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Cell cycle and complement inhibitors may be specific for treatment of spinal cord injury in aged and young mice: transcriptomic analyses

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Neural Regeneration Research 2018年第3期13卷 518-527页

作者： Ming Hao xin-ran ji Hua Chen Wei Zhang Li-cheng Zhang Li-hai Zhang Pei-fu Tang Ning Lu Department of Orthopedic Surgery General Hospital of People’s Liberation Army (301 Hospital)

Previous studies have reported age-specific pathological and functional outcomes in young and aged patients suffering spinal cord injury,but the mechanisms remain poorly understood. In this study, we examined mice with spinal cord injury. Gene expression profiles from the Gene Expression Omnibus database （accession number GSE93561） were used, including spinal cord samples from 3 young injured mice （2–3-months old, induced by Impactor at Th9 level） and 3 control mice （2–3-months old, no treatment）, as well as 2 aged injured mice （15–18-months old, induced by Impactor at Th9 level） and 2 control mice （15–18-months old, no treatment）. Differentially expressed genes （DEGs） in spinal cord tissue from injured and control mice were identified using the Linear Models for Microarray data method,with a threshold of adjusted P 〈 0.05 and ｜logFC（fold change）｜〉 1.5. Protein–protein interaction networks were constructed using data from the STRING database, followed by module analysis by Cytoscape software to screen crucial genes. Kyoto encyclopedia of genes and genomes pathway and Gene Ontology enrichment analyses were performed to investigate the underlying functions of DEGs using Database for Annotation, Visualization and Integrated Discovery. Consequently, 1,604 and 1,153 DEGs were identified between injured and normal control mice in spinal cord tissue of aged and young mice, respectively. Furthermore, a Venn diagram showed that 960 DEGs were shared among aged and young mice, while 644 and 193 DEGs were specific to aged and young mice, respectively. Functional enrichment indicates that shared DEGs are involved in osteoclast differentiation, extracellular matrix–receptor interaction, nuclear factor-kappa B signaling pathway, and focal adhesion. Unique genes for aged and young injured groups were involved in the cell cycle （upregulation of PLK1） and complement （upregulation of C3） activation, respectively. These findings were confirmed by functional analysis of genes in module

关键词： nerve regeneration spinal cord injury aged young transcriptome differentially expressed genes protein-protein interaction network function enrichment inflammation cell cycle complement neural regeneration

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Epidural electrical stimulation effectively restores locomotion function in rats with complete spinal cord injury

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Neural Regeneration Research 2021年第3期16卷 573-579页

作者： Song Wang Li-Cheng Zhang Hai-Tao Fu Jun-Hao Deng Gao-Xiang Xu Tong Li xin-ran ji Pei-Fu Tang School of Medicine Nankai UniversityTianjinChina Department of Orthopedics Chinese PLA General HospitalBeijingChina Department of Orthopedics The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Characteristic Medical Center of the Chinese People’s Armed Police Force TianjinChina

Epidural electrical stimulation can restore limb motor function after spinal cord injury by reactivating the surviving neural *** previous epidural electrical stimulation studies,single electrode sites and continuous tetanic stimulation have often been *** this stimulation,the body is prone to declines in tolerance and locomotion *** the present study,rat models of complete spinal cord injury were established by vertically cutting the spinal cord at the T8 level to eliminate disturbance from residual nerve fibers,and were then subjected to epidural electrical *** flexible extradural electrode had good anatomical topology and matched the shape of the spinal canal of the implanted ***,the electrode stimulation site was able to be accurately applied to the L2–3 and S1 segments of the spinal *** evaluate the biocompatibility of the implanted epidural electrical stimulation electrodes,GFAP/Iba-1 doublelabeled immunofluorescence staining was performed on the spinal cord below the electrodes at 7 days after the electrode *** results revealed no significant differences in the numbers or morphologies of microglia and astrocytes in the spinal cord after electrode implantation,and there was no activated Iba-1~+cell aggregation,indicating that the implant did not cause an inflammatory response in the spinal *** gait analysis showed that,at 3 days after surgery,gait became coordinated in rats with spinal cord injury under burst *** regained locomotion could clearly distinguish the support phase and the swing phase and dynamically adjust with the frequency of stimulus *** evaluate the matching degree between the flexible epidural electrode(including three stimulation contacts),vertebral morphology,and the level of the epidural site of the stimulation electrode,micro-CT was used to scan the thoracolumbar vertebrae of rats before and after electrode ***

