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Current Strategies of Surface Modifications to Polyurethane Biomaterials for Vascular Grafts

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Chinese Medical Sciences Journal 2023年第4期38卷 279-285页

作者： Huai-Gu Huang Tao Xiang yue-xin chen Department of Vascular Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Burns and Plastic Surgery Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou 563000China

As the number of patients suffering from cardiovascular diseases and peripheral vascular diseases rises,the constraints of autologous transplantation remain *** a result,artificial vascular grafts must be *** of proteins,platelets and bacteria on implants can result in stenosis,thrombus formation,and postoperative infection,which can be fatal for an ***,as a commonly used biomaterial,has been modified in various ways to deal with the adhesions of proteins,platelets,and bacteria and to stimulate endothelium *** this review,we briefly summarize the mechanisms behind adhesions,overview the current strategies of surface modifications of polyurethane biomaterials used in vascular grafts,and highlight the challenges that need to be addressed in future studies,aiming to gain a more profound understanding of how to develop artificial polyurethane vascular grafts with an enhanced implantation success rate and reduced side effect.

关键词： surface modification polyurethane vascular graft adhesion

Antiviral treatment for chronic hepatitis B: Safety, effectiveness, and prognosis

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World Journal of Clinical Cases 2019年第14期7卷 1784-1794页

作者： Ya-Li Wu cheng-Li Shen xin-yue chen International Medical Department Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Division of Surgical Oncology James Cancer HospitalThe Ohio State University Wexner Medical CenterColumbusOH 43210United States

The goal of chronic hepatitis B (CHB) therapy is to improve the patient prognosis through the sustained inhibition of viral replication. However, due to the uncertainty and potentially unlimited duration of the treatment course, nucleus(t)ide analogue (NA) resistance and safety, financial costs and patient compliance, different endpoints of antiviral treatment have been proposed in CHB prevention and treatment guidelines. Different treatment endpoints are closely associated with the safety of drug withdrawal and improvements in prognosis. Antiviral treatment suppresses HBV DNA replication, drug withdrawal leads to relapse, and long-term treatment causes drug safety and resistance issues. Although hepatitis B e antigen seroconversion based on HBV DNA inhibition is considered as “a satisfactory endpoint”, drug withdrawal still leads to high relapse rates. Hepatitis B surface antigen (HBsAg) clearance is the “ideal endpoint” in terms of the safety of drug withdrawal and improvements in prognosis. However, the HBsAg clearance rate is low using the conventional single drug treatment and fixed course regimens. Recently, the application of an “optimized antiviral treatment strategy” has improved the HBsAg clearance rate, and make an “ideal endpoint” possible. This article reviews the different antiviral treatment endpoints in terms of the safety of drug withdrawal, improvements in prognosis and relevant advances.

关键词： Chronic hepatitis B Antiviral treatment endpoint Safety Prognosis improvement Hepatitis B surface antigen clearance

Spectrum-effect relationship between HPLC fingerprints and bioactive components of Radix Hedysari on increasing the peak bone mass of rat

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Journal of Pharmaceutical Analysis 2019年第4期9卷 266-273页

作者： xin-yue chen San-Hu Gou Zhi-Qiang Shi Zhi-Yuan Xue Shi-Lan Feng School of Pharmacy Lanzhou University

The traditional Chinese medicine of Radix Hedysari plays an important role in invigorating gas for ascending, benefiting blood for promoting production of fluid, and promoting circulation for removing obstruction in collaterals, which is consistent with the principle of treatment for osteoporosis. This study is designed to investigate the bioactive components on increasing peak bone mass (PBM) by exploring the spectrum-effect relationship between chromatography fingerprints and effect. Multiple indicators are selected to evaluate the pharmacological activity. In fingerprints, 21 common peaks are obtained, five of which are identified. Furthermore, gray relational analysis (GRA) is a quantitative method of gray system theory and is used to describe the correlation degree of common peaks and pharmacological activities with relational value. 21 components are then divided into three different regions, of which ononin and calycosin play an extremely significant role in increasing PBM. In addition, factor analysis and hierarchical cluster analysis (HCA) are used to screen the optimal producing area for Radix Hedysari. This provides a comprehensive and efficient method to improve the quality evaluation of Radix Hedysari, confirming the bioactive components for PBM-enhancement and further develop its medicinal value.

