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Chinese Chemical Letters 2011年第9期22卷 1036-1038页

作者： xin jian song Yu Shao xing Gao Dong Key Laboratory of Biological Resources Protection and Utilization of Hubei Province Hubei University for Nationalities Enshi 445000 China Medical School Hubei University for Nationalities Enshi 445000 China

A facile microwave-assisted procedure for synthesis of novel fluorinated pyrazolo[3,4-d]pyrimidine derivatives containing 1,3,4-thiadiazole is described. This protocol presented such advantages as short reaction time, high yields, simple purification and environmentally benign procedures. Their antitumor activities were evaluated against HL-60 by an MTT assay. The preliminary results indicated that some title compounds exhibit more potent antitumor inhibitory activity than doxorubicin （DOX）.

关键词： Pyrazolo[3,4-d]pyrimidine 1,3,4-Thiadiazole Microwave-assisted synthesis Antitumor activity

Synthesis and Bioactivity of Novel Fluorinated Heteroaromatic Ureas

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Chinese Chemical Letters 2006年第11期17卷 1443-1446页

作者： xin jian song Xiao Hong TAN Yan Gang WANG School of Chemical ＆ Environmental Engineering Hubei Institute for Nationalities Enshi 445000 CollegeofChemistryl Central China Normal University Wuhan 430079

In order to find new urea cytokinins, a series of novel fluorinated heteroaromatic ureas have been designed and synthesized, The crystal structure of 3g was further determined by single crystal X-ray diffraction to obtain the structural feature of this class of urea compounds. The preliminary bioassay showed that some title compounds have good cytokinin activity.

关键词： Fluorinated compound heteroaromatic urea synthesis crystal structure cytokinin activity.

Location of Caspase 3-like Protease in the Development of Sieve Element and Tracheary Element of Stem in Cucurbita moschata

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Journal of Integrative Plant Biology 2008年第12期50卷 1499-1507页

作者： Xia Hao Jie Qian Shan Xu xin song jian Zhu School of Life Science and Technology Tongji University Shanghai 200092 China

The casepase is considered to regulate the process of programmed cell death in the development of organisms. In this study, caspase 3-like protease was detected by immunohistochemistry and immunoelectron microscopy during the development of sieve element and tracheary element of stem in Cucurbita moschata Duch. Antibody with brown color （under light microscopy） and gold particles （under transmission electron microscopy） for detecting caspase 3-like protease was mainly displayed in inner phloem, external phloem and xylem in the region close to procambium. From the results it was considered that caspase 3-like protease did exist in vascular elements and played different roles during the development of sieve and tracheary elements, and different types of programmed cell death might be carried out. The caspase 3-like protease mainly participated in making cytoplasmic streaming cease and in degrading P-protein bodies; however, it rarely participated in the function for signal transferring in the developmental sieve element. However, it might induce calcium accumulation for rupturing the tonoplast in the signal of PCD in the developmental tracheary element.

关键词： caspase 3-like protease Cucurbita moschata immunoelectron microscopy P-protein bodies programmed cell death.

A nanosilica/exfoliated graphene composite film-modified electrode for sensitive detection of methyl parathion

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Chinese Chemical Letters 2016年第9期27卷 1541-1546页

作者： Ju Fu Xiao-Hong Tan Yao-Hua Li xin-jian song Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province Hubei University for Nationalities School of Chemical and Environmental Engineering Hubei University for Nationalities

Graphene nanosheets （GS） were easily prepared through liquid-phase exfoliation of graphite powder in N,N-dimethylformamide （DMF） with the assistance of sodium citrate. Then, GS was coated onto a glassy carbon electrode （GCE） surface by drop to fabricate a GS]GCE nanointerface. Subsequently, by using tetraethylorthosilicate sol as precursor, nanosilica was electrochemically deposited onto the GS]GCE surface to produce a nanocomposite film electrode （nanosilicaJGSJGCE）. Electrochemical behaviors of methyl parathion （MP） on the nanosilica/GS/GCE surface were investigated thoroughly. It was found that the nanosilicaJGS nanocomposites can improve the redox peak currents of MP significantly due to the synergetic effect. The oxidation peak current was linearly related to MP concentration in the range from 0.0005 μmol/L to 5.6 μmol/L. The detection limit was calculated to be 0.07 nmol/L （SJN = 3）. The developed method was used to determine MP in real samples. The recoveries were in the range from 95.4% to 104.2%, demonstrating satisfactory results.

