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VSMC Proliferation in VSMCs Stimulated by AngⅡ Requires Cooperative Interaction Between KLF5 and c-Jun

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VSMC Proliferation in VSMCs Stimulated by AngⅡ Requires Coo...

2008年全国生物化学与分子生物学学术大会

作者： Yu Liu Chao Wang ming He xin-ming Zhao Fang meng Bin Zheng Jin-kun Wen Mei Han (Department of Biochemistry and Molecular Biology,Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017)

Proliferation of vascular smooth muscle cells (VSMCs) is critical for remodeling cardiovascular diseases, such as hypertension,atherosclerosis and restenosis after percutaneous transluminal coronary angioplasty (PTCA). Angiotensin Ⅱ (AngⅡ) is an important contributor to the initiation of pathophysiological events that leads to

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洪水灾害下化工装置的脆弱性评估

安全与环境学报 2016年第6期16卷 19-23页

作者：魏彤彤钱新明袁梦琦北京理工大学爆炸科学与技术国家重点实验室北京100081 中国人民武装警察部队学院消防工程系河北廊坊065000

针对洪水灾害下化工装置的脆弱性评估,提出了综合考虑洪水类型、装置结构特征和危险物质泄漏模式的脆弱性定量评估方法。该方法在厘定化工装置结构破坏模式、破坏等级和物质泄漏风险等级的前提下,构建洪水作用下装置的结构极限状态方程... 详细信息

针对洪水灾害下化工装置的脆弱性评估,提出了综合考虑洪水类型、装置结构特征和危险物质泄漏模式的脆弱性定量评估方法。该方法在厘定化工装置结构破坏模式、破坏等级和物质泄漏风险等级的前提下,构建洪水作用下装置的结构极限状态方程,获得结构极限状态曲线和结构失效控制参数阈值,进而得到结构破坏概率和危险物质泄漏频率,并将这两个参数作为洪水灾害脆弱性快速评估指标。以常压立式储罐为分析对象,对上述方法进行详细阐述,并结合实例验证了方法的适用性。结果表明,结构极限状态曲线可以用于快速区分结构安全状态和失效状态,临界装量系数是决定储罐洪水脆弱性的关键工艺参数,随罐壁高度和储液密度增加,洪水灾害脆弱性逐渐降低。

关键词：安全工程化工装置洪水灾害脆弱性风险评估

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基于参考作物法的玛河灌区棉花耗水强度研究

节水灌溉 2017年第5期 90-92,97页

作者：曹玉斌何新林吕廷波辛明亮王萌萌石培君石河子大学水利建筑工程学院新疆石河子832000 现代节水灌溉兵团重点试验室新疆石河子832000

基于玛纳斯河流域中游平原灌区及其周边24个气象站点2013年的气象资料,采用分段单值平均法计算棉花作物系数,利用参考作物法确定灌区各站点棉花不同生育期耗水强度,结合Arc GIS空间插值,分析灌区棉花耗水强度在不同生育期和灌区空间尺... 详细信息

基于玛纳斯河流域中游平原灌区及其周边24个气象站点2013年的气象资料,采用分段单值平均法计算棉花作物系数,利用参考作物法确定灌区各站点棉花不同生育期耗水强度,结合Arc GIS空间插值,分析灌区棉花耗水强度在不同生育期和灌区空间尺度上的变化规律,并确定灌区棉花设计耗水强度。结果表明:灌区棉花全生育期耗水强度呈现先增大后减小的变化趋势,大小顺序为花铃期(5.64~6.84 mm/d)>蕾期(3.74~4.70 mm/d)>吐絮期(2.00~2.50 mm/d)>苗期(1.62~1.76 mm/d);灌区棉花全生育期平均耗水强度自西南向东北呈现递增趋势,介于3.45~3.98 mm;玛河灌区棉花设计耗水强度应在5.69~6.45 mm间选取。

关键词：玛河灌区棉花耗水强度参考作物法空间尺度

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微机原理与单片机课程体系改革

实验科学与技术 2008年第4期6卷 73-74,88页

作者：杨明欣孟芳成都信息工程学院电子基础教学实验中心成都610066

微机原理及单片机是电类专业承前启后的重要课程,是电子基础知识和计算机技术综合应用的平台,是电子类学生进一步学习提高的基础,也是将来就业的基本技能。文中就微机及单片机课程综合改革进行了探讨,分析了课程改革的必要性,介绍了改... 详细信息

微机原理及单片机是电类专业承前启后的重要课程,是电子基础知识和计算机技术综合应用的平台,是电子类学生进一步学习提高的基础,也是将来就业的基本技能。文中就微机及单片机课程综合改革进行了探讨,分析了课程改革的必要性,介绍了改革的具体措施及利弊,实施的方案与效果,对相关学校进行同类改革有一定的参考价值。