关键词： Factor analysis Gray relational analysis Hierarchical cluster analysis Peak bone mass Radix Hedysari Spectrum-effect relationship

Uterine Arteriovenous Malformation:Inducedby A Cesarean Scar Pregnancy

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Journal of Reproduction and Contraception 2013年第1期24卷 55-59页

作者： Lin ZHUANG De-xin chen yue-hong YAO Department of Obstetrics and Gynecology Sichuan Provincial Hospital for Women and Children

Cesarean scar pregnancy （CSP） occurs when a gestation sac is implanted in the previous lower segment cesarean scar. The incidence of CSP is increasing worldwide. Uterine ateriovenous malformation （UA VM） is a rare gynecologic disease. Both of these diseases can cause severe vaginal bleeding and produce high morbidity rate. We describe a ease of UA VM induced by a CSP. The patient suffered intermittent vaginal bleeding after two dilatation and curettage （D＆C） one month before admission. The suspected diagnosis of CSP and UA VM were made after using transvaginal ultra- sound with color Doppler and human chorionic gonadotropin （hCG） examination. Resection of the involved area including the cesarean scar and UA VM by laparotomy was performed successfully and the diagnosis was confirmed by the last pathologic result.

关键词： cesarean scar pregnancy (CSP) ectopic pregnancy uterine arteriovenousmalformation (UAVM) mobilization cesarean section hysterectomy

NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

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Frontiers of Medicine 2010年第2期4卷 177-184页

作者： Ya-Song WU xin-yue chen Ying SHI Hao WU De-Xi chen Yu SUN Fu-Jie ZHANG Division of Treatment and Care National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Center for Infectious Diseases Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Beijing Ditan Hospital Beijing 100015China

Potent combination antiretroviral therapy(cART)has signiﬁcantly improved the life expectancy of people living with human immunodeﬁciency virus(HIV),but it has many side effects such as lipodystrophy(LD),hepatic steatosis,and lactic *** reverse transcriptase inhibitors(NRTIs)could damage the mito-chondria by inhibiting the human DNA polymerase gamma,leading to mtDNA ***,it remains uncertain whether NRTIs could induce the hypervariable region(HV)mutations of the D loop of mitochondria in Chinese HIV/AIDS patients,and whether that effect is different between individuals with and without ***,30 Chinese AIDS patients who were receiving antiretroviral drugs were recruited,among which 16 had symptomatic LD and 14 did *** samples were collected prior to and after 96 weeks of *** DNA was extracted from peripheral blood mononuclear cells(PBMCs).Fragments of 728 bp in length containing HV 2 were ampliﬁed by standard polymerase chain reaction(PCR).Direct DNA-sequencing analysis techni-ques were used to detect mitochondrial sequence variants between paired longitudinal *** were compared with the revised Cambridge Reference Sequence(rCRS)to determine mutation or *** showed that two years after ART,totally seven cases exhibited sequence variations,ﬁve individuals showed 73 A!G revised variation(two with and three without LD),while two cases of LD were found to have other nucleotide *** was no new alteration in individuals without *** conclusion,NRTIs could induce mutation of mtDNA HV 2,which might contribute to the development of LD.

关键词： nucleoside reverse transcriptase inhibitors human immunodeﬁciency virus mitochondrial DNA D loop mutation

Effects of antiviral agents and HBV genotypes on intrahepaticcovalently closed circular DNA in HBeAg-positive chronichepatitis B patients

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World Journal of Gastroenterology 2008年第8期14卷 1268-1273页

作者： Hai-Ying Lu Li-Wei Zhuang Yan-Yan Yu Chong-Wen Si Jun Li Jian-Jun Zhang Zheng Zeng xin-yue chen Zhong-Hou Han Yong chen Departnlent of Infectious Diseases Peking University First Hospital Beijing 100034 China Beijing Zhongfuyouxin Beijing 100085 China Beijing You'an Hospital Beijing 100054 China Qinhuangdao Third Hospital Qinhuangdao 066000 Hebei Province China Huai'an Infectious Disease Hospital Huai'an 223300 Jiangsu Province China