关键词： behavior injury model neurological function rat recovery regeneration repair spinal cord

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Effects of Calcium Sulfate Combined with Platelet-rich Plasma on Restoration of Long Bone Defect in Rabbits

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Chinese Medical Journal 2016年第5期129卷 557-561页

作者： Hua Chen xin-ran ji Qun Zhang Xue-Zhong Tian Bo-Xun Zhang Pei-Fu Tang Department of Orthopaedics Chinese People's Liberation Army General Hospital Beijing 100038 China Department of Orthopaedics People's Hospital of Tianjin Tianjin 300131 China

Background：The treatment for long bone defects has been a hot topic in the field of regenerative *** study aimed to evaluate the therapeutic effects of calcium sulfate （CS） combined with platelet-rich plasma （PRP） on long bone defect ***：A radial bone defect model was constructed through an osteotomy using New Zealand *** rabbits were randomly divided into four groups （n =10 in each group）：a CS combined with PRP （CS-PRP） group,a CS group,a PRP group,and a positive （recombinant human bone morphogenetic protein-2） control *** was prepared from autologous blood using a two-step centrifugation ***-PRP was obtained by mixing hemihydrate CS with *** and histologic micrographs were *** percentage of bone regenerated bone area in each rabbit was calculated at 10 ***-way analysis of variance was performed in this ***：The radiographs and histologic micrographs showed bone restoration in the CS-PRP and positive control groups,while nonunion was observed in the CS and PRP *** percentages of bone regenerated bone area in the CS-PRP （84.60 ± 2.87%） and positive control （52.21 ± 4.53%） groups were significantly greater than those in the CS group （12.34 ± 2.17%） and PRP group （16.52 ± 4.22%）（P 〈 0.001）.In addition,the bone strength of CS-PRP group （43.l 0 ± 4.10%） was significantly greater than that of the CS group （20.10 ± 3.70%） or PRP group （25.10 ± 2.10%）（P 〈 0.001）.Conclusion：CS-PRP functions as an effective treatment for long bone defects through stimulating bone regeneration and enhancing new bone strength.

关键词： Bone Restoration Calcium Sulfate Long Bone Defect Platelet-rich Plasma

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Clinical study on the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes

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World Journal of Diabetes 2025年第1期16卷 58-64页

作者： ji-Kui Wang Di Zhang jin-Feng Wang Wan-Lin Lu jing-Yuan Wang Shi-Feng Liang ran Liu jing-xin jiang Hong-Tao Li Xuan Yang Department of General Thoracic Surgery Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina Department of Health Management Center Liaoning Electric Power Center HospitalShenyang 110000Liaoning ProvinceChina

BACKGROUND At present,the existing internal medicine drug treatment can alleviate the high glucose toxicity of patients to a certain extent,to explore the efficacy of laparoscopic jejunoileal side to side anastomosis in the treatment of type 2 diabetes,the report is as *** To investigate the effect of jejunoileal side-to-side anastomosis on metabolic parameters in patients with type 2 diabetes mellitus(T2DM).METHODS We retrospectively analyzed the clinical data of 78 patients with T2DM who were treated via jejunoileal lateral *** indicators were collected preoperatively,as well as at 3 and 6 months *** metabolic indicators analyzed included body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),fasting blood glucose(FBG),2-hour blood glucose(PBG),glycated hemoglobin(HbA1c),fasting C-peptide,2-hour C-peptide(PCP),fasting insulin(Fins),2-hour insulin(Pins),insulin resistance index(HOMA-IR),βCellular function index(HOMA-β),alanine aminotransferase,aspartate aminotransferase,serum total cholesterol(TC),low-density lipoprotein cholesterol(L DL-C),triglycerides(TG),high-density lipoprotein,and uric acid(UA)*** SBP,DBP,PBG,HbA1c,LDL-C,and TG were all significantly lower 3 months postoperative vs preoperative values;body weight,BMI,SBP,DBP,FBG,PBG,HbA1c,TC,TG,UA,and HOMA-IR values were all significantly lower 6 months postoperative vs at 3 months;and PCP,Fins,Pins,and HOMA-βwere all significantly higher 6 months postoperative vs at 3 months(all P<0.05).CONCLUSION Side-to-side anastomosis of the jejunum and ileum can effectively treat T2DM and improve the metabolic index levels associated with it.

