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Analysis of the urinary peptidome associated with Helicobacter pylori infection

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World Journal of Gastroenterology 2011年第5期17卷 618-624页

作者： Di Xiao Fan-Liang Meng Li-Hua He Yi-xin gu jian-Zhong Zhang National Institute for Communicable Disease Controland Prevention Chinese Center for Disease Control and Pre-vention Beijing 102206 China

AIM： To investigate the relationship between urinary peptide changes and Helicobacter pylori （H. pylorl） infection using urinary peptidome profiling. METHODS： The study was performed in volunteers （n = 137） who gave informed consent. Urinary peptides were enriched by magnetic beads based weak cation exchange chromatography＇and spectrums acquired by matrix-assisted laser desorption/ionization time-of-flight （MALDI-TOF） mass spectrometry （MS）. ClinProTools bioinformatics software was used for statistical analysis and the recognition of peptide patterns. The marker peptides were identified by LTQ Obitrap XL tandem MS. RESULTS： Approximately 50 proteins or peptides which loaded onto the magnetic beads were detected by MAL-DI-TOF MS. By optimizing the parameters of the model, the Genetic Algorithm model had good recognition capability （97%） and positive predictive value （94%）. Based on the model, 2 markers with molecular masses of 6788 and 1912 Da were found that differentiated between H. pylori positive and negative volunteers. The m/z 1912 sequence was parsed as SKQFTSSTSYN- RGDSTF. The peptide was identified as isoform 1 of the fibrinogen a chain precursor, whose concentration in urine was markedly higher in H. pylori infected volunteers than in H. pylori non-infected ones. CONCLUSION： The appearance of urinary fibrinogen degradation products is caused by an active H. pyloriinduced process.

关键词： Urinary peptidome profiling MB-matrix-assisted laser desorption/ionization time-of-flight massspectrometry Helicobacter pylori Fibrinogen degrada-tion products

PREPARATION OF ENANTIOMERICALLY PURE SYN-4,5-DIHYDROXY CARBOXYLIC ACID LACTONES BY MICROBIAL REDUCTION

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Chinese Chemical Letters 1991年第5期2卷 345-346页

作者： jian xin gu Zu Yi LI guo Qiang LIN Shanghai Institute of Organic Chemistry Academia Sinica 345 Lingling LuShanghai 200032

Enantiomerically pure syn-4,5-dihydroxy carboxylic acid lactones were prepared by microbial reduction of acyl lactones with resting cell of Aspergillus niger.

关键词： SYN PREPARATION OF ENANTIOMERICALLY PURE SYN-4,5-DIHYDROXY CARBOXYLIC ACID LACTONES BY MICROBIAL REDUCTION ACID

BIOTRANSFORMATION OF α-DIKETONES-SYNTHESIS OF OPTICALLY ACTIVE α-KETOLS

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Chinese Chemical Letters 1995年第6期6卷 457-458页

作者： jian xin gu Zu Yi Li guo Qiang Lin(Shanghai Institute of Organic Chemistry,Chinese Academyof Sciences,Fenglin Lu 354,Shanghai 200032) Chinese Acad Sci Shanghai Inst Organ Chem Shanghai 200032 Peoples R China

Asymmetric reduction of some α-diketones such as 1-phenyl-1,2-propanedione and substituted benzils with fungus Geotrichum sp.G38 afforded corresponding optically edhe α-ketols in excellent chemical and optical yields.

