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Memory Trace for Fear Extinction:Fragile yet Reinforceable

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Neuroscience Bulletin 2024年第6期40卷 777-794页

作者： Ying liu Shuai Ye xin-ni li Wei-Guang li Department of Rehabilitation Medicine State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceHuashan HospitalInstitute for Translational Brain ResearchFudan UniversityShanghai200032China

Fear extinction is a biological process in which learned fear behavior diminishes without anticipated reinforcement,allowing the organism to re-adapt to ever-changing *** on the behavioral hypothesis that extinction is new learning and forms an extinction memory,this new memory is more readily forgettable than the original fear *** brain’s cellular and synaptic traces underpinning this inherently fragile yet reinforceable extinction memory remain *** questions are about the whereabouts of the engram neurons that emerged during extinction learning and how they constitute a dynamically evolving functional construct that works in concert to store and express the extinction *** this review,we discuss recent advances in the engram circuits and their neural connectivity plasticity for fear extinction,aiming to establish a conceptual framework for understanding the dynamic competition between fear and extinction memories in adaptive control of conditioned fear responses.

关键词： Fear extinction memory Memory trace Fear relapse Medial prefrontal cortex Basolateral amygdala Ventral hippocampus Insular cortex Synaptic adaptations

Rapid and easy determination of morphine in chafing dish condiments with colloidal gold labeling based lateral flow strips

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Food Science and Human Wellness 2019年第1期8卷 40-45页

作者： Wei Chen xin-ni li Qian Wu li Yao Jianguo Xu School of Food and Biological Engineering Engineering Research Center of Bio-processMOEHefei University of TechnologyHefei230009China

In order to enhance the flavor of chafing dish and increase the attraction of consumers,the poppy shell is reported to be illegally added to the condiments of chafing *** this research,a rapid,simple,and convenient method based on the classic immunochromatographic lateral flow strip(LFS)with gold nanoparticles(GNPs)labeling was developed for easy monitoring of morphine(MOP),an effective component of poppy *** optimized conditions,this developed LFS can well realize the detection of target MOP in the condiments of chafing dish in less than 10 min without any complicated *** limit of detection(LOD)can be achieved as low as 0.1 ppb for standard MOP or the MOP spiked condiments of chafing *** these results of the research strongly demonstrate that this established LFS method can be successfully applied in practical rapid and accurate on-site screening of poppy shell in condiments of chafing dish.

关键词： Morphine(MOP) Gold nanoparticles(GNPs) Lateral flow strip(LFS) Chafing dish condiments

Comparative genomics of Helicobacter pylori

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World Journal of Gastroenterology 2009年第32期15卷 3984-3991页

作者： Quan-Jiang Dong Qing Wang Ying-nin xin ni li Shi-Ying Xuan Department of Gastroenterology Qingdao Municipal Hospital Qingdao 266071 Shandong Province China

Genomic sequences have been determined for a number of strains of Helicobacter pylori （H pylori） and related bacteria. With the development of microarray analysis and the wide use of subtractive hybridization techniques, comparative studies have been carried out with respect to the interstrain differences between H pylori and inter-species differences in the genome of related bacteria. It was found that the core genome of H pylori constitutes 1111 genes that are determinants of the species properties. A great pool of auxiliary genes are mainly from the categories of cag pathogenicity islands, outer membrane proteins, restriction-modification system and hypothetical proteins of unknown function. Persistence of H pylori in the human stomach leads to the diversification of the genome. Comparative genomics suggest that a host jump has occurs from humans to felines. Candidate genes specific for the development of the gastric diseases were identified. With the aid of proteomics, population genetics and other molecular methods, future comparative genomic studies would dramatically promote our understanding of the evolution, pathogenesis and microbiology of Hpylori.

关键词： Helicobacterpylori Genomics Pathogenesis Cancer

Neuronal and synaptic adaptations underlying the benefits of deep brain stimulation for Parkinson’s disease

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Translational Neurodegeneration 2023年第1期12卷 90-110页

作者： Wenying Xu Jie Wang xin-ni li Jingxue liang Lu Song Yi Wu Zhenguo liu Bomin Sun Wei-Guang li Department of Rehabilitation Medicine Huashan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceFudan UniversityShanghai 200032China Department of Neurosurgery Center for Functional NeurosurgeryRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Neurology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Ministry of Education-Shanghai Key Laboratory for Children’s Environmental Health Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

