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World Journal of Hepatology 2024年第6期16卷 966-972页

作者： Tao Zeng Shu-Ru Chen Hao-Qiang liu Yu-Tian Chong xin-hua li Department of Infectious Diseases Key Laboratory of Liver Disease of Guangdong ProvinceThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Blood Transfusion The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Erythropoietic protoporphyria(EPP)is a rare genetic disorder stemming from ferrochelatase gene mutations,which leads to abnormal accumulation of protoporphyrin IX primarily in erythrocytes,skin,bone marrow and *** porphyria-related severe liver damage is rare,its consequences can be severe with limited treatment *** SUMMARY This case study highlights a successful intervention for a 35-year-old male with EPP-related liver impairment,employing a combination of red blood cell(RBC)exchange and therapeutic plasma exchange(TPE).The patient experienced significant symptom relief and a decrease in bilirubin levels following multiple PE sessions and an RBC *** The findings suggest that this combined approach holds promise for managing severe hepatic impairment in EPP.

关键词： Erythropoietic protoporphyria Red blood cell exchange Plasma exchange Delta-aminolevulinic acid Ferrochelatase Case report

Prognostic value of neutrophil-to-lymphocyte ratio in end-stage liver disease:A meta-analysis

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World Journal of Hepatology 2024年第3期16卷 477-489页

作者： Xiang-Hao Cai Yun-Ming Tang Shu-Ru Chen Jia-Hui Pang Yu-Tian Chong Hong Cao xin-hua li Department of Infectious Disease Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND The neutrophil-to-lymphocyte ratio(NLR)is commonly utilized as a prognostic indicator in end-stage liver disease(ESLD),encompassing conditions like liver failure and decompensated ***,some studies have contested the prognostic value of NLR in *** To investigate the ability of NLR to predict *** Databases,such as Embase,PubMed,Web of Science,Cochrane library,China National Knowledge Infrastructure,Weipu,and Wanfang,were comprehensively searched to identify studies published before October 2022 assessing the prognostic ability of NLR to predict mortality in patients with *** sizes were calculated using comprehensive meta-analysis software and SATAT *** A total of thirty studies involving patients with end-stage liver disease(ESLD)were included in the *** the pooled results of eight studies,it was observed that the Neutrophil-to-Lymphocyte Ratio(NLR)was significantly higher in non-survivors compared to survivors(random-effects model:standardized mean difference=1.02,95%confidence interval=0.67-1.37).Additionally,twenty-seven studies examined the associations between NLR and mortality in ESLD patients,reporting either hazard ratios(HR)or odds ratios(OR).The combined findings indicated a link between NLR and ESLD mortality(randomeffects model;univariate HR=1.07,95%CI=1.05-1.09;multivariate HR=1.07,95%CI=1.07-1.09;univariate OR=1.29,95%CI=1.18-1.39;multivariate OR=1.29,95%CI=1.09-1.49).Furthermore,subgroup and meta-regression analyses revealed regional variations in the impact of NLR on ESLD mortality,with Asian studies demonstrating a more pronounced *** Increased NLR in patients with ESLD is associated with a higher risk of mortality,particularly in Asian *** is a useful prognostic biomarker in patients with ESLD.

关键词： Neutrophil-to-lymphocyte ratio End stage liver diseases Prognosis Meta-analysis Mortality

Unsteady simulation for a high-speed train entering a tunnel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第12期12卷 957-963页

作者： xin-hua li Jian DENG Da-wei CHEN Fang-fang XIE Yao ZHENG School of Aeronautics and Astronautics Zhejiang University Hangzhou 310027 China National Engineering Laboratory for System Integration of High-Speed Train （South） CSR Qingdao Sifang Co. Ltd Qingdao 266111 China

In order to study the unsteady aerodynamics effects in railway tunnels,the 3D Reynolds average Navier-Stokes equations of a viscous compressible fluid are solved,and the two-equation k-ε model is used in the simulation of turbulence,while the dynamic grid technique is employed for moving *** focus on obtaining the changing tendencies of the aerodynamic force of the train and the aerodynamic pressures on the tunnel wall and train surface,and discovering the relationship between the velocity of the train and the intensity of the micro pressure wave at the tunnel *** is shown that the amplitudes of the pressure changes in the tunnel and on the train surface are both approximately proportional to the square of the train speed,so are the microwave and the drag of the train.

