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Three-Dimensional Microstructures and Tensile Properties of Pure Iron During Equal Channel Angular Pressing

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Journal of Iron and Steel Research International 2011年第12期18卷 40-44页

作者： YANG Gang YANG Mu-xin LIU zheng-dong wang Chang Central Iron and Steel Research Institute Beijing 100081 China

Commercial pure iron billets having diameter of 60 mm and length of 180 mm were subjected to equal channel angular pressing（ECAP） at 350 ℃ for 1 to 4 passes via route *** evolutions on three planes（X,Y,Z planes） were characterized by optical microscopy and transmission electron microscopy（TEM）.It was found that after four passes an ultrafine microstructure could be formed on the X plane,but a band structure remained on the Z ***,the mechanical properties exhibited apparent dependence on the *** strength in the x and y directions was higher than that in the z *** microstructural refinement and mechanical properties were discussed in terms of experimental results.

关键词： iron ECAP UFG microstructure mechanical property

Diabetes mellitus is a risk factor of acute kidney injury in liver transplantation patients

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Hepatobiliary & Pancreatic Diseases International 2021年第3期20卷 215-221页

作者： Yu-Jia wang Jian-Hua Li Yi Guan Qiong-Hong Xie Chuan-Ming Hao zheng-xin wang Division of Nephrology Huashan HospitalFudan UniversityShanghai 200040China Division of General Surgery Huashan HospitalFudan UniversityShanghai 200040China

Background: Diabetes mellitus has become an increasing global health burden with rapid growing prevalence. Patients with diabetes have higher susceptibility to acute kidney injury(AKI). Liver transplantation(LT) predisposes the kidney to injury. However, the association between diabetes and AKI in LT patients remains unclear. Methods: We conducted a retrospective cohort study examining risk factors for AKI in patients undergone orthotopic LT. Potential risk factors including baseline estimated glomerular filtration rate(e GFR), the model for end-stage liver disease(MELD) score, diabetes, hypertension and intraoperative blood loss were screened. The primary endpoint was AKI occurrence. Multivariate logistic regression was used to analyze the association between potential risk factors and AKI. Results: A total of 291 patients undergone orthotopic LT were included in the present study. Among them, 102 patients(35.05%) developed AKI within 5 days after LT. Diabetes was identified as an independent risk factor for AKI. Patients who developed AKI had worse graft function recovery and higher mortality within 14 days after LT compared to those who did not develop AKI. AKI patients with diabetes had a significant decline of e GFR within the first postoperative year, compared with patients who did not develop AKI and who developed AKI but without diabetes. Conclusions: Diabetes is an independent risk factor for AKI after orthotopic LT. AKI is associated with delayed graft function recovery and higher mortality in short-term postoperative period. Diabetic patients who developed AKI after LT experience a faster decline of e GFR within the first year after surgery.

关键词： Acute kidney injury Liver transplantation Diabetes Renal function

Immune evasion mechanisms and therapeutic strategies in gastric cancer

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 216-229页

作者： En-Si Ma zheng-xin wang Meng-Qi Zhu Jing Zhao Department of General Surgery Huashan HospitalFudan UniversityShanghai 200040China Institute of Organ Transplantation Fudan UniversityShanghai 200040China Department of Infectious Diseases Huashan HospitalFudan UniversityShanghai 200040China Cancer Metastasis Institute Fudan UniversityShanghai 200040China

Gastric cancer(GC)is a malignancy with a high incidence and *** tumor immune microenvironment plays an important role in promoting cancer development and supports GC *** evidence shows that GC cells can exert versatile mechanisms to remodel the tumor immune microenvironment and induce immune *** this review,we systematically summarize the intricate crosstalk between GC cells and immune cells,including tumor-associated macrophages,neutrophils,myeloid-derived suppressor cells,natural killer cells,effector T cells,regulatory T cells,and B *** focus on how GC cells alter these immune cells to create an immunosuppressive microenvironment that protects GC cells from immune *** conclude by compiling the latest progression of immune checkpoint inhibitor-based immunotherapies,both alone and in combination with conventional ***-cytotoxic Tlymphocyte-associated protein 4 and anti-programmed cell death protein 1/programmed death-ligand 1 therapy alone does not provide substantial clinical benefit for GC ***,the combination of immune checkpoint inhibitors with chemotherapy or targeted therapy has promising survival advantages in refractory and advanced GC *** review provides a comprehensive understanding of the immune evasion mechanisms of GC,and highlights promising immunotherapeutic strategies.