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Adversarial data splitting for domain generalization

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Science China(Information Sciences) 2024年第5期67卷 28-42页

作者： Xiang gu jian SUN Zongben XU School of Mathematics and Statistics Xi'an Jiaotong University

Domain generalization aims to learn a model that is generalizable to an unseen target domain,which is a fundamental and challenging task in machine learning for out-of-distribution generalization. This paper proposes a novel domain generalization approach that enforces the learned model to be able to generalize well over the train/val subset splitting of the training dataset. This idea is modeled herein as an adversarial data splitting framework, formulated as a min-max optimization problem inspired by the metalearning approach. The min-max optimization problem is solved by iteratively splitting the training dataset into the training and val subsets to maximize the domain shift measured by the objective function and updating the model parameters to enable the model to generalize well from the training subset to the val subset by minimizing the objective function. This adversarial training approach does not assume the known domain labels of the training data; instead, it automatically investigates the “hard” splitting of the train/val subsets to learn the generalizable model. Extensive experimental results using three benchmark datasets demonstrate the superiority of this approach. In addition, we derive a generalization error bound for the theoretical understanding of our proposed approach.

关键词： domain generalization adversarial learning data splitting meta-learning out of distribution

A Coupled Thermomechanical Crack Propagation Behavior of Brittle Materials by Peridynamic Differential Operator

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 339-361页

作者： Tianyi Li xin gu Qing Zhang College of Architectural Engineering Jiangsu Open UniversityNanjing210036China Department of Engineering Mechanics Hohai UniversityNanjing211100China

This study proposes a comprehensive,coupled thermomechanical model that replaces local spatial derivatives in classical differential thermomechanical equations with nonlocal integral forms derived from the peridynamic differential operator(PDDO),eliminating the need for calibration *** model employs a multi-rate explicit time integration scheme to handle varying time scales in multi-physics *** simulations conducted on granite and ceramic materials,this model demonstrates its *** successfully simulates thermal damage behavior in granite arising from incompatible mineral expansion and accurately calculates thermal crack propagation in ceramic slabs during *** account for material heterogeneity,the model utilizes the Shuffle algorithm andWeibull distribution,yielding results that align with numerical simulations and experimental *** coupled thermomechanical model shows great promise for analyzing intricate thermomechanical phenomena in brittle materials.

关键词： Peridynamic differential operator thermomechanical coupling heterogeneity numerical simulation

Health diagnosis of ultrahigh arch dam performance using heterogeneous spatial panel vector model

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Water Science and Engineering 2024年第2期17卷 177-186页

作者： Er-feng Zhao xin Li Chong-shi gu The National Key Laboratory of Water Disaster Prevention Hohai UniversityNanjing 210098China NationalEngineering Research Centerof Water Resources Eficient Utilization and Engineering Safety Hohai UniversityNanjing 20098China

Currently,more than ten ultrahigh arch dams have been constructed or are being constructed in *** control is essential to long-term operation of these *** study employed the flexibility coefficient and plastic complementary energy norm to assess the structural safety of arch dams.A comprehensive analysis was conducted,focusing on differences among conventional methods in characterizing the structural behavior of the Xiaowan arch dam in ***,the spatiotemporal characteristics of the measured performance of the Xiaowan dam were explored,including periodicity,convergence,and time-effect *** findings revealed the governing mechanism of main ***,a heterogeneous spatial panel vector model was developed,considering both common factors and specific factors affecting the safety and performance of arch *** model aims to comprehensively illustrate spatial heterogeneity between the entire structure and local regions,introducing a specific effect quantity to characterize local deformation ***,the proposed model was applied to the Xiaowan arch dam,accurately quantifying the spatiotemporal heterogeneity of dam ***,the spatiotemporal distri-bution characteristics of environmental load effects on different parts of the dam were reasonably *** of the model prediction enhances its credibility,leading to the formulation of health diagnosis criteria for future long-term operation of the Xiaowan *** findings not only enhance the predictive ability and timely control of ultrahigh arch dams'performance but also provide a crucial basis for assessing the effectiveness of engineering treatment measures.

