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Analysis of large datasets for identifying molecular targets in intestinal polyps and metabolic disorders

BIOCELL 2024年第3期48卷 415-429页

作者： SHAN ou YUN XU QINGLAN LIU TIANWEN YANG WEI CHEN XIU YUAN xin ZUO PENG SHI JIE YAO Department of Gastroenterology The First Affiliated Hospital of Chongqing Medical and Pharmaceutical CollegeChongqingChina

Background:The interrelation between intestinal polyps,metabolic syndrome(MetS),and colorectal cancer(CRC)is a critical area of *** research focuses on pinpointing potential molecular targets to understand the link between intestinal polyp formation,metabolic irregularities,and CRC ***:We examined clinical samples from patients with intestinal polyps coexisting with MetS and compared them with samples from patients with standard intestinal *** sequencing and public database analysis were employed to identify significant pathways and *** targets were then validated through immunohistochemistry(IHC).Following the RNA interference of key target expression,a series of experiments,including the cell counting kit-8 assay,colony formation,wound healing,and Transwell assays,were ***:Comparative analysis revealed 75 up-regulated and 61 down-regulated differentially expressed genes(DEGs)in the MetS polyp group *** *** encyclopedia of genes and genomes(KEGG)pathway enrichment suggested these DEGs were primarily associated with cell cycle and *** with comparative toxicogenomics database(CTD)and the cancer genome atlas(TCGA)databases highlighted 44 key CRC-related *** interaction networks indicated connections of purkinje cell protein 4(PCP4),olfactomedin 1(OLFM1),fibronectin 1(FN1),and transforming growth factor beta 3(TGF-β3)with the mitogen-activated protein kinase(MAPK)*** correlation studies suggested higher risk associations with FN1,PCP4,and TGF-β3,while OLFM1 was identified as a lower risk *** analysis revealed a decrease in OLFM1 in MetS-associated intestinal *** interference with OLFM1 in polyp epithelial cells,there was a significant enhancement in cell proliferation,colony formation,and cell migration and invasion ***:our study highlights a significant decrease in OLFM1 expression in MetS-associated intestinal

关键词： Colorectal cancer Metabolic syndrome Intestinal polyp OLFM1 Exosome

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The incidence and predictors of high-degree atrioventricular block in patients with bicuspid aortic valve receiving selfexpandable transcatheter aortic valve implantation

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Journal of Geriatric Cardiology 2021年第10期18卷 825-835页

作者： Yuan-Weixiang ou Jing-Jing HE Xuan ZHou Guo-Yong LI Yan-Biao LIAO xin WEI Yong PENG Yuan FENG Mao CHEN Department of Cardiac Catheterization Laboratory West China HospitalSichuan UniversitySichuanChina Department of Cardiology West China HospitalSichuan UniversitySichuanChina Department of Radiology West China HospitalSichuan UniversitySichuanChina

BACKGRouND The high-degree atrioventricular block(HAVB)in patients with bicuspid aortic valve(BAV)treated with transcatheter aortic valve implantation(TAVI)remains *** study aims to explore this poorly understood subject of mech-anisms and predictors for HAVB in BAV self-expandable TAVI *** We retrospectively included 181 BAV patients for *** computed tomography data,the curvature of ascending aorta(AAo)was quantified by the angle(AAo angle)between annulus and the cross-section at 35 mm above annulus(where the stent interacts with AAo the most).The valvular anatomy and leaflet calcification were also *** The 30-day HAVB rate was 16.0%(median time to HAVB was three days).Type-1 morphology was found in 79 pat-ients(43.6%)(left-and right-coronary cusps fusion comprised 79.7%).Besides implantation below membrane septum,large AAo angle[odds ratio(OR)=1.08,P=0.016]and type-1 morphology(OR=4.97,P=0.001)were found as the independent predictors for *** with baseline right bundle branch block,these predictors showed strong predictability for HAVB with area under the cure of 0.84(sensitivity=62.1%,specificity=92.8%).Bent AAo and calcified raphe had a synergistic effect in facilita-ting high implantation,though the former is associated with at-risk deployment(device implanted above annulus+prothesis pop-out,versus straight AAo:9.9%vs.2.2%,P=0.031).CONCLUSIONS AAo curvature and type-1 morphology are novel predictors for HAVB in BAV patients following self-expandable *** patients with bent AAo or calcified raphe,a progressive approach to implant the device above the lower edge of membrane septum is favored,though should be done cautiously to avoid pop-out.

