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Effect of Stereotactic Body Radiation Therapy on Diverse Organ Lesions in Advanced Non-Small Cell Lung Cancer Patients Receiving Immune Checkpoint Inhibitors

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Current Medical Science 2023年第2期43卷 344-359页

作者： Kui-kui ZHU Jie-lin WEI Yun-hong XU Jun LI xin-rui rao Ying-zhuo XU Bi-yuan xinG Si-jia ZHANG Lei-chong CHEN Xiao-rong DONG Sheng ZHANG Zheng-yu LI Cui-wei LIU rui MENG Gang WU Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Objective The combination of stereotactic body radiation therapy(SBRT)and immune checkpoint inhibitors(ICIs)is actively being explored in advanced non-small-cell lung cancer(NSCLC)***,little is known about the optimal fractionation and radiotherapy target lesions in this *** study investigated the effect of SBRT on diverse organ lesions and radiotherapy dose fractionation regimens on the prognosis of advanced NSCLC patients receiving *** The medical records of advanced NSCLC patients consecutively treated with ICIs and SBRT were retrospectively reviewed at our institution from Dec.2015 to *** were grouped according to radiation ***-free survival(PFS)and overall survival(OS)were recorded using the Kaplan-Meier method and compared between different treatment groups using the log-rank(Mantel-Cox)*** A total of 124 advanced NSCLC patients receiving ICIs combined with SBRT were identified in this *** sites included lung lesions(lung group,n=43),bone metastases(bone group,n=24),and brain metastases(brain group,n=57).Compared with the brain group,the mean PFS(mPFS)in the lung group was significantly prolonged by 13.3 months(8.5 months vs.21.8 months,HR=0.51,95%CI:0.28–0.92,P=0.0195),and that in the bone group prolonged by 9.5 months with a 43%reduction in the risk of disease progression(8.5 months vs.18.0 months,HR=0.57,95%CI:0.29–1.13,P=0.1095).The mPFS in the lung group was prolonged by 3.8 months as compared with that in the bone *** mean OS(mOS)in the lung and bone groups was longer than that of the brain group,and the risk of death decreased by up to 60%in the lung and bone groups as compared with that of the brain *** SBRT was concurrently given with ICIs,the mPFS in the lung and brain groups were significantly longer than that of the bone group(29.6 months vs.16.5 months vs.12.1 months).When SBRT with 8–12 Gy per fraction was combined with ICIs,the mPFS in the lung group wa

关键词： advanced non-small cell lung cancer stereotactic body radiation therapy dose fractionation regimens immune checkpoint inhibitors organ-specific prognoses

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Jurassic integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 1195-1228页

作者： Jianguo LI xin rao Lin MU Xiaohui CUI xin LI Hui LUO Peixue LIU Center for Excellence in Life and Paleoenvironment Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Nanjing College University of Chinese Academy of SciencesNanjing 211135China

The Qinghai-Tibetan Plateau experienced a unique geological evolution during the Jurassic,driven by the termination of the Palaeotethys and the reduction of the *** Indian Plate separated from the northern margin of Gondwana and drifted northward from the Southern *** that the timing of strata serves as the basis for reconstructing geological history,the present work aimed to develop a new multiple stratigraphic and chronologic framework for the Jurassic strata of the Qinghai-Tibetan Plateau region via a synthesis of the material on lithostratigraphy,palaeontology,iso-radiometric dating,magnetostratigraphy,and other techniques with an emphasis on recent progress and *** new framework included the Jurassic System from the four major subdivisions of the plateau:the Baryan Har,Qiangtang,Lhasa-Gandise,and Southern Xizang(Himalaya).Ultimately,a more complete,refined biostratigraphic sequence was proposed,comprising the most common fossils in the plateau and those that are stratigraphically significant for the Jurassic stratigraphy,including ammonites,bivalves,brachiopods,foraminifera,radiolarians,and dinoflagellate cysts for the marine strata,and pollen and spores,and charophytes for the terrestrial *** biostratigraphic framework was correlated with the Jurassic international standard zonation of the Geological Time Scale 2020 via standard or representative species or genera of *** on this framework,we constructed a lateral correlation of the Jurassic strata between different basins of the *** palaeontologic correlation in the present work shows that the Lhasa-Gandise Block had a closer relationship with the Qiangtang Block than with the Southern Xizang Himalaya during the Jurassic ***,the Lhasa-Gandise Block and Qiangtang Block shared similar marine fauna features of the north marginal East *** contrasts the opinion suggesting that the Yarlung Zangbo Tethys was a small back-arc basin.A c