关键词：微机原理单片机教学改革

丙戊酸联合骨髓间充质干细胞移植对大鼠脊髓损伤的影响

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中国临床药理学杂志 2017年第8期33卷 714-717页

作者：张振梁杨新明孟宪勇胡长波成垚昱康聪河北北方学院研究生院河北张家口075000 河北北方学院附属第一医院骨科河北张家口075000

目的研究腹腔注射丙戊酸(VPA)辅佐骨髓间充质干细胞(BMSCs)对大鼠脊髓损伤(SCI)后神经功能恢复的作用。方法选择雄性3~4周龄SD幼鼠,体外分离培养BMSCs,收集第3代BMSCs。动物脊髓损伤模型选用改良的Allen’s法制作。假手术组,只切除椎板... 详细信息

目的研究腹腔注射丙戊酸(VPA)辅佐骨髓间充质干细胞(BMSCs)对大鼠脊髓损伤(SCI)后神经功能恢复的作用。方法选择雄性3~4周龄SD幼鼠,体外分离培养BMSCs,收集第3代BMSCs。动物脊髓损伤模型选用改良的Allen’s法制作。假手术组,只切除椎板,不打击脊髓。按照体重将8周龄雄性SD大鼠随机分为5组(每组均12只):除了假手术组以外,模型组、VPA组、移植组及联合组均进行SCI;然后,模型组与假手术组均腹腔注射0.9%氯化钠,并一次性在损伤节段脊髓(或相当于损伤节段的脊髓)注入0.9%氯化钠1 mL;移植组在损伤节段脊髓注入1×10~6mL^(-1)BMSCs 1 mL;VPA组腹腔注射VPA,按300 mg·kg^(-1)·d^(-1)每12 h给药1次;联合组是移植组+VPA组。在SCI后7,14 d,先进行后肢运动功能评分(BBB)。用免疫组化法检定半胱氨酸天冬氨酸蛋白酶3(Caspase-3)蛋白表达情况,通过脱氧核糖核苷酸末端转移酶介导的缺口末端标记法(TUNEL)染色观察脊髓组织切片神经细胞凋亡情况。结果在SCI后14 d,假手术组、模型组、丙戊酸组、移植组和联合组的BBB评分分别为21,(4.51±0.41),(7.25±0.95),(7.32±0.55),(9.76±0.95)分。3个治疗组的BBB评分较模型组均明显增高,差异均有统计学意义(均P<0.05)。在SCI后14 d,假手术组、模型组、丙戊酸组、移植组和联合组的Caspase-3的表达分别为(1.64±0.41)%,(26.22±4.81)%,(21.21±4.04)%,(21.47±3.32)%,(16.15±3.09)%,3个治疗组的Caspase-3表达明显低于模型组,差异均有统计学意义(均P<0.05)。假手术组、模型组、丙戊酸组、移植组和联合组的细胞凋亡率分别为(4.18±0.39)%,(40.51±3.81)%,(19.95±2.04)%,(20.87±2.32)%,(12.83±1.09)%,与模型组相比,3个治疗组的凋亡指数较低,差异均有统计学意义(均P<0.05)。结论腹腔注射VPA辅佐BMSCs移植对SCI后运动神经功能的恢复效果显著,其机制可能和下调Caspase-3的表达、抑制凋亡有关。

关键词：丙戊酸骨髓间充质干细胞脊髓损伤细胞凋亡半胱氨酸天冬氨酸蛋白酶3

Bionic stab-resistant body armor based on triangular pyramid structure

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Defence Technology（防务技术） 2021年第3期17卷 792-799页

作者： Ya-xin Guo meng-qi Yuan xin-ming Qian State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China

A stab-resistant substrate was designed and realized with a triangular pyramidal structure, inspired by the biological armor model in nature. The stab-resistance behavior and dynamic response mechanisms were studied through numerical simulation and experimental testing of a knife impacting a substrate,and an optimal structural design was obtained accordingly, with a tilted angle of 22.5and optimal thickness of 1.2 mm. It was shown that the triangular pyramidal structure generated twice the internal energy of the knife than the flat substrate due to the dispersing effect of the structure. The force parallel to the inclination caused a significant scratch on the substrate surface, while the force perpendicular caused obvious substrate deformation. A new riveting method was used to form the total layer, which passed the GA 68-2008 standard. The stab-resistant clothing coupled with the reduced wearing burden could provide effective protection and avoid fatal injuries on security personnel working in dangerous environments. The method provided may enlighten the future design and manufacturing of stabresistant clothing.