关键词： patients anatomy implantation

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Batch synthesis of rare-earth nickelates electronic phase transition perovskites via rare-earth processing intermediates

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Rare Metals 2022年第10期41卷 3495-3503页

作者： Xiao-Yu Li Zi-Ang Li Feng-Bo Yan Hao Zhang Jia-ou Wang xin-You Ke Yong Jiang Nuo-Fu Chen Ji-Kun Chen School of New Energy North China Electric Power UniversityBeijing102206China School of Materials Science and Engineering University of Science and Technology BeijingBeijing100083China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China Department of Mechanical and Aerospace Engineering Case Western Reserve UniversityClevelandOH44106USA

The rare-earth nickelates(RENiO_(3)) exhibit an exceptional complex electronic phase diagram and multiple electronic phase transitions that enrich promising applications in correlated electronic devices beyond conventional ***,the practical applications of RENiO_(3) are challenged by their intrinsic thermodynamic metastability in material synthesis and high material ***,developing an economical strategy to achieve the batch synthesis of RENiO_(3) is of vital *** this work,we enlarged the synthesis amount of RENiO_(3) up to 20 g per batch using chloride(KCI) assisted molten salt *** optimizing the reaction conditions,the powder of RENiO_(3) with the cubic shape and average size of ~2μm was effectively synthesized,while their phase purity exceeded 95%.In addition,the cost to synthesize RENiO_(3) was further reduced by using rare-earth extraction intermediate products as the raw materials,instead of using the pure rare-earth *** also achieved wide adjustments in the metal-to-insulator-transition temperature from160 to 420 K without significantly reducing the transition *** enlarging the synthesis amount and the reducing the cost,it paves the way to the device application of RENiO_(3).

关键词： Quantum materials Rare-earth nickelates Metastable materials Perovskite oxides

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Progress on High Voltage PEO-based Polymer Solid Electrolytes in Lithium Batteries

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Chemical Research in Chinese Universities 2022年第3期38卷 735-743页

作者： Hou Wenhui ou Yu LIU Kai Department of Chemical Engineering Tsinghua UniversityBeijing100084P.R.China

Polymer electrolytes have attracted great interest for next-generation lithium-based batteries on account of safety and high energy *** this review,we assess recent progress on the design of poly(ethylene oxide)(PEO)-based solid polymer electrolytes in high voltage lithium batteries and identify possible side reactions between PEO-based electrolytes and existing *** provide an overview of the ways to enhance high voltage resistance of PEO-based *** include components blend,molecular design and interface *** these efforts,we want to present new insights into rational design of PEO-based electrolytes to develop solid-state lithium batteries for advanced performance.

关键词： Poly(ethylene oxide) Lithium battery High voltage Molecular design Interface modification

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Block Basis for Modular Coinvariants of Pseudo-Reflection Groups

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Algebra Colloquium 2024年第1期31卷 41-48页

作者： Ke ou School of Statistics and Mathematics Yunnan University of Finance and Economics Kunming 650221China

We investigate the block basis for modular coinvariants of finite pseudo-reflection *** are particularly interested in the case of a subgroup G of the parabolic subgroups of GLn(q)which generalizes the Weyl groups of ... 详细信息

关键词： modular invariant theory pseudo-reflection group block basis coinvariant

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Molecular mechanisms of cellular metabolic homeostasis in stem cells

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International Journal of Oral Science 2023年第4期15卷 527-539页

作者： Xiaoyu Li ou Jiang Songlin Wang Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction Beijing Laboratory of Oral Health and Beijing Stomatological HospitalCapital Medical UniversityBeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Immunology Research Center for Oral and Systemic Health Beijing Friendship HospitalCapital Medical UniversityBeijingChina Laboratory for Oral and General Health Integration and Translation Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Research Unit of Tooth Development and Regeneration Chinese Academy of Medical SciencesBeijingChina

Many tissues and organ systems have intrinsic regeneration capabilities that are largely driven and maintained by tissue-resident stem cell populations. In recent years, growing evidence has demonstrated that cellular metabolic homeostasis plays a central role in mediating stem cell fate, tissue regeneration, and homeostasis. Thus, a thorough understanding of the mechanisms that regulate metabolic homeostasis in stem cells may contribute to our knowledge on how tissue homeostasis is maintained and provide novel insights for disease management. In this review, we summarize the known relationship between the regulation of metabolic homeostasis and molecular pathways in stem cells. We also discuss potential targets of metabolic homeostasis in disease therapy and describe the current limitations and future directions in the development of these novel therapeutic targets.

关键词： homeostasis maintained mechanisms

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X-RAY POWDER DIFFRACTION DATA AND STRUCTURE REFINEMENT OF COMPouND ErNi_2Si_2

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中国有色金属学会会刊：英文版 1998年第4期8卷 91-94页

作者： Yan, JL ou, XL Zeng, LM Guangxi Univ Inst Mat Sci Nanning 530004 Peoples R China Tianjin Elect Mat Res Inst Tianjin 300192 Peoples R China

１ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｒａｒｅｅａｒｔｈｃｏｍｐｏｕｎｄｓＲＥＴ２Ｓｉ２，ｗｈｅｒｅＲＥｉｓａｒａｒｅｅａｒｔｈｅｌｅｍｅｎｔａｎｄＴｉｓａｔｒａｎｓｉｔｉｏｎｍｅｔａｌｅｌｅｍｅｎｔ，ｈａｖｅｂｅｅｎｓｔ... 详细信息

１ＩＮＴＲＯＤＵＣＴＩＯＮＴｈｅｒａｒｅｅａｒｔｈｃｏｍｐｏｕｎｄｓＲＥＴ２Ｓｉ２，ｗｈｅｒｅＲＥｉｓａｒａｒｅｅａｒｔｈｅｌｅｍｅｎｔａｎｄＴｉｓａｔｒａｎｓｉｔｉｏｎｍｅｔａｌｅｌｅｍｅｎｔ，ｈａｖｅｂｅｅｎｓｔｕｄｉｅｄｗｉｔｈｇｒｅａｔｉｎ?..