关键词： Biostratigraphy Chronostratigraphy Correlation Yarlung Zangbo suture Bangong Co-Nujiang suture Tethys

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Side ionic-gated perovskite/graphene heterojunction synaptic transistor with bipolar photoresponse for neuromorphic computing

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Photonics Research 2024年第6期12卷 1167-1174页

作者： XIAOYING HE MINGHAO XU SHILIN LIU KUN WANG BOWEN CAO LAN rao XIANGJUN xin School of Electronic Engineering and Beijing Key Laboratory of Space-Ground Interconnection and Convergence Beijing University of Posts and TelecommunicationsBeijing 100876China Key Laboratory of Semiconductor Materials Science Beijing Key Laboratory of Low Dimensional Semiconductor Materials and DevicesInstitute of SemiconductorsChinese Academy of SciencesBeijing 100083China

By combining the good charge transport property of graphene and the excellent photo-carrier generation char-acteristic of perovskite nanocrystal,we propose and demonstrate an ionic-gated synaptic transistor based on CsPbBr_(3)∕graphene heterojunction for bipolar *** the potential barrier of the CsPbBr_(3)∕graphene heterojunction by the ionic-gate of the electrical double-layer effect can promote the sepa-ration of photogenerated carriers and effectively retard their *** the ionic-gate-tunable Fermi level of graphene and the pinning effect of perovskite nanocrystal,the bipolar photocurrent responses correspond-ing to the excitatory and inhibitory short-term and long-term plasticity are realized by adjusting the negative gate bias.A series of synaptic functions including logic operation,Morse coding,the optical memory and electrical erasure effect,and light-assisted re-learning have also been demonstrated in an optoelectronic collaborative ***,the excellent optical synaptic behaviors also contribute to the handwritten font recognition accuracy of-95%in artificial neural network *** results pave the way for the fabrication of bipolar photoelectric synaptic transistors and bolster new directions in the development of future integrated human ret-inotopic vision neuromorphic systems.

关键词： perovskite ionic Morse

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Effectiveness of C-Reactive Protein as a Tuberculosis Screening Test Among HIV-Infected Individuals—Shanghai,China,2021-2023

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China CDC weekly 2024年第35期6卷 891-895页

作者： Lixin rao Zheyuan Wu Jing Chen Zhen Ning xin Shen Shanghai Municipal Center for Disease Control and Prevention ShanghaiChina

Summary What is already known about this topic?The World Health Organization(WHO)has recommended the inclusion of the C-reactive protein(CRP)test in active tuberculosis(ATB)screening algorithms among human immunodeficiency virus(HIV)-infected *** performance of the CRP test in African regions has been *** is added by this report?This study analyzed data from a big data platform of Shanghai medical records together with infectious disease surveillance systems.

关键词： Infect tuberculosis records

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Dimethylamine oxalate manipulating CsPbI_(3) perovskite film crystallization process for high efficiency carbon electrode based perovskite solar cells

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Journal of Energy Chemistry 2024年第6期93卷 221-228,I0006页

作者： Wenran Wang xin Peng Jianxin Zhang Jiage Lin Rong Huang Guizhi Zhang Huishi Guo Zhenxiao Pan xinhua Zhong Huashang rao Key Laboratory for Biobased Materials and Energy of Ministry of Education College of Materials and EnergySouth China Agricultural UniversityGuangzhou 510642GuangdongChina College of Chemistry and Civil Engineering Shaoguan UniversityShaoguan 512005GuangdongChina Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region Shaoguan UniversityShaoguan 512005GuangdongChina

Crystallization process determines the quality of perovskite films and the performances of resultant perovskite solar cells(PSCs).Dimethylamine oxalate has been proven as a multifunctional modulator,and is explored as an efficient additive in manipulating the crystallization process of CsPbI_(3) perovskite *** one hand,oxalate serves as the precipitator that facilitates the nucleation process of *** larger size of intermediate is conductive to the larger size and smaller grain boundaries of resultant *** the other hand,in subsequent annealing process,the phase conversion and growth process of transient perovskite can be decelerated due to the strong interactions of oxalate with both dimethylamine cation(DMA^(+))and Pb^(2+).Due to the optimized crystallization kinetics,the morphology and quality of CsPbI_(3) perovskite films are comprehensively improved with lower defect concentrations,and charge recombination loss is effectively *** from the optimized crystal quality of perovskite films,the carbon electrode-based CsPbI_(3) PSCs exhibit a champion efficiency of 18.48%.This represents one of the highest levels among all hole transport layer-free inorganic perovskite solar cells.