Deep brain stimulation(DBS)is a well-established and effective treatment for patients with advanced Parkinson’s disease(PD),yet its underlying mechanisms remain ***,primarily conducted in animal models,provides a unique approach that allows cell type-and projection-specific modulation that mirrors the frequency-dependent stimulus effects of ***-DBS research in animal models plays a pivotal role in unraveling the neuronal and synaptic adaptations that contribute to the efficacy of DBS in PD ***-induced neuronal responses rely on a complex interplay between the distributions of presynaptic inputs,frequency-dependent synaptic depression,and the intrinsic excitability of postsynaptic *** orchestration leads to conversion of firing patterns,enabling both antidromic and orthodromic modulation of neural *** these mechanisms is vital for decoding position-and programming-dependent effects of ***,patterned stimulation is emerging as a promising strategy yielding long-lasting therapeutic *** on the neuronal and synaptic adaptations to DBS may pave the way for the development of more enduring and precise modulation *** technologies,such as adaptive DBS or directional electrodes,can also be integrated for circuit-specific *** insights hold the potential to greatly improve the effectiveness of DBS and advance PD treatment to new levels.

关键词： Parkinson’s disease Deep brain stimulation Optogenetics Opto-DBS Synaptic adaptation Orthodromic effects Antidromic effects Long-lasting therapeutic effects

AlGaN/GaN HEMTs on 4-Inch Silicon Substrates in the Presence of 2.7-μm -Thick Epilayers with the Maximum Off-State Breakdown Voltage of 500 V

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Chinese Physics Letters 2014年第3期31卷 129-132页

作者： YU xin-xin ni Jin-Yu li Zhong-Hui KONG Cen ZHOU Jian-Jun DONG Xun PAN Lei KONG Yue-Chan CHEN Tang-Sheng Science and Technology on Monolithic Integrated Circuits and Modules Laboratory Nanjing Electronic Devices Institute Nanjing 210016

We report on the high breakdown performance of AlGaN/GaN high electron mobility transistors （HEMTs） grown on 4-inch silicon substrates. The HEMT structure including three Al-content step-graded AlGaN transition layers has a total thickness of 2.7 μm. The HEMT with a gate width WG of 300 μm acquires a maximum off-state breakdown voltage （BV） of 550 V and a maximum drain current of 527 mA/mm at a gate voltage of 2 V. It is found that BV is improved with the increase of gate-drain distance LGD until it exceeds 8 μm and then BV is tended to saturation. While the maximum drain current drops continuously with the increase of LGD. The HEMT with a WG of 3 mm and a LGD of 8 μm obtains an off-state BV of 500 V. Its maximum leakage current is just 13 μA when the drain voltage is below 400 V. The device exhibits a maximum output current of 1 A with a maximum transconductance of 242 mS.

关键词： High electron mobility transistors

四通胶囊预防下肢骨折术后深静脉血栓形成的临床研究

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中国矫形外科杂志 2010年第14期18卷 1214-1216页

作者：赵龙倪新丽泰安市中医二院山东泰安271000

[目的]研究四通胶囊在预防下肢骨折术后深静脉血栓(DVT)形成中的作用。[方法]下肢骨折手术患者240例。其中80例患者行四通胶囊口服治疗10 d,80例应用低分子肝素钠皮下注射10 d,80例患者纳入空白对照组。定期采用下肢彩色多普勒检查,凝... 详细信息

[目的]研究四通胶囊在预防下肢骨折术后深静脉血栓(DVT)形成中的作用。[方法]下肢骨折手术患者240例。其中80例患者行四通胶囊口服治疗10 d,80例应用低分子肝素钠皮下注射10 d,80例患者纳入空白对照组。定期采用下肢彩色多普勒检查,凝血酶原时间检查并记录患肢情况。[结果]接受四通胶囊治疗的患者中仅4例发现深静脉血栓,无1例出现凝血酶原时间异常;接受低分子肝素钠治疗的患者中8例发现深静脉血栓,但因出现凝血酶原时间延长而停止治疗的患者有11例。空白对照组治疗的患者有28例发现深静脉血栓。组间差异显著(P<0.01)。[结论]四通胶囊对下肢骨折术后DVT的发生具有预防作用。

关键词：四通胶囊下肢骨折深静脉血栓

关节镜清理加中药灌洗治疗膝关节骨性关节炎探讨

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中国矫形外科杂志 2006年第19期14卷 1511-1512页

作者：赵龙王新东倪新丽山东省泰安市中医二院骨伤科 271000

[目的]探讨中药灌洗治疗膝关节骨性关节炎的临床效果。[方法]首先应用关节镜清理关节，再应用中药进行关节内灌洗，研究采用3组对比，以单纯清理、加用玻璃酸钠两组对比，以观察中药效果。[结果]随诊7～16个月，22例膝关节骨性关节炎病... 详细信息