关键词： Gastric cancer Immune evasion Immune checkpoint Immunotherapy Microenvironment

Directed Molecular Evolution of Nitrite Oxido-reductase by DNA-shuffling

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Biomedical and Environmental Sciences 2007年第2期20卷 113-118页

作者： JUN-WEN LI JIN-LAI zheng xin-WEI wang MIN JIN FU-HUAN CHAO Institute of Environment and Health 1 Dali Road Tianjin 300050 China

Objective To devellop directly molecular evolution Of nitrite oxido-reductase using DNA-shuffling technique because nitrobacteria grow extremelly slow and are unable to nitrify effectively inorganic nitrogen in wastewater treatmem. Methods The norB gene coding the ntitrite oxido-reductase in nitrobacteria was cloned and sequenced. Then, directed molecular evolution of nitrite oxido-reductase was developed by DNA-shuffling of 15 norB genes from different nitrobacteria. Results After DNA-shuffling with sexual PeR and staggered extension process PCR, the sequence was differem from its parental DNA fragmems and the homology ranged from 98% to 99%. The maximum nitrification rate of the modified bacterium of X16 by DNA-shuffling was up to 42.9 mg/L.d, which was almost 10 times higher than that of its parental bacteria. Furthermore, the modified bacterium had the same characteristics of its parental bacteria of E. coli and could grow rapidly in normal cultures. Conclusion DNA-shuffling was successfully used to engineer E. coli, which had norB gene and could degrade inorganic nitrogen effectively.

关键词： Directed evolution DNA-shuffling Nitrite oxido-reductase norB gene Nitrobacteria

Ex vivo liver resection and auto-transplantation as an alternative for the treatment of liver malignancies: Progress and challenges

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 117-122页

作者： xin Yang Lu Lu Wen-Wei Zhu Yi-Feng Tao Cong-Huan Shen Jin-Hong Chen zheng-xin wang Lun-Xiu Qin Hepatobiliary Surgery and Liver Transplantation Centers Department of General SurgeryHuashan Hospital&Cancer Metastasis InstituteFudan UniversityShanghai 200040China

Hepatectomy is still the major curative treatment for patients with liver ***,it is still a big challenge to remove the tumors in the central posterior area,especially if their location involves the retrohepatic inferior vena cava and hepatic *** vivo liver resection and auto-transplantation(ELRA),a hybrid technique of the traditional liver resection and transplantation,has brought new hope to these patients and therefore becomes a valid alternative to liver *** to its technical difficulty,ELRA is still concentrated in a few hepatobiliary centers that have experienced surgeons in both liver resection and liver *** efficacy and safety of this technique has already been demonstrated in the treatment of benign liver diseases,especially in the advanced alveolar ***,the application of ELRA for liver malignances has gained more ***,standardization of clinical practice norms and international consensus are still *** prognostic impact in these oncologic patients also needs further *** this review,we summarized the principles and recent progresses on ELRA.

关键词： Ex vivo liver resection Liver auto-transplantation Oncology Liver malignancies

Bcl-2 expression is a poor predictor for hepatocellular carcinoma prognosis of andropause-age patients

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Cancer Biology & Medicine 2016年第4期13卷 459-468页

作者： Xiao-Fei Zhang xin Yang Hu-Liang Jia Wen-Wei Zhu Lu Lu Wei Shi Hao Zhang Jin-Hong Chen Yi-Feng Tao zheng-xin wang Jun Yang Lian-xin wang Ming Lu Yan zheng Jing Zhao Qiong-Zhu Dong Lun-Xiu Qin Department of General Surgery Huashan Hospital & Cancer Metastasis Institute Fudan University Department of General Surgery Qidong Hospital Cancer Research Center Institutes of Biomedical Science Fudan University

Objective: The expression of B-cell lymphoma 2(Bcl-2) seems to be influenced by the endocrine environment. Numerous reports demonstrate the diverse expression of Bcl-2 family members under sex steroid regulation. With the exception of estrogen-related tumors, androgen-related tumors have shown their characteristics in Bcl-2 expression. In this study, the status of Bcl-2 expression in male hepatocellular carcinoma(HCC) patients was examined to verify the high incidence of HCC in ***: Tumor tissue microarray was used to examine Bcl-2 expression levels in 374 HCC cases including 306 males and 68 females. Kaplan-Meier method, log-rank test, and Cox proportional hazards model were applied to investigate the predictive value of Bcl-2 in HCC ***: Immunohistochemistry analysis showed that male patients with higher Bcl-2 levels had significantly longer median survival time and recurrence time than those with lower levels. However, no significant differences in outcomes were found between different Bcl-2 levels in female patients. When the male patients were stratified into several age points, the level of Bcl-2expression showed poorer predictive efficiency in the 45–49 and 55–60 age groups in andropause-age patients compared with other age groups. Bcl-2 was an independent prognostic factor for both overall survival(P < 0.0001) and recurrence time(P =0.0001) in male patients. After excluding male patients in the 45–60 age group, the predictive efficiency was enhanced(n = 147,OS, P = 0.0002, TTR, P < 0.0001).Conclusions: Bcl-2 expression is an independent predictor of survival and recurrence in male HCC. Bcl-2 levels may also be regulated by androgens or androgen receptors in male HCC patients. Bcl-2 levels change and exhibit poor predictive efficiency when androgen levels vary dramatically(andropause age).