关键词： High-speed train Aerodynamics Railway tunnel Numerical analysis

Cortical bone trajectory screws in the treatment of lumbar degenerative disc disease in patients with osteoporosis

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World Journal of Clinical Cases 2022年第36期10卷 13179-13188页

作者： Song Guo Kai Zhu Mei-Jun Yan xin-hua li Jun Tan Department of Orthopedics Surgery Shanghai General HospitalShanghai Jiao Tong UniversityShanghai 200080China Department of OrthopedicsⅡ Qingdao No.8 People’s HospitalQingdao 266121Shandong ProvinceChina Department of Orthopedics United Family HealthcareShanghai 200336China

Lumbar degenerative disc disease(DDD)in the elderly population remains a global health problem,especially in patients with *** in the elderly can cause failure of internal *** bone trajectory(CBT)is an effective,safe and minimally invasive technique for the treatment of lumbar DDD in patients with *** this review,we analyzed the anatomy,biomechanics,and advantages of the CBT technique in lumbar DDD and revision ***,the clinical trials and case reports,indications,advancements and limitations of this technique were further discussed and ***,we concluded that the CBT technique can be a practical,effective and safe alternative to traditional pedicle screw fixation,especially in DDD patients with osteoporosis.

关键词： Lumbar degenerative disc diseases Cortical bone trajectory screw Anatomy Biomechanics Indications Clinical trials and case reports Advancements

cDNA cloning, prokaryotic expression and purification of rat α-synuclein

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Neuroscience Bulletin 2006年第1期22卷 29-33页

作者： xin li Yao-hua li Jun-Yan HAN Shun YU Biao CHEN Department of Neurobiology Beijing Institute of Geriatrics Xuanwu Hospital of Capital University of Medical Sciences Beijing 100053

Objective To clone the cDNA of rat α-Syn gene, investigate its prokaryotic expression and produce purified recombinant rat α-Syn protein. Methods Rat α-Syn cDNA was amplified from the rat brain total RNA by RT-PCR and was cloned into pGEX-4T-1, a prokaryotic expressing vector. The recombinant plasmid containing rat α-Syn gene was transformed into E. Coli BL21 to express a fusion protein with rat α-Syn protein tagged by glutathione-S-transferase （GST）. The fusion protein was then cleaved by thrombin during passing through the GST-agarose 4B column to release the recombinant rat α-Syn protein. The recombinant rat a-Syn protein was further purified using Superdex S200 gel filtration. Results DNA sequencing confirmed that the cloned cDNA contained 420 base pairs encoding 140 amino acids, which was identical to the reported amino acid sequence of rat α-Syn. After transformation, the recombinant plasmid pGEX-ra-Syn expressed a soluble protein that was inducible by IPTG. The purified recombinant protein was shown to be single band on SDS-PAGE, with a molecular size of around 18000, which was identical to the reported molecular size of rat α-Syn. Western blot analysis demonstrated that the recombinant protein was recognized by specific antibody against α-Syn. Conclusion The rat α-Syn gene was successfully expressed in prokaryotic expression system and highly purified rat α-Syn recombinant protein was produced.

