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2,3-Butanediol from the leachates of pine needles induces the resistance of Panax notoginseng to the leaf pathogen Alternaria panax

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Plant Diversity 2023年第1期45卷 104-116页

作者： Tian-Yao Li Chen Ye Yi-Jie Zhang Jun-xing Zhang Min Yang Xia-Hong He xin-yue mei Yi-Xiang Liu You-Yong Zhu Hui-Chuan Huang Shu-Sheng Zhu School of Agriculture Yunnan UniversityKunming650500China State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan Agricultural UniversityKunming650201China Key Laboratory of Agro-Biodiversity and Pest Management of Education Ministry of China Yunnan Agricultural UniversityKunming650201China Southwest Forestry University Kunming650224China

Compared with the use of monocultures in the field,cultivation of medicinal herbs in forests is an effective strategy to alleviate disease.Chemical interactions between herbs and trees play an important role in disease suppression in forests.We evaluated the ability of leachates from needles of Pinus armandii to induce resistance in Panax notoginseng leaves,identified the components via gas chromatography-mass spectrometry(GC-MS),and then deciphered the mechanism of 2,3-Butanediol as the main component in the leachates responsible for resistance induction via RNA sequencing(RNA-seq).Prespraying leachates and 2,3-Butanediol onto leaves could induce the resistance of P.notoginseng to Alternaria panax.The RNA-seq results showed that prespraying 2,3-Butanediol onto leaves with or without A.panax infection upregulated the expression of large number of genes,many of which are involved in transcription factor activity and the mitogen-activated protein kinase(MAPK) signaling pathway.Specifically,2,3-Butanediol spraying resulted in jasmonic acid(JA)-mediated induced systemic resistance(ISR) by activating MYC2 and ERF1.Moreover,2,3-Butanediol induced systemic acquired resistance(SAR) by upregulating pattern-triggered immunity(PTI)-and effector-triggered immunity(ETI)-related genes and activated camalexin biosynthesis through activation of WRKY33.Overall,2,3-Butanediol from the leachates of pine needles could activate the resistance of P.notoginseng to leaf disease infection through ISR,SAR and camalexin biosynthesis.Thus,2,3-Butanediol is worth developing as a chemical inducer for agricultural production.

关键词： Pinus armandii Allelopathy Herbs Induce resistance Diversity Leaf disease

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Present situation and prospect of immunotherapy for unresectable locally advanced esophageal cancer during peri-radiotherapy

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 1-7页

作者： Feng-mei Wang Peng Mo Xue Yan xin-yue Lin Zhi-Chao Fu Department of Obstetrics and Gynecology Fuzong Clinical Medical College(900th Hospital)Fujian Medical UniversityFuzhou 350025Fujian ProvinceChina Department of Obstetrics and Gynecology Dongfang HospitalXiamen UniversityFuzhou 350025Fujian ProvinceChina Department of Radiotherapy Fuzong Clinical Medical College(900th Hospital)Fujian Medical UniversityFuzhou 350025Fujian ProvinceChina Department of Radiotherapy Dongfang HospitalXiamen UniversityFuzhou 350025Fujian ProvinceChina

Four major studies(Checkmate577,Keynote-590,Checkmate649 and Attraction-4)of locally advanced esophageal cancer published in 2020 have established the importance of immunotherapy,represented by anti-programmed death protein(PD)-1 in postoperative adjuvant treatment and advanced first-line treatment of locally advanced or advanced esophageal cancer and esophagogastric junction cancer,from the aspects of proof of concept,long-term survival,overall survival rate and progression-free survival.For unresectable or inoperable nonmetastatic esophageal cancer,concurrent radiotherapy and chemotherapy is the standard treatment recommended by various guidelines.Because its curative effect is still not ideal,it is necessary to explore radical radiotherapy and chemotherapy in the future,and it is considered to be promising to combine them with immunotherapeutic drugs such as anti-PD-1.This paper mainly discusses how to combine radical concurrent radiotherapy and chemotherapy with immunotherapy for unresectable local advanced esophageal cancer.