关键词： Ultrahigh arch dam Structural performance Deformation behavior Diagnosis criterion Panel data model

Grain refinement of 5A06 aluminum alloy welds caused by tungsten inert gas welding arc characteristics under Ar-He alternating gas supply conditions:a coupled method of water-cooled copper plate test/numerical simulation

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Journal of Iron and Steel Research International 2024年第3期31卷 767-777页

作者： Hong-bin Dai jian Miao Jia-xin Lin School of Materials Science and Engineering Harbin University of Science and TechnologyHarbin 150040HeilongjiangChina

The welding arc,as a carrier for the conversion of electrical energy to thermal energy,has a direct impact on the quality of welding by its properties and *** the tungsten inert gas(TIG)welding process under the condition of Ar-He alternating gas supply,the arc is alternately converted between Ar arc and He arc with an alternating gas supply cycle,which has obvious arc change *** FLUENT software was used to numerically simulate the characteristics of the TIG arc under the condition of alternating gas supply,and the arc temperature field,arc pressure,electric potential and current density distribution under the condition of alternating gas supply were *** with the real-time data of arc pressure measured by the water-cooled copper plate with holes,it is proved that the TIG arc has obvious dynamic characteristics under the condition of Ar-He alternating gas *** unique dynamic TIG arc acts on the 5A06 aluminum alloy weld,causing the molten pool to stir,resulting in uniform microstructure and grain refinement at the weld,and thereby improving the mechanical properties of the welded joint.

关键词： Alternating gas supply Grain refinement Numerical simulation Tungsten argon arc morphology Microstructure Mechanical property

Experimental Investigation on Vertical Hydraulic Transport of Ores in Deepsea Mining

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China Ocean Engineering 2024年第1期38卷 42-53页

作者： LIU Lei LIU jian-cheng LI xin XU Li-xin ZHANG Xiu-zhan State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Sanya Yazhou Bay Institution of Deep-sea Sci-Tech Shanghai Jiao Tong UniversitySanya 572000China China Merchants Marine And Offshore Research Institute Co. Ltd.Shenzhen 518067China China Merchants Deepsea Research Institute(Sanya)Co. Ltd.Sanya 572000China School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Deepsea mining has been proposed since the 1960s to alleviate the lack of resources on *** hydraulic transport of collected ores from the seabed to the sea surface is considered the most promising method for industrial *** the present study,an indoor model test of the vertical hydraulic transport of particles was conducted.A noncontact optical method has been proposed to measure the local characteristics of the particles inside a vertical pipe,including the local concentration and particle *** hydraulic gradient of ore transport was evaluated with various particle size distributions,particle densities,feeding concentrations and mixture flow *** transport,the local concentration is larger than the feeding concentration,whereas the particle velocity is less than the mixture *** qualitative effects of the local concentration and local fluid velocity on the particle velocity and slip velocity were *** local fluid velocity contributes significantly to particle velocity and slip velocity,whereas the effect of the local concentration is marginal.A higher feeding concentration and mixture flow velocity result in an increased hydraulic *** effect of the particle size gradation is slight,whereas the particle density plays a crucial role in the transport.

关键词： deepsea mining vertical hydraulic transport experiment flow characteristics

Hemorrhagic cystitis in gastric cancer after nanoparticle albuminbound paclitaxel:A case report

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1084-1090页

作者： xin-Jie Zhang jian Lou Department of Cancer Center The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND The advanced first-line regimen for advanced gastric cancer is based on a combination of fluoropyrimidine and platinum and/or paclitaxel(PTX),forming a two-or three-drug *** to conventional PTX,nanoparticle albumin-bound PTX(Nab-PTX)has better therapeutic effects and fewer adverse effects reported in ***-PTX is a great option for patients presenting with advanced gastric ***,we highlight an adverse event(hemorrhagic cystitis)of Nab-PTX in advanced gastric *** SUMMARY A 55-year-old male was diagnosed with lymph node metastasis after a laparo-scopic-assisted radical gastrectomy for gastric cancer that was treated by Nab-PTX and S-1(AS).On the 15th day after treatment with AS,he was diagnosed with hemorrhagic *** Physicians should be aware that hemorrhagic cystitis is a potential adverse event associated with Nab-PTX treatment.

关键词： Nanoparticle albumin-bound paclitaxel Hemorrhagic cystitis Gastric cancer Adverse event Case report