关键词： Exfoliated graphene Nanosilica Modified electrodes Methyl parathion Electrochemical sensor

Facile synthesis of novel fluorinated thieno[2,3-d]pyrimidine derivatives containing 1,3,4-thiadiazole

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Chinese Chemical Letters 2012年第5期23卷 549-552页

作者： xin jian song Zheng Chao Duan Yu Shao xing Gao Dong Key Laboratory of Biological Resources Protection and Utilization of Hubei Province Hubei University for NationalitiesEnshi 445000China Medical School Hubei University for NationalitiesEnshi 445000China

A series of novel fluorinated thieno[2,3-d]pyrimidine derivatives incorporating 1,3,4-thiadiazole were synthesized by a facile microwave-assisted procedure,including the cyclization of 2-aminothiophene-3-carbonitrile with trifluoroacetic acid,chlorination and nucleophilic substitution *** protocol offered such advantages as mild reaction conditions,short reaction time, simple puritication and good *** structures of the products were characterized by ~1H NMR,MS,elemental analysis and Xray diffraction.

关键词： Thieno[2.3-d]pyrimidine 1 3 4-Thiadiazole Trifluoromethyl Microwave-assisted synthesis

Clinical Characteristics,Diagnosis,and Therapeutics of COVID-19:A Review

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Current Medical Science 2023年第6期43卷 1066-1074页

作者： Na-na XIE Wen-cong ZHANG Jia CHEN Fang-bing TIAN jian-xin song Department of Infectious Diseases Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)that suddenly emerged at the end of December 2019 and caused coronavirus disease 2019(COVID-19)continues to afflict humanity,not only seriously affecting healthcare systems but also leading to global social and economic *** of August 2022,there were approximately 580 million confirmed cases of COVID-19 and approximately 6.4 million confirmed deaths due to this *** data are sufficient to highlight the seriousness of SARS-CoV-2 *** most patients with COVID-19 present primarily with respiratory symptoms,an increasing number of extrapulmonary systemic symptoms and manifestations have been associated with *** the outbreak of COVID-19,much has been learned about the disease and its causative ***,great effort has been aimed at developing treatments and drug interventions to treat and reduce the incidence of *** this narrative review,we provide a brief overview of the epidemiology,mechanisms,clinical manifestations,diagnosis,and therapeutics of COVID-19.

关键词： coronavirus disease 2019 severe acute respiratory syndrome coronavirus 2 mechanism clinical manifestations diagnosis therapeutics

Anycast service model and its QoS routing algorithm

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Journal of Central South University 2001年第2期8卷 135-139页

作者： WANG jian xin, CHEN song qiao, CHEN jian er (College of Information Science and Engineering, Central South University, Changsha 410083, China) 1. College of Information Science and Engineering Central South University 410083 Changsha China

In the Internet, a group of replicated servers is commonly used in order to improve the scalability of network service. Anycast service is a new network service that can improve network load distribution and simplify certain applications. In this paper, the authors described a simple anycast service model in the Internet without significant affecting the routing and protocol processing infrastructure that was already in place, and proposed an anycast QoS routing algorithm for this model. The algorithm used randomized method to balance network load and improve its performance. Several new techniques are proposed in the algorithm, first, theminimum hops for each node are used in the algorithm, which are used as metric for computing the probability of possible out links. The metric is pre computed for each node in the network, which can simplify the network complexity and provide the routing process with useful information. Second, randomness is used at the link level and depends dynamically on the routing configuration. This provides great flexibility for the routing process, prevents the routing process from overusing certain fixed routing paths, and adequately balances the delay of the routing path. the authors assess the quality of QoS algorithm in terms of the acceptance ratio on anycast QoS requests, and the simulation results on a variety of network topologies and on various parameters show that the algorithm has good performances and can balance network load effectively.