关键词： α-synuclein rat recombinant protein purification

Microbial Activity in a Temperate Forest Soil as Affected by Elevated Atmospheric CO_2

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Pedosphere 2010年第4期20卷 427-435页

作者： ZHENG Jun-Qiang HAN Shi-Jie ZHOU Yu-Mei REN Fei-Rong xin li-hua ZHANG Yan Forestry Center Institute of Applied Ecology Chinese Academy of Sciences 72 Wenhua Road Shenyang 110016 （China）

Microorganisms play a key role in the response of soil ecosystems to the rising atmospheric carbon dioxide （CO2） as they mineralize organic matter and drive nutrient cycling. To assess the effects of elevated CO2 on soil microbial C and N immobilization and on soil enzyme activities, in years 8 （2006） and 9 （2007） of an open-top chamber experiment that begun in spring of 1999, soil was sampled in summer, and microbial biomass and enzyme activity related to the carbon （C）, nitrogen （N） and phosphorus （P） cycling were measured. Although no effects on microbial biomass C were detected, changes in microbial biomass N and metabolic activity involving C, N and P were observed under elevated CO2. Invertase and .dehydrogenase activities were significantly enhanced by different degrees of elevated CO2. Nitrifying enzyme activity was significantly （P 〈 0.01） increased in the August 2006 samples that received the elevated COs treatment, as compared to the samples that received the ambient treatment. Denitrifying enzyme activity was significantly （P 〈 0.04） decreased by elevated COs treatments in the August 2006 and June 2007 （P 〈 0.09） samples, β-N-acetylglucosaminidase activity was increased under elevated CO2 by 7% and 25% in June and August 2006, respectively, compared to those under ambient CO2. The results of June 2006 samples showed that acid phosphatase activity was significantly enhanced under elevated CO2. Overall, these results suggested that elevated CO2 might cause changes in the belowground C, N and P cycling in temperate forest soils.

关键词： CO2 enrichment microbial biomass soil carbon cycling soil nitrogen cycling

Advancements in S-scheme heterojunction materials for photocatalytic environmental remediation

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Journal of Materials Science & Technology 2024年第2期169卷 182-198页

作者： Changliang Nie Xiaohan Wang Ping Lu Yukun Zhu xin li hua Tang School of Environmental Science and Engineering State Key Laboratory of Bio-fibers and Eco-textilesQingdao UniversityQingdao266071China Institute of Biomass Engineering Key Laboratory of Energy Plants Resource and UtilizationMinistry of Agriculture and Rural AffairsSouth China Agricultural UniversityGuangzhou510642China School of Environmental Science and Engineering Shandong UniversityQingdao266237China

Recently,S-scheme heterojunctions have gained considerable attention in the field of photocatalytic environmental remediation as their potential to achieve efficient spatial charge separation coupled with strong redox ***,this review provides an overview of the current state-of-the-art in the development of S-scheme-based photocatalysts for the purification of environmental *** review first covers the fundamentals of heterogeneous photocatalysis for environmental ***,an introduction to the background,mechanism,design principles,and characterization techniques of S-scheme heterojunctions is ***,the review presents a comparison and summary of using various S-scheme photocatalysts for the removal of several target pollutants,such as bacteria,heavy metals,nitrogen oxides,antibiotics,and ***,the modification strategies of S-scheme heterojunction photocatalysts are also ***,a brief discussion of the challenges and prospects associated with S-scheme photocatalytic systems is demonstrated.

关键词： S-scheme heterojunctions Photocatalyst Pollutant Environmental remediation

Interpretation of the Standards of Basic Dataset of Chronic Diseases Behavior Risk Factor Surveillance in Adults

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Biomedical and Environmental Sciences 2024年第5期37卷 551-556页

作者： ZHAO Yan Fang ZHANG Mei WEI Wen Qiang SUN Ke xin li xin hua WANG li Min National Center for Chronic and Noncommunicable Disease Control and Prevention(NCNCD) Chinese Center for Disease Control and PreventionBeijing 100050China Cancer Hospital Chinese Academy of Medical SciencesBeijing 100021China Chinese Center for Disease Control and Prevention Beijing 102206China People's Medical Publishing House Beijing 100021China

BACKGROUND China’s Behavioral Risk Factor Surveillance System(BRFSS)originated from the World Bankfunded HealthⅦLoan Project in the 1990s,which conducted behavioral risk factor surveillance in seven cities and one province^([1]).Drawing on the World Health Organization’s(WHO)STEPwise approach to surveillance(STEPs)and the *** Risk Factor Surveillance System(BRFSS)^([2,3]).