关键词： Esophageal carcinoma Locally advanced Radiotherapy Immunotherapy

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Contents of Phytosterols in Vegetables and Fruits Commonly Consumed in China

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Biomedical and Environmental Sciences 2008年第6期21卷 449-453页

作者： JUN-HUA HAN yue-xin YANG mei-YUAN FENG Institute of Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100050 China

Objective To quantify five specific dietary phytosterols and phytostanols in vegetables and fruits commonly consumed in China. Methods A total of 34 different kinds of vegetables and 33 kinds of fruits were chosen according to the consuming habit of Chinese people. All the samples were purchased from two shops in Beijing. The contents of phytosterols （13-sitosterol, campesterol, stigmasterol, 13-sitostanol, and campestanol） were analyzed by GLC method which was established by our laboratory, and the total phytosterols were calculated. Results The total phytosterol content in vegetables ranged 1.1-53.7 mg/100 g edible portion. The highest concentration was found in pea, cauliflower, broccoli, and romaine lettuce. The phytosterol contents in fruits ranged 1.6-32.6 mg/100 g, the highest concentration was found in navel orange, tangerine, and mango. Conclusion The phytosterol contents in vegetables and fruits are not as high as those in edible oils, but because of the large amount of consumption, they also play an important role in increasing the people＇s phytosterols intake, indicating that increased intake of vegetables and fruits with higher phytosterol contents helps increase the phytosterol intake in China.

关键词： Phytosterol Vegetables Fruits China

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TL1A Promotes Fibrogenesis in Colonic Fibroblasts via the TGF-β1/Smad3 Signaling Pathway

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Current Medical Science 2024年第3期44卷 519-528页

作者： Jia SONG Dong-lei SUN Chen-yang LI Yu-xin LUO Qian LIU yue YAO Hong ZHANG Ting-ting YANG mei SONG xin-li BAI Xiao-lan ZHANG Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesShijiazhuang050000China Department of Pediatrics The Second Hospital of Hebei Medical UniversityShijiazhuang050000China

Objective Intestinal fibrosis is a refractory complication of inflammatory bowel disease(IBD).Tumor necrosis factor ligand-related molecule-1A(TL1A)is important for IBD-related intestinal fibrosis in a dextran sodium sulfate(DSS)-induced experimental colitis model.This study aimed to explore the effects of TL1A on human colonic fibroblasts.Methods A trinitrobenzene sulfonic acid(TNBS)-induced experimental colitis model of LCK-CD2-TL1A-GFP transgenic(Tg)or wild-type(WT)mice was established to determine the effect and mechanism of TL1A on intestinal fibrosis.The human colonic fibroblast CCD-18Co cell line was treated concurrently with TL1A and human peripheral blood mononuclear cell(PBMC)supernatant.The proliferation and activation of CCD-18Co cells were detected by BrdU assays,flow cytometry,immunocytochemistry and Western blotting.Collagen metabolism was tested by Western blotting and real-time quantitative polymerase chain reaction(RT-qPCR).Results The level of collagen metabolism in the TNBS+ethyl alcohol(EtOH)/Tg group was greater than that in the TNBS+EtOH/WT group.Transforming growth factor-β1(TGF-β1)and p-Smad3 in the TNBS+EtOH/Tg group were upregulated as compared with those in the TNBS+EtOH/WT group.The proliferation of CCD-18Co cells was promoted by the addition of human PBMC supernatant supplemented with 20 ng/mL TL1A,and the addition of human PBMC supernatant and TL1A increased CCD-18Co proliferation by 24.4%at 24 h.TL1A promoted cell activation and increased the levels of COL1A2,COL3A1,and TIMP-1 in CCD-18Co cells.Treatment of CCD-18Co cells with TL1A increased the expression of TGF-β1 and p-Smad3.Conclusion TL1A promotes TGF-β1-mediated intestinal fibroblast activation,proliferation,and collagen deposition and is likely related to an increase in the TGF-β1/Smad3 signaling pathway.