关键词： ErNi 2Si 2 X ray powder diffraction Rietveld structure refinement

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Recent Progress in Boosted PDT Induced Immunogenic Cell Death for Tumor Immunotherapy

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Chemical Research in Chinese Universities 2021年第1期37卷 83-89页

作者： LI Jun ou Hanlin DING Dan State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive MaterialsMinistry of EducationCollege of Life SciencesNankai UniversityTianjin300071P.R.China

With the rapid development of materials science,photosensitive materials have been widely used in the field of immunogenic cell death(ICD),which was on account of the reactive oxygen species(ROS)generation by photosensitizer under light irradiation inducing cellular oxidative stress during the dying of *** researches related to photodynamic therapy(PDT)induced ICD were conducted and exhibited brilliant performance in cancer ***,a variety of different strategies for PDT induced ICD have been summarized and discussed to provide researchers more inspiration for cancer immunotherapy.

关键词： Photodynamic therapy Immunogenic cell death Damage-associated molecular pattern

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Anti-inflammatory mechanism of rhein in treating asthma based on network pharmacology

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Journal of Traditional Chinese Medicine 2022年第2期42卷 296-303页

作者： FENG Junfang CHEN ou WANG Yibiao Department of Pediatrics the Second HospitalCheeloo College of MedicineShandong UniversityJinan 250033China School of Nursing Cheeloo College of MedicineShandong UniversityJinan 250012China

OBJECTIVE:To predict the anti-inflammatory targets and related pathways of rhein in the treatment of asthma by using network pharmacology,and to further explore its potential mechanism in ***:The corresponding targets of rhein were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),and the rhein-target network was constructed with Cytoscape 3.7.1 *** Genbank and Drugbank databases were used to collect and screen asthma targets,and the rhein-target-disease interaction network was constructed.A target protein-protein interaction(PPI)network was constructed using the STRING database to screen key ***,Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis was used to identify biological processes and signaling *** anti-asthmatic effects of rhein were tested in vitro,and the expression levels of proteins in the mitogen-activated protein kinase/nuclear factor kappa-B(MAPK/NF-κB)signaling pathway were assessed by western blot ***:Altogether,83 targets of rhein were screened in the relevant databases,989 targets of asthma were obtained in the National Center for Biotechnology Information(NCBI)GENE *** network analysis and KEGG pathway enrichment analysis predicted that rhein could regulate the epidermal active growth factor receptor(EGFR),mitogen-activated protein kinase 14(MAPK14),tumour necrosis factor receptor superfamily member 1A(TNFRSF1A),receptor tyrosineprotein kinase erb B-2(ERBB2),and other signaling ***,we selected the MAPK signaling pathway to determine the anti-inflammatory effects of ***,further in vitro experiments demonstrated that rhein was shown to inhibit HBE cells ***:The anti-inflammatory mechanism of rhein in the treatment of asthma may be related to EGFR,MAPK14,TNFRSF1A and ERBB2 as well as their signaling *** prevent the exacerbation of asthma,instead of targeting a

关键词： asthma rhein anti-inflammatory agents pharmacology drug development

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Enhanced dispersibility and thermal stability of β-cyclodextrin functionalized graphene

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Chinese Chemical Letters 2014年第2期25卷 355-358页

作者： Shu-Peng Zhang Bin Liu Cheng-Yin Li Wei Chen Zhi-Jian Yao Dong-Ting Yao rong-Bing Yu Hai-ou Song School of Chemical Engineering Nanjing University of Science and Technology School of the Environment Nanjing University

A series of β-cyclodextrin （CDs） functionalized graphene nanohybrids have been successfully fabricated utilizing the classical covalent modification methods at different reaction temperatures. It is very interesting that although both CDs and graphene oxide （GO） could he easily decomposed, the effective combination of GO with CDs leads to significantly enhanced thermal stability of graphene derivatives （GO-CDs）. Moreover, the introduction of CDs could dramatically improve the dispersibility promotion of our products in both polar/protic and nonpolar/aprotic solvents, which will contribute to the preparation of polymer nanocomposites and increase of their thermal stability. The improved thermal degradation temperatures can be obtained for polyvinyl alcohol after filling with as little as 1 wt.% of the hybrid. The obtained products could be potentially used in heat-retardant or thermal-control materials.

关键词： β-Cyclodextrin Functionalized graphene Dispersibility Thermal stability

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