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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui jiang Hui-Li Kang Yi jiang Hua-Wei Zhang Xiao-mei Song Yu-Ze Li Wen-Li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

Liquid-solid interface control of BFe10-1-1 cupronickel alloy tubes during HCCM horizontal continuous casting and its effect on the microstructure and properties

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International Journal of Minerals,Metallurgy and Materials 2013年第8期20卷 748-758页

作者： Jun mei xin-hua Liu Yan-bin jiang Song Chen Jian-xin Xie Key Laboratory for Advanced Materials Processing(MOE) University of Science and Technology Beijing Institute for advanced Materials and Technology University of Science and Technology Beijing

Based on horizontal continuous casting with a heating-cooling combined mold （HCCM） technology, this article investigated the effects of processing parameters on the liquid-solid interface （LSI） position and the influence of LSI position on the surface quality, microstructure, texture, and mechanical properties of a BFe10-1-1 tube （φ50 mm × 5 mm）. HCCM efficiently improves the temperature gradient in front of the LSI. Through controlling the LSI position, the radial columnar-grained microstructure that is commonly generated by cooling mold casting can be eliminated, and the axial columnar-grained microstructure can be obtained. Under the condition of 1250℃ melting and holding temperature, 1200-1250℃ mold heating temperature, 50-80 mm/min mean drawing speed, and 500-700 L/h cooling water flow rate, the LSI position is located at the middle of the transition zone or near the entrance of the cooling section, and the as-cast tube not only has a strong axial columnar-grained microstructure （{hkl}〈621〉, {hkl}〈221〉） due to strong axial heating conduction during solidification but also has smooth internal and external surfaces without cracks, scratches, and other macroscopic defects due to short solidified shell length and short contact length between the tube and the mold at high temperature. The elongation and tensile strength of the tube are 46.0%-47.2% and 210-221 MPa, respectively, which can be directly used for the subsequent cold-large-strain processing.

关键词： copper-nickel alloys tubes continuous casting interfaces textures mechanical properties

Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat

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World Journal of Gastroenterology 2016年第46期22卷 10180-10188页

作者： Wei jiang mei-Hua Guo xin Hai Pharmacy Department First Affiliated Hospital of Harbin Medical University

AIM To evaluate the hepatoprotective effect of lycopene(Ly) on non-alcoholic fatty liver disease(NAFLD) in rat. METHODS A rat model of NAFLD was first established by feeding a high-fat diet for 14 wk. Sixty-five rats were randomly divided into normal group, model group and Ly treatment groups. Alanine aminotransferase(ALT), aspartate aminotransferase(AST), triglycerides(TG), total cholesterol(TC) in serum and low density lipoproteincholesterol(LDL-C), high density lipoprotein-cholesterol(HDL-C), free fatty acid(FFA), malondialdehyde(MDA), superoxide dismutase(SOD), glutathione(GSH) in liver tissue were evaluated, respectively. While the hepatoprotective effect was also confirmed by histopathological analysis, the expression levels of TNF-α and cytochrome P450(CYP) 2E1 in rat liver were determined by immunohistochemistry *** A significant decrease was observed in the levels of serum AST(2.07-fold), ALT(2.95-fold), and the blood lipid TG(2.34-fold) and TC(1.66-fold) in the dose of 20 mg/kg Ly-treated rats(P < 0.01), compared to the model group. Pretreatment with 5, 10 and 20 mg/kg of Ly significantly raised the levels of antioxidant enzyme SOD in a dose-dependent manner,to 90.95 ± 9.56, 109.52 ± 11.34 and 121.25 ± 10.68(P < 0.05, P < 0.01), as compared with the model group. Similarly, the levels of GSH were significantly increased(P < 0.05, P < 0.01) after the Ly treatment. Meanwhile, pretreatment with 5, 10 and 20 mg/kg of Ly significantly reduced MDA amount by 30.87, 45.51 and 54.49% in the liver homogenates, respectively(P < 0.01). The Ly treatment group showed significantly decreased levels of lipid products LDL-C(P < 0.05, P < 0.01), improved HDL-C level and significantly decreased content of FFA, compared to the model group(P < 0.05, P < 0.01). Furthermore, the Ly-treated group also exhibited a down-regulated TNF-α and CYP2E1 expression, decreased infiltration of liver fats and reversed histopathological changes, all in a dosedependent manner(P < 0.