[目的]探讨中药灌洗治疗膝关节骨性关节炎的临床效果。[方法]首先应用关节镜清理关节，再应用中药进行关节内灌洗，研究采用3组对比，以单纯清理、加用玻璃酸钠两组对比，以观察中药效果。[结果]随诊7～16个月，22例膝关节骨性关节炎病人，应用上述治疗，优17例，良3例，差2例，优良率为90．9％。[结论]中药关节内灌洗在治疗膝关节骨性关节炎中有较好的疗效。

关键词：关节镜清理中药灌洗膝关节骨性关节炎

基于移动互联网技术儿童哮喘自我管理工具的构建与应用研究

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中国全科医学 2017年第28期20卷 3542-3547页

作者：喜雷皇惠杰倪鑫向莉首都医科大学附属北京儿童医院过敏反应科北京市100045 北京市通州区妇幼保健院儿科 101101 首都医科大学附属北京儿童医院耳鼻咽喉头颈外科北京市100045

目的研发基于移动互联网技术的儿童哮喘自我管理工具并予以临床应用实践,初步探索移动互联网技术应用于儿童哮喘自我管理的临床价值。方法根据儿童哮喘管理的基本要素,研发基于Android手机操作系统的儿童轻松呼吸远程管理APP,测试并优化... 详细信息

目的研发基于移动互联网技术的儿童哮喘自我管理工具并予以临床应用实践,初步探索移动互联网技术应用于儿童哮喘自我管理的临床价值。方法根据儿童哮喘管理的基本要素,研发基于Android手机操作系统的儿童轻松呼吸远程管理APP,测试并优化APP的使用功能。选取2016年2—6月在首都医科大学附属北京儿童医院过敏反应科就诊并确诊的64例支气管哮喘患儿,根据患儿监护人的意愿,分为APP管理组28例和传统日记卡管理组36例。APP管理组采用智能手机下载APP,远程管理哮喘患儿;传统日记卡管理组采用传统纸质版日记卡记录哮喘患儿症状、用药等情况。比较管理前和随访1个月后两组患儿的哮喘控制率、儿童哮喘控制测试(C-ACT)得分,随访1个月后两组患儿用药依从性、自我管理执行情况[记录症状天数和记录峰值呼气流速(PEFR)天数],并评估患儿监护人对APP管理的满意度和认可度。结果完成1个月随访的APP管理组患儿18例,传统日记卡管理组患儿33例。管理前和管理1个月后,两组患者支气管哮喘控制率、C-ACT得分比较,差异均无统计学意义(P>0.05);管理后,两组患儿支气管哮喘控制率、C-ACT得分均高于管理前,差异有统计学意义(P0.05);记录症状天数比较,差异有统计学意义(P<0.05)。APP管理组16例哮喘患儿监护人中,对APP管理的满意度为93.7%(15/16),认可度为81.3%(13/16)。结论儿童哮喘自我管理工具有较高的接受度和满意度,但在提高哮喘控制率、C-ACT得分及用药依从性方面没有显著优势,未来需进一步优化APP功能,并开展大样本随机对照研究。

关键词：哮喘疾病管理因特网软件儿童

医护患团队护理在2型糖尿病伴抑郁患者中的实施意义

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糖尿病新世界 2020年第16期23卷 128-130页

作者：倪新丽山东省泰安市中医二院老年病科山东泰安271000

目的探讨医护患团队护理在2型糖尿病伴抑郁患者中的实施意义。方法按照随机数字法选取2018年9月—2019年7月该院收治的64例2型糖尿病伴抑郁患者作为该文研究对象,将其分为对照组与观察组,每组32例。对照组运用常规护理干预,在此基础上,... 详细信息

目的探讨医护患团队护理在2型糖尿病伴抑郁患者中的实施意义。方法按照随机数字法选取2018年9月—2019年7月该院收治的64例2型糖尿病伴抑郁患者作为该文研究对象,将其分为对照组与观察组,每组32例。对照组运用常规护理干预,在此基础上,观察组运用医护患团队护理干预,比较两组患者护理前后的焦虑、抑郁评分餐后2 h血糖、空腹血糖水平,护理满意度。结果护理前,对比两组患者焦虑、抑郁情况,差异无统计学意义(P>0.05),护理后,对照组高于观察组,差异有统计学意义(P0.05),护理后,对照组高于观察组,差异有统计学意义(P<0.05);对照组患者护理满意度与观察组对比,差异有统计学意义(P<0.05)。结论医护患团队护理在2型糖尿病伴抑郁患者中的应用效果显著。

关键词：医护患团队护理 2型糖尿病伴抑郁应用效果