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Acta Pharmacologica Sinica 2004年第1期 37-42页

作者： Chi WANG,Tian-hui CHANG, xin-hua zhang, huai-liang WANG Department of Clinical Pharmacology, China Medical University, Shengyang 110001, China

AIM: To study the effects of dl-praeruptorin A (Pd-Ia) on nucleus factor-κB (NF-κB) activativity and tumor necrosis factor-α(TNF-α)expression in ischemia-reperfusion (I/R) myocardium. METHODS: Langendorff’s isolated rat heart was subjected to a 10-min ischemia followed by a 30-min reperfusion. NF-κB activity in nucleus was analyzed by Sandwich Enzyme-Linked Immunosorbent Assay (ELISA). TNF-α level in cytoplasm was measured by

关键词： dl-praeruptorin A myocardial ischemia reperfusion injury nucleus factor-κB tumor necrosis factor-α

High prevalence of aspirin resistance in elderly patients with cardiovascular disease and metabolic syndrome

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Journal of Geriatric Cardiology 2016年第6期13卷 531-536页

作者： Lin LIU Ying-Hui GAO Jian CAO hua-xin zhang Li FAN Guo-Liang HU Yi-xin HU Xiao-Li LI Xiao ZOU Jian-hua LI Nanlou Respiratory Disease Department Chinese PLA General Hospital Beijing China Peking University Hepatology Institute Peking University People's Hospital Peking University Beijing China Nanlou Clinical Lab Chinese PLA General Hospital Beijing China Department of Clinical Laboratory of South Building Chinese PLA General Hospital Beijing China Clinical Department of South Building Chinese PLA General Hospital Beijing China

Background Metabolic syndrome is known to be a prothrombotic state. We undertook this study to examine a hypothesis that aspirin resistance may be associated with metabolic syndrome, and to assess other potential determinants of aspirin resistance in patients with cardiovascular disease （CVD）. Methods A total of 469 elderly patients with CVD were recruited. One hundred and seventy-two patients with metabolic syndrome and 297 without metabolic syndrome （control group） received daily aspirin therapy （〉 75 mg） over one month. Platelet aggregation was measured by light transmission aggregometry （LTA）. Aspirin resistance was defined as 〉 20% arachidonic acid （AA）- and 〉 70% adenosine diphosphate （ADP）-induced aggregation according to LTA. Aspirin semi-responders were defined as meeting one （but not both） of these criteria. Results By LTA, 38 of 469 （8.1%） patients were aspirin resistant. The prevalence of aspirin resistance was higher in the metabolic syndrome group compared with the control group [11.6 % vs. 6.6%, odds ratio （OR） = 2.039; 95% confidence interval （CI）： 1.047-3.973]. In the multivariate logistic regression analysis, metabolic syndrome （OR = 4.951, 95% CI： 1.440-17.019, P = 0.011） was a significant risk factor for aspirin resistance. Conclusions A significant number of patients with CVD and metabolic syndrome are resistant to aspirin therapy. This might further increase the risk of cardiovascular morbidity and mortality in these patients.

关键词： Aspirin resistance Cardiovascular disease Metabolic syndrome

Time Series Analysis on the Ratio for Pixels with Abnormal Brightness Temperature Increase and Its Variation Before Some Earthquakes with M_S≥5.0 in the Taiwan Region

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Earthquake Research in China 2007年第4期21卷 437-444页

作者： Liu Fang xin hua zhang Tiebao Lu Qian Ren Yuexia Earthquake Administration of Sichuan Province Chengdu 610041 China

In the study of the application of MODIS satellite remote sensing data to earthquake prediction, the paper puts forward for the first time a quantitative method to estimate the ratio for the pixels with abnormal brightness temperature (BT) increase and a preliminary scheme for cloud removal. The principle is that, firstly, the cloudless data observed by the same satellite at the same period of time but in different days (usually 1 day to 3 days) are mosaiced to get high ratio of clear sky, and then the BT variation curve and mean square difference (MSD) of each pixel are calculated with the data from the covered area to determine daily whether the BT data of the day is normal or not at a certain pixel by using double the MSD as the criterion. The ratio for the pixels with abnormal BT increase can be calculated by dividing the total number of abnormal pixels with the total pixels of the whole area. Analysis on a series of recent earthquakes in the Taiwan Region shows that the ratio for pixels with abnormal BT increase, which normally undulates around zero, has a sudden enhancement 1 day to 20 days before medium-strong earthquakes. It is expected that a new method for identifying earthquake auspice could be found through special studies in regions with frequent seismic activity by analyzing the change of the ratio for the pixels with abnormal BT increase from MODIS satellite remote sensing infrared (IR) information from which the effect of clouds has been removed to a certain extent.