关键词： QoS anycast service network routing randomized algorithm

Facile synthesis and antitumor activity of novel 2-trifluoromethylthieno[2,3-d]pyrimidine derivatives

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Chinese Chemical Letters 2014年第7期25卷 1006-1010页

作者： xin-jian song Ping Yang Hui Gao Yan Wang xing-Gao Dong Xiao-Hong Tan Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province Hubei Minzu University College of Forestry and Horticulture Hubei Minzu University

A series of novel 2-trifluoromethylthieno[2,3-d]pyrimidine derivatives were synthesized by a facile three-step procedure that afforded advantages of mild reaction conditions, simple protocol and good yields. The structures of the final compounds were confirmed by 1R, NMR, El-MS, elemental analysis, and X-ray diffraction. Preliminary bioassay results showed that some of the analogs exhibit excellent antitumor activity against MCF-7 and HepG2, especially compounds 3a, 3b, 3e and 3h exhibited higher activity than the positive control gefitinib.

关键词： Thieno[2,3-d]pyrimidine Gewald reaction Trifluoromethyl Facile synthesis Anritumor activity

Highly dispersed MgInCe-mixed metal oxides catalyzed direct carbonylation of glycerol and CO_(2)into glycerol carbonate

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Chinese Journal of Chemical Engineering 2024年第8期72卷 153-163页

作者： Xufang Chen xin Shu Yanru Zhu jian Zhang Zhigang Chai Hongyan song Zhe An Jing He State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China Quzhou Institute for Innovation in Resource Chemical Engineering Quzhou 324000China

Glycerol carbonate,an important glycerol value-added product,has been widely used as an active intermediate and inert solvent in the synthesis of cosmetics,detergents,chemical intermediates,polymers,and so *** direct carbonylation from glycerol with CO_(2)is considered a promising route,but still tough work due to the thermodynamic stability and the kinetic inertness of CO_(2).In this work,highlyselective direct carbonylation of glycerol and CO_(2)into glycerol carbonate has been achieved over highly dispersed MgInCe-mixed metal oxides(MgInCe-MMO),which were prepared through the topological transformation derived from the MgInCe-layered double hydroxides(MgInCe-LDHs).By precisely modulating the surface basic-acidic properties and the oxygen vacancies,an efficient carbonylation of glycerol with CO_(2)has been achieved with a selectivity of up to>99%to glycerol *** investigation into the synergistic catalysis of base-acid sites and oxygen vacancies has been clarified.

关键词： Catalytic reaction engineering Glycerol carbonate Direct carbonylation from glycerol Carbon dioxide Mixed metal oxides Synergistic catalysis

Rational design of Ce-doped CdS/N-rGO photocatalyst enhanced interfacial charges transfer for high effective degradation of tetracycline

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Journal of Materials Science & Technology 2024年第6期173卷 137-148页

作者： Huijie Wang Yang Wan Binrong Li jian Ye Jiahao Gan Jiejing Liu xin Liu Xianghai song Weiqiang Zhou xin Li Pengwei Huo Institute of Green Chemistry and Chemical Technology School of Chemistry&Chemical EngineeringJiangsu UniversityZhenjiang 212013China National and Local Joint Engineering Laboratory of Municipal Sewage Resource Utilization Technology School of Environmental Science and EngineeringSuzhou University of Science and TechnologySuzhou 215009China Institute of Biomass Engineering Key Laboratory of Energy Plants Resource and UtilizationMinistry of Agriculture and Rural AffairsSouth China Agricultural UniversityGuangzhou 510642China

The charge carrier separation efficiency and the adsorption capacity of the photocatalyst usually affect the degradation rate of ***,Cerium-doped leaf-like CdS(Ce-CdS)modified with ultrathin N-doped rGO(N-rGO)composites were successfully constructed(Ce-CdS/N-rGO)to investigate the removal efficiency of tetracycline(TC).X-ray photoelectron spectroscopy(XPS)and photoelectrochemical results revealed that Ce ions doped in CdS acting as the electron capture sites facilitated the interfacial charge *** calculation(DFT)results indicated that the interfacial effect between Ce-CdS and ultrathin N-rGO promoted the transfer of photogenerated electrons under the synergistic effect between the doping and interface modification *** optimized Ce5-CdS/N-rGO20 composites had the maximum TC removal capability(94.5%)and maintained a stable cycling *** addition,the adsorption-driven photocatalytic degradation pathway of TC was studied through mass spectrometry(MS)and in-situ Fourier transform infrared spectroscopy(in-situ FTIR).This study will provide an effective strategy for the construction of efficient photocatalytic composites for wastewater treatment.

关键词： Interfacial charges transfer Adsorption-driven photocatalytic degradation Synergistic effect Doping strategy Leaf-like CdS