关键词： Lycopene Antioxidant Hepatoprotective Non-alcoholic fatty liver Cytochrome P450 2E1

Ginsenoside Rg_3 inhibit hepatocellular carcinoma growth via intrinsic apoptotic pathway

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World Journal of Gastroenterology 2011年第31期17卷 3605-3613页

作者： Jian-Wen jiang xin-mei Chen xin-Hua Chen Shu-Sen Zheng The Key Lab of Combined Multi-organ Transplantation Ministry of Public HealthThe Department of Hepatobiliary and Pancreatic SurgeryFirst Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina The Department of Pharmacy Shandong Traditional Chinese Medicine UniversityJinan 250355Shandong ProvinceChina

AIM:To investigate the anti-tumor function of ginsenoside Rg3 on hepatocellular carcinoma(HCC) in vitro and in vivo,and its ***:Hep1-6 and HepG2 cells were treated by Rg3 in different concentrations(0,50,100 and 200 μg/mL) in *** incubation for 0,6,12,24 and 48 h,cell viability was measured by 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide *** was identified by terminal deoxynucleotidyl transferasemediated dUTP-biotin nick end ***-3 activity was measured by chromophore p-nitroanilide and flow ***-2 family proteins were ascertained by *** membrane potentialwas detected by 5,5',6' 6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolylcarbocyanine *** liver tumor-bearing C57Bl6 mice were divided randomly into 4 groups for intra-tumor injection of saline,ginsenoside Rg3,cyclophosphamide(CTX) and ginsenoside Rg3 + CTX ***:The survival time was followed up to 102 *** mice in the Rg3 + CTX group showed significant increased survival time compared with those in the control group(P < 0.05).Rg3 could inhibit HCC cell proliferation and induce cell apoptosis in vitro in the concentration and time dependent *** also induced mitochondria membrane potential to ***-3 activation can be blocked by the inhibitor *** was up-regulated while Bcl-2 and Bcl-XL were down-regulated after Rg3 ***:Our data suggested that Rg3 alone or combined with CTX inhibited tumor growth in vivo and prolonged mouse survival time by inducing HCC cell apoptosis via intrinsic pathway by expression alterations of Bcl-2 family proteins.

关键词： Ginsenoside Rg3 Apoptosis Hepatocellular Carcinoma Bcl-2 family proteins Cyclophosphamide

Ultraviolet Resistance and Antimicrobial Properties of ZnO in the Polypropylene Materials:A Review

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Journal of Materials Science & Technology 2015年第4期31卷 331-339页

作者： mei Li Gu Li Juan jiang Zishou Zhang xin Dai Kancheng Mai Key Laboratory of Polymeric Composites and Functional Materials of Ministry of Education Guangdong Provincial Key Laboratory of High Performance Polymer-based CompositesSchool of Chemistry and Chemical EngineeringSun Yat-sen University

ZnO is a multifunctional material with UV-blocking,antimicrobial,photo-catalytic activity and selfcleaning *** application of ZnO has become an interesting subject both in science and industries in the polymer materials.A great number of investigation indicated that introduction of ZnO can improve ultraviolet resistance and endow antimicrobial properties of polypropylene(PP) materials to broaden the application range and prolong the usage life of polypropylene *** mini-review contains examples of recent research advances on ultraviolet resistance and antimicrobial properties of ZnO in the filled polypropylene *** is found that ultraviolet resistance and antimicrobial properties of ZnO supported on the surface of other inorganic particles are higher than those of nanoand micro-ZnO particles,which may inspire further developments of filled PP and its copolymer materials with high ultraviolet resistance and antimicrobial properties.

关键词： Ultraviolet resistance Antimicrobial properties Po

上海市松江区呼吸系统疾病死亡与三种大气污染物的关联性

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上海预防医学 2017年第7期29卷 552-555,558页

作者：蔡滨欣朱美英姜永根黄丽妹陆慧萍陈岚李咏梅上海市松江区疾病预防控制中心上海201620 上海市松江区中心医院上海201600

目的探究大气污染物PM_(10)、SO_2、NO_2与呼吸系统疾病死亡的关联性。方法汇总上海市松江区2011—2012年大气污染数据,并收集户籍人口呼吸系统死亡的全部病例,采用时间分层-病例交叉设计方法分析两者间关系,并对不同年龄别、性别人群... 详细信息

目的探究大气污染物PM_(10)、SO_2、NO_2与呼吸系统疾病死亡的关联性。方法汇总上海市松江区2011—2012年大气污染数据,并收集户籍人口呼吸系统死亡的全部病例,采用时间分层-病例交叉设计方法分析两者间关系,并对不同年龄别、性别人群的超额死亡风险进行分析。结果 SO_2、NO_2与呼吸系统疾病死亡相关,当NO_2浓度每增加10μg/m^3时,在lag0时间点上导致呼吸系统死亡发生率明显提高[OR=1.061(1.000,1.126)];与女性相比,NO_2明显增加了男性呼吸系统疾病死亡风险[OR=1.109(1.031,1.194)]。结论大气污染可增加人群呼吸系统疾病死亡的风险,对男性尤甚。

关键词：大气污染物呼吸系统疾病死亡病例交叉设计

Microwave absorption properties of SiC@SiO2@Fe3O4 hybrids in the 2–18 GHz range

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International Journal of Minerals,Metallurgy and Materials 2017年第7期24卷 804-813页