关键词： Solar cells Perovskite CsPbI_(3) Carbon electrodes Oxalate

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MBTI Assessment as Social Currency:A New Digital Cultural Phenomenon in the Meta-media Era

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Contemporary Social Sciences 2024年第4期9卷 53-67页

作者： rao Quan Chen rui School of Literature Journalism&CommunicationXihua UniversityChengduSichuan610039China

The MBTI assessment has become a hot topic online and a common method for netizens to identify themselves across China’s social *** netizens generally consider the results of their MBTI assessments as personal emblems suitable for public display,leading to a remarkably widespread cultural *** structured interviews,this study has found that Internet users are experiencing a psychological crisis of identity due to the dual influences of technological embodiment and the meta-media ecology ***,their behavior on social platforms can be regarded as an invisible form of affective *** date,researchers have not paid adequate attention to the immense popularity of MBTI assessment in China,and they have not fully investigated whether MBTI assessment is a symbolic representation of the current identity crisis in the context of meta-media and digital *** study has two purposes:First,this study aims to explore whether the dynamic interactions of the MBTI assessment are a form of social ***,it aims to construct an MBTI topic production chain to help understand MBTI’s underlying mechanisms regarding the interactions,the reasons behind its popularity,and the reflection on broader social phenomena.

关键词： MBTI meta-media digital labor social currency

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Fabricating AC/DC nanogenerators based on single ZnO nanowires by using a nanomanipulator in a scanning electron microscope

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Nanotechnology and Precision Engineering 2024年第2期7卷 25-31页

作者： Mei Liu Mengfan He Aristide Djoulde Lingdi Kong Weilin Su xin Bai Jinbo Chen Jinjun rao Zhiming Wang Shanghai Key Laboratory of Intelligent Manufacturing and Robotics School of Mechatronic Engineering and AutomationShanghai UniversityShanghai 200444China Guangdong Provincial Key Laboratory of Fuel Cell Technology School of Chemistry and Chemical EngineeringSouth China University of TechnologyGuangzhou 510641China

Single zinc oxide nanowires(ZnO NWs)are promising for nanogenerators because of their excellent semiconducting and piezoelectric properties,but characterizing the latter efficiently is *** reported here,an electrical breakdown strategy was used to construct single ZnO NWs with a specific *** the high operability of a nanomanipulator in a scanning electron microscope,ZnO-NW-based twoprobe and three-probe structures were constructed for fabricating AC/DC nanogenerators,*** a ZnO NW,an AC output of between−15.31 mV and 5.82 mV was achieved,while for a DC nanogenerator,an output of24.3 mV was ***,the three-probe structure’s output method was changed to verify the distribution of piezoelectric charges when a single ZnO NW is bent by a probe,and DC outputs of different amplitudes were *** study provides a low-cost,highly convenient,and operational method for studying the AC/DC output characteristics of single NWs,which is beneficial for the further development of nanogenerators.

关键词： Zinc oxide nanowire Piezoelectric properties Nanomanipulator SEM AC/DC nanogenerators

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Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp.c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1a/XBP-1s axis and JNK signaling

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Acta Pharmaceutica Sinica B 2024年第1期14卷 304-318页

作者： Yong rao rui Su Chenyan Wu xingxing Chai Jinjian Li Guanyu Yang Junjie Wu Tingting Fu Zhongping Jiang Zhikai Guo Congjun Xu Ling Huang Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou 570200China Hainan Key Laboratory of Tropical Microbe Resources Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural Sciences&Key Laboratory for Biology and Genetic Resources of Tropical Crops of Hainan ProvinceHainan Institute for Tropical Agricultural ResourcesHaikou 571101China School of Pharmaceutical Sciences Guangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510275China Laboratory Animal Center of Guangdong Medical University Dongguan 523808China