关键词： funded Basic originated

Effect of tungsten carbide particles on microstructure and mechanical properties of Cu alloy composite bit matrix

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Journal of Iron and Steel Research International 2024年第2期31卷 519-530页

作者： Ding-qian Dong Feng-yuan He xin-hui Chen Hui li Kai-hua Shi Hui-wen Xiong xin Xiang li Zhang College of Mechanical Engineering Sichuan University of Science and EngineeringZigong643000SichuanChina State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083HunanChina Zigong Cemented Carbide Co. Ltd.Zigong643011SichuanChina Material Corrosion and Protection Key Laboratory of Sichuan Province Sichuan University of Science and EngineeringZigong643000SichuanChina

Copper alloy composite bit matrix was prepared by pressureless vacuum infiltration,using at least one of the three kinds of tungsten carbide particles,for example,irregular cast tungsten carbide,monocrystalline tungsten carbide and sintered reduced tungsten carbide *** effects of powder particle morphology,particle size and mass fraction of tungsten carbide on the microstructure and mechanical properties of copper alloy composite were investigated by means of scanning electron microscopy,X-ray diffraction and abrasive wear test in *** results show that tungsten carbide morphology and particle size have obvious effects on the mechanical properties of copper alloy *** tungsten carbide partially dissolved in the copper alloy binding phase,and layers of Cu_(0.3)W_(0.5)Ni_(0.1)Mn_(0.1)C phase with a thickness of around 8–15μm were formed on the edge of the cast tungsten *** 45%irregular crushed fine cast tungsten carbide and 15%monocrystalline cast tungsten carbide were used as the skeleton,satisfactory comprehensive performance of the reinforced copper alloy composite bit matrix was obtained,with the bending strength,impact toughness and hardness reaching 1048 MPa,4.95 J/cm^(2) and 43.6 HRC,*** main wear mechanism was that the tungsten carbide particles firstly protruded from the friction surface after the copper alloy matrix was worn,and then peeled off from the matrix when further wear occurred.

关键词： Polycrystalline diamond compact Pressureless vacuum infiltration Copper alloy composite bit matrix Microstructure characterization Abrasive wear behavior

Subgrain-assisted spontaneous grain refinement in rapid solidification of undercooled melts

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Journal of Materials Science & Technology 2024年第7期174卷 234-248页

作者： Jianbao Zhang Dongpeng hua Dexu Cui xin li Ke hua Yixuan He Haifeng Wang Yuhong Zhao State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi’an 710072China School of Materials Science and Engineering North University of ChinaTaiyuan 030051China

The grain refinement mechanism for rapid solidification of undercooled melts is still an open problem even after 60 years of on-going *** this work,rapid solidification of undercooled Ni and equi-atomic FeCoNiPd melts was studied and spontaneous grain refinement was found at both low and high *** a detailed electron backscattered diffraction analysis,subgrain-induced grain orien-tation scattering and splitting were found to occur along with the transition from coarse dendrites to fine equiaxed grains at low and high undercooling,respectively,indicating that subgrains play an im-portant role during the formation of fine equiaxed *** this basis,a compromise mechanism of subgrain-assisted spontaneous grain refinement was *** the dendrite re-melting induced thermo-mechanical process and fluid flow induced dendrite deformation occur simultaneously during the post-recalescence stage,stress accumulation would be maximum at both low and high undercooling,thus inducing dynamic recrystallization,during which the formation and rotation of subgrains make the grain orientations scattering and even ***,the grain/subgrain size of undercooled FeCoNiPd ascribing to its unique co-segregation behavior keeps almost invariable from low to high undercooling,indicating that the co-segregation strategy would be effective to inhibit grain growth after rapid solidifi-cation and would be useful in practice.

关键词： Rapid solidification Undercooling Spontaneous grain refinement Grain growth High entropy alloy