作者： Peng Zhou Jun-hong Chen Meng Liu Peng jiang Bin Li xin-mei Hou National Engineering Research Center for Advanced Rolling Technology University of Science and Technology Beijing Beijing 100083 China School of Material Science and Engineering University of Science and Technology Beijing Beijing 100083 China Collaborative Innovation Center of Steel Technology University of Science and Technology Beijing Beijing 100083 China

To enhance the microwave absorption performance of silicon carbide nanowires（SiCNWs）, SiO_2 nanoshells with a thickness of approximately 2 nm and Fe_3O_4 nanoparticles were grown on the surface of SiCNWs to form SiC@SiO_2@Fe_3O_4 hybrids. The microwave absorption performance of the SiC@SiO_2@Fe_3O_4 hybrids with different thicknesses was investigated in the frequency range from 2 to 18 GHz using a free-space antenna-based system. The results indicate that SiC@SiO_2@Fe_3O_4 hybrids exhibit improved microwave absorption. In particular, in the case of an SiC@SiO_2 to iron（III） acetylacetonate mass ratio of 1：3, the microwave absorption with an absorber of 2-mm thickness exhibited a minimum reflection loss of-39.58 d B at 12.24 GHz. With respect to the enhanced microwave absorption mechanism, the Fe_3O_4 nanoparticles coated on SiC@SiO_2 nanowires are proposed to balance the permeability and permittivity of the materials, contributing to the microwave attenuation.

关键词： silicon carbide nanowires hybrids microwave absorption mechanism impedance match

Genome-wide identification and characterization of the JAZ gene family and its expression patterns under various abiotic stresses in Sorghum bicolor

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Journal of Integrative Agriculture 2022年第12期21卷 3540-3555页

作者： DU Qiao-li FANG Yuan-peng jiang Jun-mei CHEN mei-qing LI Xiang-yang XIE xin Key Laboratory of Agricultural Microbiology College of AgricultureGuizhou UniversityGuiyang 550025P.R.China State Key Laboratory Breeding Base of Green Pesticides and Agricultural Bioengineering/Key Laboratory of Green Pesticides and Agricultural Bioengineering Ministry of EducationGuizhou UniversityGuiyang 550025P.R.China

The jasmonate ZIM domain(JAZ)protein belongs to the TIFY((TIF[F/Y]XG)domain protein)family,which is composed of several plant-specific proteins that play important roles in plant growth,development,and defense ***,the mechanism of the sorghum JAZ family in response to abiotic stress remains *** the present study,a total of 17 JAZ genes were identified in sorghum using a Hidden Markov Model *** addition,real-time quantification polymerase chain reaction(RT-qPCR)was used to analyze the gene expression patterns under abiotic *** on phylogenetic tree analysis,the sorghum JAZ proteins were mainly divided into nine subfamilies.A promoter analysis revealed that the SbJAZ family contains diverse types of promoter cis-acting elements,indicating that JAZ proteins function in multiple pathways upon stress stimulation in *** to RT-qPCR,SbJAZ gene expression is ***,under cold,hot,polyethylene glycol,jasmonic acid,abscisic acid,and gibberellin treatments,the expression patterns of SbJAZ genes were distinctly different,indicating that the expression of SbJAZ genes may be coordinated with different ***,the overexpression of SbJAZ1 in Escherichia coli was found to promote the growth of recombinant cells under abiotic stresses,such as PEG 6000,NaCl,and 40℃ ***,our findings help us to better understand the potential molecular mechanisms of the SbJAZ family in sorghum in response to abiotic stresses.

关键词： Sorghum bicolor gene family identification JAZ family abiotic stress expression pattern

Galvanic corrosion behavior of AZ91D alloy/45 steel couple under magnetic field

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Journal of Magnesium and Alloys 2024年第9期12卷 3794-3805页

作者： xin Zhang Wan mei Zehua Zhou Shaoqun jiang Gang Wang Xiangru Shi Zehua Wang College of Mechanics and Materials Hohai UniversityNanjing211100China

Galvanic corrosion behavior of AZ91D alloy/45 steel couple in 3.5 wt.%NaCl solution under 0,0.2 and 0.4 T magnetic field were studied by microstructure observation,immersion test and electrochemical *** mixed potential theory was used to estimate the galvanic current density and the mixed potential of the galvanic corrosion between AZ91D alloy and 45 *** results indicated that magnetic field could accelerate the corrosion of AZ91D alloy,and impede the corrosion process of 45 *** effect of magnetic field on corrosion sensibility and corrosion rate of these two alloys increased as the intensity *** galvanic corrosion rate of the couple was accelerated by magnetic *** the magnetic field intensity rising,the galvanic corrosion sensibility and corrosion rate of the couple *** effects of magnetic field on the galvanic corrosion performance of the couple and the corrosion behavior of AZ91D alloy and 45 steel were due to the appearance of field gradient force and magnetohydrodynamic(MHD)*** mixed potential theory has a certain accuracy to estimate the Ecouple and icouple values in this work.

关键词： Magnetic field Corrosion behavior Galvanic corrosion The mixed potential theory