关键词： Metabolic diseases Type 2 diabetes Jejunoileal side-to-side anastomosis Glycolipid metabolism Islet function

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Role of nutrition in diabetes mellitus and infections

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World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： Xue-Lu Yu Li-Yun Zhou Xiao Huang xin-Yue Li Ming-Ke Wang ji-Shun Yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals

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Brain age estimation:premise,promise,and problems

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Neural Regeneration Research 2025年第8期20卷 2313-2314页

作者： Jarrad Perron ji Hyun Ko Graduate Program in Biomedical Engineering Price Faculty of EngineeringUniversity of ManitobaWinnipegMBCanada PrairieNeuro Research Centre Kleysen Institute for Advanced MedicineHealth Sciences CentreWinnipegMBCanada Department of Human Anatomy and Cell Science Rady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada

Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,South Korea,Europe,and North *** old age is the most significant predictor of dementia,global healthcare systems must rise to the challenge of providing care for those with neurodegenerative disorders.

关键词： estimation providing birth

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Effect of cholesterol metabolism on hepatolithiasis

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World Journal of Gastroenterology 2025年第1期31卷 157-162页

作者： Lin Zheng Zi-Yu Ye Jun-ji Ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

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Knotted Solitons in an Interacting Mixture of a Charged and a Neutral Superfluid for Neutron Stars

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Communications in Theoretical Physics 2009年第9期52卷 555-560页

作者： REN ji-Rong GUO Heng ZHANG xin-Hui LI ran Institute of Theoretical Physics Lanzhou University Lanzhou 730000 China

By making use of the decomposition of U（1） gauge potential theory and the C-mapping method we discuss a mixture of interacting neutral and charged Bose condensates, which is supposed being realized in the interior of neutron stars in the form of a coexistent neutron superfluid and protonic superconductor. We propose that this system possesses vortex lines and two classes of knotted solitons. The topological charge of the vortex lines are characterized by the Hopf indices and the Brower degrees of φ-mapping, and the knotted solitons are described by nontrivial Hopf invariant and the BF action respectively.

关键词： neutron stars topological excitations spontaneous breaking of gauge symmetries

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Smelting practice of scrap addition in blast furnace and theoretical analysis of cost saving

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Journal of Iron and Steel Research International 2020年第9期27卷 1005-1010页

作者： Yong Deng jian-liang Zhang ran Liu Ke-xin jiao Bing-ji Yan Institute for Metallurgical Engineering and Technology North China University of Science and TechnologyTangshan 063210HebeiChina College of Metallurgy and Energy Ministry of Education Key Laboratory of Modern Metallurgy TechnologyNorth China University of Science and TechnologyTangshan 063210HebeiChina School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Iron and Steel Soochow UniversitySuzhou 215137JiangsuChina

The recycling of scrap has attracted more attention in recent years,and scrap can be used as iron-bearing material to smelt hot *** smelting practice of blast furnace(BF)with scrap addition in China was investigated,with the types of scrap being small pieces of scrap,such as crushed materials,light and thin materials,and small compacts which were easy to be added into *** higher productivity of BFs with scrap addition was observed compared with that of BFs without scrap addition at the same volume,and the positive correlation between production increase rate and addition amount of scrap was *** reducing agent rate of most BFs with scrap addition was lower than the average reducing agent rate at the same volume,while the gas utilization of BFs with scrap addition would not be reduced *** theoretical analysis of cost saving was carried out as well,and the results indicated that the cost could be saved by scrap *** melting and carburizing were the two main processes of scrap in BF,in which three steps were involved in the melting process of *** amount of carburization depended on the carbon content of hot metal in hearth and the original carbon content in *** calculation showed that the coke rate could be reduced by 27 kg with 100 kg scrap addition per ton of hot metal,and the saving cost was decided by the amount of scrap and the actual situation of BF.

关键词： Blast furnace Scrap addition Smelting practice Cost saving

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Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen Li Leilei Liang Baoshan Zhang Yi Yang Guangbin ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

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