AIM： To evaluate the effects of antiviral agents and HBV genotypes on intrahepatic covalently closed circular DNA （ccc DNA） in HBeAg-positive chronic hepatitis B patients.METHODS： Seventy-one patients received lamivudine （n = 35）, or sequential therapy with lamivudine- interferon alpha 2b （IFN-α 2b, n = 24） for 48 wk, or IFN-α 2b （n = 12） for 24 wk. All subjects were followed up for 24 wk. Intrahepatic ccc DNA was measured quantitatively by PCR. HBV genotypes were analyzed by PCR-RFLP.RESULTS： Sequential lamivudine- INF-α therapy, lamivudine and INF-α monotherapy reduced ccc DNA of 1.7 log, 1.4 log and 0.8 log, respectively （P 〈 0.05）. Seventeen out of the 71 patieots developed HBeAg seroconversion, the reduction of ccc DNA in the HBeAg seroconversion patients was more significant than that in the HBeAg positive patients （3.0 log vs 1.6 log, P = 0.0407）. Twenty-four weeks after antiviral therapy withdrawal, 16 patients had a sustained virological response, the baseline intrahepatic ccc DNA in the patients with a sustained virological response was significantly lower than that in the patients with virological rebound （4.6 log vs 5.4 log, P = 0.0472）. HBV genotype C accounted for 85.9% （n = 61）, and genotype B for 14.1% （n = 10）, respectively, in the 71 patients. There was no significant difference in the change of ccc DNA level between HBV genotypes C and B （2.1 log vs 1.9 log）.CONCLUSION： Forty-eight week sequential lamivudine- INF-α therapy and lamivudine monotherapy reduce ccc DNA more significantly than 24-wk INF-α monotherapy. Low baseline intrahepatic ccc DNA level may predict the long-term efficacy of antiviral treatment. HBV genotypes C and B have no obvious influence on ccc DNA load.

关键词： Covalently closed circular DNA, Hepatitis Bvirus Sequential therapy Lamivudine Interferon

Intrahepatic HBV DNA as a predictor of antivirus treatment efficacy in HBeAg-positive chronic hepatitis B patients

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World Journal of Gastroenterology 2007年第20期13卷 2878-2882页

作者： Hai-Ying Lu Li-Wei Zhuang Yan-Yan Yu Hadad Ivan Chong-Wen Si Zheng Zeng Jun Li Dong-Ming Hou xin-yue chen Zhong-Hou Han Yong chen Department of Infectious Diseases Peking University First Hospital Beijing 100034 China Indiana University School of Medicine Indianapolis IN 46202 United States Beijing You'an Hospital Beijing 100054 China Qinhuangdao Third Hospital Qinhuangdao 066000 Hebei Province China Huai'an Infectious Disease Hospital Huai'an 223300 Jiangsu Province China

AIM： To evaluate the effect of antiviral agents on intrahepatic HBV DNA in HBeAg-positive chronic hepatitis B patients. METHODS： Seventy-one patients received treatment with lamivudine, interferon alpha （IFN-α2b） or sequential therapy with lamivudine-IFN-α2b for 48 wk. All subjects were followed up for 24 wk. Serum and intrahepatic HBV DNA were measured quantitatively by PCR. HBV genotypes were analyzed by PCR-RFLP. RESULTS： At the end of treatment, the intrahepatic HBV DNA level in 71 patients decreased from a mean of （6.1 ± 1.0） Iog10 to （4.9± 1.4） Iog10. Further, a larger decrease was seen in the intrahepatic HBV DNA level in patients with HBeAg seroconversion. Intrahepatic HBV DNA level （before and after treatment） was not significantly affected by the patients＇ HBV genotype, or by the probability of virological flare after treatment. CONCLUSION： Intrahepatic HBV DNA can be effectively lowered by antiviral agents and is a significant marker for monitoring antivirus treatment. Low intrahepatic HBV DNA level may achieve better efficacy of antivirus treatment.