关键词： Hepatocellular carcinoma andropause Bcl-2 prognosis androgen

Sinusoidal obstruction syndrome related to tacrolimus following liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2020年第3期19卷 299-302页

作者： Li Li Yue Dong Rui-Dong Li Yi-Feng Tao Cong-Huan Shen zheng-xin wang Department of General Surgery Huashan HospitalFudan University12 Middle Urumqi RoadShanghai 200040China Institute of Organ Transplantation Fudan UniversityShanghai 200040China Department of Pharmacy Huashan HospitalFudan UniversityShanghai 200040China

To the Editor:Sinusoidal obstruction syndrome(SOS),also known as venoocclusive disease,is characterized by fibrotic occlusion of small hepatic veins and congestion of sinusoids[1].This syndrome is mainly observed in hematopoietic stem cell transplantation(HSCT)and its incidence in liver transplantation(LT)ranges from 1.9%to 2.9%[2,3].Although rare,severe SOS following LT can cause liver graft dysfunction with poor prognosis[3].

关键词： Sinus obstruction liver

Successful adult-to-pediatric liver transplantation of discarded partial liver allograft with benign caudate lobe tumor

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Hepatobiliary & Pancreatic Diseases International 2023年第1期22卷 92-95页

作者： Jia-Hao Pei Cong-Huan Shen Rui-Dong Li Yi-Feng Tao Lu Lu zheng-xin wang Department of General Surgery Huashan Hospital of Fudan UniversityShanghai 200040China

To the Editor:Pediatric liver transplantation is the only treatment option for end-stage liver disease in children,and the 5-year and 20-year survival rates after living donor liver transplantation(LDLT)can reach 91.5% and 84.2%[1].Many Asian countries,including China,have begun to develop LDLT and achieved good ***,the shortage of donor livers in children remains a serious problem.

关键词： liver pediatric donor

The AGH score is a predictor of disease-free survival and targeted therapy efficacy after liver transplantation in patients with hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2023年第3期22卷 245-252页

作者： Jian-Hua Li Tuo Chen Hao xing Rui-Dong Li Cong-Huan Shen Quan-Bao Zhang Yi-Feng Tao zheng-xin wang Department of General Surgery Huashan HospitalFudan University12 Urumqi Road(M)Shanghai 200040China Department of Intensive Care Unit Huashan HospitalFudan University12 Urumqi Road(M)Shanghai 200040China

Background:Liver transplantation(LT)is the“cure”therapy for patients with hepatocellular carcinoma(HCC).However,some patients encounter HCC recurrence after ***,there is no effective methods to identify the LT patients who have high risk of HCC recurrence and would benefit from adjuvant targeted *** present study aimed to establish a scoring system to predict HCC recurrence of HCC patients after LT among the Chinese population,and to evaluate whether these patients are suitable for adjuvant targeted ***:Clinical data of HCC patients who underwent LT from March 2015 to June 2019 were retrospectively collected and ***:A total of 201 patients were included in the *** multivariate Cox analysis suggested that preoperative alpha-fetoprotein(AFP)>200μg/L(HR=2.666,95%CI:1.515-4.690;P=0.001),glutamyl transferase(GGT)>96 U/L(HR=1.807,95%CI:1.012-3.224;P=0.045),and exceeding the Hangzhou criteria(HR=2.129,95%CI:1.158-3.914;P=0.015)were independent risk factors for poor disease-free survival(DFS)in patients with HCC who underwent *** established an AFP-GGT-Hangzhou(AGH)scoring system based on these factors,and divided cases into high-,moderate-,and low-risk *** differences in overall survival(OS)and disease-free survival(DFS)rates among the three groups were significant(P<0.05).The efficacy of the AGH scoring system to predict DFS was better than that of the Hangzhou criteria,UCSF criteria,Milan criteria,and TNM *** in the high-risk group,we found that lenvatinib significantly improved prognosis compared with that of the control group(P<0.05).Conclusions:The AGH scoring system provides a convenient and effective way to predict HCC recurrence after LT in HCC patients in *** with a high-risk AGH score may benefit from lenvatinib adjuvant therapy after LT.

关键词： Liver transplantation Hepatocellular carcinoma Prognosis Adjuvant targeted therapy Predicting