关键词： MODIS Satellite thermal infrared data Ratio for pixels with abnormal BTincrease Earthquake

Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting Xiang Xiangxin xing Xuyun hua Yuwen zhang xin Xue Jiajia Wu Mouxiong Zheng He Wang Jianguang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

Congenital agenesis of seminal vesicle

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Asian Journal of Andrology 2005年第4期7卷 449-452,页

作者： Hong-Fei Wu Di Qiao Li-xin Qian Ning-Hong Song Ning-Han Feng Li-xin hua Wei zhang Department of Urology First Affiliated Hospital of Nanjing Medical University Nanjing 210029 China

Congenital agenesis of the seminal vesicle （CASV） is frequently associated with congenital absence of the vas deferens （CAVD） or ipsilateral congenital vasoureteral communication. We reported two cases of a rare condition that the vas deferens open ectopically into Mullerian duct cyst associated with agenesis of the ipsilateral seminal vesicle. The diagnosis was confirmed by vasography. Transurethral unroofing of the Mullerian duct cyst was performed in both patients with favourable results, however, assisted reproductive technology （ART） was still necessary for them to father children.

关键词： seminal vesicle vas deferens congenital abnormalities vasography

Synthesis,structures and redox properties of copper（Ⅱ） complexes of flexible tetrapyridyl ligands

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Synthesis,structures and redox properties of copper（Ⅱ） co...

TMEM16A and myocardin form a positive feedback loop that is disrupted by KLF5 during Ang Ⅱ induced vascular remodeling

中国化学会第九届全国无机化学学术会议

作者： Xian-Hong Zhu Peng Li hua-xin zhang School of Chemistry and Chemical Engineering Guangxi University Guangxi Colleges and Universities Key Laboratory of Applied Chemistry Technology and Resource Development

Copper complexes play important roles for developing functionalized materials owing to their rich properties such as catalysis,optics,and magnetism.[1,2]While the properties of complexes are associated with their composition and structures,it is important to understand how the structures are affected by some *** have prepared a series of flexible tetrapyridyl ligands tpen（N,N,N’,N’-tetrakis（2-pyridyl-methyl）ethylenediamine）,tppn（N,N,N’,N’-tetrakis（2-pyridyl-methyl）-l,3-propanediamine）and tpbn（N,N,N’,N’-tetrakis（2-pyridyl-methyl）-l,4-butanediamine）with two,three and four methylene carbons between the two nitrogen atoms,*** these ligands were used to react with copper（Ⅱ）salts,a mononuclear complex was obtained for tpen whereas dinclear complexes for tppn and *** some bidentate ligands such as 2,2’-bipyridine were added to the reaction systems,the incorporation of the bidentate ligands into the complex systems depended on the flexible *** have investigated the redox behaviors of the copper complexes in aqueous solutions and found that they were p H dependent.

关键词： copper complex crystal structure redox property

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TMEM16A and myocardin form a positive feedback loop that is ...

浅埋煤层坚硬直接顶破断诱发冲击地压机理及防治

脂质组学与脂蛋白的新功能——第十二届全国脂质与脂蛋白学术会议

作者： xin-hua zhang Bin Zheng Jin-kun Wen Department of Biochemistry and Molecular Biology Key Laboratory of Neural and Vascular BiologyMinistry of EducationHebei Medical University

TMEM16A protein is recently identified as an important component of Ca+-dependent Cl-channels(CaCCs)in vascular smooth muscle cells(VSMCs).However,the functions of TMEM16A protein and the mechanisms responsible for regulating TMEM16A gene expression in the vessels remain largely *** we showed that myocardin activated TMEM16A expression by forming a complex with SRF bound to the CArG of the TMEM16A