关键词： Intrahepatic HBV DNA Histology Antivira therapy HBV genotype

Outcomes of Chimney and/or Periscope Techniques in the Endovascular Management of Complex Aortic Pathologies

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Chinese Medical Journal 2017年第17期130卷 2095-2100页

作者： Zhi-Yuan Wu Zuo-Guan chen Li Ma Yong-Peng Diao yue-xin chen Chang-Wei Liu yue-Hong Zheng Bao Liu Yong-Jun Li Department of Vascular Surgery Beijing Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100730 China Department of Vascular Surgery Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730 China

Background：The chimney/periscope technique has been used to address complex aortic *** study aimed to report the outcomes and experiences of chimney and/or periscope grafts （CPGs） used in the endovascular management of complex aortic ***：Twenty-two patients with complex aortic pathologies were retrospectively studied from January 2013 to August 2016 in two vascular centers of teaching *** patients were diagnosed using computed tomography angiography （CTA）.The patients were followed up at postoperative 1,3,6,and 12 months and yearly thereafter with X-ray,ultrasound,and/or ***：Twenty-two cases （17 males;mean age 60.7 ＆#177; 16.3 years） with complex aortic pathologies were *** patients underwent CPGs only,and the other three cases underwent the simultaneous implantation of chimney/periscope and fenestrated/scallop ***-six arteries were managed with forty CPGs during the *** angiographies revealed two Type Ⅰ endoleaks,one Type Ⅲ endoleak,and one Type Ⅳ *** intraoperative complications included brachial thrombosis,external iliac artery rupture,and left renal *** 30-day mortality was *** mean follow-up was 26.1 ＆#177; 10.1 months with a range of 2-39 *** the follow-up,two Type Ⅰ endoleaks and one Type Ⅳ endoleak were *** right renal stent occlusion occurred in the 5th month and turned patent after *** patients died during the follow-up,one due to an aneurysm rupture as a Type Ⅰ endoleak,and two due to myocardial *** instant technical success was 96%.The primary and secondary patencies were 92%and 96%,*** overall survival rates were 95%,84%,and 84% at 12,24,and 36 months,*** migration was not observed in any ***：Chimney/periscope techniques could be used to tackle complex aortic pathologies,but the indications must be strictly controlled,and additional experiences are required

关键词： Anetlrysm Chimney/Periscope Technique Complex Aortic Pathologies Dissection Endovascular Aortic Repair

Contrast-enhanced Ultrasound in Detecting Endoleaks with Failed Computed Tomography Angiography Diagnosis after Endovascular Abdominal Aortic Aneurysm Repair

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Chinese Medical Journal 2015年第18期128卷 2491-2497页

作者： Xiao Yang yue-xin chen Bo Zhang Yu-xin Jiang Chang-Wei Liu Rui-Na Zhao Qiong Wu Da-Ming Zhang Department of Ultrasound Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Vascular Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Radiology Peking Union Medical College Hospital ChineseAcademy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background： Endovascular aneurysnl repair （EVAR） is one of the first-line therapies of abdominal aortic aneurysms. Postoperative endoleak is the most common complication of EVAR. Computed tomography angiography （CTA）, which is routine for follow-up, has side effects （e.g., radiation） and also has a certain percentage of missed diagnosis. Preliminary studies on contrast-enhanced ultrasound （CEUS） have shown that the sensitivity of CEUS for detecting endoleak is no lower than that of CTA. To investigate the advantages of CEUS, we conducted CEUS examinations of post-EVAR cases in which CTA failed to detect endoleak or could not verify the type of endoleak. Methods： Post-EVAR patients, who were clinically considered to have endoleak and met the inclusion criteria were enrolled between March 2013 and November 2014. All of the patients underwent color Doppler flow imaging （CDFI） and a CEUS examination. Size, location, microbubble dispersion, and hemodynamic characteristics of leaks were recorded. Comparison between the diagnosis of CEUS and CDF1 was conducted using Fisher＇s exact test and clinical outcomes of all patients were followed up. Results： Sixteen patients were enrolled, and 12 （75%） had endoleaks with verified types by CEUS. Among 12 cases of endoleaks were positive by CEUS, 10 were CDFl-positive, and the four CEUS-negative cases were all negative by CDFI. The diagnostic values of CEUS and CDFI were statistically difl＇erent （P = 0,008）. Six patients with high-pressure endoleaks received endovascular re-intervention guided by CEUS results. One patient with type Ⅲ endoleak had open surgery when endovascular repair failed. Conclusions： C EUS is a new, safe, and effective means for detection ofendoleaks post-EVAR. This technique can be used as a supplement for routine CTA follow-up to provide more detailed information on endoleak and its category.

关键词： Abdominal Aortic Aneurysnl: Color Doppler Flow Imaging Contrast-enhanced Ultrasound: Endoleak EndovascularAneurysm Repair