关键词： Stab resistant Impact behavior Body armor Finite element analysis

Bifunctional bridging capping layer enables 24.5% efficiency of perovskite solar cells with polymer-based hole transport materials

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Science China Chemistry 2025年第1期 350-359页

作者： Can Zhu Yiyang Wang Lei meng Beibei Qiu Jing Li Shucheng Qin Ke Hu xin Jiang Wenbin Lai Minchao Liu Zhe Liu Chenxing Lu Jinyuan Zhang Yongfang Li Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences School of Chemical Science University of Chinese Academy of Sciences Key Laboratory of Solid State Optoelectronic Devices of Zhejiang Province College of Physics and Electronic Information Engineering Zhejiang Normal University Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of Sciences Laboratory of Advanced Optoelectronic Materials College of Chemistry Chemical Engineering and Materials ScienceSoochow University

Developing a bridge capping layer between perovskite and hole transport layer materials（HTMs） in the n-i-p perovskite solar cells（pero-SCs） is an effective approach to modify the morphology of HTMs and passivate the perovskite ***, we select the quinoxaline-based bifunctional passivation agent, quinoxalin-6-yl-methylamine hydrochloride（Qx MACl）,as the bridging layer, and a D-A copolymer PBQ12 containing the same quinoxaline unit as an HTM for the n-i-p pero-SCs. Due to the π-π stacking among the common quinoxaline units in the bridge layer and HTM, Qx MACl induces the π-π stacking of the PBQ12 film and improves the film morphology of HTMs with better conductivity. Additionally, Qx MACl can effectively passivate the perovskite surface, and PBQ12 possesses appropriate energy levels and high hole mobility. The pero-SCs based on FAPbI3with PBQ12/Qx MACl treatment showed a higher power conversion efficiency（PCE） of 24.05% and outstanding stability, maintaining 95.4% and 92.1% of its initial PCE after 750 h of storage and after over 800 h of thermal annealing at 85 °C, respectively. To further enhance the PCE of the PBQ12/Qx MACl-based devices, we developed a non-metal ion dopant for the PBQ12 HTM. Through trace doping of PBQ12 HTM by the non-metal ion dopant, the PCE of the PBQ12/Qx MACl-based devices reached 25.24%（the calibrated PCE of 24.55% by the National Institute of Metrology, China）.

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Inter-Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding, Sensing and Thermal Management

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NANO-MICRO LETTERS 2025年第1期17卷 1-18页

作者： Li, Xufeng Chen, Chunyan Li, Zhenyang Yi, Peng Zou, Haihan Deng, Gao Fang, ming He, Junzhe Sun, xin Yu, Ronghai Shui, Jianglan Pan, Caofeng Liu, Xiaofang Beihang Univ Sch Mat Sci & Engn Beijing 100191 Peoples R China Beihang Univ Inst Atom Mfg Beijing 100191 Peoples R China Tianmushan Lab Xixi Octagon City Hangzhou 310023 Peoples R China Beijing Inst Environm Features Sci & Technol Electromagnet Scattering Lab Beijing 100854 Peoples R China

Unique inter-skeleton conductive films are constructed in polymer *** resistance change of the foam can reach four orders of magnitude under *** foam exhibits strain-adaptive electromagnetic interference shielding performance, anti-interference pressure sensor with high sensitivity over a wide pressure range and compression-regulated Joule heating function. Conductive polymer foam (CPF) with excellent compressibility and variable resistance has promising applications in electromagnetic interference (EMI) shielding and other integrated functions for wearable electronics. However, its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during deformation. Here, an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under compression. Unique inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton (denoted as AMLM-PM foam). Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive films. Therefore, the resistance change of AMLM-PM reaches four orders of magnitude under compression. Moreover, the inter-skeleton conductive films can improve the mechanical strength of foam, prevent the leakage of liquid metal and increase the scattering area of EM wave. AMLM-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness, solving the problem of traditional CPFs upon compression. The upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam Liquid metal Electromagnetic interference shielding

关中-天水经济区对日软件外包人才培养模式研究

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现代计算机 2016年第18期22卷 13-17页

作者：欧阳宏基郭新明葛萌咸阳师范学院计算机学院咸阳712000

对日软件外包已成为我国软件产业外包的一个重要分支,但是人才资源短缺仍然是制约对日软件外包发展的一个重要瓶颈。针对该问题,介绍最近几年我国对日软件外包的新特点,然后分析关中-天水经济区在对日软件外包方面的优势,最后根据对日... 详细信息

对日软件外包已成为我国软件产业外包的一个重要分支,但是人才资源短缺仍然是制约对日软件外包发展的一个重要瓶颈。针对该问题,介绍最近几年我国对日软件外包的新特点,然后分析关中-天水经济区在对日软件外包方面的优势,最后根据对日外包业务的基本流程和低端人才需求情况,提出"日语文化学习+技术平台驱动教学内容+教师日企挂职锻炼+真实外包案例训练"的培养模式,希望能为关中-天水经济区内高等院校以及相关软件企业在对日软件外包人才培养方面起到一定的借鉴作用。

关键词：关中-天水经济区对日软件外包人才培养模式