logistic-AB

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Recent advances in electrochemical performance of Mg-based electrochemical energy storage materials in supercapacitors:Enhancement and mechanism

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Journal of Magnesium and Alloys 2024年第1期12卷 35-58页

作者： Yuntao Xiao xinfang Zhang Can Wang Jinsong rao Yuxin Zhang College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

The application of Mg-based electrochemical energy storage materials in high performance supercapacitors is an essential step to promote the exploitation and utilization of magnesium resources in the field of energy ***,the inherent chemical properties of magnesium lead to poor cycling stability and electrochemical reactivity,which seriously limit the application of Mg-based materials in ***,in this review,more than 70 research papers published in recent 10 years were collected and *** representative research works were selected,and the results of various regulative strategies to improve the electrochemical performance of Mg-based materials were *** effects of various regulative strategies(such as constructing nanostructures,synthesizing composites,defect engineering,and binder-free synthesis,etc.)on the electrochemical performance and their mechanism are demonstrated using spinelstructured MgX_(2)O_(4) and layered structured Mg-X-LDHs as *** addition,the application of magnesium oxide and magnesium hydroxide in electrode materials,MXene's solid spacers and hard templates are ***,the challenges and outlooks of Mg-based electrochemical energy storage materials in high performance supercapacitors are also discussed.

关键词： Supercapacitor Electrochemical energy storage Mg-based materials

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