Lipotoxicity is a pivotal factor that initiates and exacerbates liver injury and is involved in the development of metabolic-associated fatty liver disease(MAFLD).However,there are few reported lipotoxicity ***,we identified a natural anti-lipotoxicity candidate,HN-001,from the marine fungus Aspergillus ***-001 dose-and time-dependently reversed palmitic acid(PA)-induced hepatocyte *** protection was associated with IRE-1a-mediated XBP-1 splicing inhibition,which resulted in suppression of XBP-1s nuclear translocation and transcriptional *** of XBP-1s attenuated lipotoxicity,but no additional ameliorative effect of HN-001 on lipotoxicity was observed in XBP-1s knockdown ***,the ER stress and lipotoxicity amelioration was associated with *** HN-001 and the PLA2 inhibitor MAFP inhibited PLA2 activity,reduced lysophosphatidylcholine(LPC)level,subsequently ameliorated *** contrast,overexpression of PLA2 caused exacerbation of lipotoxicity and weakened the anti-lipotoxic effects of ***,HN-001 treatment suppressed the downstream pro-apoptotic JNK *** vivo,chronic administration of HN-001(i.p.)in mice alleviated all manifestations of MAFLD,including hepatic steatosis,liver injury,inflammation,and *** effects were correlated with PLA2/IRE-1a/XBP-1s axis and JNK signaling *** data indicate that HN-001 has therapeutic potential for MAFLD because it suppresses lipotoxicity,and provide a natural structural basis for developing anti-MAFLD candidates.

关键词： Lipotoxicity MAFLD ER stress IRE-1a XBP-1s JNK PLA2

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Multiscale control of MnO_(2) growth via[WO_(6)]-perturbed[MnO_(6)]assembly toward a favorable balance between capacitance and rate performance

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Rare Metals 2024年第4期43卷 1658-1671页

作者： Jin-Kang Liu Tian-Shuo Yang Zhi-Bin Ren Adekunle-Adedapo Obisanya xin-Yi Tan Yan-Di rao Jun-Shuang Zhou Fa-Ming Gao Jian-Ren Wang Hebei Key Laboratory of Applied Chemistry Yanshan UniversityQinhuangdao066004China

Although pseudocapacitive manganese dioxide(MnO_(2))integrates the high-power merit of carbonaceous materials with the high-energy merit of battery-type materials,it still has a long way to go in achieving a more satisfactory balance of higher energy and power density,and in decoupling the relationship of structural characteristics with energy storage *** realize such goals,a bottom-up[WO_(6)]-perturbed[MnO_(6)]assembly strategy has been developed here due to their similar structure,yet mismatched lattice *** facile protocol is capable of finely controlling the morphology and crystal structure of MnO_(2)by adjusting its internal[WO_(6)]***,the as-prepared W_xMnO_(2)is treated as an ideal platform to scrutinize the correlations of the structure with the energy storage *** operando Raman spectra and finite element analysis have fully demonstrated the superiority of the locally ordered defects-enriched structure of W_(0.02)-MnO_(2),which could reach a favorable balance between the ion diffusion equilibrium time and the number of active *** a result,the W_(0.02)-MnO_(2)is able to deliver a high capacitance of 292 F·g^(-1)at a current density of 1 A·g^(-1)and a remarkable rate performance with a 60%capacity retention at a current density of 50 A·g^(-1).The further unveiled structure-performance relationship provides a guideline for the design of better pseudocapacitive energy storage devices.

关键词： Supercapacitors Pseudocapacitive materials MnO_(2) Tungsten doping Crystal structure regulation

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Enhanced Hybrid Equilibrium Strategy in Fog-Cloud Computing Networks with Optimal Task Scheduling

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Computers, Materials & Continua 2024年第5期79卷 2647-2672页

作者： Muchang rao Hang Qin School of Computer Science Yangtze UniversityJingzhou434000China

More devices in the Intelligent Internet of Things(AIoT)result in an increased number of tasks that require low latency and real-time responsiveness,leading to an increased demand for computational *** computing’s low-latency performance issues in AIoT scenarios have led researchers to explore fog computing as a complementary ***,the effective allocation of resources for task execution within fog environments,characterized by limitations and heterogeneity in computational resources,remains a formidable *** tackle this challenge,in this study,we integrate fog computing and cloud *** begin by establishing a fog-cloud environment framework,followed by the formulation of a mathematical model for task ***,we introduce an enhanced hybrid Equilibrium Optimizer(EHEO)tailored for AIoT task *** overarching objective is to decrease both the makespan and energy consumption of the fog-cloud system while accounting for task *** proposed EHEO method undergoes a thorough evaluation against multiple benchmark algorithms,encompassing metrics likemakespan,total energy consumption,success rate,and average waiting *** experimental results unequivocally demonstrate the superior performance of EHEO across all assessed ***,in the most favorable conditions,EHEO significantly diminishes both the makespan and energy consumption by approximately 50%and 35.5%,respectively,compared to the secondbest performing approach,which affirms its efficacy in advancing the efficiency of AIoT task scheduling within fog-cloud networks.

关键词： Artificial intelligence of things fog computing task scheduling equilibrium optimizer differential evaluation algorithm local search

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