关键词： tumor necrosis factor ligand-related molecule-1A fibrosis inflammatory bowel disease myofibroblasts transforming growth factor-β1

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Digital Transformation:The Impact of e-CNY on Securities Institutions and Financial Systems in China

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Proceedings of Business and Economic Studies 2024年第2期7卷 38-45页

作者： xinyue mei Shanghai University Shanghai 200444China

In recent years,the rapid advancement of emerging technologies such as big data,blockchain,and artificial intelligence has accelerated the transformation of currencies,shifting from materialization towards digitization and electronization.The e-CNY stands out as a prime example of China’s pioneering digital financial innovation globally.Governed by the central bank,it embodies the national agenda.As the e-CNY’s application field and reach expand,its relationship with the financial market grows increasingly intimate.As a significant participant in China’s financial landscape and a proactive responder to national policies,the securities industry is profoundly influenced by the e-CNY across various domains.Therefore,this paper undertakes a theoretical analysis of the e-CNY’s implementation within securities institutions,concluding that it will usher in a new paradigm for the entire financial system.

关键词： e-CNY Securities institutions Digital transformation

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Experimental study on the size effect on the equation of state of concretes under shock loading

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Defence Technology（防务技术） 2024年第3期33卷 160-167页

作者： mei Li Jian Cui Yanchao Shi Baijian Tang xin Chen Key Laboratory of Coast Civil Structural Safety of the Ministry of Education Tianjin UniversityTianjin 300072China School of Civil Engineering Suzhou University of Science and Technology1701 Binhe RoadSuzhou 215011JiangsuChina School of Civil Engineering Tianjin UniversityTianjin 300072China

Adopting the classical theory of hydrocodes,the constitutive relations of concretes are separated into an equation of state(EoS)which describes the volumetric behavior of concrete material and a strength model which depicts the shear properties of concrete.The experiments on the EoS of concrete is always challenging due to the technical difficulties and equipment limitations,especially for the specimen size effect on the EoS.Although some researchers investigate the shock properties of concretes by fly-plate impact tests,the specimens used in their tests are usually in one size.In this paper,the fly-plate impact tests on concrete specimens with different sizes are performed to investigate the size effect on the shock properties of concrete materials.The mechanical background of the size effect on the shock properties are revealed,which is related to the lateral rarefaction effect and the deviatoric stress produced in the specimen.According to the tests results,the modified EoS considering the size effect on the shock properties of concrete are proposed,which the bulk modulus of concrete is unpredicted by up to 20% if size effects are not accounted for.

关键词： Concrete Equation of state Size effect Shock wave Fly-plate impact test

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Detecting bulk and edge exceptional points in non-Hermitian systems through generalized Petermann factors

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Frontiers of physics 2024年第2期19卷 169-177页

作者： yue-Yu Zou Yao Zhou Li-mei Chen Peng Ye School of Physics State Key Laboratory of Optoelectronic Materials and Technologiesand Guangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesSun Yat-sen UniversityGuangzhou 510275China

Non-orthogonality in non-Hermitian quantum systems gives rise to tremendous exotic quantum phenomena,which can be fundamentally traced back to non-unitarity.In this paper,we introduce an interesting quantity(denoted asη)as a new variant of the Petermann factor to directly and efficiently measure non-unitarity and the associated non-Hermitian physics.By tuning the model parameters of underlying non-Hermitian systems,we find that the discontinuity of bothηand its first-order derivative(denoted as■η)pronouncedly captures rich physics that is fundamentally caused by non-unitarity.More concretely,in the 1D non-Hermitian topological systems,two mutually orthogonal edge states that are respectively localized on two boundaries become non-orthogonal in the vicinity of discontinuity ofηas a function of the model parameter,which is dubbed"edge state transition".Through theoretical analysis,we identify that the appearance of edge state transition indicates the existence of exceptional points(EPs)in topological edge states.Regarding the discontinuity of■η,we investigate a two-level non-Hermitian model and establish a connection between the points of discontinuity of■ηand EPs of bulk states.By studying this connection in more general lattice models,we find that some models have discontinuity of■η,implying the existence of EPs in bulk states.