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煤炭学报 2017年第2期42卷 510-517页

作者：李新华张向东辽宁工程技术大学土木与交通学院辽宁阜新123000 神华新疆能源有限责任公司新疆乌鲁木齐830027

针对浅埋缓倾斜煤层坚硬直接顶下回采工作面冲击地压问题,采用微震及矿压监测方法确定了坚硬直接顶超前工作面破断的位置及顶板周期来压步距,在此基础上分析了回采工作面冲击地压的能量来源和致灾机理,建立了坚硬直接顶超前工作面破断... 详细信息

针对浅埋缓倾斜煤层坚硬直接顶下回采工作面冲击地压问题,采用微震及矿压监测方法确定了坚硬直接顶超前工作面破断的位置及顶板周期来压步距,在此基础上分析了回采工作面冲击地压的能量来源和致灾机理,建立了坚硬直接顶超前工作面破断的力学模型,推导了直接顶初次破断和周期破断的步距公式并计算得到了直接顶超前工作面的破断距离。结果表明,直接顶的周期破断步距以及破断产生的矿震能量均比基本顶周期来压步距及矿震能量小,但由于直接顶距离煤层近以及直接顶超前工作面破断位置距离煤壁过小,坚硬直接顶的周期破断引起的动载增大了工作面冲击地压危险。据此确定了在巷道进行直接顶预裂爆破以增大直接顶超前工作面煤壁破断距离的冲击地压治理措施,微震监测结果显示超前预裂爆破有效降低了工作面冲击地压危险。

关键词：坚硬直接顶冲击地压致灾机理防治

A prospective study comparing endoscopic subcutaneous mastectomy plus immediate reconstruction with implants and breast conserving surgery for breast cancer

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Chinese Medical Journal 2009年第24期122卷 2945-2950页

作者： FAN Lin-jun JIANG Jun YANG xin-hua zhang Yi LI xing-gang CHEN Xian-chun ZHONG Ling Center of Breast Disease Southwest Hospital Third Military Medical University Chongqing 400038 China

Background Breast conserving surgery （BCS） has been the standard surgical procedure for the treatment of early breast cancer. Endoscopic subcutaneous mastectomy （ESM） plus immediate reconstruction with implants is an emerging procedure. The objective of this prospective study was to evaluate the clinical outcomes of these two surgical procedures in our clinical setting. Methods From March 2004 to October 2007, 43 patients with breast cancer underwent ESM plus axillary lymph node dissection and immediate reconstruction with implants, while 54 patients underwent BCS. The clinical and pathological characteristics, surgical safety, and therapeutic effects were compared between the two groups. Results There were no significant differences in the age, clinical stage, histopathologic type of tumor, operative blood loss, postoperative drainage time, and postoperative complications between the two groups （P 〉0.05）. The postoperative complications were partial necrosis of the nipple and superficial skin flap in the ESM patients, and hydrops in the axilla and residual cavity in the BCS patients. There was no significant difference in the rate of satisfactory postoperative cosmetic outcomes between the ESM （88.4%, 38/43） and BCS （92.6%, 50/54） patients （P 〉0.05）. During follow-up of 6 months to 4 years, all patients treated with ESM were disease-free, but 3 patients who underwent BCS had metastasis or recurrence -- one of these patients died of multiple organ metastasis. Conclusions After considering the wide indications for use, high surgical safety, and favorable cosmetic outcomes, we conclude that ESM plus axillary lymph node dissection and immediate reconstruction with implants -- the new surgery of choice for breast cancer -- warrants serious consideration as the prospective next standard surgical procedure.

关键词： breast neoplasm endoscope subcutaneous mastectomy segmental mastectomy," breast implant

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HBH144混凝土搅拌站

建筑机械 2005年第7期25卷 95-96页

作者：信华章三一重工股份有限公司湖南长沙410100

HBH144混凝土搅拌站是三一重工股份有限公司与日本光洋(以下简称KYC)机械产业株式会社合作开发的具有高可靠性、高生产率的混凝土搅拌站。

关键词：混凝土搅拌站三一重工股份有限公司高可靠性合作开发株式会社机械产业高生产率