关键词： non-Hermitian Su−Schrieffer−Heeger(SSH)model exceptional point

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Time evolutions of scalar field perturbation in Schwarzschild de-Sitter black hole from Einstein-scalar–Gauss–Bonnet theory

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Communications in Theoretical Physics 2024年第1期76卷 76-81页

作者： Cheng Xu Zhen-Hao Yang Xiao-mei Kuang Rui-Hong yue Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou225009China

The scalar-free black hole could be unstable against the scalar field perturbation when it is coupled to a Gauss–Bonnet(GB)invariant in a special form.It is known that the tachyonic instability in this scenario is triggered by the sufficiently strong GB coupling.In this paper,we focus on the time domain analysis of massive scalar field perturbation around the Schwarzschild de-Sitter black hole in Einstein-scalar–Gauss–Bonnet gravity.By analyzing the scalar field propagation,we find that the scalar field will finally grow when the GB coupling is large enough.This could lead to the instability of the background black hole.Furthermore,we demonstrate how the mass of the scalar field and the GB coupling strength affect the onset of tachyonic instability.

关键词： black hole perturbation scalar-Einstein-Gauss-Bonnet gravity time domain evolution me

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Exosomes from umbilical cord mesenchymal stromal cells promote the collagen production of fibroblasts from pelvic organ prolapse

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World Journal of Stem Cells 2024年第6期16卷 708-727页

作者： Lei-mei Xu xin-xin Yu Ning Zhang Yi-Song Chen Department of Gynecology Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200011China Department of Gynecology Shanghai Key Laboratory of Female Reproductive Endocrine-related DiseasesShanghai 200011China

BACKGROUND Pelvic organ prolapse(POP)involves pelvic organ herniation into the vagina due to pelvic floor tissue laxity,and vaginal structure is an essential factor.In POP,the vaginal walls exhibit abnormal collagen distribution and decreased fibroblast levels and functions.The intricate etiology of POP and the prohibition of trans-vaginal meshes in pelvic reconstruction surgery present challenges in targeted therapy development.Human umbilical cord mesenchymal stromal cells(hucMSCs)present limitations,but their exosomes(hucMSC-Exo)are promising therapeutic tools for promoting fibroblast proliferation and extracellular matrix remodeling.suppressed inflammation in POP group fibroblasts,stimulated primary fibroblast growth,and elevated collagen I(Col1)production in vitro.High-throughput RNA-seq of fibroblasts treated with hucMSC-Exo and miRNA sequencing of hucMSC-Exo revealed that abundant exosomal miRNAs downregulated matrix metalloproteinase 11(MMP11)expression.CONCLUSION HucMSC-Exo normalized the growth and function of primary fibroblasts from patients with POP by promoting cell growth and Col1 expression in vitro.Abundant miRNAs in hucMSC-Exo targeted and downregulated MMP11 expression.HucMSC-Exo-based therapy may be ideal for safely and effectively treating POP.

关键词： Pelvic organ prolapse Exosomes Fibroblasts Human umbilical cord mesenchymal stromal cells Extracellular matrix Collagen I

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Mechanical Properties and Electronic Structures of M(M=Ti,V,Cr,Mn and Fe)Dopedβ-Si_(3)N_(4) from First-Principle

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 639-644页

作者：龙敏黄福祥 XU Liangyu LI Xuemei YANG Zhou LENG yue mei Shini School of Materials Science and Engineering Chongqing University of TechnologyChongqing 400054China

The structures,mechanical properties and electronic structures of M metals(M=Ti,V,Cr,Mn and Fe)dopedβ-Si_(3)N_(4) were investigated by First-principles calculations within CASTEP.The calculated lattice parameters ofβ-Si_(3)N_(4) were consistent with previous date.The cohesive energy and formation enthalpy show that initialβ-Si_(3)N_(4) has the highest structural stability.The calculated elastic constant and the Voigt-Reuss-Hill approximation indicate that elastic moduli ofβ-Si_(3)N_(4) are slightly reduced by M doping.Based on Poisson’s and Pugh’s ratio,β-Si_(3)N_(4) is a ductile material and the toughness ofβ-Si_(3)N_(4) increases with M doping,and Fe doping exhibited the best toughness.The results of density of states,charge distributions and overlapping populations indicate thatβ-Si_(3)N_(4) has the strong covalent and ionic bond strength between N and Si.

关键词： first-principles β-Si_(3)N_(4) mechanical properties electronic structure

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